Abstract:
:Sugars are foundational to biological life and played essential roles in human evolution and dietary patterns for most of recorded history. The simple sugar glucose is so central to human health that it is one of the World Health Organization's Essential Medicines. Given these facts, it defies both logic and a large body of scientific evidence to claim that sugars and other nutrients that played fundamental roles in the substantial improvements in life- and health-spans over the past century are now suddenly responsible for increments in the prevalence of obesity and chronic non-communicable diseases. Thus, the purpose of this review is to provide a rigorous, evidence-based challenge to 'diet-centrism' and the disease-mongering of dietary sugar. The term 'diet-centrism' describes the naïve tendency of both researchers and the public to attribute a wide-range of negative health outcomes exclusively to dietary factors while neglecting the essential and well-established role of individual differences in nutrient-metabolism. The explicit conflation of dietary intake with both nutritional status and health inherent in 'diet-centrism' contravenes the fact that the human body is a complex biologic system in which the effects of dietary factors are dependent on the current state of that system. Thus, macronutrients cannot have health or metabolic effects independent of the physiologic context of the consuming individual (e.g., physical activity level). Therefore, given the unscientific hyperbole surrounding dietary sugars, I take an adversarial position and present highly-replicated evidence from multiple domains to show that 'diet' is a necessary but trivial factor in metabolic health, and that anti-sugar rhetoric is simply diet-centric disease-mongering engendered by physiologic illiteracy. My position is that dietary sugars are not responsible for obesity or metabolic diseases and that the consumption of simple sugars and sugar-polymers (e.g., starches) up to 75% of total daily caloric intake is innocuous in healthy individuals.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Archer Edoi
10.1016/j.pcad.2018.04.007subject
Has Abstractpub_date
2018-01-01 00:00:00pages
10-19issue
1eissn
0033-0620issn
1873-1740pii
S0033-0620(18)30084-7journal_volume
61pub_type
杂志文章,评审abstract::In heart failure (HF) management, noninvasive quantification of left ventricular (LV) function is rapidly evolving. Deformation parameters, such as strain, continue to challenge the central role of ejection fraction (EF) in diagnosis and prognostication of LV dysfunction in HF. The increasing recognition and use of de...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.05.007
更新日期:2020-01-01 00:00:00
abstract::During the past decade, an overall theme has emerged, validating the exploration of gender-based differences in coronary heart disease (CHD) as a basis for clinical strategies to improve outcomes for women. Underrepresentation of women in most of CHD and lack of gender-specific reporting in many clinical trials contin...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2003.08.003
更新日期:2003-11-01 00:00:00
abstract::Bicuspid aortic valve (BAV) patients are at increased risk of valve dysfunction and ascending aorta aneurysm. Imaging techniques are essential to establish diagnosis, identify complications and indicate surgical treatment. Transthoracic echocardiography (TTE) is the imaging technique of choice to diagnose BAV, valve m...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.06.003
更新日期:2020-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2002.123782
更新日期:2002-05-01 00:00:00
abstract::Tachycardia is a strong predictor of both hypertension and excessive cardiovascular risk. This association is robust and prevails after multivariate adjustments for other cardiovascular risk factors. Despite the strong evidence, various guidelines do not list tachycardia as a risk factor because of unwarranted assumpt...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2009.06.002
更新日期:2009-07-01 00:00:00
abstract::Pulmonary artery hypertension is a complex and multi-faceted disease process with numerous etiologies. Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed and highly treatable form of pulmonary hypertension. In this disease, certain patients with a history of pulmonary thromboembolic disease go ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.07.005
更新日期:2012-09-01 00:00:00
abstract::Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...
journal_title:Progress in cardiovascular diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0033-0620(96)80029-6
更新日期:1996-03-01 00:00:00
abstract::The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these mechanisms will identify novel therapeutic targets. In search of these m...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.03.002
更新日期:2019-01-01 00:00:00
abstract::Cardiovascular magnetic resonance (CMR) imaging is a recognized technique for characterization of myocardial tissue in stable ischemic heart disease. In addition, CMR is emerging as a noninvasive imaging tool that can provide supporting information to guide treatment in acute coronary syndromes (ACSs). The advantages ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2011.09.001
更新日期:2011-11-01 00:00:00
abstract::The purpose of this review was to provide an overview of the descriptive epidemiology of physical activity (PA) and exercise training in the United States. Overall, there is a low prevalence of meeting the current PA guidelines in all age, sex and race/ethnic groups. Among adults the prevalence of meeting the aerobic ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2017.01.004
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To assess the cardiorespiratory fitness (CRF) impact on the association between exercise blood pressure (BP) and mortality risk. PATIENTS AND METHODS:We assessed CRF in 15,004 US Veterans (mean age 57.5 ± 11.2 years) who completed a standardized treadmill test between January 1, 1988 and July 28, 2017 and ha...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2021.01.003
更新日期:2021-01-26 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.12.010
更新日期:2019-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(99)70006-x
更新日期:1999-07-01 00:00:00
abstract::Mitral regurgitation (MR) is one of the most commonly encountered valvular lesions in clinical practice. MR can be either primary (degenerative) or secondary (functional) depending on the etiology of MR and the pathology of the mitral valve (MV). Echocardiography is the primary diagnostic tool for MR and is key in det...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.10.001
更新日期:2018-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(96)80025-9
更新日期:1996-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2008.08.007
更新日期:2009-05-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.04.006
更新日期:2012-07-01 00:00:00
abstract::The underlying causes of hypertensive disease remain unclear. This article has attempted to highlight potential dysfunctions in arterial pressure regulation which could either initiate or sustain the hypertensive process. As has been suggested innumerable times hypertension must certainly be a multifactorial abnormali...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(76)90001-3
更新日期:1976-03-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2006.03.002
更新日期:2006-05-01 00:00:00
abstract::The changing pattern of disease in the developing world calls for a change in the structure, goals, and personnel of global health assistance. Chronic diseases are now the dominant threat to health and are becoming a challenge to economic advancement in developing economies. Because confronting these diseases, heart d...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2007.11.006
更新日期:2008-07-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(77)90004-4
更新日期:1977-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
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更新日期:1998-07-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2013.07.004
更新日期:2013-09-01 00:00:00
abstract::There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. In the majority of cases, CAD in the ACHD population is driven ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.07.018
更新日期:2018-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2014.12.003
更新日期:2015-03-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2007.11.004
更新日期:2008-03-01 00:00:00
abstract::Rigorous training remodels the heart of elite endurance athletes to produce the phenotype of the "athlete's heart." This remodeling, which advantages cardiac performance, creates challenges in the diagnosis of cardiac disorders within this population. This is particularly so for right ventricular pathologies because o...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.01.005
更新日期:2012-03-01 00:00:00
abstract::The definition of syncope has clinical and pathophysiological parts. The clinical part is that syncope is a form of transient loss of consciousness (TLOC), while the pathophysiological element is that syncope differs from other forms of TLOC by virtue of the basis of true syncope - specifically cerebral hypoperfusion....
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.10.016
更新日期:2013-01-01 00:00:00
abstract::Transcatheter therapy with the MitraClip system (Abbott Structural, Menlo Park, CA) is the most commonly used transcatheter therapy for patients with tricuspid regurgitation, with over 1000 cases performed worldwide. The procedure is an off-label approach that requires meticulous attention to anatomical features obtai...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.10.001
更新日期:2019-01-01 00:00:00
abstract::There is a strong evidence that more marked lowering of low-density lipoprotein cholesterol (LDL-C) leads to progressively lower risk of cardiovascular disease (CVD) events. The evidence on validity of this hypothesis comes from epidemiological, genetic and clinical studies. The hypothesis "the lower the better" has b...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.12.008
更新日期:2020-12-28 00:00:00