Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system.

abstract：:In this study, we assessed the ability of miR-26b-5p to regulate T cell factor 4 (TCF-4) expression and thereby control human adipose-derived mesenchymal stem cell (hADMSC) adipogenic differentiation. Adipogenic medium was used to induce hADMSC differentiation over a 6-d period. The ability of miR-26b-5p to interact w...

journal_title：Cell transplantation

authors： Luo Y,Ji H,Cao Y,Ding X,Li M,Song H,Li S,WaTableng C,Wu H,Meng J,Du H

更新日期：2020-01-01 00:00:00

abstract：:Although hepatic stem cells are believed to exist and play a critical role in developing and regenerating liver, little is known about their cell surface specificity or differentiation capabilities. To make prospective studies of hepatic stem cells possible, we established an in vitro culture system for identification...

journal_title：Cell transplantation

authors： Suzuki A,Zheng YW,Fukao K,Nakauchi H,Taniguchi H

更新日期：2001-01-01 00:00:00

abstract：:The midbrain inferior colliculus (IC), a major integrating center for auditory processing, provides a model for structural, functional, and behavioral recovery. The present study examined the role of IC in spatial sound detection, and the effects of neural transplantation in sparing of behavioral performance. Hooded r...

journal_title：Cell transplantation

authors： Zrull MC,Coleman JR

更新日期：1996-03-01 00:00:00

abstract：:Cerebral palsy (CP) is a common disability which results in permanent chronic motor disability appearing in early childhood. Recently human umbilical cord blood mesenchymal stem cell (hUCB-MSC) infusion has emerged as a promising therapeutic strategy for CP, and the treatment efficacy remains to be confirmed by clinic...

journal_title：Cell transplantation

authors： Huang L,Zhang C,Gu J,Wu W,Shen Z,Zhou X,Lu H

更新日期：2018-02-01 00:00:00

abstract：:Prairie voles show strong pair bonding with their mating partners, and they demonstrate parental behavior toward their infants, indicating that the prairie vole is a unique animal model for analysis of molecular mechanisms of social behavior. Until a recent study, the signaling pathway of oxytocin was thought to be cr...

journal_title：Cell transplantation

authors： Katayama M,Hirayama T,Horie K,Kiyono T,Donai K,Takeda S,Nishimori K,Fukuda T

更新日期：2016-01-01 00:00:00

abstract：:Human marrow stromal cells (hMSCs) provide functional benefit in rats subjected to stroke. Astrocytes are coupled into a cellular network via gap junction channels, predominantly composed of connexin-43 (Cx43) proteins. Astrocytes are believed to play a vital role in neuroprotection by providing energy substrates to n...

journal_title：Cell transplantation

authors： Gao Q,Katakowski M,Chen X,Li Y,Chopp M

更新日期：2005-01-01 00:00:00

abstract：:Sepsis is a life-threatening disease that results in excessive stimulation of the host's immune cells. In the animal study, the purpose was to investigate the roles of fresh frozen plasma (FFP) transfusion in shaping the CD4+ T lymphocytes immune response through modulating the secreted exosome protein Galectin-9 in m...

journal_title：Cell transplantation

authors： Zhang L,Zhang JP,Liu Y,Wang H,Cheng Y,Wang JH,Zhang WJ,Li ZZ,Guo JR

更新日期：2020-01-01 00:00:00

abstract：:An important challenge in pancreatic islet transplantation in association with type 1 diabetes is to define automatic high-throughput assays for evaluation of human islet function. The physiological techniques presently used are amenable to small-scale experimental samples and produce descriptive results. The postgeno...

journal_title：Cell transplantation

authors： Cabrera O,Jacques-Silva MC,Berman DM,Fachado A,Echeverri F,Poo R,Khan A,Kenyon NS,Ricordi C,Berggren PO,Caicedo A

更新日期：2008-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) may be of value in regeneration of renal tissue after damage; however, lack of biological knowledge and variability of results in animal models limit their utilization. We studied the effects of MSCs on podocytes in vitro and in vivo utilizing adriamycin (ADR) as a model of renal toxicity...

journal_title：Cell transplantation

authors： Magnasco A,Corselli M,Bertelli R,Ibatici A,Peresi M,Gaggero G,Cappiello V,Chiavarina B,Mattioli G,Gusmano R,Ravetti JL,Frassoni F,Ghiggeri GM

更新日期：2008-01-01 00:00:00

abstract：:The revascularization of islets of Langerhans transplanted in heterotopic sites like the liver by portal vein embolization or the renal subcapsular space is a major process necessary for the viability of grafted cells. This process has been extensively studied by different techniques and the results have shown that is...

journal_title：Cell transplantation

authors： Mendola JF,Conget I,Manzanares JM,Corominola H,Viñas O,Barcelo J,Gomis R

更新日期：1997-11-01 00:00:00

abstract：:Liver fibrosis is characterized by excessive accumulation of extracellular matrix components in the liver parenchyma that distorts the normal architecture and hepatic function. Progressive fibrosis could end in the advanced stage known as cirrhosis, resulting in the need to resort to liver transplantation. Amniotic me...

journal_title：Cell transplantation

authors： SantAnna LB,Hage R,Cardoso MA,Arisawa EA,Cruz MM,Parolini O,Cargnoni A,SantAnna N

更新日期：2016-12-13 00:00:00

abstract：:The hypogonadal (HPG) mouse is a mutant that lacks a functional gonadotropin-releasing hormone (GnRH) gene. In this study, female HPG mice received bilateral intrahypothalamic implants of an immortalized GnRH-secreting cell line (GT1-7). Nine mice were tested 42- 65 days after implantation to determine whether these c...

journal_title：Cell transplantation

authors： Miller GM,Silverman AJ,Roberts JL,Wendong K,Gibson MJ

更新日期：1993-05-01 00:00:00

abstract：:Cell therapy has been shown to be a promising alternative therapy for neurorestoration, and more than 30 different types of cells have been shown to possess some capability to restore lost or damaged neurological functions. Chinese physicians have successfully applied cell therapy to many neurological diseases and dam...

journal_title：Cell transplantation

authors： Chinese Branch of International Association of Neurorestoratology (IANR).,Preparatory Committee of Chinese Association of Neurorestoratology.

更新日期：2013-01-01 00:00:00

abstract：:Bisphosphonates (BPs) are widely used to treat several metabolic and oncological diseases affecting the skeletal system. Despite BPs' well-known therapeutic potential, they also displayed important side effects, among which is BPs-related osteonecrosis of the jaw, by targeting osteoclast activities, osteoblast, and os...

journal_title：Cell transplantation

authors： Di Vito A,Chiarella E,Baudi F,Scardamaglia P,Antonelli A,Giudice D,Barni T,Fortunato L,Giudice A

更新日期：2020-01-01 00:00:00

abstract：:Islet isolation involves enzymatic digestion of the interstitial matrix and mechanical disruption of the tissue. It is possible that a fundamental change of islet biology resulting from the loss of critical factors required for islet function or survival will occur. Extracellular matrix (ECM) is one of the most import...

journal_title：Cell transplantation

authors： Nagata N,Gu Y,Hori H,Balamurugan AN,Touma M,Kawakami Y,Wang W,Baba TT,Satake A,Nozawa M,Tabata Y,Inoue K

更新日期：2001-01-01 00:00:00

abstract：:Potential labels for identifying embryonic raphe neurons and a clonal, neuronally differentiating, raphe-derived cell line, RN33B, in CNS transplantation studies were tested by first characterizing the labels in vitro. The labels that were tested included 4',6-diamidino-2-phenylindole hydrochloride, 1,1'-dioctadecyl-3...

journal_title：Cell transplantation

authors： Onifer SM,White LA,Whittemore SR,Holets VR

更新日期：1993-03-01 00:00:00

abstract：:The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate, first, the effect of the donor-type MSCs from Wistar rats on the immune system of immunocompetent Lewis rats and, second, the rejec...

journal_title：Cell transplantation

authors： Merino A,Ripoll E,de Ramon L,Bolaños N,Goma M,Bestard O,Lloberas N,Grinyo JM,Ambròs JT

更新日期：2017-06-09 00:00:00

abstract：:Prognosis of patients with heart failure remains poor despite improved conventional and interventional treatment regimens. The improvement of neovascularization and repair processes by administration of bone marrow-derived cells modestly improved the recovery after acute myocardial infarction. However, circulating pat...

journal_title：Cell transplantation

authors： Honold J,Fischer-Rasokat U,Lehmann R,Leistner DM,Seeger FH,Schachinger V,Martin H,Dimmeler S,Zeiher AM,Assmus B

更新日期：2012-01-01 00:00:00

abstract：:The integrity of the blood-brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endov...

journal_title：Cell transplantation

authors： Qi X,Liu J,Wu J,Bi Y,Han C,Zhang G,Lou M,Lu J,Tang J

更新日期：2019-08-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating neurological disease. The pathophysiological mechanisms of SCI have been reported to be relevant to central nervous system injury such as brain injury. In this study, gene expression of the brain after SCI was elucidated using transcriptome analysis to characterize the tempora...

journal_title：Cell transplantation

authors： Baek A,Cho SR,Kim SH

更新日期：2017-07-01 00:00:00

abstract：:During the isolation of human islets of Langerhans the digest has repeated direct contact with the ambient atmosphere. In order to fulfill GMP requirements in clinical applications, the entire cell preparation must be performed in clean room facilities. We hypothesized that the use of a closed system, which avoids the...

journal_title：Cell transplantation

authors： Klaffschenkel RA,Biesemeier A,Waidmann M,Northoff H,Steurer W,Königsrainer A,Lembert N

更新日期：2007-01-01 00:00:00

abstract：:We investigated the effect of the activation of complement in human serum on isolated adult porcine islets using an in vitro model of pig-to-human islet transplantation. Pancreata were obtained from slaughterhouse pigs (6-8 mo old). Islets were prepared by intraductal collagenase digestion followed by purification on ...

journal_title：Cell transplantation

authors： Kin T,Nakajima Y,Kanehiro H,Aomatsu Y,Yoshimura A,Taki J,Ko S,Yagura K,Oyama T,Ohashi K,Nakano H

更新日期：1996-09-01 00:00:00

abstract：:We investigated the effects of environmental enrichment (EE) on the function of transplanted adipose stem cells (ASCs) and the combined effect of EE and ASC transplantation on neurobehavioral function in an animal model of chronic hypoxic-ischemic (HI) brain injury. HI brain damage was induced in 7-day-old mice by uni...

journal_title：Cell transplantation

authors： Seo JH,Kim H,Park ES,Lee JE,Kim DW,Kim HO,Im SH,Yu JH,Kim JY,Lee MY,Kim CH,Cho SR

更新日期：2013-01-01 00:00:00

abstract：:Transplanted embryonic stem (ES) cells, following myocardial infarction (MI), contribute to limited cardiac repair and regeneration with improved function. Therefore, novel strategies are still needed to understand the effects of genetically modified transplanted stem cells on cardiac remodeling. The present study ev...

journal_title：Cell transplantation

authors： Glass C,Singla DK

更新日期：2012-01-01 00:00:00

abstract：:The major limitation of nonhuman primate (NHP) embryonic stem (ES) cell research is inefficient genetic modification and limited knowledge of differentiation mechanisms. A genetically modified NHP-ES cell with biomarkers, such as green fluorescent protein (GFP), that allow noninvasive monitoring of transgenic cells, i...

journal_title：Cell transplantation

authors： Takada T,Suzuki Y,Kondo Y,Kadota N,Kobayashi K,Nito S,Kimura H,Torii R

更新日期：2002-01-01 00:00:00

abstract：:Prior studies have suggested the possibility of immune-mediated death of xenogeneic hepatocytes in a bioartificial liver (BAL) during hemoperfusion. This study was designed to elucidate how immunity may cause death of xenogeneic hepatocytes in the BAL. Healthy dogs were treated with a BAL containing hollow fiber membr...

journal_title：Cell transplantation

authors： Nyberg SL,Amiot B,Hardin J,Baskin-Bey E,Platt JL

更新日期：2004-01-01 00:00:00

abstract：:Mouse embryonal carcinoma cell line P19 could be differentiated to neurons or glial cells by appropriate induction. We introduced the lacZ gene driven by a calmodulin promoter into P19 cells, and cloned the transfectant CaM-Z that showed the strong expression of lacZ gene after the induction of differentiation. CaM-Z ...

journal_title：Cell transplantation

authors： Watanabe R,Takase-Yoden S,Ikeda T,Atsumi T

更新日期：1996-09-01 00:00:00

abstract：:Persistent corneal wounds result from numerous eye disorders, and to date, available treatments often fail to accelerate reepithelialization, the key initial step in wound healing. To speed reepithelialization, we explored a cell-transfer transplant method utilizing polydimethylsiloxane (PDMS) contact lenses to delive...

journal_title：Cell transplantation

authors： Pino CJ,Haselton FR,Chang MS

更新日期：2005-01-01 00:00:00

abstract：:The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has been reached as to what is ...

journal_title：Cell transplantation

authors： Di Vito A,Giudice A,Chiarella E,Malara N,Bennardo F,Fortunato L

更新日期：2019-01-01 00:00:00

abstract：:Adrenal medullary tissue including chromaffin cells was grafted intrathecally in cancer patients to relieve intractable pain. The central nervous system (CNS) is considered an immune privileged site. Therefore, non-HLA-matched and unencapsulated tissue was grafted in 15 patients and 1 sham control in a series of at le...

journal_title：Cell transplantation

authors： Tkaczuk J,Bes JC,Duplan H,Sallerin B,Tafani M,Charlet JP,Abbal M,Lazorthes Y,Ohayon E

更新日期：2000-01-01 00:00:00