Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function.

abstract：:This study aimed to identify the beneficial effects of adipose tissue-derived mesenchymal stem cells (ASCs) and ASCs that overexpress the CTLA4Ig gene (CTLA4Ig-ASCs) on established autoimmune thyroiditis and to examine changes in clinical chemistry parameters and the presence of humoral responses upon repeated long-te...

journal_title：Cell transplantation

authors： Choi EW,Lee JM,Lee HW,Yang J,Youn HY

更新日期：2015-01-01 00:00:00

abstract：:Transplantation therapies aimed at repairing neurodegenerative and neuropathological conditions of the central nervous system (CNS) have utilized and tested a variety of cell candidates, each with its own unique set of advantages and disadvantages. The use and popularity of each cell type is guided by a number of fact...

journal_title：Cell transplantation

authors： Kramer AS,Harvey AR,Plant GW,Hodgetts SI

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to define pretransplant islet culture conditions for optimum tissue engraftment in the rat islet allotransplantation model. Lewis rat islets were cultured in TCM 199/5% fetal calf serum for I day at 37 degrees C, followed by 1 day of culture at 22 degrees C. When islets from single dono...

journal_title：Cell transplantation

authors： Jahr H,Hussmann B,Eckhardt T,Bretzel RG

更新日期：2002-01-01 00:00:00

abstract：:The clinical consequences of acute liver failure are associated with high mortality. Intensive medical intervention is required to treat the symptoms of liver failure, including coagulopathy, metabolic instability, and encephalopathy. Providing temporary liver support with an extracorporeal liver assist device could s...

journal_title：Cell transplantation

authors： Gregory PG,Connolly CK,Toner M,Sullivan SJ

更新日期：2000-01-01 00:00:00

abstract：:Changes in morphology, metabolism, myosin heavy chain gene expression, and functional performances in damaged rabbit muscles with or without transplantation of primary satellite cells were investigated. For this purpose, we damaged bilaterally the fast muscle tibialis anterior (TA) with either 1.5 or 2.6 ml cardiotoxi...

journal_title：Cell transplantation

authors： Boubaker el Andalousi R,Daussin PA,Micallef JP,Roux C,Nougues J,Chammas M,Reyne Y,Bacou F

更新日期：2002-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing–remitting MS (RRMS) while t...

journal_title：Cell transplantation

authors： Cobo M,Anderson P,Benabdellah K,Toscano MG,Muñoz P,García-Pérez A,Gutierrez I,Delgado M,Martin F

更新日期：2013-01-01 00:00:00

abstract：:A population of Hoechst 33342-stained cells, termed side population (SP) cells, can reconstitute the hematopoietic system of syngeneic mice. This study examined whether limiting numbers of SP cells can repopulate mice across a xenogeneic MHC class I barrier. SP cells were isolated from HLA.B7 and HLA.A2.1 transgenic m...

journal_title：Cell transplantation

authors： Jackson JD,Zhou G,Kuszynski CA,Cai J,Fox IJ

更新日期：2002-01-01 00:00:00

abstract：:During in vivo intracerebral infusions, the ability to perform accurate targeting towards a 3D-specific point allows control of the anatomical variable and identification of the effects of variations in other factors. Intraoperative MRI navigation systems are currently being used in the clinic, yet their use in nonhum...

journal_title：Cell transplantation

authors： Emborg ME,Joers V,Fisher R,Brunner K,Carter V,Ross C,Raghavan R,Brady M,Raschke J,Kubota K,Alexander A

更新日期：2010-01-01 00:00:00

abstract：:Critical length nerve defects in the rat sciatic nerve model were reconstructed with chitosan nerve guides filled with Schwann cells (SCs) containing hydrogel. The transplanted SCs were naive or had been genetically modified to overexpress neurotrophic factors, thus providing a cellular neurotrophic factor delivery sy...

journal_title：Cell transplantation

authors： Meyer C,Wrobel S,Raimondo S,Rochkind S,Heimann C,Shahar A,Ziv-Polat O,Geuna S,Grothe C,Haastert-Talini K

更新日期：2016-01-01 00:00:00

abstract：:Articular cartilage is an avascular tissue composed of chondrocytes, a unique cell type responsible for abundant matrix synthesis and maintenance. When damaged, it never heals spontaneously under physiological circumstances. Therefore, the delivery of mesenchymal stem cells using hydrogel has been considered for cart...

journal_title：Cell transplantation

authors： Merceron C,Portron S,Masson M,Lesoeur J,Fellah BH,Gauthier O,Geffroy O,Weiss P,Guicheux J,Vinatier C

更新日期：2011-01-01 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:The anatomical specificity of axon growth from fetal pig septal xenografts was studied by transplanting septal cells from E30-35 pig fetuses into cholinergic deafferented (192-IgG-saporin-infused) rats or into aged rats (> 18 months). Cell suspensions (100,000 cells/microl) were injected bilaterally into the dorsal an...

journal_title：Cell transplantation

authors： Deacon T,Whatley B,LeBlanc C,Lin L,Isacson O

更新日期：1999-01-01 00:00:00

abstract：:The choice of enzyme blend is critical for successful islet isolation. Islet yield, viability, integrity, and function are important factors that influence the outcome of islet transplantation. Liberase HI has been used as a standard enzyme for pancreas digestion and has successfully produced islets that reversed dia...

journal_title：Cell transplantation

authors： Iglesias I,Valiente L,Shiang KD,Ichii H,Kandeel F,Al-Abdullah IH

更新日期：2012-01-01 00:00:00

abstract：:Persistent corneal wounds result from numerous eye disorders, and to date, available treatments often fail to accelerate reepithelialization, the key initial step in wound healing. To speed reepithelialization, we explored a cell-transfer transplant method utilizing polydimethylsiloxane (PDMS) contact lenses to delive...

journal_title：Cell transplantation

authors： Pino CJ,Haselton FR,Chang MS

更新日期：2005-01-01 00:00:00

abstract：:Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have confirmed these findings but have not determined whether physical contact between MSC and islets is required or whether th...

journal_title：Cell transplantation

authors： Brandhorst H,Brandhorst D,Abraham A,Acreman S,Schive SW,Scholz H,Johnson PRV

更新日期：2020-01-01 00:00:00

abstract：:The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for the treatment of cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including the ability to undergo ...

journal_title：Cell transplantation

authors： Scuderi N,Ceccarelli S,Onesti MG,Fioramonti P,Guidi C,Romano F,Frati L,Angeloni A,Marchese C

更新日期：2013-01-01 00:00:00

abstract：:The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW)...

journal_title：Cell transplantation

authors： Nuryyev RL,Uhlendorf TL,Tierney W,Zatikyan S,Kopyov O,Kopyov A,Ochoa J,Van Trigt W,Malone CS,Cohen RW

更新日期：2017-11-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous trans...

journal_title：Cell transplantation

authors： Furlani D,Li W,Pittermann E,Klopsch C,Wang L,Knopp A,Jungebluth P,Thedinga E,Havenstein C,Westien I,Ugurlucan M,Li RK,Ma N,Steinhoff G

更新日期：2009-01-01 00:00:00

abstract：:International standards for stem cell treatment of neurological disorders have not yet been established. In particular, specific quantitative methods have not yet been adopted to assess the effectiveness of stem cell treatment. The aim of this study is to evaluate the functional changes detectable by conventional neu...

journal_title：Cell transplantation

authors： Frolov AA,Bryukhovetskiy AS

更新日期：2012-01-01 00:00:00

abstract：:Grafting autologous cultured satellite cells in irreversibly injured rat extensor digitorum longus EDL muscle leads to myofiber regeneration at the grafting site. In this study, we investigated whether cell grafts induced functional improvement and correlated mechanophysiological findings with histological observation...

journal_title：Cell transplantation

authors： Alameddine HS,Louboutin JP,Dehaupas M,Sébille A,Fardeau M

更新日期：1994-01-01 00:00:00

abstract：:Near infrared fluorescence (NIRF) optical imaging is a technique particularly powerful when studying in vivo processes at the molecular level in preclinical animal models. We recently demonstrated liver irradiation under the additional stimulus of partial hepatectomy as being an effective primer in the rat liver repop...

journal_title：Cell transplantation

authors： Koenig S,Krause P,Hosseini AS,Dullin C,Rave-Fraenk M,Kimmina S,Entwistle AL,Hermann RM,Hess CF,Becker H,Christiansen H

更新日期：2009-01-01 00:00:00

abstract：:Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment. In this review, we attempt to give a brief overview of the animal models of PD currently used, with a more comprehensive focus on the advantage...

journal_title：Cell transplantation

authors： Soderstrom K,O'Malley J,Steece-Collier K,Kordower JH

更新日期：2006-01-01 00:00:00

abstract：:Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In the present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis in vivo. To explore the mechanisms, the character...

journal_title：Cell transplantation

authors： Ma F,Chen D,Chen F,Chi Y,Han Z,Feng X,Li X,Han Z

更新日期：2015-01-01 00:00:00

abstract：:Adequate regulation of glucose levels by a microencapsulated pancreatic islet graft requires a minute-to-minute regulation of blood glucose. To design such a transplant, it is mandatory to have sufficient insight in factors influencing the kinetics of insulin secretion by encapsulated islets. The present study investi...

journal_title：Cell transplantation

authors： de Haan BJ,Faas MM,de Vos P

更新日期：2003-01-01 00:00:00

abstract：:The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate, first, the effect of the donor-type MSCs from Wistar rats on the immune system of immunocompetent Lewis rats and, second, the rejec...

journal_title：Cell transplantation

authors： Merino A,Ripoll E,de Ramon L,Bolaños N,Goma M,Bestard O,Lloberas N,Grinyo JM,Ambròs JT

更新日期：2017-06-09 00:00:00

abstract：:It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump...

journal_title：Cell transplantation

authors： Fisher WE

更新日期：1999-09-01 00:00:00

abstract：:Adrenal medullary tissue including chromaffin cells was grafted intrathecally in cancer patients to relieve intractable pain. The central nervous system (CNS) is considered an immune privileged site. Therefore, non-HLA-matched and unencapsulated tissue was grafted in 15 patients and 1 sham control in a series of at le...

journal_title：Cell transplantation

authors： Tkaczuk J,Bes JC,Duplan H,Sallerin B,Tafani M,Charlet JP,Abbal M,Lazorthes Y,Ohayon E

更新日期：2000-01-01 00:00:00

abstract：:The present study aimed to elucidate the mechanisms by which hydrogen sulfide (H2S) attenuates left ventricular remodeling after myocardial infarction (MI). MI was created in mice by left coronary artery ligation. One group of mice received injections of the H2S donor sodium hydrosulfide (NaHS) immediately before and ...

journal_title：Cell transplantation

authors： Wu T,Li H,Wu B,Zhang L,Wu SW,Wang JN,Zhang YE

更新日期：2017-05-09 00:00:00

abstract：:New treatment paradigms that slow or reverse progression of chronic kidney disease (CKD) are needed to relieve significant patient and healthcare burdens. We have shown that a population of selected renal cells (SRCs) stabilized disease progression in a mass reduction model of CKD. Here, we further define the cellular...

journal_title：Cell transplantation

authors： Kelley R,Bruce A,Spencer T,Werdin E,Ilagan R,Choudhury S,Rivera E,Wallace S,Guthrie K,Jayo M,Xu F,Rao AN,Humphreys BD,Presnell S,Bertram T

更新日期：2013-01-01 00:00:00

abstract：:At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts...

journal_title：Cell transplantation

authors： Gao LR,Zhang NK,Ding QA,Chen HY,Hu X,Jiang S,Li TC,Chen Y,Wang ZG,Ye Y,Zhu ZM

更新日期：2013-01-01 00:00:00