Use of allogeneic bone marrow labeled with neomycin resistance gene to examine bone marrow-derived chimerism in experimental organ transplantation.

abstract：:Liver transplantation is the only existing modality for treating decompensated liver cirrhosis. Several factors, such as nonavailability of donors, combined with operative risks, complications associated with rejection, usage of immunosuppressive agents, and cost intensiveness, make this strategy available to only a f...

journal_title：Cell transplantation

authors： Khan AA,Shaik MV,Parveen N,Rajendraprasad A,Aleem MA,Habeeb MA,Srinivas G,Raj TA,Tiwari SK,Kumaresan K,Venkateswarlu J,Pande G,Habibullah CM

更新日期：2010-01-01 00:00:00

abstract：:ET-Kyoto solution (ET-K) is an extracellular-type organ preservation solution containing the cytoprotective disaccharide, trehalose. A previous study reported the supplement of dibutyryl cyclic adenosine monophosphate (db-cAMP) in conventional ET-K to attenuate lung ischemia-reperfusion injury. In this study, the effi...

journal_title：Cell transplantation

authors： Zhao X,Koshiba T,Nakamura T,Tsuruyama T,Li Y,Bando T,Wada H,Tanaka K

更新日期：2008-01-01 00:00:00

abstract：:Apoptosis is a vital pathological factor that accounts for the poor prognosis of traumatic spinal cord injury (t-SCI). The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is a critical regulator for energy metabolism and proven to have antiapoptotic effects. This study aimed to investigate the neuroprote...

journal_title：Cell transplantation

authors： Gao L,Wang C,Qin B,Li T,Xu W,Lenahan C,Ying G,Li J,Zhao T,Zhu Y,Chen G

更新日期：2020-01-01 00:00:00

abstract：:Embedded-culture of pancreatic beta-cells derived from a transgenic mouse insulinoma (MIN6 cells) was studied in vitro and in vivo. The MIN6 cells were enmeshed in an agarose-PVMA-collagen matrix for long-term maintenance. The cells formed islet-like cell clusters (ICCs) in the mixed matrix. When 10 mmol/L nicotinamid...

journal_title：Cell transplantation

authors： Ohgawara H,Miyazaki J,Karibe S,Tashiro F,Akaike T,Hashimoto Y

更新日期：1995-05-01 00:00:00

abstract：:Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed and tested in clinical phase III trials for Alzheimer's disease, can re...

journal_title：Cell transplantation

authors： Hsueh SC,Lecca D,Greig NH,Wang JY,Selman W,Hoffer BJ,Miller JP,Chiang YH

更新日期：2019-09-01 00:00:00

abstract：:Persistent fetal vasculature (PFV) is a potentially serious developmental anomaly in human eyes, which results from a failure of the primary vitreous and the hyaloid vascular systems to regress during development. Recent findings from our laboratory indicate that fibrovascular membranes harvested from subjects with P...

journal_title：Cell transplantation

authors： Chen G,Ma J,Shatos MA,Chen H,Cyr D,Lashkari K

更新日期：2012-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing–remitting MS (RRMS) while t...

journal_title：Cell transplantation

authors： Cobo M,Anderson P,Benabdellah K,Toscano MG,Muñoz P,García-Pérez A,Gutierrez I,Delgado M,Martin F

更新日期：2013-01-01 00:00:00

abstract：:Cell therapies consist in transplanting healthy cells into a disabled tissue with the goal to repopulate it and restore its function at least partially. In muscular diseases, most of the time, myoblasts are chosen for their expansion capacity in culture. Nevertheless, cell transplantation has limitations, among them,...

journal_title：Cell transplantation

authors： Gérard C,Dufour C,Goudenege S,Skuk D,Tremblay JP

更新日期：2012-01-01 00:00:00

abstract：:Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment. In this review, we attempt to give a brief overview of the animal models of PD currently used, with a more comprehensive focus on the advantage...

journal_title：Cell transplantation

authors： Soderstrom K,O'Malley J,Steece-Collier K,Kordower JH

更新日期：2006-01-01 00:00:00

abstract：:Direct reprogramming of an adult cell into another differentiated lineage-such as fibroblasts into neurons, cardiomyocytes, or blood cells-without passage through an undifferentiated pluripotent stage is a new area of research that has recently emerged alongside stem cell technology and induced pluripotent stem cell r...

journal_title：Cell transplantation

authors： Nizzardo M,Simone C,Falcone M,Riboldi G,Comi GP,Bresolin N,Corti S

更新日期：2013-01-01 00:00:00

abstract：:Despite recent advances and promising results in children, liver cell transplantation (LCT) should still be regarded as an experimental therapy. Several substantial complications are known from animal studies and individual patients. However, safety data on liver cell infusion in children are scarce. We used LCT in fo...

journal_title：Cell transplantation

authors： Meyburg J,Hoerster F,Schmidt J,Poeschl J,Hoffmann GF,Schenk JP

更新日期：2010-01-01 00:00:00

abstract：:During in vivo intracerebral infusions, the ability to perform accurate targeting towards a 3D-specific point allows control of the anatomical variable and identification of the effects of variations in other factors. Intraoperative MRI navigation systems are currently being used in the clinic, yet their use in nonhum...

journal_title：Cell transplantation

authors： Emborg ME,Joers V,Fisher R,Brunner K,Carter V,Ross C,Raghavan R,Brady M,Raschke J,Kubota K,Alexander A

更新日期：2010-01-01 00:00:00

abstract：:Mouse embryonal carcinoma cell line P19 could be differentiated to neurons or glial cells by appropriate induction. We introduced the lacZ gene driven by a calmodulin promoter into P19 cells, and cloned the transfectant CaM-Z that showed the strong expression of lacZ gene after the induction of differentiation. CaM-Z ...

journal_title：Cell transplantation

authors： Watanabe R,Takase-Yoden S,Ikeda T,Atsumi T

更新日期：1996-09-01 00:00:00

abstract：:We investigated the effect of the activation of complement in human serum on isolated adult porcine islets using an in vitro model of pig-to-human islet transplantation. Pancreata were obtained from slaughterhouse pigs (6-8 mo old). Islets were prepared by intraductal collagenase digestion followed by purification on ...

journal_title：Cell transplantation

authors： Kin T,Nakajima Y,Kanehiro H,Aomatsu Y,Yoshimura A,Taki J,Ko S,Yagura K,Oyama T,Ohashi K,Nakano H

更新日期：1996-09-01 00:00:00

abstract：:Cellular transplantation strategies utilizing intraspinal or intrathecal olfactory ensheathing cells (OECs) have been reported as beneficial for spinal cord injury (SCI). However, there are many disadvantages of these methods, including additional trauma to the spinal cord parenchyma and technical challenges. Therefor...

journal_title：Cell transplantation

authors： Zhang L,Zhuang X,Chen Y,Xia H

更新日期：2019-12-01 00:00:00

abstract：:Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have confirmed these findings but have not determined whether physical contact between MSC and islets is required or whether th...

journal_title：Cell transplantation

authors： Brandhorst H,Brandhorst D,Abraham A,Acreman S,Schive SW,Scholz H,Johnson PRV

更新日期：2020-01-01 00:00:00

abstract：:The integrity of the blood-brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endov...

journal_title：Cell transplantation

authors： Qi X,Liu J,Wu J,Bi Y,Han C,Zhang G,Lou M,Lu J,Tang J

更新日期：2019-08-01 00:00:00

abstract：:Nerve growth factor (NGF) exerts both trophic (cell survival) and tropic (axonal growth-promoting) effects on several neuronal populations. In particular, its robust ability to prevent lesion-induced and spontaneous age-related basal forebrain cholinergic neuronal degeneration, and to promote mnemonic recovery, has su...

journal_title：Cell transplantation

authors： Tuszynski MH

更新日期：2000-09-01 00:00:00

abstract：:The mechanisms of donor hepatocyte integration into recipient liver are not fully understood. We investigated mechanisms of both the integration and interaction of transplanted hepatocytes with host liver cells as well as the repopulation of the host organ following intraportal transplantation. Mature hepatocytes were...

journal_title：Cell transplantation

authors： Koenig S,Stoesser C,Krause P,Becker H,Markus PM

更新日期：2005-01-01 00:00:00

abstract：:The clinical consequences of acute liver failure are associated with high mortality. Intensive medical intervention is required to treat the symptoms of liver failure, including coagulopathy, metabolic instability, and encephalopathy. Providing temporary liver support with an extracorporeal liver assist device could s...

journal_title：Cell transplantation

authors： Gregory PG,Connolly CK,Toner M,Sullivan SJ

更新日期：2000-01-01 00:00:00

abstract：:Several molecular therapies require the implantation of cells that secrete biotherapeutic molecules and imaging the location and microenvironment of the cellular implant to ascertain its function. We demonstrate noninvasive in vivo magnetic resonance imaging (MRI) of self-assembled microcontainers that are capable of ...

journal_title：Cell transplantation

authors： Gimi B,Artemov D,Leong T,Gracias DH,Gilson W,Stuber M,Bhujwalla ZM

更新日期：2007-01-01 00:00:00

abstract：:Hepatocyte transplantation (HT) has become an effective therapy for patients with metabolic inborn errors. We report the clinical outcome of four children with metabolic inborn errors that underwent HT, describing the cell infusion protocol and the metabolic outcome of transplanted patients. Cryopreserved hepatocytes...

journal_title：Cell transplantation

authors： Ribes-Koninckx C,Ibars EP,Calzado Agrasot MÁ,Bonora-Centelles A,Miquel BP,Vila Carbó JJ,Aliaga ED,Pallardó JM,Gómez-Lechón MJ,Castell JV

更新日期：2012-01-01 00:00:00

abstract：:Insufficient oxygenation can limit the long-term survival of encapsulated islets in subcutaneous tissue. Transplantation of coencapsulated pig islets with adipose or bone marrow mesenchymal stem cells (AMSCs or BM-MSCs, respectively) was investigated with regard to implant vascularization, oxygenation, and diabetes co...

journal_title：Cell transplantation

authors： Vériter S,Gianello P,Igarashi Y,Beaurin G,Ghyselinck A,Aouassar N,Jordan B,Gallez B,Dufrane D

更新日期：2014-01-01 00:00:00

abstract：:We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet t...

journal_title：Cell transplantation

authors： Slavin S,Weiss L,Xia W,Gross DJ

更新日期：1996-11-01 00:00:00

abstract：:A large proportion of islets are lost after transplantation partly due to a lack of functional vasculature. Islets revascularize from host tissue but the process takes up to 2 weeks and has been suggested to result in reduced vascular density in engrafted islets. We describe a method for observing and quantifying the ...

journal_title：Cell transplantation

authors： Jones GL,Juszczak MT,Hughes SJ,Kooner P,Powis SH,Press M

更新日期：2007-01-01 00:00:00

abstract：:Cell-based therapy for the bladder has its beginnings in the 1990s with the successful isolation and culture of bladder smooth muscle cells. Since then, several attempts have been made to artificially implant native cell types and stem cell-derived cells into damaged bladders in the form of single-cell injectables or ...

journal_title：Cell transplantation

authors： Gopinath C,Ponsaerts P,Wyndaele JJ

更新日期：2015-01-01 00:00:00

abstract：:It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump...

journal_title：Cell transplantation

authors： Fisher WE

更新日期：1999-09-01 00:00:00

abstract：:A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To identify morphological characteristics of transplanted donor cells, HESCs were transfected with a GFP lentiviral vector. Gene expression ...

journal_title：Cell transplantation

authors： Wakeman DR,Weiss S,Sladek JR,Elsworth JD,Bauereis B,Leranth C,Hurley PJ,Roth RH,Redmond DE

更新日期：2014-01-01 00:00:00

abstract：:Previously, we found that hepatocyte growth factor receptor (c-Met)-and alpha-fetoprotein (AFP)-expressing cells were present in adult rat bone marrow, and that these cells also expressed hematopoietic stem cell markers, such as CD34, Thy-1, and c-Kit. When bone marrow cells were cultured in a hepatocyte growth medium...

journal_title：Cell transplantation

authors： Miyazaki M,Masaka T,Akiyama I,Nakashima E,Sakaguchi M,Huh NH

更新日期：2004-01-01 00:00:00

abstract：:Autologous brain cell transplantation might be useful for repairing lesions and restoring function of the central nervous system. We have demonstrated that adult monkey brain cells, obtained from cortical biopsy and kept in culture for a few weeks, exhibit neural progenitor characteristics that make them useful for br...

journal_title：Cell transplantation

authors： Brunet JF,Redmond DE Jr,Bloch J

更新日期：2009-01-01 00:00:00