ZNF281 knockdown induced osteogenic differentiation of human multipotent stem cells in vivo and in vitro.

abstract：:It is widely believed that human embryonic stem (huES) cells may represent a valid alternative to donor pancreata as a source of islets for transplantation. Much is known about the transcription factors whose sequential activation results in the generation of islets during pancreatic development. This knowledge has be...

journal_title：Cell transplantation

authors： Dominguez-Bendala J,Pastori RL,Ricordi C,Inverardi L

更新日期：2006-01-01 00:00:00

abstract：:Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Most experimental approaches to increase transplanted cells' engraftment involve recipient-centered deleterious methods such as partial hepatectomy or irradiation which may be unsuitable in the clinic....

journal_title：Cell transplantation

authors： Fagg WS,Liu N,Yang MJ,Cheng K,Chung E,Kim JS,Wu G,Fair J

更新日期：2017-12-01 00:00:00

abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...

journal_title：Cell transplantation

authors： Silini AR,Magatti M,Cargnoni A,Parolini O

更新日期：2017-04-13 00:00:00

abstract：:We investigated the effects of transplantation of CXCR4-overexpressing adipose tissue-derived stem cells (ADSCs) into a mouse diabetic hindlimb ischemia model on homing and engraftment as early as 48 h after transplant. CXCR4-overexpressing ADSCs were intramuscularly or intravenously injected into diabetic mice with h...

journal_title：Cell transplantation

authors： Kim M,Kim DI,Kim EK,Kim CW

更新日期：2017-02-16 00:00:00

abstract：:Porcine neonatal islet-like cell clusters (NICCs) may be an attractive source of insulin-producing tissue for xenotransplantation in type I diabetic patients. We examined the functional and immunohistochemical outcome of the islet grafts in vitro during long-term culture and in vivo after transplantation to athymic nu...

journal_title：Cell transplantation

authors： Nielsen TB,Yderstraede KB,Schrøder HD,Holst JJ,Brusgaard K,Beck-Nielsen H

更新日期：2003-01-01 00:00:00

abstract：:Pigs share many anatomical and physiological features with humans, offering a unique and viable model for biomedical research. Although porcine female germline stem cells (FGSCs) were identified in the juvenile ovary, no reports described the isolation and purification of FGSCs from the pig at sexual maturity. Here, w...

journal_title：Cell transplantation

authors： Hou L,Wang J,Li X,Wang H,Liu G,Xu B,Mei X,Hua X,Wu J

更新日期：2018-08-01 00:00:00

abstract：:Hepatocyte transplantation has been proposed as a technique for bridging patients to whole-organ transplantation, for providing metabolic support during liver failure, and for replacing whole-organ transplantation in certain metabolic liver diseases. Assessment of hepatocyte engraftment has been difficult to measure, ...

journal_title：Cell transplantation

authors： Mas VR,Maluf DG,Thompson M,Ferreira-Gonzalez A,Fisher RA

更新日期：2004-01-01 00:00:00

abstract：:The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has been reached as to what is ...

journal_title：Cell transplantation

authors： Di Vito A,Giudice A,Chiarella E,Malara N,Bennardo F,Fortunato L

更新日期：2019-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) may be of value in regeneration of renal tissue after damage; however, lack of biological knowledge and variability of results in animal models limit their utilization. We studied the effects of MSCs on podocytes in vitro and in vivo utilizing adriamycin (ADR) as a model of renal toxicity...

journal_title：Cell transplantation

authors： Magnasco A,Corselli M,Bertelli R,Ibatici A,Peresi M,Gaggero G,Cappiello V,Chiavarina B,Mattioli G,Gusmano R,Ravetti JL,Frassoni F,Ghiggeri GM

更新日期：2008-01-01 00:00:00

abstract：:The use of biomaterials has been demonstrated as a viable strategy to promote cell survival and cardiac repair. However, limitations on combinational cell-biomaterial therapies exist, as cellular behavior is influenced by the microenvironment and physical characteristics of the material. Among the different scaffolds ...

journal_title：Cell transplantation

authors： Gaetani R,Yin C,Srikumar N,Braden R,Doevendans PA,Sluijter JP,Christman KL

更新日期：2016-01-01 00:00:00

abstract：:Ten mongrel dogs were used in this study. Diabetes was chemically induced in 7 dogs, and 3 dogs served as normal controls. For each diabetic dog, 5 million human bone marrow-derived mesenchymal stem cells/kg were differentiated to form insulin-producing cells using a trichostatin-based protocol. Cells were then loaded...

journal_title：Cell transplantation

authors： Gabr MM,Zakaria MM,Refaie AF,Ismail AM,Khater SM,Ashamallah SA,Azzam MM,Ghoneim MA

更新日期：2018-06-01 00:00:00

abstract：:A new extracorporeal bioartificial liver using alginate-entrapped hepatocytes was developed and evaluated for its ability to correct the lack of bilirubin conjugation in the Gunn rat. Hepatocytes were harvested from Sprague-Dawley rats by the two-step collagenase perfusion method and then immobilized in Ca(++)-alginat...

journal_title：Cell transplantation

authors： Fremond B,Malandain C,Guyomard C,Chesne C,Guillouzo A,Campion JP

更新日期：1993-11-01 00:00:00

abstract：:Pancreatic islet transplantation is limited by shortage of donor organs. Although beta-cell lines could be used, their secretion of insulin is characteristically glucose independent and immunoisolation is required. Here we show that intrasplenic transplantation of encapsulated glucose-responsive mouse insulinoma cells...

journal_title：Cell transplantation

authors： Aoki T,Hui H,Umehara Y,LiCalzi S,Demetriou AA,Rozga J,Perfettit R

更新日期：2005-01-01 00:00:00

abstract：:Porcine islets show notoriously low insulin secretion levels in response to glucose stimulation. While this is somehow expected in the case of immature islets isolated from fetal and neonatal pigs, disappointingly low secretory responses are frequently reported in studies using in vitro-maturated fetal and neonatal is...

journal_title：Cell transplantation

authors： Mourad NI,Perota A,Xhema D,Galli C,Gianello P

更新日期：2017-05-09 00:00:00

abstract：:Diabetes affects millions of people worldwide, and β-cell replacement is one of the promising new strategies for treatment. Induced pluripotent stem cells (iPSCs) can differentiate into any cell type, including pancreatic β cells, providing a potential treatment for diabetes. However, the molecular mechanisms underlyi...

journal_title：Cell transplantation

authors： Huang Y,Wan J,Guo Y,Zhu S,Wang Y,Wang L,Guo Q,Lu Y,Wang Z

更新日期：2017-08-01 00:00:00

abstract：:A population of Hoechst 33342-stained cells, termed side population (SP) cells, can reconstitute the hematopoietic system of syngeneic mice. This study examined whether limiting numbers of SP cells can repopulate mice across a xenogeneic MHC class I barrier. SP cells were isolated from HLA.B7 and HLA.A2.1 transgenic m...

journal_title：Cell transplantation

authors： Jackson JD,Zhou G,Kuszynski CA,Cai J,Fox IJ

更新日期：2002-01-01 00:00:00

abstract：:Ischemia-reperfusion and immunosuppressive therapy are a major cause of progressive renal failure after kidney transplantation. Recent studies have shown that administration of bone marrow mesenchymal stem cells (MSCs) improves kidney functional recovery in the acute phase of post ischemia-reperfusion injury. In the ...

journal_title：Cell transplantation

authors： Alfarano C,Roubeix C,Chaaya R,Ceccaldi C,Calise D,Mias C,Cussac D,Bascands JL,Parini A

更新日期：2012-01-01 00:00:00

abstract：:In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction. Based on this finding, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n = 15) and control group (n = 15)] with middle cer...

journal_title：Cell transplantation

authors： Chen DC,Lin SZ,Fan JR,Lin CH,Lee W,Lin CC,Liu YJ,Tsai CH,Chen JC,Cho DY,Lee CC,Shyu WC

更新日期：2014-01-01 00:00:00

abstract：:Stroke is one of the most devastating diseases worldwide. In recent years, a great number of studies have focused on the effects of microRNAs (miRNAs) on stroke and the results demonstrated that the expressions of miRNAs are associated with the prognosis of stroke. In the present study, we review relevant articles reg...

journal_title：Cell transplantation

authors： Xu W,Gao L,Zheng J,Li T,Shao A,Reis C,Chen S,Zhang J

更新日期：2018-12-01 00:00:00

abstract：:Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and can be promoted by immunosuppressants. However, there is no prevention or treatment for HCC recurrence after LT. Here we describe a clinical-scale method for an adoptive immunotherapy approach that...

journal_title：Cell transplantation

authors： Ohira M,Nishida S,Tryphonopoulos P,Tekin A,Selvaggi G,Moon J,Levi D,Ricordi C,Ishiyama K,Tanaka Y,Ohdan H,Tzakis AG

更新日期：2012-01-01 00:00:00

abstract：:Intrauterine inflammation is a significant cause of injury to the developing fetal brain. Using a preterm fetal sheep model of in utero infection, we asked whether human amnion epithelial cells (hAECs) were able to reduce inflammation-induced fetal brain injury. Surgery was undertaken on pregnant sheep at ∼105 days ge...

journal_title：Cell transplantation

authors： Yawno T,Sabaretnam T,Li J,McDonald C,Lim R,Jenkin G,Wallace EM,Miller SL

更新日期：2017-04-13 00:00:00

abstract：:Mouse embryonal carcinoma cell line P19 could be differentiated to neurons or glial cells by appropriate induction. We introduced the lacZ gene driven by a calmodulin promoter into P19 cells, and cloned the transfectant CaM-Z that showed the strong expression of lacZ gene after the induction of differentiation. CaM-Z ...

journal_title：Cell transplantation

authors： Watanabe R,Takase-Yoden S,Ikeda T,Atsumi T

更新日期：1996-09-01 00:00:00

abstract：:Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Therefore, we explore...

journal_title：Cell transplantation

authors： Wege H,Chui MS,Le HT,Strom SC,Zern MA

更新日期：2003-01-01 00:00:00

abstract：:The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease. The clinical application of neural transplantation using NSC will therefo...

journal_title：Cell transplantation

authors： McLeod M,Hong M,Sen A,Sadi D,Ulalia R,Behie LA,Mendez I

更新日期：2006-01-01 00:00:00

abstract：:Prairie voles show strong pair bonding with their mating partners, and they demonstrate parental behavior toward their infants, indicating that the prairie vole is a unique animal model for analysis of molecular mechanisms of social behavior. Until a recent study, the signaling pathway of oxytocin was thought to be cr...

journal_title：Cell transplantation

authors： Katayama M,Hirayama T,Horie K,Kiyono T,Donai K,Takeda S,Nishimori K,Fukuda T

更新日期：2016-01-01 00:00:00

abstract：:Clinically, many candidates for islet transplantation are already immunized, which increases their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device has been shown to protect against allograft rejection in nonimmunized recipients. However, the capacity of the TheraCyte™ device to ...

journal_title：Cell transplantation

authors： Kumagai-Braesch M,Jacobson S,Mori H,Jia X,Takahashi T,Wernerson A,Flodström-Tullberg M,Tibell A

更新日期：2013-01-01 00:00:00

abstract：:To overcome common disadvantages of standard cultured epidermal sheet grafts (CEG) we have developed a new technique of transplanting cultured human keratinocytes suspended as single cells in a fibrin-glue matrix (Keratinocyte-fibrin-glue suspension-KFGS). In an athymic mouse model with reproducible standardized full ...

journal_title：Cell transplantation

authors： Horch RE,Bannasch H,Kopp J,Andree C,Stark GB

更新日期：1998-05-01 00:00:00

abstract：:As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their cross-talk is not y...

journal_title：Cell transplantation

authors： Gong L,Tian X,Zhou J,Dong Q,Tan Y,Lu Y,Wu J,Zhao Y,Liu X

更新日期：2019-08-01 00:00:00

abstract：:A newly developed immunosuppressant, FTY720, has a unique mechanism that is quite different from those of conventional immunosuppressants, and is presumed to be mediated through decreases in the number of peripheral lymphocytes, especially helper T cells. This study was performed to ascertain whether this innovative d...

journal_title：Cell transplantation

authors： Yamasaki T,Inoue K,Hayashi H,Gu Y,Setoyama H,Ida J,Cui W,Kawakami Y,Kogire M,Imamura M

更新日期：1998-07-01 00:00:00

abstract：:Human marrow stromal cells (hMSCs) provide functional benefit in rats subjected to stroke. Astrocytes are coupled into a cellular network via gap junction channels, predominantly composed of connexin-43 (Cx43) proteins. Astrocytes are believed to play a vital role in neuroprotection by providing energy substrates to n...

journal_title：Cell transplantation

authors： Gao Q,Katakowski M,Chen X,Li Y,Chopp M

更新日期：2005-01-01 00:00:00