Liver tissue engineering utilizing hepatocytes propagated in mouse livers in vivo.

abstract：:The hypogonadal (HPG) mouse is a mutant that lacks a functional gonadotropin-releasing hormone (GnRH) gene. In this study, female HPG mice received bilateral intrahypothalamic implants of an immortalized GnRH-secreting cell line (GT1-7). Nine mice were tested 42- 65 days after implantation to determine whether these c...

journal_title：Cell transplantation

authors： Miller GM,Silverman AJ,Roberts JL,Wendong K,Gibson MJ

更新日期：1993-05-01 00:00:00

abstract：:Regenerative medicine aims to repair and regenerate damaged cells, tissues, and organs in order to restore function. Regeneration can be obtained either by cell replacement or by stimulating the body's own repair mechanisms. Importantly, a favorable environment is required before any regenerative signal can stimulate ...

journal_title：Cell transplantation

authors： Silini AR,Magatti M,Cargnoni A,Parolini O

更新日期：2017-04-13 00:00:00

abstract：:Radiotherapy is an effective treatment for brain tumors but often results in cognitive deficits in survivors. Transplantation of embryonic or brain-derived neural stem/progenitor cells (BNSPCs) ameliorated cognitive impairment after irradiation (IR) in animal models. However, such an approach in patients requires a cl...

journal_title：Cell transplantation

authors： Osman AM,Zhou K,Zhu C,Blomgren K

更新日期：2014-01-01 00:00:00

abstract：:In order to fully characterize and determine the therapeutic potential of adult neural progenitor cells (NPCs), it is important to be able to isolate and study NPCs from animals such as rats, in which there are existing models of brain injury and disease. The focus of this study was to characterize the cultivation, di...

journal_title：Cell transplantation

authors： Chen K,Hughes SM,Connor B

更新日期：2007-01-01 00:00:00

abstract：:Neural progenitor cells (NPCs) overexpressing fibroblast growth factor 2 (FGF-2) have the distinct tendency to associate with the vasculature and establish multiple proliferative clusters in the perivascular environment after transplantation into the cerebral cortex. Strikingly, the vascular clusters of progenitor cel...

journal_title：Cell transplantation

authors： Tsupykov O,Kanemitsu M,Smozhanik E,Skibo G,Dayer AG,Kiss JZ

更新日期：2016-01-01 00:00:00

abstract：:As a featured ocular inflammatory disease, autoimmune uveitis is the major cause of blindness in the clinic. Although current immunosuppressive regimens can alleviate the progression of autoimmune uveitis, they have serious side effects. Therefore, an alternative therapeutic strategy is urgently required. The present ...

journal_title：Cell transplantation

authors： Li J,Qiu C,Zhang Z,Yuan W,Ge Z,Tan B,Yang P,Liu J,Zhu X,Qiu C,Lai D,Guo L,Yu L

更新日期：2018-10-01 00:00:00

abstract：:As a putative marker of cerebral small vessel disease, cerebral microbleeds (CMBs) have been associated with vascular cognitive impairment. Both iron accumulation and amyloid protein precursor (APP) dysregulation are recognized as pathological hallmarks underlying the progression of CMBs, but their cross-talk is not y...

journal_title：Cell transplantation

authors： Gong L,Tian X,Zhou J,Dong Q,Tan Y,Lu Y,Wu J,Zhao Y,Liu X

更新日期：2019-08-01 00:00:00

abstract：:We investigated the effects of environmental enrichment (EE) on the function of transplanted adipose stem cells (ASCs) and the combined effect of EE and ASC transplantation on neurobehavioral function in an animal model of chronic hypoxic-ischemic (HI) brain injury. HI brain damage was induced in 7-day-old mice by uni...

journal_title：Cell transplantation

authors： Seo JH,Kim H,Park ES,Lee JE,Kim DW,Kim HO,Im SH,Yu JH,Kim JY,Lee MY,Kim CH,Cho SR

更新日期：2013-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) migrate to injury sites and aid in tissue repair. However, clinical success is poor and is partially due to limited HSC recruitment. We hypothesized that HSC pretreatment with H2O2 would enhance their recruitment to injured gut. As HSCs are rare cells, the number of primary cells obtain...

journal_title：Cell transplantation

authors： Kavanagh DP,Yemm AI,Alexander JS,Frampton J,Kalia N

更新日期：2013-01-01 00:00:00

abstract：:Ischemic stroke remains a serious threat to human life. There are limited effective therapies for the treatment of stroke. We have previously demonstrated that angiogenesis and neurogenesis in the brain play an important role in functional recovery following ischemic stroke. Recent studies indicate that increased arte...

journal_title：Cell transplantation

authors： Wei ZZ,Chen D,Liu LP,Gu X,Zhong W,Zhang YB,Wang Y,Yu SP,Wei L

更新日期：2018-04-01 00:00:00

abstract：:Gammopathies, multiple myeloma, and amyloidosis are plasma dyscrasias characterized by clonal proliferation and immunoglobulin overproduction. Renal impairment is the most common and serious complication with an incidence of 20-30% patients at the diagnosis. Kidney transplant has not been considered feasible in the pr...

journal_title：Cell transplantation

authors： Baraldi O,Grandinetti V,Donati G,Comai G,Battaglino G,Cuna V,Capelli I,Sala E,La Manna G

更新日期：2016-01-01 00:00:00

abstract：:The choice of enzyme blend is critical for successful islet isolation. Islet yield, viability, integrity, and function are important factors that influence the outcome of islet transplantation. Liberase HI has been used as a standard enzyme for pancreas digestion and has successfully produced islets that reversed dia...

journal_title：Cell transplantation

authors： Iglesias I,Valiente L,Shiang KD,Ichii H,Kandeel F,Al-Abdullah IH

更新日期：2012-01-01 00:00:00

abstract：:To overcome common disadvantages of standard cultured epidermal sheet grafts (CEG) we have developed a new technique of transplanting cultured human keratinocytes suspended as single cells in a fibrin-glue matrix (Keratinocyte-fibrin-glue suspension-KFGS). In an athymic mouse model with reproducible standardized full ...

journal_title：Cell transplantation

authors： Horch RE,Bannasch H,Kopp J,Andree C,Stark GB

更新日期：1998-05-01 00:00:00

abstract：:Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently...

journal_title：Cell transplantation

authors： Díaz D,Recio JS,Weruaga E,Alonso JR

更新日期：2012-01-01 00:00:00

abstract：:To learn more about nonimmune-mediated islet graft failure, we transplanted different preparations (preps) of isolated human islets under the kidney capsule of streptozotocin (STZ)-diabetic nude mice. One month after the implantation of 1,000 or 2,000 islets, grafts were harvested for morphological, immunohistochemica...

journal_title：Cell transplantation

authors： Davalli AM,Perego L,Bertuzzi F,Finzi G,La Rosa S,Blau A,Placidi C,Nano R,Gregorini L,Perego C,Capella C,Folli F

更新日期：2008-01-01 00:00:00

abstract：:The major limitation of nonhuman primate (NHP) embryonic stem (ES) cell research is inefficient genetic modification and limited knowledge of differentiation mechanisms. A genetically modified NHP-ES cell with biomarkers, such as green fluorescent protein (GFP), that allow noninvasive monitoring of transgenic cells, i...

journal_title：Cell transplantation

authors： Takada T,Suzuki Y,Kondo Y,Kadota N,Kobayashi K,Nito S,Kimura H,Torii R

更新日期：2002-01-01 00:00:00

abstract：:Pancreatic beta cell lines may offer an abundant source of cells for beta-cell replacement in type I diabetes. Using regulatory elements of the bacterial tetracycline (tet) operon for conditional expression of SV40 T antigen oncoprotein in transgenic mouse beta cells, we have shown that reversible immortalization is a...

journal_title：Cell transplantation

authors： Milo-Landesman D,Surana M,Berkovich I,Compagni A,Christofori G,Fleischer N,Efrat S

更新日期：2001-01-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder that occurs in patients with a mutation in the huntingtin or IT15 gene. Patients are plagued by early cognitive signs, motor deficits, and psychiatric disturbances. Symptoms are attributed to cell death in the striatum and disruption of cortical-str...

journal_title：Cell transplantation

authors： Ramaswamy S,Shannon KM,Kordower JH

更新日期：2007-01-01 00:00:00

abstract：:Since donor T-cells' allorecognition of host antigens is a prerequisite for the onset of graft-versus-host disease (GVHD), blocking their cellular signaling pathways can decrease the severity of GVHD. We hypothesized that epigallocatechin-3-gallate (EGCG), due to its strong affinity to macromolecules, would adhere to...

journal_title：Cell transplantation

authors： Kanamune J,Iwanaga Y,Kina T,Noguchi H,Matsumura K,Uemoto S,Hyon SH

更新日期：2012-01-01 00:00:00

abstract：:Direct reprogramming of an adult cell into another differentiated lineage-such as fibroblasts into neurons, cardiomyocytes, or blood cells-without passage through an undifferentiated pluripotent stage is a new area of research that has recently emerged alongside stem cell technology and induced pluripotent stem cell r...

journal_title：Cell transplantation

authors： Nizzardo M,Simone C,Falcone M,Riboldi G,Comi GP,Bresolin N,Corti S

更新日期：2013-01-01 00:00:00

abstract：:We examined a possible protective effect of the nonpeptidyl low molecular weight radical scavenger IAC [bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decanedioate di-hydrochloride] on isolated human islet cells against isolation and culture oxidative stress. Islets isolated from pancreases of nondiabetic multiorgan ...

journal_title：Cell transplantation

authors： Mancarella R,Del Guerra S,Masini M,Bugliani M,Valgimigli L,Pedulli GF,Paolini M,Canistro D,Armando A,Soleti A,Filipponi F,Mosca F,Boggi U,Del Prato S,Marchetti P,Lupi R

更新日期：2008-01-01 00:00:00

abstract：:The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW)...

journal_title：Cell transplantation

authors： Nuryyev RL,Uhlendorf TL,Tierney W,Zatikyan S,Kopyov O,Kopyov A,Ochoa J,Van Trigt W,Malone CS,Cohen RW

更新日期：2017-11-01 00:00:00

abstract：:An important challenge in pancreatic islet transplantation in association with type 1 diabetes is to define automatic high-throughput assays for evaluation of human islet function. The physiological techniques presently used are amenable to small-scale experimental samples and produce descriptive results. The postgeno...

journal_title：Cell transplantation

authors： Cabrera O,Jacques-Silva MC,Berman DM,Fachado A,Echeverri F,Poo R,Khan A,Kenyon NS,Ricordi C,Berggren PO,Caicedo A

更新日期：2008-01-01 00:00:00

abstract：:Techniques for medical tissue regeneration require an abundant source of human adult stem cells. There is increasing evidence that adipose stem cells contribute to restoration of tissue vascularization and organ function. The object of our study was to isolate and characterize adult adipose-derived stem cells from pat...

journal_title：Cell transplantation

authors： Folgiero V,Migliano E,Tedesco M,Iacovelli S,Bon G,Torre ML,Sacchi A,Marazzi M,Bucher S,Falcioni R

更新日期：2010-01-01 00:00:00

abstract：:Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the represen...

journal_title：Cell transplantation

authors： Yakoub AM,Sadek M

更新日期：2018-03-01 00:00:00

abstract：:Successful transplantation of cadaver embryonic neural tissue is highly dependent on the method used to obtain the tissue. It is important that the tissue not be contaminated bacteriologically by vaginal flora during the procedure, and that it not be disrupted mechanically. A low-pressure aspiration abortion technique...

journal_title：Cell transplantation

authors： Nauert GM,Freeman TB

更新日期：1994-03-01 00:00:00

abstract：:Hepatocyte-based biological therapies are increasingly envisioned for temporary support in acute liver failure and provision of specific-liver functions in liver-based metabolic deficiency. One of the hurdles to develop such therapies is severe shortage of human livers for hepatocyte isolation. To address the issue, w...

journal_title：Cell transplantation

authors： Kobayashi N,Tanaka N

更新日期：2002-07-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that occurs sporadically and causes parkinsonism, cerebellar, autonomic, urinary, and pyramidal dysfunction in many combinations. Progressive L-dopa-unresponsive parkinsonism due to underlying striatonigral degeneration dominates the clinical syndrome in th...

journal_title：Cell transplantation

authors： Wenning GK,Tison F,Scherfler C,Puschban Z,Waldner R,Granata R,Ghorayeb I,Poewe W

更新日期：2000-03-01 00:00:00

abstract：:Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited an...

journal_title：Cell transplantation

authors： Gonzalez R,Garitaonandia I,Poustovoitov M,Abramihina T,McEntire C,Culp B,Attwood J,Noskov A,Christiansen-Weber T,Khater M,Mora-Castilla S,To C,Crain A,Sherman G,Semechkin A,Laurent LC,Elsworth JD,Sladek J,Snyder EY,

更新日期：2016-11-01 00:00:00

abstract：:The estimated frequency of MSCs in BM is about 0.001-0.01% of total nucleated cells. Most commonly, one applied therapeutic cell dose is about 1-5 million MSCs/kg body weight, necessitating a reliable, fast, and safe expansion system. The limited availability of MSCs demands for an extensive ex vivo amplification step...

journal_title：Cell transplantation

authors： Rojewski MT,Fekete N,Baila S,Nguyen K,Fürst D,Antwiler D,Dausend J,Kreja L,Ignatius A,Sensebé L,Schrezenmeier H

更新日期：2013-01-01 00:00:00