Abstract：
:Multiple sclerosis is a disease characterized by inflammation and demyelination located in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model for multiple sclerosis (MS). Although the roles of T cells in MS/EAE have been well investigated, little is known about the functions of other immune cells in the neuroinflammation model. Here we found that an essential cytokine transforming growth factor β (TGF-β) which could mediate the differentiation of Th17/regulatory T cells was implicated in the natural killer (NK) cells' activity in EAE. In EAE mice, TGF-β expression was first increased at the onset and then decreased at the peak, but the expressions of TGF-β receptors and downstream molecules were not affected in EAE. When we immunized the mice with MOG antigen, it was revealed that TGF-β treatment reduced susceptibility to EAE with a lower clinical score than the control mice without TGF-β. Consistently, inflammatory cytokine production was reduced in the TGF-β treated group, especially with downregulated pathogenic interleukin-17 in the central nervous system tissue. Furthermore, TGF-β could increase the transcription level of NK cell marker NCR1 both in the spleen and in the CNS without changing other T cell markers. Meanwhile TGF-β promoted the proliferation of NK cell proliferation. Taken together, our data demonstrated that TGF-β could confer protection against EAE model in mice through NK cells, which would be useful for the clinical therapy of MS.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
Xu J,Wang Y,Jiang H,Sun M,Gao J,Xie Adoi
10.1177/0963689719852354subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1155-1160issue
9-10eissn
0963-6897issn
1555-3892journal_volume
28pub_type
杂志文章abstract：:Schwann cells naturally support axonal regeneration after injury in the peripheral nervous system, and have also shown a significant, albeit limited, ability to support axonal growth and remyelination after grafting to the central nervous system (CNS). It is possible that Schwann cell-induced axonal growth in the CNS ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/s0963-6897(97)00166-8
更新日期：1998-03-01 00:00:00
abstract：:The technologies for adipose tissue harvesting, processing, and transplantation have substantially evolved in the past two decades. Clinically driven advancements have paralleled a significant improvement in the understanding of cellular, molecular, and immunobiological events surrounding cell and tissue transplantati...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.3727/096368910X507187
更新日期：2010-01-01 00:00:00
abstract：:We previously demonstrated that mesenchymal cells from human amniotic membrane (hAMTCs) inhibit the generation and maturation of monocyte-derived dendritic cells (DCs) in vitro. Considering the crucial role of DCs in the immune response and that epithelial cells of the human amniotic membrane (hAECs) share some of the...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368914X684033
更新日期：2015-01-01 00:00:00
abstract：:Cell escape occurs after intramyocardial injection for treatment of myocardial infarction (MI) and then the migrated cells might be entrapped by extracardiac organs. We investigated the fate of migrated bone marrow-derived mesenchymal stromal cells (MSCs) and their impact on lung, liver, and spleen. MI model was creat...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368910X513982
更新日期：2010-01-01 00:00:00
abstract：:Early graft loss in islet transplantation means that a large amount of donor islets is required. Endothelial cells and endothelial colony-forming cells (ECFCs) have been reported to improve instant blood-mediated inflammatory reaction (IBMIR) in vitro. In this study, we examined if ECFC-coated porcine islets would pre...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X661364
更新日期：2014-03-01 00:00:00
abstract：:The main purpose of this work has been to establish a new culturing technique to improve the chondrogenic commitment of isolated adult human chondrocytes, with the aim of being used during cell-based therapies or tissue engineering strategies. By using a rather novel technique to generate scaffold-free three-dimension...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368908786576499
更新日期：2008-01-01 00:00:00
abstract：:The nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) was discovered by coincidence in the 1980s and has since been widely used in the investigation of T1D and diabetic complications. The current in vivo study was originally designed to prospectively assess whether hyperglycemia onset is associated with phy...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689720939127
更新日期：2020-01-01 00:00:00
abstract：:We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet t...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/s0963-6897(96)00085-1
更新日期：1996-11-01 00:00:00
abstract：:It is currently said that CO has anti-inflammatory and antiapoptosis effects and it has attracted attention as a medical gas. We used CO for rat hearts and conducted a preservation experiment. We isolated rat hearts, placed them into a specially made chamber, filled the chamber with a gas mixture of PCO (4,000 hPa) a...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368911X605547
更新日期：2012-01-01 00:00:00
abstract：:Hepatocyte transplantation and artificial organ hepatic support require a number of functionally mature hepatocytes. However, their growth activity and functional behaviors are much smaller in culture after isolation from the liver. We examined whether continuously differentiating hepatocytes from multipotent hepatic ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000003108747028
更新日期：2003-01-01 00:00:00
abstract：:Spinal cord injury (SCI) is a devastating neurological disease. The pathophysiological mechanisms of SCI have been reported to be relevant to central nervous system injury such as brain injury. In this study, gene expression of the brain after SCI was elucidated using transcriptome analysis to characterize the tempora...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689717715822
更新日期：2017-07-01 00:00:00
abstract：:We examined a possible protective effect of the nonpeptidyl low molecular weight radical scavenger IAC [bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decanedioate di-hydrochloride] on isolated human islet cells against isolation and culture oxidative stress. Islets isolated from pancreases of nondiabetic multiorgan ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368908787236639
更新日期：2008-01-01 00:00:00
abstract：:Adequate regulation of glucose levels by a microencapsulated pancreatic islet graft requires a minute-to-minute regulation of blood glucose. To design such a transplant, it is mandatory to have sufficient insight in factors influencing the kinetics of insulin secretion by encapsulated islets. The present study investi...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000003108747226
更新日期：2003-01-01 00:00:00
abstract：:As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their cross-talk is not y...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689719831707
更新日期：2019-08-01 00:00:00
abstract：:Efficient repopulation by transplanted hepatocytes in the severely injured liver is essential for their clinical application in the treatment of acute hepatic failure. We studied here whether and how the transplanted hepatocytes are able to efficiently repopulate the toxin-induced acute injured liver. Male dipeptidyl ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368909X12483162196647
更新日期：2009-01-01 00:00:00
abstract：:To overcome common disadvantages of standard cultured epidermal sheet grafts (CEG) we have developed a new technique of transplanting cultured human keratinocytes suspended as single cells in a fibrin-glue matrix (Keratinocyte-fibrin-glue suspension-KFGS). In an athymic mouse model with reproducible standardized full ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/s0963-6897(98)00005-0
更新日期：1998-05-01 00:00:00
abstract：:Heart failure continues to be a major health care concern with relatively few options for severely advanced heart failure patients. The hallmark of heart failure is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen c...
journal_title：Cell transplantation
pub_type： 临床试验,杂志文章
doi：10.3727/096368911X637461
更新日期：2013-01-01 00:00:00
abstract：:Our purpose was to evaluate whether or not and when phenotypic modulation of smooth muscle cells (SMCs) in hybrid vascular prostheses preincorporated with SMCs occurs upon implantation. Two types of hybrid vascular grafts incorporated with vascular cells derived from canine jugular veins were prepared: grafts containi...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.3727/096368916X693699
更新日期：2017-04-13 00:00:00
abstract：:It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/096368979900800511
更新日期：1999-09-01 00:00:00
abstract：:The present study was designed to evaluate the use of collagen gel loaded with human retinal pigment epithelium (ARPE19) in cellular transfer and to assess its viability within the gel. Collagen solution was prepared by dissolving calfskin in hydrochloric acid to make a final concentration of 2.0 mg/ml and this was mi...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000004783983666
更新日期：2004-01-01 00:00:00
abstract：:ET-Kyoto solution (ET-K) is an extracellular-type organ preservation solution containing the cytoprotective disaccharide, trehalose. A previous study reported the supplement of dibutyryl cyclic adenosine monophosphate (db-cAMP) in conventional ET-K to attenuate lung ischemia-reperfusion injury. In this study, the effi...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000008783906928
更新日期：2008-01-01 00:00:00
abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368914X681595
更新日期：2015-01-01 00:00:00
abstract：:Ischemia-reperfusion and immunosuppressive therapy are a major cause of progressive renal failure after kidney transplantation. Recent studies have shown that administration of bone marrow mesenchymal stem cells (MSCs) improves kidney functional recovery in the acute phase of post ischemia-reperfusion injury. In the ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X640448
更新日期：2012-01-01 00:00:00
abstract：:An important challenge in pancreatic islet transplantation in association with type 1 diabetes is to define automatic high-throughput assays for evaluation of human islet function. The physiological techniques presently used are amenable to small-scale experimental samples and produce descriptive results. The postgeno...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The long-term durability of agarose microencapsulated islets against autoimmunity was evaluated in NOD mice. Islets were isolated from 6-8-week-old prediabetic male NOD mice and microencapsulated in 5% agarose hydrogel. Microencapsulated or nonencapsulated islets were transplanted into the omental pouch of spontaneous...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000006783981954
更新日期：2006-01-01 00:00:00
abstract：:Articular cartilage is an avascular tissue composed of chondrocytes, a unique cell type responsible for abundant matrix synthesis and maintenance. When damaged, it never heals spontaneously under physiological circumstances. Therefore, the delivery of mesenchymal stem cells using hydrogel has been considered for cart...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368910X557191
更新日期：2011-01-01 00:00:00
abstract：:Recently, FDA approved the clinical use of autologous fibroblasts (LAVIV™) for the improvement of nasolabial fold wrinkles in adults. The use of autologous fibroblasts for the augmentation of dermal and subcutaneous defects represents a potentially exciting natural alternative to the use of other filler materials for ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X659844
更新日期：2014-01-01 00:00:00
abstract：:Oligodendrocyte (OL) replacement can be a promising strategy for spinal cord injury (SCI) repair. However, the poor posttransplantation survival and inhibitory properties to axonal regeneration are two major challenges that limit their use as donor cells for repair of CNS injuries. Therefore, strategies aimed at enhan...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X661373
更新日期：2013-01-01 00:00:00
abstract：:Although cells isolated from fetal liver are one of the major sources for liver tissue engineering, it is still very difficult to induce them to fully differentiate in vitro into mature hepatocytes. We therefore investigated the effects of nicotinamide (NA), dimethyl sulfoxide (DMSO), and oncostatin M (OSM) on differe...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
