FUNCTIONAL ASSESSMENT OF INTRAHYPOTHALAMIC IMPLANTS OF IMMORTALIZED GONADOTROPIN-RELEASING HORMONE-SECRETING CELLS IN FEMALE HYPOGONADAL MICE.

abstract：:Cell therapies consist in transplanting healthy cells into a disabled tissue with the goal to repopulate it and restore its function at least partially. In muscular diseases, most of the time, myoblasts are chosen for their expansion capacity in culture. Nevertheless, cell transplantation has limitations, among them,...

journal_title：Cell transplantation

authors： Gérard C,Dufour C,Goudenege S,Skuk D,Tremblay JP

更新日期：2012-01-01 00:00:00

abstract：:Recent advances in islet transplantation using highly purified islets and effective immunosuppression strategies have resulted in substantial improvement in achieving insulin independence in type 1 diabetes patients. However, there are side effects from long-term immunosuppression, and transplant rejection and/or the ...

journal_title：Cell transplantation

authors： Kobayashi N

更新日期：2008-01-01 00:00:00

abstract：:Cellular transplantation strategies utilizing intraspinal or intrathecal olfactory ensheathing cells (OECs) have been reported as beneficial for spinal cord injury (SCI). However, there are many disadvantages of these methods, including additional trauma to the spinal cord parenchyma and technical challenges. Therefor...

journal_title：Cell transplantation

authors： Zhang L,Zhuang X,Chen Y,Xia H

更新日期：2019-12-01 00:00:00

abstract：:In this study the time course of homing and the body distribution of systemically delivered bone marrow mesenchymal stem cells (BM-MSCs) after myocardial infarction (MI) were evaluated. BM-MSCs were isolated from Wistar rats, expanded in vitro, and their phenotypical characterization was performed by flow cytometer. R...

journal_title：Cell transplantation

authors： Assis AC,Carvalho JL,Jacoby BA,Ferreira RL,Castanheira P,Diniz SO,Cardoso VN,Goes AM,Ferreira AJ

更新日期：2010-01-01 00:00:00

abstract：:Critical length nerve defects in the rat sciatic nerve model were reconstructed with chitosan nerve guides filled with Schwann cells (SCs) containing hydrogel. The transplanted SCs were naive or had been genetically modified to overexpress neurotrophic factors, thus providing a cellular neurotrophic factor delivery sy...

journal_title：Cell transplantation

authors： Meyer C,Wrobel S,Raimondo S,Rochkind S,Heimann C,Shahar A,Ziv-Polat O,Geuna S,Grothe C,Haastert-Talini K

更新日期：2016-01-01 00:00:00

abstract：:Stem cell transplantation represents a promising therapeutic approach for myocardial ischemia/reperfusion (I/R) injury, where cortical bone-derived stem cells (CBSCs) stand out and hold superior cardioprotective effects on myocardial infarction than other types of stem cells. However, the molecular mechanism underlyin...

journal_title：Cell transplantation

authors： Li T,Su Y,Yu X,Mouniir DSA,Masau JF,Wei X,Yang J

更新日期：2018-08-01 00:00:00

abstract：:One of the goals of islet transplantation is to transplant viable islets without host immunosuppression. The present study was designed to determine whether pretreatment of islets with mitomycin-C (MMC) followed by culture enhances islet survival in a rat-to-mouse xenogeneic combination. WS(RT1k) rat islets pretreated...

journal_title：Cell transplantation

authors： Gunji T,Saito T,Sato Y,Matsuyama S,Ise K,Kimura T,Anazawa T,Gotoh M

更新日期：2008-01-01 00:00:00

abstract：:It is currently said that CO has anti-inflammatory and antiapoptosis effects and it has attracted attention as a medical gas. We used CO for rat hearts and conducted a preservation experiment. We isolated rat hearts, placed them into a specially made chamber, filled the chamber with a gas mixture of PCO (4,000 hPa) a...

journal_title：Cell transplantation

authors： Hatayama N,Naito M,Hirai S,Yoshida Y,Kojima T,Seki K,Li XK,Itoh M

更新日期：2012-01-01 00:00:00

abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...

journal_title：Cell transplantation

authors： Hossne NA,Cruz E,Buffolo E,Coimbra AC,Machado J,Goldenberg RC,Regazzi G,Azevedo S,Invitti AL,Rodrigues Branco JN,Rodrigues de Oliveira JS,Stolf NA,Miller LW,Sanberg PR

更新日期：2015-01-01 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Therefore, we explore...

journal_title：Cell transplantation

authors： Wege H,Chui MS,Le HT,Strom SC,Zern MA

更新日期：2003-01-01 00:00:00

abstract：:The present study aimed to elucidate the mechanisms by which hydrogen sulfide (H2S) attenuates left ventricular remodeling after myocardial infarction (MI). MI was created in mice by left coronary artery ligation. One group of mice received injections of the H2S donor sodium hydrosulfide (NaHS) immediately before and ...

journal_title：Cell transplantation

authors： Wu T,Li H,Wu B,Zhang L,Wu SW,Wang JN,Zhang YE

更新日期：2017-05-09 00:00:00

abstract：:Investigations indicate that an extract of green tea, polyphenol, can significantly increase the culture survival rate of rat islets without deteriorating their functionality. In this study, we examined the effect of adding polyphenol to islets isolated from human pancreata and nonhuman primate pancreata. Islets were ...

journal_title：Cell transplantation

authors： Zhang G,Matsumoto S,Hyon SH,Qualley SA,Upshaw L,Strong DM,Reems JA

更新日期：2004-01-01 00:00:00

abstract：:Grafting autologous cultured satellite cells in irreversibly injured rat extensor digitorum longus EDL muscle leads to myofiber regeneration at the grafting site. In this study, we investigated whether cell grafts induced functional improvement and correlated mechanophysiological findings with histological observation...

journal_title：Cell transplantation

authors： Alameddine HS,Louboutin JP,Dehaupas M,Sébille A,Fardeau M

更新日期：1994-01-01 00:00:00

abstract：:Hepatocyte-based biological therapies are increasingly envisioned for temporary support in acute liver failure and provision of specific-liver functions in liver-based metabolic deficiency. One of the hurdles to develop such therapies is severe shortage of human livers for hepatocyte isolation. To address the issue, w...

journal_title：Cell transplantation

authors： Kobayashi N,Tanaka N

更新日期：2002-07-01 00:00:00

abstract：:Prairie voles show strong pair bonding with their mating partners, and they demonstrate parental behavior toward their infants, indicating that the prairie vole is a unique animal model for analysis of molecular mechanisms of social behavior. Until a recent study, the signaling pathway of oxytocin was thought to be cr...

journal_title：Cell transplantation

authors： Katayama M,Hirayama T,Horie K,Kiyono T,Donai K,Takeda S,Nishimori K,Fukuda T

更新日期：2016-01-01 00:00:00

abstract：:The cytology of peritoneal washing fluids for gastric cancer is the most basic method for judging peritoneal micrometastasis. However, the clinical value of this method is not clear at present. A retrospective analysis was performed on 277 patients with pathologically proven and surgically treated gastric cancer. The ...

journal_title：Cell transplantation

authors： Jiang RP,Xiong XJ,Qiu XS,Wang EH,Wu GP

更新日期：2019-11-01 00:00:00

abstract：:The objective of this study was to define pretransplant islet culture conditions for optimum tissue engraftment in the rat islet allotransplantation model. Lewis rat islets were cultured in TCM 199/5% fetal calf serum for I day at 37 degrees C, followed by 1 day of culture at 22 degrees C. When islets from single dono...

journal_title：Cell transplantation

authors： Jahr H,Hussmann B,Eckhardt T,Bretzel RG

更新日期：2002-01-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder that occurs in patients with a mutation in the huntingtin or IT15 gene. Patients are plagued by early cognitive signs, motor deficits, and psychiatric disturbances. Symptoms are attributed to cell death in the striatum and disruption of cortical-str...

journal_title：Cell transplantation

authors： Ramaswamy S,Shannon KM,Kordower JH

更新日期：2007-01-01 00:00:00

abstract：:Peripheral blood samples from HIV-seropositive individuals enrolled in a pilot clinical trial investigating the use of allogeneic dendritic cell therapy were evaluated for mixed chimerism. In this study, dendritic cells from HLA-identical, HIV-seronegative siblings were used. Patients received an infusion of dendritic...

journal_title：Cell transplantation

authors： Shapero MH,Kundu SK,Engleman E,Laus R,van Schooten WC,Merigan TC

更新日期：2000-05-01 00:00:00

abstract：:We transplanted adult whole bone marrow prelabeled with bromodeoxyuridine (BrdU) into the ischemic boundary zone of the adult rat brain at 1 day after 2 h of middle cerebral artery occlusion (MCAo). Approximately 3.3% of 10(6) transplanted bone marrow cells were BrdU reactive at 14 days after MCAo. BrdU-reactive cells...

journal_title：Cell transplantation

authors： Li Y,Chen J,Chopp M

更新日期：2001-01-01 00:00:00

abstract：:A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To identify morphological characteristics of transplanted donor cells, HESCs were transfected with a GFP lentiviral vector. Gene expression ...

journal_title：Cell transplantation

authors： Wakeman DR,Weiss S,Sladek JR,Elsworth JD,Bauereis B,Leranth C,Hurley PJ,Roth RH,Redmond DE

更新日期：2014-01-01 00:00:00

abstract：:Hepatocyte transplantation is dependent on the availability of good quality human hepatocytes isolated from donor liver tissue. Hepatocytes obtained from livers rejected for transplantation on the grounds of steatosis are often of low viability and not suitable for clinical use. The aim of this study was to evaluate t...

journal_title：Cell transplantation

authors： Sagias FG,Mitry RR,Hughes RD,Lehec SC,Patel AG,Rela M,Mieli-Vergani G,Heaton ND,Dhawan A

更新日期：2010-01-01 00:00:00

abstract：:Bone marrow (BM) cells may interact with coronary endothelium and modulate coronary atherosclerosis. We investigated the time course of coronary luminal loss and changes in conductance after intracoronary injection of enriched hematopoietic BM stem cells in patients with previous myocardial infarction (MI). Among 24 p...

journal_title：Cell transplantation

authors： Vanderheyden M,Vercauteren S,Mansour S,Delrue L,Vandekerckhove B,Heyndrickx GR,Van Haute I,De Bruyne B,Timmermans F,Wijns W,Bartunek J

更新日期：2007-01-01 00:00:00

abstract：:Pancreatic islet transplantation has the potential to be an effective treatment for type 1 diabetes mellitus. While recent improvements have improved 1-year outcomes, follow-up studies show a persistent loss of graft function/survival over 5 years. One possible cause of islet transplant failure is the immunosuppressan...

journal_title：Cell transplantation

authors： Johnson JD,Ao Z,Ao P,Li H,Dai LJ,He Z,Tee M,Potter KJ,Klimek AM,Meloche RM,Thompson DM,Verchere CB,Warnock GL

更新日期：2009-01-01 00:00:00

abstract：:The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease. The clinical application of neural transplantation using NSC will therefo...

journal_title：Cell transplantation

authors： McLeod M,Hong M,Sen A,Sadi D,Ulalia R,Behie LA,Mendez I

更新日期：2006-01-01 00:00:00

abstract：:At present, there are still significant barriers that impede the clinical use of hESCs and iPS cells, including ethics, immunorejection, tumorigenesis from hESCs, and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts...

journal_title：Cell transplantation

authors： Gao LR,Zhang NK,Ding QA,Chen HY,Hu X,Jiang S,Li TC,Chen Y,Wang ZG,Ye Y,Zhu ZM

更新日期：2013-01-01 00:00:00

abstract：:The long-term durability of agarose microencapsulated islets against autoimmunity was evaluated in NOD mice. Islets were isolated from 6-8-week-old prediabetic male NOD mice and microencapsulated in 5% agarose hydrogel. Microencapsulated or nonencapsulated islets were transplanted into the omental pouch of spontaneous...

journal_title：Cell transplantation

authors： Kobayashi T,Aomatsu Y,Iwata H,Kin T,Kanehiro H,Hisanga M,Ko S,Nagao M,Harb G,Nakajima Y

更新日期：2006-01-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency ...

journal_title：Cell transplantation

authors： Takahashi H,Koda M,Hashimoto M,Furuya T,Sakuma T,Kato K,Okawa A,Inada T,Kamiya K,Ota M,Maki S,Takahashi K,Yamazaki M,Mannoji C

更新日期：2016-01-01 00:00:00

abstract：:Pigs share many anatomical and physiological features with humans, offering a unique and viable model for biomedical research. Although porcine female germline stem cells (FGSCs) were identified in the juvenile ovary, no reports described the isolation and purification of FGSCs from the pig at sexual maturity. Here, w...

journal_title：Cell transplantation

authors： Hou L,Wang J,Li X,Wang H,Liu G,Xu B,Mei X,Hua X,Wu J

更新日期：2018-08-01 00:00:00