Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart.

abstract：:Human marrow stromal cells (hMSCs) provide functional benefit in rats subjected to stroke. Astrocytes are coupled into a cellular network via gap junction channels, predominantly composed of connexin-43 (Cx43) proteins. Astrocytes are believed to play a vital role in neuroprotection by providing energy substrates to n...

journal_title：Cell transplantation

authors： Gao Q,Katakowski M,Chen X,Li Y,Chopp M

更新日期：2005-01-01 00:00:00

abstract：:Functional demands on a bioartificial liver support (BAL) device are not limited to biosynthetic activities, but must also encompass metabolic removal of potentially toxic substances. For most BALs, however, the concept and design are exclusively directed to biosynthetic support. To add the ability to metabolize and r...

journal_title：Cell transplantation

authors： Takahashi M,Sakurai M,Enosawa S,Omasa T,Tsuruoka S,Matsumura T

更新日期：2006-01-01 00:00:00

abstract：:The transplantation of encapsulated dopamine-secreting cells into the striatum represents one potential means of treating Parkinson's disease. The present study investigated the ability of encapsulated PC12 cells, which are derived from rat pheochromocytoma, to supply L-dopa and dopamine into the primate brain in the ...

journal_title：Cell transplantation

authors： Date I,Shingo T,Yoshida H,Fujiwara K,Kobayashi K,Ohmoto T

更新日期：2000-09-01 00:00:00

abstract：:Previous studies in humans with type 1 diabetes mellitus (T1D) and in nonobese diabetic mice have investigated the beneficial immunomodulatory potential of aerobic physical activity. Performing high volume of aerobic exercise may favorably regulate autoimmunity in diabetes. We tested whether increased physical activit...

journal_title：Cell transplantation

authors： Adamo M,Codella R,Casiraghi F,Ferrulli A,Macrì C,Bazzigaluppi E,Terruzzi I,Inverardi L,Ricordi C,Luzi L

更新日期：2017-01-24 00:00:00

abstract：:Clinically, many candidates for islet transplantation are already immunized, which increases their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device has been shown to protect against allograft rejection in nonimmunized recipients. However, the capacity of the TheraCyte™ device to ...

journal_title：Cell transplantation

authors： Kumagai-Braesch M,Jacobson S,Mori H,Jia X,Takahashi T,Wernerson A,Flodström-Tullberg M,Tibell A

更新日期：2013-01-01 00:00:00

abstract：:Transplanted embryonic stem (ES) cells, following myocardial infarction (MI), contribute to limited cardiac repair and regeneration with improved function. Therefore, novel strategies are still needed to understand the effects of genetically modified transplanted stem cells on cardiac remodeling. The present study ev...

journal_title：Cell transplantation

authors： Glass C,Singla DK

更新日期：2012-01-01 00:00:00

abstract：:Since donor T-cells' allorecognition of host antigens is a prerequisite for the onset of graft-versus-host disease (GVHD), blocking their cellular signaling pathways can decrease the severity of GVHD. We hypothesized that epigallocatechin-3-gallate (EGCG), due to its strong affinity to macromolecules, would adhere to...

journal_title：Cell transplantation

authors： Kanamune J,Iwanaga Y,Kina T,Noguchi H,Matsumura K,Uemoto S,Hyon SH

更新日期：2012-01-01 00:00:00

abstract：:Ex vivo embryonic liver explant culture is a novel and attractive approach to obtain abundant hepatic and hematopoietic stem cells. Gene therapy of autologous hepatic and hematopoietic stem cells represents an alternative therapeutic approach to liver transplantation for genetic and metabolic disorders. In this study ...

journal_title：Cell transplantation

authors： Monga SPS,Tang Y,Candotti F,Rashid A,Wildner O,Mishra B,Iqbal S,Mishra L

更新日期：2001-01-01 00:00:00

abstract：:The hypogonadal (HPG) mouse is a mutant that lacks a functional gonadotropin-releasing hormone (GnRH) gene. In this study, female HPG mice received bilateral intrahypothalamic implants of an immortalized GnRH-secreting cell line (GT1-7). Nine mice were tested 42- 65 days after implantation to determine whether these c...

journal_title：Cell transplantation

authors： Miller GM,Silverman AJ,Roberts JL,Wendong K,Gibson MJ

更新日期：1993-05-01 00:00:00

abstract：:The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has been reached as to what is ...

journal_title：Cell transplantation

authors： Di Vito A,Giudice A,Chiarella E,Malara N,Bennardo F,Fortunato L

更新日期：2019-01-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple different cell types contribute to the regulation of stem and progenitor cel...

journal_title：Cell transplantation

authors： Mattiucci D,Maurizi G,Leoni P,Poloni A

更新日期：2018-05-01 00:00:00

abstract：:The midbrain inferior colliculus (IC), a major integrating center for auditory processing, provides a model for structural, functional, and behavioral recovery. The present study examined the role of IC in spatial sound detection, and the effects of neural transplantation in sparing of behavioral performance. Hooded r...

journal_title：Cell transplantation

authors： Zrull MC,Coleman JR

更新日期：1996-03-01 00:00:00

abstract：:The third-generation NOD/LtSz-scid/IL2Rγ(null) (NOD/SCID IL2Rγ(null)) mouse represents a significantly improved xenograft model allowing high levels of human leukocyte engraftment over extended follow up. One remaining limitation of this mouse model, however, is the low level of circulating human erythrocytes. We esta...

journal_title：Cell transplantation

authors： Hayakawa J,Hsieh MM,Anderson DE,Phang O,Uchida N,Washington K,Tisdale JF

更新日期：2010-01-01 00:00:00

abstract：:Astrocytes protection and functional regulation are important strategies to protect against neuronal damage caused by ischemia. Activation of the delta opioid receptor (DOR) could reduce astrocytes damage, although the mechanism remains unclear. The present study aimed to test the effect of DOR activation on autophagy...

journal_title：Cell transplantation

authors： Wang S,Cao X,Duan Y,Zhang G

更新日期：2019-06-01 00:00:00

abstract：:The choice of enzyme blend is critical for successful islet isolation. Islet yield, viability, integrity, and function are important factors that influence the outcome of islet transplantation. Liberase HI has been used as a standard enzyme for pancreas digestion and has successfully produced islets that reversed dia...

journal_title：Cell transplantation

authors： Iglesias I,Valiente L,Shiang KD,Ichii H,Kandeel F,Al-Abdullah IH

更新日期：2012-01-01 00:00:00

abstract：:Radiotherapy is an effective treatment for brain tumors but often results in cognitive deficits in survivors. Transplantation of embryonic or brain-derived neural stem/progenitor cells (BNSPCs) ameliorated cognitive impairment after irradiation (IR) in animal models. However, such an approach in patients requires a cl...

journal_title：Cell transplantation

authors： Osman AM,Zhou K,Zhu C,Blomgren K

更新日期：2014-01-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) have been applied for cell therapy because of their roles in angiogenesis and neovascularization in ischemic tissue. However, adverse responses caused by EPC therapy have not been fully investigated. In this study, a human peripheral blood sample was collected from a healthy donor a...

journal_title：Cell transplantation

authors： Lee SH,Ra JC,Oh HJ,Kim MJ,Setyawan EMN,Choi YB,Yang JW,Kang SK,Han SH,Kim GA,Lee BC

更新日期：2019-07-01 00:00:00

abstract：:Future improvements in the recovery and function of pancreatic islets following cryopreservation will require a more precise quantification of the stresses that occur at each stage of the cryopreservation protocol. Changes in solution osmolality during the addition and dilution of cryoprotectants and during freezing a...

journal_title：Cell transplantation

authors： Zieger MA,Woods EJ,Lakey JR,Liu J,Critser JK

更新日期：1999-05-01 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates vascular maturation and immune response. Diabetes decreases Ang1 expression and disrupts Ang1/Tie2 signaling activity. Vasculotide is an Ang1 mimetic peptide, and has anti-inflammatory effects. In this study, we test the hypothesis that vasculotide treatment induces neuroprotection and d...

journal_title：Cell transplantation

authors： Venkat P,Yan T,Chopp M,Zacharek A,Ning R,Van Slyke P,Dumont D,Landschoot-Ward J,Liang L,Chen J

更新日期：2018-12-01 00:00:00

abstract：:Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency. With time, however, dedifferentiation or malignant transformation of the ectopically transplanted cells may be pos...

journal_title：Cell transplantation

authors： Lupp A,Danz M,Müller D

更新日期：2003-01-01 00:00:00

abstract：:The anatomical specificity of axon growth from fetal pig septal xenografts was studied by transplanting septal cells from E30-35 pig fetuses into cholinergic deafferented (192-IgG-saporin-infused) rats or into aged rats (> 18 months). Cell suspensions (100,000 cells/microl) were injected bilaterally into the dorsal an...

journal_title：Cell transplantation

authors： Deacon T,Whatley B,LeBlanc C,Lin L,Isacson O

更新日期：1999-01-01 00:00:00

abstract：:Islet isolation involves enzymatic digestion of the interstitial matrix and mechanical disruption of the tissue. It is possible that a fundamental change of islet biology resulting from the loss of critical factors required for islet function or survival will occur. Extracellular matrix (ECM) is one of the most import...

journal_title：Cell transplantation

authors： Nagata N,Gu Y,Hori H,Balamurugan AN,Touma M,Kawakami Y,Wang W,Baba TT,Satake A,Nozawa M,Tabata Y,Inoue K

更新日期：2001-01-01 00:00:00

abstract：:Exenatide is an analog of the incretin hormone glucagon-like peptide (GLP-1) that is used for the treatment of T2D for their metabolic effects. In addition to its insulinotropic effects, exenatide increases functional islet mass and improves their survival. Improved outcomes have been reported in recent clinical isle...

journal_title：Cell transplantation

authors： Cechin SR,Pérez-Álvarez I,Fenjves E,Molano RD,Pileggi A,Berggren PO,Ricordi C,Pastori RL

更新日期：2012-01-01 00:00:00

abstract：:Prior studies have suggested the possibility of immune-mediated death of xenogeneic hepatocytes in a bioartificial liver (BAL) during hemoperfusion. This study was designed to elucidate how immunity may cause death of xenogeneic hepatocytes in the BAL. Healthy dogs were treated with a BAL containing hollow fiber membr...

journal_title：Cell transplantation

authors： Nyberg SL,Amiot B,Hardin J,Baskin-Bey E,Platt JL

更新日期：2004-01-01 00:00:00

abstract：:In previous work, we engineered functional cell sheets using bone marrow-derived mesenchymal stem cells (BM-MSCs) to promote islet graft survival. In the present study, we hypothesized that a cell sheet using dermal fibroblasts could be an alternative to MSCs, and then we aimed to evaluate the effects of this cell she...

journal_title：Cell transplantation

authors： Matsushima H,Kuroki T,Adachi T,Kitasato A,Ono S,Tanaka T,Hirabaru M,Kuroshima N,Hirayama T,Sakai Y,Soyama A,Hidaka M,Takatsuki M,Kin T,Shapiro J,Eguchi S

更新日期：2016-01-01 00:00:00

abstract：:Oligodendrocyte (OL) replacement can be a promising strategy for spinal cord injury (SCI) repair. However, the poor posttransplantation survival and inhibitory properties to axonal regeneration are two major challenges that limit their use as donor cells for repair of CNS injuries. Therefore, strategies aimed at enhan...

journal_title：Cell transplantation

authors： Hu JG,Wang XF,Deng LX,Liu NK,Gao X,Chen JH,Zhou FC,Xu XM

更新日期：2013-01-01 00:00:00

abstract：:In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells (BMMSCs) transfected with connective ti...

journal_title：Cell transplantation

authors： Zhu S,Zhang B,Man C,Ma Y,Liu X,Hu J

更新日期：2014-04-01 00:00:00

abstract：:The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease. The clinical application of neural transplantation using NSC will therefo...

journal_title：Cell transplantation

authors： McLeod M,Hong M,Sen A,Sadi D,Ulalia R,Behie LA,Mendez I

更新日期：2006-01-01 00:00:00

abstract：:New treatment paradigms that slow or reverse progression of chronic kidney disease (CKD) are needed to relieve significant patient and healthcare burdens. We have shown that a population of selected renal cells (SRCs) stabilized disease progression in a mass reduction model of CKD. Here, we further define the cellular...

journal_title：Cell transplantation

authors： Kelley R,Bruce A,Spencer T,Werdin E,Ilagan R,Choudhury S,Rivera E,Wallace S,Guthrie K,Jayo M,Xu F,Rao AN,Humphreys BD,Presnell S,Bertram T

更新日期：2013-01-01 00:00:00

abstract：:Sepsis is a life-threatening disease that results in excessive stimulation of the host's immune cells. In the animal study, the purpose was to investigate the roles of fresh frozen plasma (FFP) transfusion in shaping the CD4+ T lymphocytes immune response through modulating the secreted exosome protein Galectin-9 in m...

journal_title：Cell transplantation

authors： Zhang L,Zhang JP,Liu Y,Wang H,Cheng Y,Wang JH,Zhang WJ,Li ZZ,Guo JR

更新日期：2020-01-01 00:00:00