Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: a randomized controlled clinical trial.

abstract：:Bisphosphonates (BPs) are widely used to treat several metabolic and oncological diseases affecting the skeletal system. Despite BPs' well-known therapeutic potential, they also displayed important side effects, among which is BPs-related osteonecrosis of the jaw, by targeting osteoclast activities, osteoblast, and os...

journal_title：Cell transplantation

authors： Di Vito A,Chiarella E,Baudi F,Scardamaglia P,Antonelli A,Giudice D,Barni T,Fortunato L,Giudice A

更新日期：2020-01-01 00:00:00

abstract：:Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood-brain barrier...

journal_title：Cell transplantation

authors： Chen J,Jin H,Xu H,Peng Y,Jie L,Xu D,Chen L,Li T,Fan L,He P,Ying G,Gu C,Wang C,Wang L,Chen G

更新日期：2019-11-01 00:00:00

abstract：:In Alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. The fimbria-fornix aspiration is a well-known animal model mimicking hippocampal cholinergic deficiency. The aim of the present study was to use in vivo lipid-mediated gene transfer to introduce an expression vector ...

journal_title：Cell transplantation

authors： Weis C,Kaufmann WA,Humpel C

更新日期：2001-01-01 00:00:00

abstract：:Neuroblastoma, a malignant tumor of the sympathetic nervous system, is an aggressive extracranial tumor in childhood. Long noncoding RNAs (lncRNAs) have been discovered to play a key role in the eukaryotic regulatory gene network and be involved in a wide variety of biological processes. We observed that the expressio...

journal_title：Cell transplantation

authors： Pan W,Wu A,Yu H,Yu Q,Zheng B,Yang W,Tian D,Gao Y,Li P

更新日期：2020-01-01 00:00:00

abstract：:Porcine neonatal islet-like cell clusters (NICCs) may be an attractive source of insulin-producing tissue for xenotransplantation in type I diabetic patients. We examined the functional and immunohistochemical outcome of the islet grafts in vitro during long-term culture and in vivo after transplantation to athymic nu...

journal_title：Cell transplantation

authors： Nielsen TB,Yderstraede KB,Schrøder HD,Holst JJ,Brusgaard K,Beck-Nielsen H

更新日期：2003-01-01 00:00:00

abstract：:Critical length nerve defects in the rat sciatic nerve model were reconstructed with chitosan nerve guides filled with Schwann cells (SCs) containing hydrogel. The transplanted SCs were naive or had been genetically modified to overexpress neurotrophic factors, thus providing a cellular neurotrophic factor delivery sy...

journal_title：Cell transplantation

authors： Meyer C,Wrobel S,Raimondo S,Rochkind S,Heimann C,Shahar A,Ziv-Polat O,Geuna S,Grothe C,Haastert-Talini K

更新日期：2016-01-01 00:00:00

abstract：:Multiple sclerosis is a disease characterized by inflammation and demyelination located in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model for multiple sclerosis (MS). Although the roles of T cells in MS/EAE have been well investigated, little is known about ...

journal_title：Cell transplantation

authors： Xu J,Wang Y,Jiang H,Sun M,Gao J,Xie A

更新日期：2019-09-01 00:00:00

abstract：:Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled reaching movements. Fetal GABAergic transplants can physically replace the lost striatal cells but with only partial success in functional recovery. Here, we aime...

journal_title：Cell transplantation

authors： Klein A,Lane EL,Dunnett SB

更新日期：2013-01-01 00:00:00

abstract：:The mechanisms of donor hepatocyte integration into recipient liver are not fully understood. We investigated mechanisms of both the integration and interaction of transplanted hepatocytes with host liver cells as well as the repopulation of the host organ following intraportal transplantation. Mature hepatocytes were...

journal_title：Cell transplantation

authors： Koenig S,Stoesser C,Krause P,Becker H,Markus PM

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease (RVD) complicated by metabolic syndrome (MetS), we tested ...

journal_title：Cell transplantation

authors： Eirin A,Zhu XY,Jonnada S,Lerman A,van Wijnen AJ,Lerman LO

更新日期：2018-07-01 00:00:00

abstract：:Sciatic nerve injuries, not uncommon in trauma with a limited degree of functional recovery, are considered a persistent clinical, social, and economic problem worldwide. Accumulating evidence suggests that stem cells can promote the tissue regeneration through various mechanisms. The aim of the present study was to i...

journal_title：Cell transplantation

authors： Chuang MH,Ho LH,Kuo TF,Sheu SY,Liu YH,Lin PC,Tsai YC,Yang CH,Chu CM,Lin SZ

更新日期：2020-01-01 00:00:00

abstract：:Hepatocyte transplantation has been proposed as a technique for bridging patients to whole-organ transplantation, for providing metabolic support during liver failure, and for replacing whole-organ transplantation in certain metabolic liver diseases. Assessment of hepatocyte engraftment has been difficult to measure, ...

journal_title：Cell transplantation

authors： Mas VR,Maluf DG,Thompson M,Ferreira-Gonzalez A,Fisher RA

更新日期：2004-01-01 00:00:00

abstract：:Hepatocyte-based biological therapies are increasingly envisioned for temporary support in acute liver failure and provision of specific-liver functions in liver-based metabolic deficiency. One of the hurdles to develop such therapies is severe shortage of human livers for hepatocyte isolation. To address the issue, w...

journal_title：Cell transplantation

authors： Kobayashi N,Tanaka N

更新日期：2002-07-01 00:00:00

abstract：:We developed a reliable and quantitative method for measuring the dynamic process of unidirectional two-dimensional (2-D) tissue formation of endothelial cells (ECs) in vitro. The culturing of bovine ECs in an assembled culture chamber provided a square monolayered cell sheet with a linear margin when disassembled at ...

journal_title：Cell transplantation

authors： Niu S,Matsuda T

更新日期：1992-01-01 00:00:00

abstract：:The effect of tensile stress on the orientation and phenotype of arterial smooth muscle cells (SMCs) cultured in three-dimensional (3D) type I collagen gels was morphologically investigated. Ring-shaped hybrid tissues were prepared by thermal gelation of a cold mixed solution of type I collagen and SMCs derived from b...

journal_title：Cell transplantation

authors： Kanda K,Matsuda T

更新日期：1994-11-01 00:00:00

abstract：:The objective of this study was to define pretransplant islet culture conditions for optimum tissue engraftment in the rat islet allotransplantation model. Lewis rat islets were cultured in TCM 199/5% fetal calf serum for I day at 37 degrees C, followed by 1 day of culture at 22 degrees C. When islets from single dono...

journal_title：Cell transplantation

authors： Jahr H,Hussmann B,Eckhardt T,Bretzel RG

更新日期：2002-01-01 00:00:00

abstract：:New treatment paradigms that slow or reverse progression of chronic kidney disease (CKD) are needed to relieve significant patient and healthcare burdens. We have shown that a population of selected renal cells (SRCs) stabilized disease progression in a mass reduction model of CKD. Here, we further define the cellular...

journal_title：Cell transplantation

authors： Kelley R,Bruce A,Spencer T,Werdin E,Ilagan R,Choudhury S,Rivera E,Wallace S,Guthrie K,Jayo M,Xu F,Rao AN,Humphreys BD,Presnell S,Bertram T

更新日期：2013-01-01 00:00:00

abstract：:As an alternative to drug immunosuppression, attempts at inducing donor-specific tolerance by intrathymic (IT) inoculations to transplant recipient of donor origin alloantigenic products has proven very promising. Using fiber optic thoracoscopy, a technique for the study of this phenomena was developed for the dog. We...

journal_title：Cell transplantation

authors： Schachner RD,Qian T,Strasser S,Brendel MD,Alejandro R,Mintz DH

更新日期：1994-07-01 00:00:00

abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...

journal_title：Cell transplantation

authors： Silini AR,Magatti M,Cargnoni A,Parolini O

更新日期：2017-04-13 00:00:00

abstract：:Human islet allografts are well known to induce full and sustained remission of hyperglycemia, with complete normalization of key metabolic parameters. Nevertheless, acquiring human islets, even from cadaveric human donor pancreases, remains a significant impediment to successful transplantation therapy for diabetes. ...

journal_title：Cell transplantation

authors： Luca G,Calvitti M,Nastruzzi C,Macchiarulo G,Becchetti E,Neri LM,Capitani S,Basta G,Brunetti P,Calafiore R,Cameron DF

更新日期：2006-01-01 00:00:00

abstract：:The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for the treatment of cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including the ability to undergo ...

journal_title：Cell transplantation

authors： Scuderi N,Ceccarelli S,Onesti MG,Fioramonti P,Guidi C,Romano F,Frati L,Angeloni A,Marchese C

更新日期：2013-01-01 00:00:00

abstract：:After a unilateral striatal lesion, animals have generally been seen to have a bilateral impairment in paw reaching, with the contralateral paw being more affected. However, most studies to date have not used a pretraining paradigm to assess maximal capacity for paw reaching, to compare with any lesion-induced loss. T...

journal_title：Cell transplantation

authors： Fricker-Gates RA,Smith R,Muhith J,Dunnett SB

更新日期：2003-01-01 00:00:00

abstract：:Stem cell-based therapy shows great potential in stroke patients. Intra-artery infusion exhibits greater biological distribution compared to intravenous delivery. In addition, umbilical cord mesenchymal stem cells (UCMSCs) have several advantages compared with other types of stem cells. The aim of this study was to ev...

journal_title：Cell transplantation

authors： Jiang Y,Zhu W,Zhu J,Wu L,Xu G,Liu X

更新日期：2013-01-01 00:00:00

abstract：:At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts...

journal_title：Cell transplantation

authors： Gao LR,Zhang NK,Ding QA,Chen HY,Hu X,Jiang S,Li TC,Chen Y,Wang ZG,Ye Y,Zhu ZM

更新日期：2013-01-01 00:00:00

abstract：:"Proof-of-principle" that cell replacement therapy works for neurodegeneration has been reported, but only using donor cells collected from fetal brain tissue obtained from surgical terminations of pregnancy. Surgical terminations of pregnancy represent an increasingly limited supply of donor cells due to the tendenc...

journal_title：Cell transplantation

authors： Kelly CM,Precious SV,Torres EM,Harrison AW,Williams D,Scherf C,Weyrauch UM,Lane EL,Allen ND,Penketh R,Amso NN,Kemp PJ,Dunnett SB,Rosser AE

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to investigate the clinical efficacy of neural stem/progenitor cell (NS/PC) transplantation to treat severe cortical visual impairment (CVI), a sequela of neonatal brain injury. Fifty-two patients with cerebral injury and CVI were randomly divided into two groups: the treatment group (n =...

journal_title：Cell transplantation

authors： Luan Z,Qu S,Du K,Liu W,Yang Y,Wang Z,Cui Y,Du Q

更新日期：2013-01-01 00:00:00

abstract：:Periosteal autografts have the potential to regenerate articular cartilage defects, but this potential is limited by the patient's age. Allograft transplantation from a young donor to an older recipient might bypass this limitation. The effect of the time delay, between death and harvesting of a periosteal graft, on t...

journal_title：Cell transplantation

authors： O'Driscoll SW,Meisami B,Miura Y,Fitzsimmons JS

更新日期：1999-11-01 00:00:00

abstract：:Cell-based therapy for the bladder has its beginnings in the 1990s with the successful isolation and culture of bladder smooth muscle cells. Since then, several attempts have been made to artificially implant native cell types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or ...

journal_title：Cell transplantation

authors： Gopinath C,Ponsaerts P,Wyndaele JJ

更新日期：2015-01-01 00:00:00

abstract：:Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the represen...

journal_title：Cell transplantation

authors： Yakoub AM,Sadek M

更新日期：2018-03-01 00:00:00

abstract：:Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of 10 consecutive stroke patients were treated by combination cell transplantation on the basis of an ...

journal_title：Cell transplantation

authors： Chen L,Xi H,Huang H,Zhang F,Liu Y,Chen D,Xiao J

更新日期：2013-01-01 00:00:00