Abstract:
:The repetitive respiratory events that characterize obstructive sleep apnea (OSA) are each followed by abrupt increases in heart rate and in pulmonary and systemic artery pressure and by sudden decreases in right and left ventricular stroke volume. The changes in systemic pressure may be profound, with patients who are normotensive while awake having systolic pressures approaching 300 mm Hg after apnea termination. Because of these dramatic hemodynamic oscillations during sleep, many clinicians and investigators have postulated a connection between sleep-disordered breathing and cardiovascular morbidity and even mortality. This review critically examines the evidence for such a causal relationship. We begin, however, by reviewing the normal hemodynamic changes that occur during sleep. We then describe the acute hemodynamic events associated with OSA. Finally, we summarize the evidence for and against a causal connection between sleep apnea and cardiovascular morbidity.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Weiss JW,Launois SH,Anand A,Garpestad Edoi
10.1053/pcad.1999.0410367subject
Has Abstractpub_date
1999-03-01 00:00:00pages
367-76issue
5eissn
0033-0620issn
1873-1740pii
S0033-0620(99)00030-4journal_volume
41pub_type
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journal_title:Progress in cardiovascular diseases
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journal_title:Progress in cardiovascular diseases
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journal_title:Progress in cardiovascular diseases
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journal_title:Progress in cardiovascular diseases
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