Abstract:
:The HTLV-1 singly spliced open reading frame I protein, p12(I), is highly unstable and appears to be necessary for persistent infection in rabbits. Here we demonstrate that p12(I) forms dimers through two putative leucine zipper domains and that its stability is augmented by specific proteasome inhibitors. p12(I) is ubiquitylated, and mutations of its unique carboxy-terminus lysine residue to an arginine greatly enhance its stability. Interestingly, analysis of 53 independent HTLV-1 strains revealed that the natural p12(I) alleles found in ex vivo samples of tropical spastic paraparesis-HTLV-1-associated myelopathy patients contain a Lys at position 88 in some cases, whereas arginine is consistently found at position 88 in HTLV-1 strains from all adult T-cell leukemia-lymphoma (ATLL) cases and healthy carriers studied. This apparent segregation of different alleles in tropical spastic paraparesis-HTLV-associated myelopathy and ATLL or healthy carriers may be relevant in vivo, since p12(I) binds the interleukin-2 receptor beta and gammac chains, raising the possibility that the two natural alleles might affect differently the regulation of these molecules.
journal_name
J Viroljournal_title
Journal of virologyauthors
Trovato R,Mulloy JC,Johnson JM,Takemoto S,de Oliveira MP,Franchini Gdoi
10.1128/JVI.73.8.6460-6467.1999subject
Has Abstractpub_date
1999-08-01 00:00:00pages
6460-7issue
8eissn
0022-538Xissn
1098-5514journal_volume
73pub_type
杂志文章abstract::We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not a...
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.64.11.5412-5419.1990
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.1.4.738-746.1967
更新日期:1967-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.2.299-305.1978
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更新日期:1986-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.69.9.5445-5454.1995
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.2.450-456.1980
更新日期:1980-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.2.1107-1114.1995
更新日期:1995-02-01 00:00:00