Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine.

abstract：:The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW)...

journal_title：Cell transplantation

authors： Nuryyev RL,Uhlendorf TL,Tierney W,Zatikyan S,Kopyov O,Kopyov A,Ochoa J,Van Trigt W,Malone CS,Cohen RW

更新日期：2017-11-01 00:00:00

abstract：:Acute kidney injury (AKI) is a major clinical problem that still has no established treatment. We investigated the efficacy of cultured human peripheral blood mononuclear cells (PBMNCs) for AKI. Ischemia/reperfusion injury (IRI) was used to induce AKI in male nonobese diabetic (NOD/severe combined immunodeficiency) mi...

journal_title：Cell transplantation

authors： Ohtake T,Kobayashi S,Slavin S,Mochida Y,Ishioka K,Moriya H,Hidaka S,Matsuura R,Sumida M,Katagiri D,Noiri E,Okada K,Mizuno H,Tanaka R

更新日期：2018-03-01 00:00:00

abstract：:Liver fibrosis is characterized by excessive accumulation of extracellular matrix components in the liver parenchyma that distorts the normal architecture and hepatic function. Progressive fibrosis could end in the advanced stage known as cirrhosis, resulting in the need to resort to liver transplantation. Amniotic me...

journal_title：Cell transplantation

authors： SantAnna LB,Hage R,Cardoso MA,Arisawa EA,Cruz MM,Parolini O,Cargnoni A,SantAnna N

更新日期：2016-12-13 00:00:00

abstract：:This study examined how the difference in pore size of porous scaffolds affected the in vitro chondrogenic differentiation of seeded adipose stem cells (ASCs) and the in vivo cartilage repair of ASC/scaffold construct. ASCs were isolated from 18 rabbits and seeded in a porous poly (ε-caprolactone) (PCL) scaffold with ...

journal_title：Cell transplantation

authors： Im GI,Ko JY,Lee JH

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease (RVD) complicated by metabolic syndrome (MetS), we tested ...

journal_title：Cell transplantation

authors： Eirin A,Zhu XY,Jonnada S,Lerman A,van Wijnen AJ,Lerman LO

更新日期：2018-07-01 00:00:00

abstract：:The aim of this work was to determine the effect of nicotine desensitization on dopamine (DA) release in the dorsal striatum and shell of the nucleus accumbens (NAc) from brain slices. In vitro fast-scan cyclic voltammetry analysis was used to evaluate dopamine release in the dorsal striatum and the NAc shell of Sprag...

journal_title：Cell transplantation

authors： Chen YH,Lin BJ,Hsieh TH,Kuo TT,Miller J,Chou YC,Huang EY,Hoffer BJ

更新日期：2019-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing–remitting MS (RRMS) while t...

journal_title：Cell transplantation

authors： Cobo M,Anderson P,Benabdellah K,Toscano MG,Muñoz P,García-Pérez A,Gutierrez I,Delgado M,Martin F

更新日期：2013-01-01 00:00:00

abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...

journal_title：Cell transplantation

authors： Silini AR,Magatti M,Cargnoni A,Parolini O

更新日期：2017-04-13 00:00:00

abstract：:Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to interruption of spinal pathways and secondary neurodegenerative processes. The transplant of neural stem cells (NSCs) is a promising approach for the repair of SCI. Reprogramming of adult somatic cells into induced pluripoten...

journal_title：Cell transplantation

authors： López-Serrano C,Torres-Espín A,Hernández J,Alvarez-Palomo AB,Requena J,Gasull X,Edel MJ,Navarro X

更新日期：2016-10-01 00:00:00

abstract：:The estimated frequency of MSCs in BM is about 0.001-0.01% of total nucleated cells. Most commonly, one applied therapeutic cell dose is about 1-5 million MSCs/kg body weight, necessitating a reliable, fast, and safe expansion system. The limited availability of MSCs demands for an extensive ex vivo amplification step...

journal_title：Cell transplantation

authors： Rojewski MT,Fekete N,Baila S,Nguyen K,Fürst D,Antwiler D,Dausend J,Kreja L,Ignatius A,Sensebé L,Schrezenmeier H

更新日期：2013-01-01 00:00:00

abstract：:Bone nonunion is a pathological condition in which all bone healing processes have stopped, resulting in abnormal mobility between 2 bone segments. The incidence of bone-related injuries will increase in an aging population, leading to such injuries reaching epidemic proportions. Tissue engineering and cell therapy us...

journal_title：Cell transplantation

authors： Dufrane D

更新日期：2017-09-01 00:00:00

abstract：:Human amniotic membrane (hAM) is the innermost layer of fetal membranes, which surrounds the developing fetus and forms the amniotic cavity. hAM and hAM-derived cells possess many properties that make them suitable for use in regenerative medicine, such as low immunogenicity, promotion of epithelization, anti-inflamma...

journal_title：Cell transplantation

authors： Ramuta TŽ,Kreft ME

更新日期：2018-01-01 00:00:00

abstract：:Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and can be promoted by immunosuppressants. However, there is no prevention or treatment for HCC recurrence after LT. Here we describe a clinical-scale method for an adoptive immunotherapy approach that...

journal_title：Cell transplantation

authors： Ohira M,Nishida S,Tryphonopoulos P,Tekin A,Selvaggi G,Moon J,Levi D,Ricordi C,Ishiyama K,Tanaka Y,Ohdan H,Tzakis AG

更新日期：2012-01-01 00:00:00

abstract：:Myoblast transplantation is being considered as a potential strategy to improve muscle function in myopathies; hence, it is important to identify the transplanted cells and to have available efficient reagents to track these cells. We first validated a human to mouse xenotransplantation model warranting the complete a...

journal_title：Cell transplantation

authors： Praud C,Vauchez K,Lombes A,Fiszman MY,Vilquin JT

更新日期：2008-01-01 00:00:00

abstract：:Early graft loss in islet transplantation means that a large amount of donor islets is required. Endothelial cells and endothelial colony-forming cells (ECFCs) have been reported to improve instant blood-mediated inflammatory reaction (IBMIR) in vitro. In this study, we examined if ECFC-coated porcine islets would pre...

journal_title：Cell transplantation

authors： Jung HS,Kim MJ,Hong SH,Lee YJ,Kang S,Lee H,Chung SS,Park JS,Park KS

更新日期：2014-03-01 00:00:00

abstract：:Future improvements in the recovery and function of pancreatic islets following cryopreservation will require a more precise quantification of the stresses that occur at each stage of the cryopreservation protocol. Changes in solution osmolality during the addition and dilution of cryoprotectants and during freezing a...

journal_title：Cell transplantation

authors： Zieger MA,Woods EJ,Lakey JR,Liu J,Critser JK

更新日期：1999-05-01 00:00:00

abstract：:Cell and tissue culture techniques have improved considerably since the first attempts to maintain explants of animal tissue in vitro. The two major developments that have allowed these improvements are the ability to produce continuous cell lines, thus allowing reproducible results to be obtained, and the definition ...

journal_title：Cell transplantation

authors： Clayton HA,London NJ

更新日期：1996-01-01 00:00:00

abstract：:Critical limb ischemia in diabetic patients is associated with high rates of morbidity and mortality. Suboptimal responses to the available medical and surgical treatments are common in these patients, who also demonstrate limited vascular homeostasis. Neovasculogenesis induced by stem cell therapy could be a useful ...

journal_title：Cell transplantation

authors： Ruiz-Salmeron R,de la Cuesta-Diaz A,Constantino-Bermejo M,Pérez-Camacho I,Marcos-Sánchez F,Hmadcha A,Soria B

更新日期：2011-01-01 00:00:00

abstract：:Diabetes affects millions of people worldwide, and β-cell replacement is one of the promising new strategies for treatment. Induced pluripotent stem cells (iPSCs) can differentiate into any cell type, including pancreatic β cells, providing a potential treatment for diabetes. However, the molecular mechanisms underlyi...

journal_title：Cell transplantation

authors： Huang Y,Wan J,Guo Y,Zhu S,Wang Y,Wang L,Guo Q,Lu Y,Wang Z

更新日期：2017-08-01 00:00:00

abstract：:Prairie voles show strong pair bonding with their mating partners, and they demonstrate parental behavior toward their infants, indicating that the prairie vole is a unique animal model for analysis of molecular mechanisms of social behavior. Until a recent study, the signaling pathway of oxytocin was thought to be cr...

journal_title：Cell transplantation

authors： Katayama M,Hirayama T,Horie K,Kiyono T,Donai K,Takeda S,Nishimori K,Fukuda T

更新日期：2016-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of t...

journal_title：Cell transplantation

authors： Kološa K,Motaln H,Herold-Mende C,Koršič M,Lah TT

更新日期：2015-01-01 00:00:00

abstract：:Pancreas procurement for islet isolation and transplantation is limited by concerns for the detrimental effects of postmortem ischemia. Hypothermic machine perfusion (HMP) preservation technology has had a major impact in circumventing ischemic injury in clinical kidney transplantation and is applied here to the prese...

journal_title：Cell transplantation

authors： Taylor MJ,Baicu S,Greene E,Vazquez A,Brassil J

更新日期：2010-01-01 00:00:00

abstract：:We transplanted adult whole bone marrow prelabeled with bromodeoxyuridine (BrdU) into the ischemic boundary zone of the adult rat brain at 1 day after 2 h of middle cerebral artery occlusion (MCAo). Approximately 3.3% of 10(6) transplanted bone marrow cells were BrdU reactive at 14 days after MCAo. BrdU-reactive cells...

journal_title：Cell transplantation

authors： Li Y,Chen J,Chopp M

更新日期：2001-01-01 00:00:00

abstract：:Islet transplantation as a therapy or cure for type 1 diabetes has significant promise but has been limited by islet mass requirements and long-term graft failure. The intrahepatic and intravascular site may be responsible for significant loss of transplanted islets. Nonencapsulating biomaterial scaffolds provide a st...

journal_title：Cell transplantation

authors： Gibly RF,Zhang X,Lowe WL Jr,Shea LD

更新日期：2013-01-01 00:00:00

abstract：:Somatic stem cells can be isolated from a variety of sources. Although some studies have suggested that somatic stem cells may represent a cell population that is very similar to embryonic stem (ES) cells, it remains unclear whether somatic stem cells retain the potential to differentiate into any cell type derived fr...

journal_title：Cell transplantation

authors： Oishi K,Noguchi H,Yukawa H,Hayashi S

更新日期：2009-01-01 00:00:00

abstract：:The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has been reached as to what is ...

journal_title：Cell transplantation

authors： Di Vito A,Giudice A,Chiarella E,Malara N,Bennardo F,Fortunato L

更新日期：2019-01-01 00:00:00

abstract：:Simple and efficient freezing methods with maximal postthawing recovery form the basis of ideal cryopreservation. Taurine (2-amino ethanesulfonic acid), an end-product of sulphur amino acid metabolism, is one of the most abundant free amino acids in the body. The membrane stabilizing, free radical scavenging, and osmo...

journal_title：Cell transplantation

authors： Hardikar AA,Risbud MV,Remacle C,Reusens B,Hoet JJ,Bhonde RR

更新日期：2001-01-01 00:00:00

abstract：REGISTRATION NUMBER OF CLINICAL TRIALS:ChiCTR1900021317. ...

journal_title：Cell transplantation

authors： He M,Guo X,Li T,Jiang X,Chen Y,Yuan Y,Chen B,Yang G,Fan Y,Liang Z,Armstrong DG,Deng W

更新日期：2020-01-01 00:00:00

abstract：:Researchers have accumulated a decade of experience with autologous cell therapy in the treatment of critical limb ischemia (CLI). We conducted a systematic review of clinical trials in the literature to determine the safety and efficacy of cell therapy in CLI. We searched the literature for clinical trials of autolog...

journal_title：Cell transplantation

authors： Benoit E,O'Donnell TF,Patel AN

更新日期：2013-01-01 00:00:00

abstract：:Human marrow stromal cells (hMSCs) provide functional benefit in rats subjected to stroke. Astrocytes are coupled into a cellular network via gap junction channels, predominantly composed of connexin-43 (Cx43) proteins. Astrocytes are believed to play a vital role in neuroprotection by providing energy substrates to n...

journal_title：Cell transplantation

authors： Gao Q,Katakowski M,Chen X,Li Y,Chopp M

更新日期：2005-01-01 00:00:00