Factors influencing insulin secretion from encapsulated islets.

abstract：:There is still a lack of sufficient research on the mechanism behind neurogenic bladder (NB) treatment. The aim of this study was to explore the effect of overexpressed stromal cell-derived factor-1 (SDF-1) secreted by engineered immortalized mesenchymal stem cells (imMSCs) on the NB. In this study, primary bone marro...

journal_title：Cell transplantation

authors： Zhu GQ,Jeon SH,Lee KW,Cho HJ,Ha US,Hong SH,Lee JY,Kwon EB,Kim HJ,Lee SM,Kim HY,Kim SW,Bae WJ

更新日期：2020-01-01 00:00:00

abstract：:Pancreas procurement for islet isolation and transplantation is limited by concerns for the detrimental effects of postmortem ischemia. Hypothermic machine perfusion (HMP) preservation technology has had a major impact in circumventing ischemic injury in clinical kidney transplantation and is applied here to the prese...

journal_title：Cell transplantation

authors： Taylor MJ,Baicu S,Greene E,Vazquez A,Brassil J

更新日期：2010-01-01 00:00:00

abstract：:Sciatic nerve injuries, not uncommon in trauma with a limited degree of functional recovery, are considered a persistent clinical, social, and economic problem worldwide. Accumulating evidence suggests that stem cells can promote the tissue regeneration through various mechanisms. The aim of the present study was to i...

journal_title：Cell transplantation

authors： Chuang MH,Ho LH,Kuo TF,Sheu SY,Liu YH,Lin PC,Tsai YC,Yang CH,Chu CM,Lin SZ

更新日期：2020-01-01 00:00:00

abstract：:The transplantation of encapsulated dopamine-secreting cells into the striatum represents one potential means of treating Parkinson's disease. The present study investigated the ability of encapsulated PC12 cells, which are derived from rat pheochromocytoma, to supply L-dopa and dopamine into the primate brain in the ...

journal_title：Cell transplantation

authors： Date I,Shingo T,Yoshida H,Fujiwara K,Kobayashi K,Ohmoto T

更新日期：2000-09-01 00:00:00

abstract：:A new extracorporeal bioartificial liver using alginate-entrapped hepatocytes was developed and evaluated for its ability to correct the lack of bilirubin conjugation in the Gunn rat. Hepatocytes were harvested from Sprague-Dawley rats by the two-step collagenase perfusion method and then immobilized in Ca(++)-alginat...

journal_title：Cell transplantation

authors： Fremond B,Malandain C,Guyomard C,Chesne C,Guillouzo A,Campion JP

更新日期：1993-11-01 00:00:00

abstract：:We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin(-)) have the capacity to differentiate and contribute to regeneration of injured islets. In this study, we assess some of the characteristics of these cells compa...

journal_title：Cell transplantation

authors： Iskovich S,Goldenberg-Cohen N,Sadikov T,Yaniv I,Stein J,Askenasy N

更新日期：2015-01-01 00:00:00

abstract：:Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood-brain barrier...

journal_title：Cell transplantation

authors： Chen J,Jin H,Xu H,Peng Y,Jie L,Xu D,Chen L,Li T,Fan L,He P,Ying G,Gu C,Wang C,Wang L,Chen G

更新日期：2019-11-01 00:00:00

abstract：:Clinically, many candidates for islet transplantation are already immunized, which increases their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device has been shown to protect against allograft rejection in nonimmunized recipients. However, the capacity of the TheraCyte™ device to ...

journal_title：Cell transplantation

authors： Kumagai-Braesch M,Jacobson S,Mori H,Jia X,Takahashi T,Wernerson A,Flodström-Tullberg M,Tibell A

更新日期：2013-01-01 00:00:00

abstract：:Somatic stem cells can be isolated from a variety of sources. Although some studies have suggested that somatic stem cells may represent a cell population that is very similar to embryonic stem (ES) cells, it remains unclear whether somatic stem cells retain the potential to differentiate into any cell type derived fr...

journal_title：Cell transplantation

authors： Oishi K,Noguchi H,Yukawa H,Hayashi S

更新日期：2009-01-01 00:00:00

abstract：:The common use of the marrow autograft mononuclear cell (MNC) count derives from positive correlative studies following allogeneic transplantation and from earlier conflicting data regarding the value of the bone marrow autograft colony-forming unit granulocyte-macrophage (CFU-GM) assay for prediction hematologic reco...

journal_title：Cell transplantation

authors： al-Fiar F,Prince HM,Imrie K,Stewart AK,Crump M,Keating A

更新日期：1997-09-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder that occurs in patients with a mutation in the huntingtin or IT15 gene. Patients are plagued by early cognitive signs, motor deficits, and psychiatric disturbances. Symptoms are attributed to cell death in the striatum and disruption of cortical-str...

journal_title：Cell transplantation

authors： Ramaswamy S,Shannon KM,Kordower JH

更新日期：2007-01-01 00:00:00

abstract：:Isolation of islets from market-sized pigs is costly, with considerable islet losses from fragmentation occurring during isolation and tissue culture. Fetal and neonatal pigs yield insulin unresponsive islet-like cell clusters that become glucose-responsive after extended periods of time. Both issues impact clinical a...

journal_title：Cell transplantation

authors： Lamb M,Laugenour K,Liang O,Alexander M,Foster CE,Lakey JR

更新日期：2014-03-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is a dominant inherited disease caused by expanded trinucleotide repeats resulting in an increased polyglutamine tract in the gene product. As a potential therapeutic approach for SCA1, we tested antisense RNAs targeting two regions of the ataxin-1 message. Single-stranded regions ...

journal_title：Cell transplantation

authors： Gao Y,Zu T,Low WC,Orr HT,McIvor RS

更新日期：2008-01-01 00:00:00

abstract：:There is conflicting evidence favoring both the use of human serum (HS) and of human serum albumin (HSA) in human islet culture. We evaluated the effects of HS versus HSA supplementation on 1) in vitro β-cell viability and function and 2) in vivo islet graft revascularization, islet viability, β-cell death, and metabo...

journal_title：Cell transplantation

authors： Nacher M,Estil Les E,Garcia A,Nadal B,Pairó M,Garcia C,Secanella L,Novials A,Montanya E

更新日期：2016-01-01 00:00:00

abstract：:We examined whether hypoxic exposure prior to the event of transplantation would have a positive or negative effect upon later islet graft function. Mouse islets exposed to hypoxic culture were transplanted into syngeneic recipients. Islet graft function, β-cell physiology, as well as molecular changes were examined. ...

journal_title：Cell transplantation

authors： Cantley J,Walters SN,Jung MH,Weinberg A,Cowley MJ,Whitworth TP,Kaplan W,Hawthorne WJ,O'Connell PJ,Weir G,Grey ST

更新日期：2013-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency ...

journal_title：Cell transplantation

authors： Takahashi H,Koda M,Hashimoto M,Furuya T,Sakuma T,Kato K,Okawa A,Inada T,Kamiya K,Ota M,Maki S,Takahashi K,Yamazaki M,Mannoji C

更新日期：2016-01-01 00:00:00

abstract：:Endostatin (ES) is a potent inhibitor of angiogenesis and tumor growth. Continuous ES delivery of ES improves the efficacy and potency of the antitumoral therapy. The TheraCyte system is a polytetrafluoroethylene (PTFE) semipermeable membrane macroencapsulation system for implantation of genetically engineered cells s...

journal_title：Cell transplantation

authors： Malavasi NV,Rodrigues DB,Chammas R,Chura-Chambi RM,Barbuto JA,Balduino K,Nonogaki S,Morganti L

更新日期：2010-01-01 00:00:00

abstract：:In previous work, we engineered functional cell sheets using bone marrow-derived mesenchymal stem cells (BM-MSCs) to promote islet graft survival. In the present study, we hypothesized that a cell sheet using dermal fibroblasts could be an alternative to MSCs, and then we aimed to evaluate the effects of this cell she...

journal_title：Cell transplantation

authors： Matsushima H,Kuroki T,Adachi T,Kitasato A,Ono S,Tanaka T,Hirabaru M,Kuroshima N,Hirayama T,Sakai Y,Soyama A,Hidaka M,Takatsuki M,Kin T,Shapiro J,Eguchi S

更新日期：2016-01-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple different cell types contribute to the regulation of stem and progenitor cel...

journal_title：Cell transplantation

authors： Mattiucci D,Maurizi G,Leoni P,Poloni A

更新日期：2018-05-01 00:00:00

abstract：:Cloned murine endothelial cells (cEC) were used as a carrier system for introducing a foreign gene into the microvascular bed of the hind limb of inbred mice. cEC were transfected with a beta-galactosidase-neo fusion construct, which enables both selection for DNA uptake in the presence of G 418 and the staining of ce...

journal_title：Cell transplantation

authors： Schwärzler C,Webersinke G,Fässler R,Lametschwandtner A,Bauer H,Bauer HC

更新日期：1997-01-01 00:00:00

abstract：:Adipose tissue contains a mesenchymal stem cell (MSC) population known as adipose-derived stem cells (ASCs) capable of differentiating into different cell types. Our aim was to induce hepatic transdifferentiation of ASCs by sequential exposure to several combinations of cytokines, growth factors, and hormones. The mos...

journal_title：Cell transplantation

authors： Bonora-Centelles A,Jover R,Mirabet V,Lahoz A,Carbonell F,Castell JV,Gómez-Lechón MJ

更新日期：2009-01-01 00:00:00

abstract：:Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently...

journal_title：Cell transplantation

authors： Díaz D,Recio JS,Weruaga E,Alonso JR

更新日期：2012-01-01 00:00:00

abstract：:We previously demonstrated that mesenchymal cells from human amniotic membrane (hAMTCs) inhibit the generation and maturation of monocyte-derived dendritic cells (DCs) in vitro. Considering the crucial role of DCs in the immune response and that epithelial cells of the human amniotic membrane (hAECs) share some of the...

journal_title：Cell transplantation

authors： Magatti M,Caruso M,De Munari S,Vertua E,De D,Manuelpillai U,Parolini O

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer disease (AD) is a progressive neurodegenerative disease, which is characterized by loss of memory and cognitive function. In AD patients dysfunction of the cholinergic system is the main cause of cognitive disorders, and decreased activity of choline acetyltransferase (ChAT), an enzyme responsible for acety...

journal_title：Cell transplantation

authors： Park D,Joo SS,Kim TK,Lee SH,Kang H,Lee HJ,Lim I,Matsuo A,Tooyama I,Kim YB,Kim SU

更新日期：2012-01-01 00:00:00

abstract：:Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostim...

journal_title：Cell transplantation

authors： Spadaccio C,Rainer A,De Marco F,Lusini M,Gallo P,Sedati P,Muda AO,De Porcellinis S,Gregorj C,Avvisati G,Trombetta M,Chello M,Covino E,Bull DA,Patel AN,Genovese JA

更新日期：2013-01-01 00:00:00

abstract：:Stem cells from dental tissues have been isolated and established for tooth regenerative applications. However, basic characterization on their biological properties still needs to be investigated before employing them for effective clinical trials. In this study, we compared the telomere length, relative telomerase ...

journal_title：Cell transplantation

authors： Jeon BG,Kang EJ,Kumar BM,Maeng GH,Ock SA,Kwack DO,Park BW,Rho GJ

更新日期：2011-01-01 00:00:00

abstract：:Xenotransplantation of porcine fetal ventral mesencephalic (pfVM) cells to overcome the dopamine shortage in the striatum of patients with Parkinson's disease seems a viable alternative to allotransplantion of human fetal donor tissue, especially because the latter is complicated by both practical and ethical issues. ...

journal_title：Cell transplantation

authors： Koopmans J,de Haan A,Bruin E,van der Gun I,van Dijk H,Rozing J,de Leij L,Staal M

更新日期：2006-01-01 00:00:00

abstract：:A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To identify morphological characteristics of transplanted donor cells, HESCs were transfected with a GFP lentiviral vector. Gene expression ...

journal_title：Cell transplantation

authors： Wakeman DR,Weiss S,Sladek JR,Elsworth JD,Bauereis B,Leranth C,Hurley PJ,Roth RH,Redmond DE

更新日期：2014-01-01 00:00:00

abstract：:We transplanted adult whole bone marrow prelabeled with bromodeoxyuridine (BrdU) into the ischemic boundary zone of the adult rat brain at 1 day after 2 h of middle cerebral artery occlusion (MCAo). Approximately 3.3% of 10(6) transplanted bone marrow cells were BrdU reactive at 14 days after MCAo. BrdU-reactive cells...

journal_title：Cell transplantation

authors： Li Y,Chen J,Chopp M

更新日期：2001-01-01 00:00:00

abstract：:Techniques for medical tissue regeneration require an abundant source of human adult stem cells. There is increasing evidence that adipose stem cells contribute to restoration of tissue vascularization and organ function. The object of our study was to isolate and characterize adult adipose-derived stem cells from pat...

journal_title：Cell transplantation

authors： Folgiero V,Migliano E,Tedesco M,Iacovelli S,Bon G,Torre ML,Sacchi A,Marazzi M,Bucher S,Falcioni R

更新日期：2010-01-01 00:00:00