Abstract:
:In diabetic patients cardiovascular morbidity and mortality is still a major problem. Our aim was to study the effect of kidney-pancreas transplantation on survival, cardiovascular events, and causes of death in diabetic type 1 uremic patients. Three hundred and thirty-three uremic IDDM patients were enrolled in our waiting list for kidney-pancreas transplantation: 107 underwent kidney-pancreas transplantation (KP), 34 underwent kidney transplantation alone (KA), whereas 192 patients remained on dialysis (WL). Actuarial survival and causes of death were recorded over a period of 7 years. Seven-year survival rate was 75% for the KP group, 63% for the KA group, and 37% for the WL group (p = 0.001). Cardiovascular death rate was 9.8% in the KP group, 17.6% in the KA group, and 18.1% in the WL group (KP vs. WL, p = 0.05). Rate of acute myocardial infarction in the KP group was lower than in the KA group (2.4% vs. 17.6%, p = 0.005) as well as rate of acute pulmonary edema (0.8% vs. 23.5%, p = 0.0001) and rate of hypertensive patients at 1 (40.9% vs. 85.0%, p = 0.0001) and at 2 years (57.6% vs. 80%, p = 0.03). Kidney-pancreas transplant helped to obtain euglycemia with positive effects on survival and cardiovascular events.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
La Rocca E,Fiorina P,Astorri E,Rossetti C,Lucignani G,Fazio F,Giudici D,Castoldi R,Bianchi G,Di Carlo V,Pozza G,Secchi Adoi
10.1177/096368970000900621subject
Has Abstractpub_date
2000-11-01 00:00:00pages
929-32issue
6eissn
0963-6897issn
1555-3892journal_volume
9pub_type
杂志文章abstract::Pluripotent stem cells, including human embryonic stem cells and induced pluripotent stem cells, have generated much excitement about their prospects for use in cell transplantation therapies. This is largely attributable to their virtually unlimited growth potential, their ability to be precisely genetically altered ...
journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.3727/096368910X498944
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abstract::For isolated pancreatic islet cell preparations, it is important to be able to reliably assess their mass and quality, and for clinical applications, it is part of the regulatory requirement. Accurate assessment, however, is difficult because islets are spheroid-like cell aggregates of different sizes (<50 to 500 μm) ...
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journal_title:Cell transplantation
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更新日期:1998-11-01 00:00:00
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journal_title:Cell transplantation
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abstract::Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have confirmed these findings but have not determined whether physical contact between MSC and islets is required or whether th...
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pub_type: 杂志文章
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abstract::Cardiovascular disease is a major cause of morbidity, disability, and mortality in kidney transplant patients. Cumulative reports indicate that the excessive risk of cardiovascular events is not entirely explained by the increased prevalence of traditional cardiovascular risk factors. Atherosclerosis is a chronic infl...
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journal_title:Cell transplantation
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abstract::It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump...
journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.1177/096368979900800511
更新日期:1999-09-01 00:00:00
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journal_title:Cell transplantation
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journal_title:Cell transplantation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-05-01 00:00:00
abstract::Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In the present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro and metastasis in vivo. To explore the mechanisms, the character...
journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.3727/096368915X687462
更新日期:2015-01-01 00:00:00
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journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.3727/000000008783906955
更新日期:2008-01-01 00:00:00
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journal_title:Cell transplantation
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更新日期:2006-01-01 00:00:00
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journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.1016/s0963-6897(98)00021-9
更新日期:1998-07-01 00:00:00
abstract::Expression of a fluorescent reporter gene has been studied using two alternate promoters to transcribe the green fluorescent protein (gfp) from Aequorea victoria. The human cytomegalovirus (CMV) enhancer/ promoter or the human muscle-specific creatine kinase promoter (CKM) were inserted along with the gfp cDNA into a ...
journal_title:Cell transplantation
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doi:10.3727/096368911X627589
更新日期:2012-01-01 00:00:00
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journal_title:Cell transplantation
pub_type: 杂志文章
doi:10.1016/s0963-6897(97)00022-5
更新日期:1997-03-01 00:00:00
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doi:
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journal_title:Cell transplantation
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doi:
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pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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