Amnion: a potent graft source for cell therapy in stroke.

abstract：:The transplantation of porcine islets of Langerhans to treat type 1 diabetes may provide a solution to the demand for insulin-producing cells. Porcine islets encapsulated in agarose-agarose macrobeads have been shown to function in nonimmunosuppressed xenogeneic models of both streptozotocin-induced and autoimmune typ...

journal_title：Cell transplantation

authors： Holdcraft RW,Gazda LS,Circle L,Adkins H,Harbeck SG,Meyer ED,Bautista MA,Martis PC,Laramore MA,Vinerean HV,Hall RD,Smith BH

更新日期：2014-01-01 00:00:00

abstract：:Traumatic brain injury (TBI), a major cause of mortality and morbidity, affects 10 million people worldwide, with limited treatment options. We have previously shown that (-)-phenserine (Phen), an acetylcholinesterase inhibitor originally designed and tested in clinical phase III trials for Alzheimer's disease, can re...

journal_title：Cell transplantation

authors： Hsueh SC,Lecca D,Greig NH,Wang JY,Selman W,Hoffer BJ,Miller JP,Chiang YH

更新日期：2019-09-01 00:00:00

abstract：:Prognosis of patients with heart failure remains poor despite improved conventional and interventional treatment regimens. The improvement of neovascularization and repair processes by administration of bone marrow-derived cells modestly improved the recovery after acute myocardial infarction. However, circulating pat...

journal_title：Cell transplantation

authors： Honold J,Fischer-Rasokat U,Lehmann R,Leistner DM,Seeger FH,Schachinger V,Martin H,Dimmeler S,Zeiher AM,Assmus B

更新日期：2012-01-01 00:00:00

abstract：:Diabetes affects millions of people worldwide, and β-cell replacement is one of the promising new strategies for treatment. Induced pluripotent stem cells (iPSCs) can differentiate into any cell type, including pancreatic β cells, providing a potential treatment for diabetes. However, the molecular mechanisms underlyi...

journal_title：Cell transplantation

authors： Huang Y,Wan J,Guo Y,Zhu S,Wang Y,Wang L,Guo Q,Lu Y,Wang Z

更新日期：2017-08-01 00:00:00

abstract：:Stem cell transplantation represents a promising therapeutic approach for myocardial ischemia/reperfusion (I/R) injury, where cortical bone-derived stem cells (CBSCs) stand out and hold superior cardioprotective effects on myocardial infarction than other types of stem cells. However, the molecular mechanism underlyin...

journal_title：Cell transplantation

authors： Li T,Su Y,Yu X,Mouniir DSA,Masau JF,Wei X,Yang J

更新日期：2018-08-01 00:00:00

abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...

journal_title：Cell transplantation

authors： Silini AR,Magatti M,Cargnoni A,Parolini O

更新日期：2017-04-13 00:00:00

abstract：:The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite combination antiretroviral therapy (cART). There is evidence that neural stem cells (NSCs) can migrate to sites of brain injury such as those caused by inflammation and oxidative stress, which are pathological features of HAND. Thus,...

journal_title：Cell transplantation

authors： Jin J,Grimmig B,Izzo J,Brown LAM,Hudson C,Smith AJ,Tan J,Bickford PC,Giunta B

更新日期：2016-11-01 00:00:00

abstract：:Osteoarthritis (OA) is degenerative disease, leading to pain and functional disability. It is reported that polydeoxyribonucleotide (PDRN) is a suitable therapy for OA. However, the therapeutic mechanisms of PDRN in OA are not fully understood. To investigate the effect of PDRN in an in vitro model of OA, interleukin ...

journal_title：Cell transplantation

authors： Baek A,Kim Y,Lee JW,Lee SC,Cho SR

更新日期：2018-11-01 00:00:00

abstract：:Experiments are described using rats with two kinds of brain damage and consequent cognitive deficit (in the Morris water maze, three-door runway, and radial maze): 1) ischemic damage to the CA1 hippocampal cell field after four-vessel occlusion (4VO), and 2) damage to the forebrain cholinergic projection system by lo...

journal_title：Cell transplantation

authors： Gray JA,Grigoryan G,Virley D,Patel S,Sinden JD,Hodges H

更新日期：2000-03-01 00:00:00

abstract：:It is widely believed that human embryonic stem (huES) cells may represent a valid alternative to donor pancreata as a source of islets for transplantation. Much is known about the transcription factors whose sequential activation results in the generation of islets during pancreatic development. This knowledge has be...

journal_title：Cell transplantation

authors： Dominguez-Bendala J,Pastori RL,Ricordi C,Inverardi L

更新日期：2006-01-01 00:00:00

abstract：:We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin(-)) have the capacity to differentiate and contribute to regeneration of injured islets. In this study, we assess some of the characteristics of these cells compa...

journal_title：Cell transplantation

authors： Iskovich S,Goldenberg-Cohen N,Sadikov T,Yaniv I,Stein J,Askenasy N

更新日期：2015-01-01 00:00:00

abstract：:Previously, we found that hepatocyte growth factor receptor (c-Met)-and alpha-fetoprotein (AFP)-expressing cells were present in adult rat bone marrow, and that these cells also expressed hematopoietic stem cell markers, such as CD34, Thy-1, and c-Kit. When bone marrow cells were cultured in a hepatocyte growth medium...

journal_title：Cell transplantation

authors： Miyazaki M,Masaka T,Akiyama I,Nakashima E,Sakaguchi M,Huh NH

更新日期：2004-01-01 00:00:00

abstract：:Sciatic nerve injuries, not uncommon in trauma with a limited degree of functional recovery, are considered a persistent clinical, social, and economic problem worldwide. Accumulating evidence suggests that stem cells can promote the tissue regeneration through various mechanisms. The aim of the present study was to i...

journal_title：Cell transplantation

authors： Chuang MH,Ho LH,Kuo TF,Sheu SY,Liu YH,Lin PC,Tsai YC,Yang CH,Chu CM,Lin SZ

更新日期：2020-01-01 00:00:00

abstract：:Liver fibrosis is characterized by excessive accumulation of extracellular matrix components in the liver parenchyma that distorts the normal architecture and hepatic function. Progressive fibrosis could end in the advanced stage known as cirrhosis, resulting in the need to resort to liver transplantation. Amniotic me...

journal_title：Cell transplantation

authors： SantAnna LB,Hage R,Cardoso MA,Arisawa EA,Cruz MM,Parolini O,Cargnoni A,SantAnna N

更新日期：2016-12-13 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder that occurs in patients with a mutation in the huntingtin or IT15 gene. Patients are plagued by early cognitive signs, motor deficits, and psychiatric disturbances. Symptoms are attributed to cell death in the striatum and disruption of cortical-str...

journal_title：Cell transplantation

authors： Ramaswamy S,Shannon KM,Kordower JH

更新日期：2007-01-01 00:00:00

abstract：:In diabetic patients cardiovascular morbidity and mortality is still a major problem. Our aim was to study the effect of kidney-pancreas transplantation on survival, cardiovascular events, and causes of death in diabetic type 1 uremic patients. Three hundred and thirty-three uremic IDDM patients were enrolled in our w...

journal_title：Cell transplantation

authors： La Rocca E,Fiorina P,Astorri E,Rossetti C,Lucignani G,Fazio F,Giudici D,Castoldi R,Bianchi G,Di Carlo V,Pozza G,Secchi A

更新日期：2000-11-01 00:00:00

abstract：:Embryonic stem (ES) cells have the ability to generate teratomas when transplanted into immunodeficient mice, but conditions affecting the generation remain to be elucidated. Nonhuman primate cynomolgus ES cells were transplanted into immunodeficient mice under different conditions; the number of transplanted cells, p...

journal_title：Cell transplantation

authors： Kishi Y,Tanaka Y,Shibata H,Nakamura S,Takeuchi K,Masuda S,Ikeda T,Muramatsu SI,Hanazono Y

更新日期：2008-09-01 00:00:00

abstract：:This study aimed to explore the characteristics of TGFBR1-epidermal growth factor receptor (EGFR)-CTNNB1-CDH1 axis in regulating the invasion and migration in lung cancer. Using the small interfering RNA technology, EGFR was silenced in H2170 and H1299 cells. Then, the colony formation, migration, and invasion abiliti...

journal_title：Cell transplantation

authors： Liu R,Zhang Y,Ding Y,Zhang S,Pan L

更新日期：2020-01-01 00:00:00

abstract：:Gene therapy as well as methods capable of returning cells to a pluripotent state (iPS) have enabled the correction of genetic deficiencies in syngenic adult progenitors, reducing the need for immunosuppression in cell therapy approaches. However, in diseases involving mutations that lead to the complete lack of a pr...

journal_title：Cell transplantation

authors： Even Y,Bennett JL,Sekulovic S,So L,Yi L,McNagny K,Humphries RK,Rossi FM

更新日期：2011-01-01 00:00:00

abstract：:Ensheathing glia have been demonstrated to have neuroregenerative properties but this cell type from human sources has not been extensively studied because tissue samples are not easily obtained, primary cultures are slow growing, and human cell lines are not available. We previously isolated immortalized ensheathing ...

journal_title：Cell transplantation

authors： García-Escudero V,Gargini R,Gallego-Hernández MT,García-Gómez A,Martín-Bermejo MJ,Simón D,Delicado A,Moreno-Flores MT,Avila J,Lim F

更新日期：2011-01-01 00:00:00

abstract：:We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet t...

journal_title：Cell transplantation

authors： Slavin S,Weiss L,Xia W,Gross DJ

更新日期：1996-11-01 00:00:00

abstract：:Persistent fetal vasculature (PFV) is a potentially serious developmental anomaly in human eyes, which results from a failure of the primary vitreous and the hyaloid vascular systems to regress during development. Recent findings from our laboratory indicate that fibrovascular membranes harvested from subjects with P...

journal_title：Cell transplantation

authors： Chen G,Ma J,Shatos MA,Chen H,Cyr D,Lashkari K

更新日期：2012-01-01 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates vascular maturation and immune response. Diabetes decreases Ang1 expression and disrupts Ang1/Tie2 signaling activity. Vasculotide is an Ang1 mimetic peptide, and has anti-inflammatory effects. In this study, we test the hypothesis that vasculotide treatment induces neuroprotection and d...

journal_title：Cell transplantation

authors： Venkat P,Yan T,Chopp M,Zacharek A,Ning R,Van Slyke P,Dumont D,Landschoot-Ward J,Liang L,Chen J

更新日期：2018-12-01 00:00:00

abstract：:Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Most experimental approaches to increase transplanted cells' engraftment involve recipient-centered deleterious methods such as partial hepatectomy or irradiation which may be unsuitable in the clinic....

journal_title：Cell transplantation

authors： Fagg WS,Liu N,Yang MJ,Cheng K,Chung E,Kim JS,Wu G,Fair J

更新日期：2017-12-01 00:00:00

abstract：:Schwann cells naturally support axonal regeneration after injury in the peripheral nervous system, and have also shown a significant, albeit limited, ability to support axonal growth and remyelination after grafting to the central nervous system (CNS). It is possible that Schwann cell-induced axonal growth in the CNS ...

journal_title：Cell transplantation

authors： Tuszynski MH,Weidner N,McCormack M,Miller I,Powell H,Conner J

更新日期：1998-03-01 00:00:00

abstract：:Experiments on spinal cord injury (SCI) have largely focused on the transplantation of stem cells into injured spinal cords for motor recovery while neglecting to investigate bladder dysfunction. The present study was performed to investigate the effect of B10 human mesenchymal stem cells (hMSCs) directly transplanted...

journal_title：Cell transplantation

authors： Lee HJ,An J,Doo SW,Kim JH,Choi SS,Lee SR,Park SW,Song YS,Kim SU

更新日期：2015-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration in the brain and spinal cord. Progressive paralysis of the diaphragm and other respiratory muscles leading to respiratory dysfunction and failure is the most common cause of death in ALS patients. Respiratory impairment has also been s...

journal_title：Cell transplantation

authors： Garbuzova-Davis S,Shell R,Mustafa H,Hailu S,Willing AE,Sanberg PR,Borlongan CV

更新日期：2020-01-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is a dominant inherited disease caused by expanded trinucleotide repeats resulting in an increased polyglutamine tract in the gene product. As a potential therapeutic approach for SCA1, we tested antisense RNAs targeting two regions of the ataxin-1 message. Single-stranded regions ...

journal_title：Cell transplantation

authors： Gao Y,Zu T,Low WC,Orr HT,McIvor RS

更新日期：2008-01-01 00:00:00

abstract：:In multiple sclerosis (MS), a chronic inflammatory relapsing demyelinating disease, failure to control or repair damage leads to progressive neurological dysfunction and neurodegeneration. Implantation of neural stem cells (NSCs) has been shown to promote repair and functional recovery in the acute experimental autoi...

journal_title：Cell transplantation

authors： Sher F,Amor S,Gerritsen W,Baker D,Jackson SL,Boddeke E,Copray S

更新日期：2012-01-01 00:00:00