Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.

abstract：:The development of cell- and gene-based strategies for regenerative medicine offers a therapeutic option for the repair and potential regeneration of damaged cardiac tissue post-myocardial infarction (MI). Human umbilical cord subepithelial cell-derived stem cells (hUC-SECs), human bone marrow-derived mesenchymal stem...

journal_title：Cell transplantation

authors： Winters AA,Bou-Ghannam S,Thorp H,Hawayek JA,Atkinson DL,Bartlett CE,Silva FJ,Hsu EW,Moreno AP,Grainger DA,Patel AN

更新日期：2016-01-01 00:00:00

abstract：:Large-scale sterile methods for isolating hepatocytes are desirable for the development of bioartificial liver support systems. In this study the traditional centrifuge method was compared with the use of a Baylor Rapid Autologous Transfusion (BRAT) machine for isolating large quantities of porcine hepatocytes. After ...

journal_title：Cell transplantation

authors： Nieuwoudt MJ,Kreft E,Olivier B,Malfeld S,Vosloo J,Stegman F,Kunneke R,Van Wyk AJ,Van der Merwe SW

更新日期：2005-01-01 00:00:00

abstract：:To overcome common disadvantages of standard cultured epidermal sheet grafts (CEG) we have developed a new technique of transplanting cultured human keratinocytes suspended as single cells in a fibrin-glue matrix (Keratinocyte-fibrin-glue suspension-KFGS). In an athymic mouse model with reproducible standardized full ...

journal_title：Cell transplantation

authors： Horch RE,Bannasch H,Kopp J,Andree C,Stark GB

更新日期：1998-05-01 00:00:00

abstract：:Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect of DOR activation on autophagy...

journal_title：Cell transplantation

authors： Wang S,Cao X,Duan Y,Zhang G

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer disease (AD) is a progressive neurodegenerative disease, which is characterized by loss of memory and cognitive function. In AD patients dysfunction of the cholinergic system is the main cause of cognitive disorders, and decreased activity of choline acetyltransferase (ChAT), an enzyme responsible for acety...

journal_title：Cell transplantation

authors： Park D,Joo SS,Kim TK,Lee SH,Kang H,Lee HJ,Lim I,Matsuo A,Tooyama I,Kim YB,Kim SU

更新日期：2012-01-01 00:00:00

abstract：:After a unilateral striatal lesion, animals have generally been seen to have a bilateral impairment in paw reaching, with the contralateral paw being more affected. However, most studies to date have not used a pretraining paradigm to assess maximal capacity for paw reaching, to compare with any lesion-induced loss. T...

journal_title：Cell transplantation

authors： Fricker-Gates RA,Smith R,Muhith J,Dunnett SB

更新日期：2003-01-01 00:00:00

abstract：:Early graft loss in islet transplantation means that a large amount of donor islets is required. Endothelial cells and endothelial colony-forming cells (ECFCs) have been reported to improve instant blood-mediated inflammatory reaction (IBMIR) in vitro. In this study, we examined if ECFC-coated porcine islets would pre...

journal_title：Cell transplantation

authors： Jung HS,Kim MJ,Hong SH,Lee YJ,Kang S,Lee H,Chung SS,Park JS,Park KS

更新日期：2014-03-01 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are highly prevalent in young men aged 20-40 years and are one of the most common lethal solid tumors in men of this age. Due to the current unclear mechanism of tumor development, there is a lack of effective treatment, and therefore in-depth research of the molecular mechanism of ...

journal_title：Cell transplantation

authors： Luo Y,Sun Y,Li L,Mao Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease (RVD) complicated by metabolic syndrome (MetS), we tested ...

journal_title：Cell transplantation

authors： Eirin A,Zhu XY,Jonnada S,Lerman A,van Wijnen AJ,Lerman LO

更新日期：2018-07-01 00:00:00

abstract：:Cell therapy is a promising treatment modality to improve heart function in acute myocardial infarction. However, the mechanisms of action and the most suitable cell type have not been finally determined. We performed a study to compare the effects of mesenchymal stem cells (MSCs) harvested from different tissues on ...

journal_title：Cell transplantation

authors： Otto Beitnes J,Oie E,Shahdadfar A,Karlsen T,Müller RM,Aakhus S,Reinholt FP,Brinchmann JE

更新日期：2012-01-01 00:00:00

abstract：:The clinical consequences of acute liver failure are associated with high mortality. Intensive medical intervention is required to treat the symptoms of liver failure, including coagulopathy, metabolic instability, and encephalopathy. Providing temporary liver support with an extracorporeal liver assist device could s...

journal_title：Cell transplantation

authors： Gregory PG,Connolly CK,Toner M,Sullivan SJ

更新日期：2000-01-01 00:00:00

abstract：:Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently...

journal_title：Cell transplantation

authors： Díaz D,Recio JS,Weruaga E,Alonso JR

更新日期：2012-01-01 00:00:00

abstract：:In order to fully characterize and determine the therapeutic potential of adult neural progenitor cells (NPCs), it is important to be able to isolate and study NPCs from animals such as rats, in which there are existing models of brain injury and disease. The focus of this study was to characterize the cultivation, di...

journal_title：Cell transplantation

authors： Chen K,Hughes SM,Connor B

更新日期：2007-01-01 00:00:00

abstract：:Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Therefore, we explore...

journal_title：Cell transplantation

authors： Wege H,Chui MS,Le HT,Strom SC,Zern MA

更新日期：2003-01-01 00:00:00

abstract：:Islet-like cell clusters generated from human fetal pancreases between 18-24 wk gestation were able to grow and mature both morphologically and functionally after transplantation under the kidney capsule of athymic nude mice. Grafted tissue, predominantly ductal in appearance was unresponsive to glucose 2 wk after gra...

journal_title：Cell transplantation

authors： Beattie GM,Butler C,Hayek A

更新日期：1994-09-01 00:00:00

abstract：:Ischemic stroke remains a serious threat to human life. There are limited effective therapies for the treatment of stroke. We have previously demonstrated that angiogenesis and neurogenesis in the brain play an important role in functional recovery following ischemic stroke. Recent studies indicate that increased arte...

journal_title：Cell transplantation

authors： Wei ZZ,Chen D,Liu LP,Gu X,Zhong W,Zhang YB,Wang Y,Yu SP,Wei L

更新日期：2018-04-01 00:00:00

abstract：:Bisphosphonates (BPs) are widely used to treat several metabolic and oncological diseases affecting the skeletal system. Despite BPs' well-known therapeutic potential, they also displayed important side effects, among which is BPs-related osteonecrosis of the jaw, by targeting osteoclast activities, osteoblast, and os...

journal_title：Cell transplantation

authors： Di Vito A,Chiarella E,Baudi F,Scardamaglia P,Antonelli A,Giudice D,Barni T,Fortunato L,Giudice A

更新日期：2020-01-01 00:00:00

abstract：:Somatic stem cells can be isolated from a variety of sources. Although some studies have suggested that somatic stem cells may represent a cell population that is very similar to embryonic stem (ES) cells, it remains unclear whether somatic stem cells retain the potential to differentiate into any cell type derived fr...

journal_title：Cell transplantation

authors： Oishi K,Noguchi H,Yukawa H,Hayashi S

更新日期：2009-01-01 00:00:00

abstract：:Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In the present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis in vivo. To explore the mechanisms, the character...

journal_title：Cell transplantation

authors： Ma F,Chen D,Chen F,Chi Y,Han Z,Feng X,Li X,Han Z

更新日期：2015-01-01 00:00:00

abstract：:Islet transplantation as a therapy or cure for type 1 diabetes has significant promise but has been limited by islet mass requirements and long-term graft failure. The intrahepatic and intravascular site may be responsible for significant loss of transplanted islets. Nonencapsulating biomaterial scaffolds provide a st...

journal_title：Cell transplantation

authors： Gibly RF,Zhang X,Lowe WL Jr,Shea LD

更新日期：2013-01-01 00:00:00

abstract：:In Alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. The fimbria-fornix aspiration is a well-known animal model mimicking hippocampal cholinergic deficiency. The aim of the present study was to use in vivo lipid-mediated gene transfer to introduce an expression vector ...

journal_title：Cell transplantation

authors： Weis C,Kaufmann WA,Humpel C

更新日期：2001-01-01 00:00:00

abstract：:There is conflicting evidence favoring both the use of human serum (HS) and of human serum albumin (HSA) in human islet culture. We evaluated the effects of HS versus HSA supplementation on 1) in vitro β-cell viability and function and 2) in vivo islet graft revascularization, islet viability, β-cell death, and metabo...

journal_title：Cell transplantation

authors： Nacher M,Estil Les E,Garcia A,Nadal B,Pairó M,Garcia C,Secanella L,Novials A,Montanya E

更新日期：2016-01-01 00:00:00

abstract：:Cell-based therapy for the bladder has its beginnings in the 1990s with the successful isolation and culture of bladder smooth muscle cells. Since then, several attempts have been made to artificially implant native cell types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or ...

journal_title：Cell transplantation

authors： Gopinath C,Ponsaerts P,Wyndaele JJ

更新日期：2015-01-01 00:00:00

abstract：:Prognosis of patients with heart failure remains poor despite improved conventional and interventional treatment regimens. The improvement of neovascularization and repair processes by administration of bone marrow-derived cells modestly improved the recovery after acute myocardial infarction. However, circulating pat...

journal_title：Cell transplantation

authors： Honold J,Fischer-Rasokat U,Lehmann R,Leistner DM,Seeger FH,Schachinger V,Martin H,Dimmeler S,Zeiher AM,Assmus B

更新日期：2012-01-01 00:00:00

abstract：:Hepatocyte transplantation and artificial organ hepatic support require a number of functionally mature hepatocytes. However, their growth activity and functional behaviors are much smaller in culture after isolation from the liver. We examined whether continuously differentiating hepatocytes from multipotent hepatic ...

journal_title：Cell transplantation

authors： Suzuki A,Nakauchi H,Taniguchi H

更新日期：2003-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous trans...

journal_title：Cell transplantation

authors： Furlani D,Li W,Pittermann E,Klopsch C,Wang L,Knopp A,Jungebluth P,Thedinga E,Havenstein C,Westien I,Ugurlucan M,Li RK,Ma N,Steinhoff G

更新日期：2009-01-01 00:00:00

abstract：:Tissue damage by ischemia/reperfusion (I/R) results from a temporary cessation of blood flow followed by the restoration of circulation. The injury depresses mitochondrial respiration, increases the production of reactive oxygen species (ROS), decreases the mitochondrial transmembrane potential, and stimulates invasio...

journal_title：Cell transplantation

authors： Beiral HJ,Rodrigues-Ferreira C,Fernandes AM,Gonsalez SR,Mortari NC,Takiya CM,Sorenson MM,Figueiredo-Freitas C,Galina A,Vieyra A

更新日期：2014-02-01 00:00:00

abstract：:Hepatocyte transplantation is dependent on the availability of good quality human hepatocytes isolated from donor liver tissue. Hepatocytes obtained from livers rejected for transplantation on the grounds of steatosis are often of low viability and not suitable for clinical use. The aim of this study was to evaluate t...

journal_title：Cell transplantation

authors： Sagias FG,Mitry RR,Hughes RD,Lehec SC,Patel AG,Rela M,Mieli-Vergani G,Heaton ND,Dhawan A

更新日期：2010-01-01 00:00:00

abstract：:Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is a critical regulator for energy metabolism and proven to have antiapoptotic effects. This study aimed to investigate the neuroprote...

journal_title：Cell transplantation

authors： Gao L,Wang C,Qin B,Li T,Xu W,Lenahan C,Ying G,Li J,Zhao T,Zhu Y,Chen G

更新日期：2020-01-01 00:00:00

abstract：:The human neuronal cell-1 (HCN-1) line has recently been established. Under favorable conditions, these cells differentiate into mature neuronal phenotypes. Here we report on further characterization of these cells. Cultured HCN-1 cells express fibronectin immunoreactivity and grow well on fibronectin substrate but do...

journal_title：Cell transplantation

authors： Poltorak M,Isono M,Freed WJ,Ronnett GV,Snyder SH

更新日期：1992-01-01 00:00:00