Implantation of sinoatrial node cells into canine right ventricle: biological pacing appears limited by the substrate.

abstract：:Hematopoietic stem cells (HSCs) migrate to injury sites and aid in tissue repair. However, clinical success is poor and is partially due to limited HSC recruitment. We hypothesized that HSC pretreatment with H2O2 would enhance their recruitment to injured gut. As HSCs are rare cells, the number of primary cells obtain...

journal_title：Cell transplantation

authors： Kavanagh DP,Yemm AI,Alexander JS,Frampton J,Kalia N

更新日期：2013-01-01 00:00:00

abstract：:In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells (BMMSCs) transfected with connective ti...

journal_title：Cell transplantation

authors： Zhu S,Zhang B,Man C,Ma Y,Liu X,Hu J

更新日期：2014-04-01 00:00:00

abstract：:Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and can be promoted by immunosuppressants. However, there is no prevention or treatment for HCC recurrence after LT. Here we describe a clinical-scale method for an adoptive immunotherapy approach that...

journal_title：Cell transplantation

authors： Ohira M,Nishida S,Tryphonopoulos P,Tekin A,Selvaggi G,Moon J,Levi D,Ricordi C,Ishiyama K,Tanaka Y,Ohdan H,Tzakis AG

更新日期：2012-01-01 00:00:00

abstract：:Cellular transplantation strategies utilizing intraspinal or intrathecal olfactory ensheathing cells (OECs) have been reported as beneficial for spinal cord injury (SCI). However, there are many disadvantages of these methods, including additional trauma to the spinal cord parenchyma and technical challenges. Therefor...

journal_title：Cell transplantation

authors： Zhang L,Zhuang X,Chen Y,Xia H

更新日期：2019-12-01 00:00:00

abstract：:We investigated the effect of the activation of complement in human serum on isolated adult porcine islets using an in vitro model of pig-to-human islet transplantation. Pancreata were obtained from slaughterhouse pigs (6-8 mo old). Islets were prepared by intraductal collagenase digestion followed by purification on ...

journal_title：Cell transplantation

authors： Kin T,Nakajima Y,Kanehiro H,Aomatsu Y,Yoshimura A,Taki J,Ko S,Yagura K,Oyama T,Ohashi K,Nakano H

更新日期：1996-09-01 00:00:00

abstract：:The hypogonadal (HPG) mouse is a mutant that lacks a functional gonadotropin-releasing hormone (GnRH) gene. In this study, female HPG mice received bilateral intrahypothalamic implants of an immortalized GnRH-secreting cell line (GT1-7). Nine mice were tested 42- 65 days after implantation to determine whether these c...

journal_title：Cell transplantation

authors： Miller GM,Silverman AJ,Roberts JL,Wendong K,Gibson MJ

更新日期：1993-05-01 00:00:00

abstract：:Recent advances in islet transplantation using highly purified islets and effective immunosuppression strategies have resulted in substantial improvement in achieving insulin independence in type 1 diabetes patients. However, there are side effects from long-term immunosuppression, and transplant rejection and/or the ...

journal_title：Cell transplantation

authors： Kobayashi N

更新日期：2008-01-01 00:00:00

abstract：:Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the use of bovine carotid artery-derived HH cells as feeder cells. The ...

journal_title：Cell transplantation

authors： Miyamoto Y,Ikeya T,Enosawa S

更新日期：2009-01-01 00:00:00

abstract：:Human islet allografts are well known to induce full and sustained remission of hyperglycemia, with complete normalization of key metabolic parameters. Nevertheless, acquiring human islets, even from cadaveric human donor pancreases, remains a significant impediment to successful transplantation therapy for diabetes. ...

journal_title：Cell transplantation

authors： Luca G,Calvitti M,Nastruzzi C,Macchiarulo G,Becchetti E,Neri LM,Capitani S,Basta G,Brunetti P,Calafiore R,Cameron DF

更新日期：2006-01-01 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...

journal_title：Cell transplantation

authors： Hossne NA,Cruz E,Buffolo E,Coimbra AC,Machado J,Goldenberg RC,Regazzi G,Azevedo S,Invitti AL,Rodrigues Branco JN,Rodrigues de Oliveira JS,Stolf NA,Miller LW,Sanberg PR

更新日期：2015-01-01 00:00:00

abstract：:Expression of a fluorescent reporter gene has been studied using two alternate promoters to transcribe the green fluorescent protein (gfp) from Aequorea victoria. The human cytomegalovirus (CMV) enhancer/ promoter or the human muscle-specific creatine kinase promoter (CKM) were inserted along with the gfp cDNA into a ...

journal_title：Cell transplantation

authors： Bartlett RJ,Secore SL,Singer JT,Bodo M,Sharma K,Ricordi C

更新日期：1996-05-01 00:00:00

abstract：:To engineer liver tissues with a clinically significant size, in vivo evaluation of performance using large-scale animal studies are necessary before proceeding to human clinical trials. As pigs are the most suitable candidates, the development of culture conditions suitable for porcine hepatocyte progenitors is very ...

journal_title：Cell transplantation

authors： Huang H,Hanada S,Kojima N,Sakai Y

更新日期：2006-01-01 00:00:00

abstract：:Sciatic nerve injuries, not uncommon in trauma with a limited degree of functional recovery, are considered a persistent clinical, social, and economic problem worldwide. Accumulating evidence suggests that stem cells can promote the tissue regeneration through various mechanisms. The aim of the present study was to i...

journal_title：Cell transplantation

authors： Chuang MH,Ho LH,Kuo TF,Sheu SY,Liu YH,Lin PC,Tsai YC,Yang CH,Chu CM,Lin SZ

更新日期：2020-01-01 00:00:00

abstract：:Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect of DOR activation on autophagy...

journal_title：Cell transplantation

authors： Wang S,Cao X,Duan Y,Zhang G

更新日期：2019-06-01 00:00:00

abstract：:Ex vivo embryonic liver explant culture is a novel and attractive approach to obtain abundant hepatic and hematopoietic stem cells. Gene therapy of autologous hepatic and hematopoietic stem cells represents an alternative therapeutic approach to liver transplantation for genetic and metabolic disorders. In this study ...

journal_title：Cell transplantation

authors： Monga SPS,Tang Y,Candotti F,Rashid A,Wildner O,Mishra B,Iqbal S,Mishra L

更新日期：2001-01-01 00:00:00

abstract：:The third-generation NOD/LtSz-scid/IL2Rγ(null) (NOD/SCID IL2Rγ(null)) mouse represents a significantly improved xenograft model allowing high levels of human leukocyte engraftment over extended follow up. One remaining limitation of this mouse model, however, is the low level of circulating human erythrocytes. We esta...

journal_title：Cell transplantation

authors： Hayakawa J,Hsieh MM,Anderson DE,Phang O,Uchida N,Washington K,Tisdale JF

更新日期：2010-01-01 00:00:00

abstract：:The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW)...

journal_title：Cell transplantation

authors： Nuryyev RL,Uhlendorf TL,Tierney W,Zatikyan S,Kopyov O,Kopyov A,Ochoa J,Van Trigt W,Malone CS,Cohen RW

更新日期：2017-11-01 00:00:00

abstract：:The present study was designed to evaluate the use of collagen gel loaded with human retinal pigment epithelium (ARPE19) in cellular transfer and to assess its viability within the gel. Collagen solution was prepared by dissolving calfskin in hydrochloric acid to make a final concentration of 2.0 mg/ml and this was mi...

journal_title：Cell transplantation

authors： Yeung CK,Chiang SW,Chan KP,Lam DS,Pang CP

更新日期：2004-01-01 00:00:00

abstract：:At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts...

journal_title：Cell transplantation

authors： Gao LR,Zhang NK,Ding QA,Chen HY,Hu X,Jiang S,Li TC,Chen Y,Wang ZG,Ye Y,Zhu ZM

更新日期：2013-01-01 00:00:00

abstract：:Prognosis of patients with heart failure remains poor despite improved conventional and interventional treatment regimens. The improvement of neovascularization and repair processes by administration of bone marrow-derived cells modestly improved the recovery after acute myocardial infarction. However, circulating pat...

journal_title：Cell transplantation

authors： Honold J,Fischer-Rasokat U,Lehmann R,Leistner DM,Seeger FH,Schachinger V,Martin H,Dimmeler S,Zeiher AM,Assmus B

更新日期：2012-01-01 00:00:00

abstract：:Successful transplantation of cadaver embryonic neural tissue is highly dependent on the method used to obtain the tissue. It is important that the tissue not be contaminated bacteriologically by vaginal flora during the procedure, and that it not be disrupted mechanically. A low-pressure aspiration abortion technique...

journal_title：Cell transplantation

authors： Nauert GM,Freeman TB

更新日期：1994-03-01 00:00:00

abstract：:The effect of pretreatments of host muscles with metalloproteinases (MMPs) or with notexin on the migration of transplanted myoblasts was investigated. Transgenic TnILacZ mice in which the beta-galactosidase gene is under the control of a quail fast skeletal troponin I gene promoter were used as donors. A polyethylene...

journal_title：Cell transplantation

authors： Torrente Y,El Fahime E,Caron NJ,Bresolin N,Tremblay JP

更新日期：2000-07-01 00:00:00

abstract：:Nowadays, cardiac regenerative medicine is facing many limitations because of the complexity to find the most suitable stem cell source and to understand the regenerative mechanisms involved. Mesenchymal stem cells (MSCs) have shown great regenerative potential due to their intrinsic properties and ability to restore ...

journal_title：Cell transplantation

authors： Siciliano C,Chimenti I,Ibrahim M,Napoletano C,Mangino G,Scafetta G,Zoccai GB,Rendina EA,Calogero A,Frati G,De Falco E

更新日期：2015-01-01 00:00:00

abstract：:Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of 10 consecutive stroke patients were treated by combination cell transplantation on the basis of an ...

journal_title：Cell transplantation

authors： Chen L,Xi H,Huang H,Zhang F,Liu Y,Chen D,Xiao J

更新日期：2013-01-01 00:00:00

abstract：:Peripheral blood samples from HIV-seropositive individuals enrolled in a pilot clinical trial investigating the use of allogeneic dendritic cell therapy were evaluated for mixed chimerism. In this study, dendritic cells from HLA-identical, HIV-seronegative siblings were used. Patients received an infusion of dendritic...

journal_title：Cell transplantation

authors： Shapero MH,Kundu SK,Engleman E,Laus R,van Schooten WC,Merigan TC

更新日期：2000-05-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple different cell types contribute to the regulation of stem and progenitor cel...

journal_title：Cell transplantation

authors： Mattiucci D,Maurizi G,Leoni P,Poloni A

更新日期：2018-05-01 00:00:00

abstract：:Hepatocyte transplantation (HT) has become an effective therapy for patients with metabolic inborn errors. We report the clinical outcome of four children with metabolic inborn errors that underwent HT, describing the cell infusion protocol and the metabolic outcome of transplanted patients. Cryopreserved hepatocytes...

journal_title：Cell transplantation

authors： Ribes-Koninckx C,Ibars EP,Calzado Agrasot MÁ,Bonora-Centelles A,Miquel BP,Vila Carbó JJ,Aliaga ED,Pallardó JM,Gómez-Lechón MJ,Castell JV

更新日期：2012-01-01 00:00:00

abstract：:Adequate regulation of glucose levels by a microencapsulated pancreatic islet graft requires a minute-to-minute regulation of blood glucose. To design such a transplant, it is mandatory to have sufficient insight in factors influencing the kinetics of insulin secretion by encapsulated islets. The present study investi...

journal_title：Cell transplantation

authors： de Haan BJ,Faas MM,de Vos P

更新日期：2003-01-01 00:00:00

abstract：:Cell and tissue culture techniques have improved considerably since the first attempts to maintain explants of animal tissue in vitro. The two major developments that have allowed these improvements are the ability to produce continuous cell lines, thus allowing reproducible results to be obtained, and the definition ...

journal_title：Cell transplantation

authors： Clayton HA,London NJ

更新日期：1996-01-01 00:00:00