Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates.

abstract：:Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency. With time, however, dedifferentiation or malignant transformation of the ectopically transplanted cells may be pos...

journal_title：Cell transplantation

authors： Lupp A,Danz M,Müller D

更新日期：2003-01-01 00:00:00

abstract：:Establishing reliable islet potency assay is a critical and unmet issue for clinical islet transplantation. Recently, we reported that islets contained high levels of high mobility group box 1 (HMGB1) and damaged islets released HMGB1 in a mouse model. In this study, we hypothesized that the amount of released HMGB1 c...

journal_title：Cell transplantation

authors： Itoh T,Takita M,SoRelle JA,Shimoda M,Sugimoto K,Chujo D,Qin H,Naziruddin B,Levy MF,Matsumoto S

更新日期：2012-01-01 00:00:00

abstract：:The diverse requirements for a successful islet encapsulation barrier suggest the benefit of a barrier system that presents differing functionalities to encapsulated cells and host cells. Initially, multifunctional hydrogels were synthesized via the sequential photopolymerization of PEG hydrogel layers, each with diff...

journal_title：Cell transplantation

authors： Weber LM,Cheung CY,Anseth KS

更新日期：2007-11-01 00:00:00

abstract：:Neuronal progenitor cells (NPCs) derived from human embryonic stem cells (hESCs) are an excellent cell source for transplantation therapy due to their availability and ethical acceptability. However, the traditional method of expansion and differentiation of hESCs into NPCs in monolayer cultures requires a long time, ...

journal_title：Cell transplantation

authors： Qiu L,Lim YM,Chen AK,Reuveny S,Oh SK,Tan EK,Zeng L

更新日期：2016-01-01 00:00:00

abstract：:Potential labels for identifying embryonic raphe neurons and a clonal, neuronally differentiating, raphe-derived cell line, RN33B, in CNS transplantation studies were tested by first characterizing the labels in vitro. The labels that were tested included 4',6-diamidino-2-phenylindole hydrochloride, 1,1'-dioctadecyl-3...

journal_title：Cell transplantation

authors： Onifer SM,White LA,Whittemore SR,Holets VR

更新日期：1993-03-01 00:00:00

abstract：:Exenatide is an analog of the incretin hormone glucagon-like peptide (GLP-1) that is used for the treatment of T2D for their metabolic effects. In addition to its insulinotropic effects, exenatide increases functional islet mass and improves their survival. Improved outcomes have been reported in recent clinical isle...

journal_title：Cell transplantation

authors： Cechin SR,Pérez-Álvarez I,Fenjves E,Molano RD,Pileggi A,Berggren PO,Ricordi C,Pastori RL

更新日期：2012-01-01 00:00:00

abstract：:Ensheathing glia have been demonstrated to have neuroregenerative properties but this cell type from human sources has not been extensively studied because tissue samples are not easily obtained, primary cultures are slow growing, and human cell lines are not available. We previously isolated immortalized ensheathing ...

journal_title：Cell transplantation

authors： García-Escudero V,Gargini R,Gallego-Hernández MT,García-Gómez A,Martín-Bermejo MJ,Simón D,Delicado A,Moreno-Flores MT,Avila J,Lim F

更新日期：2011-01-01 00:00:00

abstract：:In this study the time course of homing and the body distribution of systemically delivered bone marrow mesenchymal stem cells (BM-MSCs) after myocardial infarction (MI) were evaluated. BM-MSCs were isolated from Wistar rats, expanded in vitro, and their phenotypical characterization was performed by flow cytometer. R...

journal_title：Cell transplantation

authors： Assis AC,Carvalho JL,Jacoby BA,Ferreira RL,Castanheira P,Diniz SO,Cardoso VN,Goes AM,Ferreira AJ

更新日期：2010-01-01 00:00:00

abstract：:Myoblast transplantation is being considered as a potential strategy to improve muscle function in myopathies; hence, it is important to identify the transplanted cells and to have available efficient reagents to track these cells. We first validated a human to mouse xenotransplantation model warranting the complete a...

journal_title：Cell transplantation

authors： Praud C,Vauchez K,Lombes A,Fiszman MY,Vilquin JT

更新日期：2008-01-01 00:00:00

abstract：:We examined whether hypoxic exposure prior to the event of transplantation would have a positive or negative effect upon later islet graft function. Mouse islets exposed to hypoxic culture were transplanted into syngeneic recipients. Islet graft function, β-cell physiology, as well as molecular changes were examined. ...

journal_title：Cell transplantation

authors： Cantley J,Walters SN,Jung MH,Weinberg A,Cowley MJ,Whitworth TP,Kaplan W,Hawthorne WJ,O'Connell PJ,Weir G,Grey ST

更新日期：2013-01-01 00:00:00

abstract：:Pancreatic islet transplantation has the potential to be an effective treatment for type 1 diabetes mellitus. While recent improvements have improved 1-year outcomes, follow-up studies show a persistent loss of graft function/survival over 5 years. One possible cause of islet transplant failure is the immunosuppressan...

journal_title：Cell transplantation

authors： Johnson JD,Ao Z,Ao P,Li H,Dai LJ,He Z,Tee M,Potter KJ,Klimek AM,Meloche RM,Thompson DM,Verchere CB,Warnock GL

更新日期：2009-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing–remitting MS (RRMS) while t...

journal_title：Cell transplantation

authors： Cobo M,Anderson P,Benabdellah K,Toscano MG,Muñoz P,García-Pérez A,Gutierrez I,Delgado M,Martin F

更新日期：2013-01-01 00:00:00

abstract：:Diabetes affects millions of people worldwide, and β-cell replacement is one of the promising new strategies for treatment. Induced pluripotent stem cells (iPSCs) can differentiate into any cell type, including pancreatic β cells, providing a potential treatment for diabetes. However, the molecular mechanisms underlyi...

journal_title：Cell transplantation

authors： Huang Y,Wan J,Guo Y,Zhu S,Wang Y,Wang L,Guo Q,Lu Y,Wang Z

更新日期：2017-08-01 00:00:00

abstract：:Epithelial wound repair assures the recovery of the epithelial barrier after wounding. During wound healing epithelial cells migrate to cover the wound surface. The presented experiments were carried out to compare the migration of human keratinocytes from primary and secondary culture on polystyrene, collagen, and fi...

journal_title：Cell transplantation

authors： Drukała J,Bandura L,Cieślik K,Korohoda W

更新日期：2001-01-01 00:00:00

abstract：:Gammopathies, multiple myeloma, and amyloidosis are plasma dyscrasias characterized by clonal proliferation and immunoglobulin overproduction. Renal impairment is the most common and serious complication with an incidence of 20-30% patients at the diagnosis. Kidney transplant has not been considered feasible in the pr...

journal_title：Cell transplantation

authors： Baraldi O,Grandinetti V,Donati G,Comai G,Battaglino G,Cuna V,Capelli I,Sala E,La Manna G

更新日期：2016-01-01 00:00:00

abstract：:Embedded-culture of pancreatic beta-cells derived from a transgenic mouse insulinoma (MIN6 cells) was studied in vitro and in vivo. The MIN6 cells were enmeshed in an agarose-PVMA-collagen matrix for long-term maintenance. The cells formed islet-like cell clusters (ICCs) in the mixed matrix. When 10 mmol/L nicotinamid...

journal_title：Cell transplantation

authors： Ohgawara H,Miyazaki J,Karibe S,Tashiro F,Akaike T,Hashimoto Y

更新日期：1995-05-01 00:00:00

abstract：:Stem cells are unique cells in the ability that can self-renew and differentiate into a wide variety of cell types, suggesting that a specific molecular control network underlies these features. To date, stem cells have been applied to many clinical therapeutic approaches. For example, hematopoietic stem cells (HSCs) ...

journal_title：Cell transplantation

authors： Liu SP,Fu RH,Yu HH,Li KW,Tsai CH,Shyu WC,Lin SZ

更新日期：2009-01-01 00:00:00

abstract：:An important challenge in pancreatic islet transplantation in association with type 1 diabetes is to define automatic high-throughput assays for evaluation of human islet function. The physiological techniques presently used are amenable to small-scale experimental samples and produce descriptive results. The postgeno...

journal_title：Cell transplantation

authors： Cabrera O,Jacques-Silva MC,Berman DM,Fachado A,Echeverri F,Poo R,Khan A,Kenyon NS,Ricordi C,Berggren PO,Caicedo A

更新日期：2008-01-01 00:00:00

abstract：:Efficient repopulation by transplanted hepatocytes in the severely injured liver is essential for their clinical application in the treatment of acute hepatic failure. We studied here whether and how the transplanted hepatocytes are able to efficiently repopulate the toxin-induced acute injured liver. Male dipeptidyl ...

journal_title：Cell transplantation

authors： Yu CH,Chen HL,Chen YH,Chang MF,Chien CS,Chang MH

更新日期：2009-01-01 00:00:00

abstract：:Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited an...

journal_title：Cell transplantation

authors： Gonzalez R,Garitaonandia I,Poustovoitov M,Abramihina T,McEntire C,Culp B,Attwood J,Noskov A,Christiansen-Weber T,Khater M,Mora-Castilla S,To C,Crain A,Sherman G,Semechkin A,Laurent LC,Elsworth JD,Sladek J,Snyder EY,

更新日期：2016-11-01 00:00:00

abstract：:Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the represen...

journal_title：Cell transplantation

authors： Yakoub AM,Sadek M

更新日期：2018-03-01 00:00:00

abstract：:Near infrared fluorescence (NIRF) optical imaging is a technique particularly powerful when studying in vivo processes at the molecular level in preclinical animal models. We recently demonstrated liver irradiation under the additional stimulus of partial hepatectomy as being an effective primer in the rat liver repop...

journal_title：Cell transplantation

authors： Koenig S,Krause P,Hosseini AS,Dullin C,Rave-Fraenk M,Kimmina S,Entwistle AL,Hermann RM,Hess CF,Becker H,Christiansen H

更新日期：2009-01-01 00:00:00

abstract：:Cardiac cell therapy with mesenchymal stem cells (MSCs) represents a promising treatment approach for end-stage heart failure. However, little is known about the underlying mechanisms and the fate of the transplanted cells. The objective of the presented work is to determine the feasibility of magnetic resonance imagi...

journal_title：Cell transplantation

authors： Drey F,Choi YH,Neef K,Ewert B,Tenbrock A,Treskes P,Bovenschulte H,Liakopoulos OJ,Brenkmann M,Stamm C,Wittwer T,Wahlers T

更新日期：2013-01-01 00:00:00

abstract：:Experiments on spinal cord injury (SCI) have largely focused on the transplantation of stem cells into injured spinal cords for motor recovery while neglecting to investigate bladder dysfunction. The present study was performed to investigate the effect of B10 human mesenchymal stem cells (hMSCs) directly transplanted...

journal_title：Cell transplantation

authors： Lee HJ,An J,Doo SW,Kim JH,Choi SS,Lee SR,Park SW,Song YS,Kim SU

更新日期：2015-01-01 00:00:00

abstract：:Posttransplant infusion of viable donor bone marrow cells (DBMC) has been shown in our previous studies to promote acceptance of incompatible kidney allografts in rhesus monkeys after treatment with polyclonal antithymocyte globulin to deplete peripheral T-lymphocytes. In this nonhuman primate model, the infusion of t...

journal_title：Cell transplantation

authors： Smith JP,Kasten-Jolly J,Rebellato L,Haisch CE,Thomas JM

更新日期：1997-07-01 00:00:00

abstract：:Recently, we described a diffusion chamber for a bioartificial endocrine pancreas (Bio-AEP). Pancreatic islet cells in the Bio-AEP device were isolated from the immune system of the host by an artificial barrier, while nutrients, electrolytes, oxygen, and bioactive secretory products were exchanged across this barrier...

journal_title：Cell transplantation

authors： Hirotani S,Eda R,Kawabata T,Fuchinoue S,Teraoka S,Agishi T,Ohgawara H

更新日期：1999-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a type of neurodegenerative disorder and the most common form of dementia. MicroRNA (miRNA) has been shown to play a role in various diseases, including AD. It also has been reported to regulate autophagy. We extracted miRNA from blood samples and constructed an miRNA-101a lentivirus vector...

journal_title：Cell transplantation

authors： Li Q,Wang Y,Peng W,Jia Y,Tang J,Li W,Zhang JH,Yang J

更新日期：2019-08-01 00:00:00

abstract：:We investigated the effect of the activation of complement in human serum on isolated adult porcine islets using an in vitro model of pig-to-human islet transplantation. Pancreata were obtained from slaughterhouse pigs (6-8 mo old). Islets were prepared by intraductal collagenase digestion followed by purification on ...

journal_title：Cell transplantation

authors： Kin T,Nakajima Y,Kanehiro H,Aomatsu Y,Yoshimura A,Taki J,Ko S,Yagura K,Oyama T,Ohashi K,Nakano H

更新日期：1996-09-01 00:00:00

abstract：:Nerve growth factor (NGF) exerts both trophic (cell survival) and tropic (axonal growth-promoting) effects on several neuronal populations. In particular, its robust ability to prevent lesion-induced and spontaneous age-related basal forebrain cholinergic neuronal degeneration, and to promote mnemonic recovery, has su...

journal_title：Cell transplantation

authors： Tuszynski MH

更新日期：2000-09-01 00:00:00

abstract：:Nowadays, cardiac regenerative medicine is facing many limitations because of the complexity to find the most suitable stem cell source and to understand the regenerative mechanisms involved. Mesenchymal stem cells (MSCs) have shown great regenerative potential due to their intrinsic properties and ability to restore ...

journal_title：Cell transplantation

authors： Siciliano C,Chimenti I,Ibrahim M,Napoletano C,Mangino G,Scafetta G,Zoccai GB,Rendina EA,Calogero A,Frati G,De Falco E

更新日期：2015-01-01 00:00:00