Evaluation of insulin secretion of isolated rat islets cultured in extracellular matrix.

abstract：:The purpose of this study was to investigate the clinical efficacy of neural stem/progenitor cell (NS/PC) transplantation to treat severe cortical visual impairment (CVI), a sequela of neonatal brain injury. Fifty-two patients with cerebral injury and CVI were randomly divided into two groups: the treatment group (n =...

journal_title：Cell transplantation

authors： Luan Z,Qu S,Du K,Liu W,Yang Y,Wang Z,Cui Y,Du Q

更新日期：2013-01-01 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) are highly prevalent in young men aged 20-40 years and are one of the most common lethal solid tumors in men of this age. Due to the current unclear mechanism of tumor development, there is a lack of effective treatment, and therefore in-depth research of the molecular mechanism of ...

journal_title：Cell transplantation

authors： Luo Y,Sun Y,Li L,Mao Y

更新日期：2020-01-01 00:00:00

abstract：:Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficien...

journal_title：Cell transplantation

authors： Chan TM,Chen JY,Ho LI,Lin HP,Hsueh KW,Liu DD,Chen YH,Hsieh AC,Tsai NM,Hueng DY,Tsai ST,Chou PW,Lin SZ,Harn HJ

更新日期：2014-01-01 00:00:00

abstract：:Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as t...

journal_title：Cell transplantation

authors： Foy TM,McIlraith M,Masters SR,Dunn JJ,Rossini AA,Shultz LD,Hesselton RA,Wagar EJ,Lipsky PE,Noelle RJ,Greiner DL

更新日期：1998-01-01 00:00:00

abstract：:Cell therapy has been shown to be a promising alternative therapy for neurorestoration, and more than 30 different types of cells have been shown to possess some capability to restore lost or damaged neurological functions. Chinese physicians have successfully applied cell therapy to many neurological diseases and dam...

journal_title：Cell transplantation

authors： Chinese Branch of International Association of Neurorestoratology (IANR).,Preparatory Committee of Chinese Association of Neurorestoratology.

更新日期：2013-01-01 00:00:00

abstract：:Adipose tissue contains a mesenchymal stem cell (MSC) population known as adipose-derived stem cells (ASCs) capable of differentiating into different cell types. Our aim was to induce hepatic transdifferentiation of ASCs by sequential exposure to several combinations of cytokines, growth factors, and hormones. The mos...

journal_title：Cell transplantation

authors： Bonora-Centelles A,Jover R,Mirabet V,Lahoz A,Carbonell F,Castell JV,Gómez-Lechón MJ

更新日期：2009-01-01 00:00:00

abstract：:To learn more about nonimmune-mediated islet graft failure, we transplanted different preparations (preps) of isolated human islets under the kidney capsule of streptozotocin (STZ)-diabetic nude mice. One month after the implantation of 1,000 or 2,000 islets, grafts were harvested for morphological, immunohistochemica...

journal_title：Cell transplantation

authors： Davalli AM,Perego L,Bertuzzi F,Finzi G,La Rosa S,Blau A,Placidi C,Nano R,Gregorini L,Perego C,Capella C,Folli F

更新日期：2008-01-01 00:00:00

abstract：:Cardiovascular diseases are related to many risk factors, such as diabetes, high blood pressure, smoking, and obesity. Myocardial infarction (MI), a cardiovascular disease, is the most common cause of cardiomyocyte death. In MI, hypoxia induces cardiomyocyte apoptosis; in particular, diabetes combined with MI has a sy...

journal_title：Cell transplantation

authors： Huang CY,Chen SY,Fu RH,Huang YC,Chen SY,Shyu WC,Lin SZ,Liu SP

更新日期：2015-01-01 00:00:00

abstract：:The limited availability of human embryonic tissue for dopamine cell transplants in Parkinson's patients has led to an increased interest in using xenogeneic donor tissue. Unfortunately, without aggressive immunosuppression, such brain xenografts are rejected by the host immune system. Chronic brain xenograft rejectio...

journal_title：Cell transplantation

authors： Veng LM,Bjugstad KB,Freed CR,Marrack P,Clarkson ED,Bell KP,Hutt C,Zawada WM

更新日期：2002-01-01 00:00:00

abstract：:Liver transplantation is the only existing modality for treating decompensated liver cirrhosis. Several factors, such as nonavailability of donors, combined with operative risks, complications associated with rejection, usage of immunosuppressive agents, and cost intensiveness, make this strategy available to only a f...

journal_title：Cell transplantation

authors： Khan AA,Shaik MV,Parveen N,Rajendraprasad A,Aleem MA,Habeeb MA,Srinivas G,Raj TA,Tiwari SK,Kumaresan K,Venkateswarlu J,Pande G,Habibullah CM

更新日期：2010-01-01 00:00:00

abstract：:In this study the time course of homing and the body distribution of systemically delivered bone marrow mesenchymal stem cells (BM-MSCs) after myocardial infarction (MI) were evaluated. BM-MSCs were isolated from Wistar rats, expanded in vitro, and their phenotypical characterization was performed by flow cytometer. R...

journal_title：Cell transplantation

authors： Assis AC,Carvalho JL,Jacoby BA,Ferreira RL,Castanheira P,Diniz SO,Cardoso VN,Goes AM,Ferreira AJ

更新日期：2010-01-01 00:00:00

abstract：:Our purpose was to evaluate whether or not and when phenotypic modulation of smooth muscle cells (SMCs) in hybrid vascular prostheses preincorporated with SMCs occurs upon implantation. Two types of hybrid vascular grafts incorporated with vascular cells derived from canine jugular veins were prepared: grafts containi...

journal_title：Cell transplantation

authors： Kanda K,Miwa H,Matsuda T

更新日期：1995-11-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is a dominant inherited disease caused by expanded trinucleotide repeats resulting in an increased polyglutamine tract in the gene product. As a potential therapeutic approach for SCA1, we tested antisense RNAs targeting two regions of the ataxin-1 message. Single-stranded regions ...

journal_title：Cell transplantation

authors： Gao Y,Zu T,Low WC,Orr HT,McIvor RS

更新日期：2008-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) displays high resistance to radiation and chemotherapy, due to the presence of a fraction of GBM stem-like cells (GSLCs), which are thus representing the target for GBM elimination. Since mesenchymal stem cells (MSCs) display high tumor tropism, we examined possible antitumor effects of t...

journal_title：Cell transplantation

authors： Kološa K,Motaln H,Herold-Mende C,Koršič M,Lah TT

更新日期：2015-01-01 00:00:00

abstract：:Bone nonunion is a pathological condition in which all bone healing processes have stopped, resulting in abnormal mobility between 2 bone segments. The incidence of bone-related injuries will increase in an aging population, leading to such injuries reaching epidemic proportions. Tissue engineering and cell therapy us...

journal_title：Cell transplantation

authors： Dufrane D

更新日期：2017-09-01 00:00:00

abstract：:In this study, we assessed the ability of miR-26b-5p to regulate T cell factor 4 (TCF-4) expression and thereby control human adipose-derived mesenchymal stem cell (hADMSC) adipogenic differentiation. Adipogenic medium was used to induce hADMSC differentiation over a 6-d period. The ability of miR-26b-5p to interact w...

journal_title：Cell transplantation

authors： Luo Y,Ji H,Cao Y,Ding X,Li M,Song H,Li S,WaTableng C,Wu H,Meng J,Du H

更新日期：2020-01-01 00:00:00

abstract：:After a unilateral striatal lesion, animals have generally been seen to have a bilateral impairment in paw reaching, with the contralateral paw being more affected. However, most studies to date have not used a pretraining paradigm to assess maximal capacity for paw reaching, to compare with any lesion-induced loss. T...

journal_title：Cell transplantation

authors： Fricker-Gates RA,Smith R,Muhith J,Dunnett SB

更新日期：2003-01-01 00:00:00

abstract：:Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment. In this review, we attempt to give a brief overview of the animal models of PD currently used, with a more comprehensive focus on the advantage...

journal_title：Cell transplantation

authors： Soderstrom K,O'Malley J,Steece-Collier K,Kordower JH

更新日期：2006-01-01 00:00:00

abstract：:Parkinson's disease (PD), while primarily associated with degeneration of nigrostriatal dopamine neurons, is now increasingly recognized to have more widespread cell loss and so the most effective cell replacement therapy should target all these neuronal losses. Neural precursor cells might be ideal in this regard as ...

journal_title：Cell transplantation

authors： Jain M,Armstrong RJ,Elneil S,Barker RA

更新日期：2006-01-01 00:00:00

abstract：:Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to interruption of spinal pathways and secondary neurodegenerative processes. The transplant of neural stem cells (NSCs) is a promising approach for the repair of SCI. Reprogramming of adult somatic cells into induced pluripoten...

journal_title：Cell transplantation

authors： López-Serrano C,Torres-Espín A,Hernández J,Alvarez-Palomo AB,Requena J,Gasull X,Edel MJ,Navarro X

更新日期：2016-10-01 00:00:00

abstract：:The main purpose of this work has been to establish a new culturing technique to improve the chondrogenic commitment of isolated adult human chondrocytes, with the aim of being used during cell-based therapies or tissue engineering strategies. By using a rather novel technique to generate scaffold-free three-dimension...

journal_title：Cell transplantation

authors： Martinez I,Elvenes J,Olsen R,Bertheussen K,Johansen O

更新日期：2008-01-01 00:00:00

abstract：:Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood-brain barrier...

journal_title：Cell transplantation

authors： Chen J,Jin H,Xu H,Peng Y,Jie L,Xu D,Chen L,Li T,Fan L,He P,Ying G,Gu C,Wang C,Wang L,Chen G

更新日期：2019-11-01 00:00:00

abstract：:The objective of this study was to define pretransplant islet culture conditions for optimum tissue engraftment in the rat islet allotransplantation model. Lewis rat islets were cultured in TCM 199/5% fetal calf serum for I day at 37 degrees C, followed by 1 day of culture at 22 degrees C. When islets from single dono...

journal_title：Cell transplantation

authors： Jahr H,Hussmann B,Eckhardt T,Bretzel RG

更新日期：2002-01-01 00:00:00

abstract：:Hepatocyte transplantation is a promising therapy for acute liver failure in humans. Recently, we succeeded in inducing various acute and chronic liver failures in nude mice. Engraftment of transplanted xenogeneic rat hepatocytes, visualized in the host liver by anti-MHC class I immunohistochemistry, revealed that liv...

journal_title：Cell transplantation

authors： Vidal I,Blanchard N,Alexandre E,Gandillet A,Chenard-Neu MP,Staedtler F,Schumacher M,Bachellier P,Jaeck D,Firat H,Heyd B,Richert L

更新日期：2008-01-01 00:00:00

abstract：:Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and can be promoted by immunosuppressants. However, there is no prevention or treatment for HCC recurrence after LT. Here we describe a clinical-scale method for an adoptive immunotherapy approach that...

journal_title：Cell transplantation

authors： Ohira M,Nishida S,Tryphonopoulos P,Tekin A,Selvaggi G,Moon J,Levi D,Ricordi C,Ishiyama K,Tanaka Y,Ohdan H,Tzakis AG

更新日期：2012-01-01 00:00:00

abstract：:Oligodendrocyte (OL) replacement can be a promising strategy for spinal cord injury (SCI) repair. However, the poor posttransplantation survival and inhibitory properties to axonal regeneration are two major challenges that limit their use as donor cells for repair of CNS injuries. Therefore, strategies aimed at enhan...

journal_title：Cell transplantation

authors： Hu JG,Wang XF,Deng LX,Liu NK,Gao X,Chen JH,Zhou FC,Xu XM

更新日期：2013-01-01 00:00:00

abstract：:A population of Hoechst 33342-stained cells, termed side population (SP) cells, can reconstitute the hematopoietic system of syngeneic mice. This study examined whether limiting numbers of SP cells can repopulate mice across a xenogeneic MHC class I barrier. SP cells were isolated from HLA.B7 and HLA.A2.1 transgenic m...

journal_title：Cell transplantation

authors： Jackson JD,Zhou G,Kuszynski CA,Cai J,Fox IJ

更新日期：2002-01-01 00:00:00

abstract：:Posttransplant infusion of viable donor bone marrow cells (DBMC) has been shown in our previous studies to promote acceptance of incompatible kidney allografts in rhesus monkeys after treatment with polyclonal antithymocyte globulin to deplete peripheral T-lymphocytes. In this nonhuman primate model, the infusion of t...

journal_title：Cell transplantation

authors： Smith JP,Kasten-Jolly J,Rebellato L,Haisch CE,Thomas JM

更新日期：1997-07-01 00:00:00

abstract：:Hepatocyte transplantation and artificial organ hepatic support require a number of functionally mature hepatocytes. However, their growth activity and functional behaviors are much smaller in culture after isolation from the liver. We examined whether continuously differentiating hepatocytes from multipotent hepatic ...

journal_title：Cell transplantation

authors： Suzuki A,Nakauchi H,Taniguchi H

更新日期：2003-01-01 00:00:00

abstract：:Biological pacing has been proposed as a physiologic counterpart to electronic pacing, and the sinoatrial node (SAN) is the general standard for biological pacemakers. We tested the expression of SAN pacemaker cell activity when implanted autologously in the right ventricle (RV). We induced complete heart block and i...

journal_title：Cell transplantation

authors： Zhang H,Lau DH,Shlapakova IN,Zhao X,Danilo P,Robinson RB,Cohen IS,Qu D,Xu Z,Rosen MR

更新日期：2011-01-01 00:00:00