Electrophysiological basis of QT dispersion measurements.

Abstract:

:Dispersion of ventricular repolarization is a now widely used term describing nonhomogeneous recovery of excitability or heterogeneity of ventricular repolarization. It is usually expressed as the difference or the range of various repolarization measurements obtained from a heart. Experimentally, an increased dispersion of ventricular repolarization was found to be tightly associated with increased propensity for ventricular arrhythmias, and, therefore, is considered an important arrhythmogenic mechanism. Noninvasively, this arrhythmogenic substrate was approached using multilead body surface potential mapping, but also QT interval dispersion (QTd) and similar electrocardiogram (ECG) variables from the 12-lead surface ECG. Standard QTd from the ECG correlates significantly with dispersion of repolarization measured from the myocardium. A causal relationship is, however, still unclear, and there are 2 main hypotheses to explain the electrophysiological basis of QTd. The local hypothesis explaining QTd with spatial differences in action potential duration mirrored in the various QT intervals competes with the global hypothesis explaining the variation in surface ECG measurements with different projections of a common T-wave vector. Notwithstanding the final explanation for QTd, and particularly for technical reasons, new markers like advanced T-wave loop variables may best reflect the abnormal repolarization substrate on the surface ECG.

journal_name

Prog Cardiovasc Dis

authors

Franz MR,Zabel M

doi

10.1053/pcad.2000.0420311

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

311-24

issue

5

eissn

0033-0620

issn

1873-1740

pii

S0033-0620(00)00025-6

journal_volume

42

pub_type

杂志文章,评审
  • Development of an entirely subcutaneous implantable cardioverter-defibrillator.

    abstract::The recent advent of an entirely subcutaneous implantable defibrillator (ICD) has provided a relevant contribution to the debate concerning the use of ICD therapy in patients at high risk for death. Although conventional transvenous ICDs have proven very effective during the past 23 years, they still appear to be limi...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2012.03.006

    authors: Lupo PP,Pelissero G,Ali H,Sanghera R,Cappato R

    更新日期:2012-05-01 00:00:00

  • The role of cardiovascular magnetic resonance in patients with acute coronary syndromes.

    abstract::Cardiovascular magnetic resonance (CMR) imaging is a recognized technique for characterization of myocardial tissue in stable ischemic heart disease. In addition, CMR is emerging as a noninvasive imaging tool that can provide supporting information to guide treatment in acute coronary syndromes (ACSs). The advantages ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2011.09.001

    authors: Dall Armellina E,Choudhury RP

    更新日期:2011-11-01 00:00:00

  • Peripheral circulation in arterial hypertension.

    abstract::The underlying causes of hypertensive disease remain unclear. This article has attempted to highlight potential dysfunctions in arterial pressure regulation which could either initiate or sustain the hypertensive process. As has been suggested innumerable times hypertension must certainly be a multifactorial abnormali...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/0033-0620(76)90001-3

    authors: Brody MJ,Zimmerman BG

    更新日期:1976-03-01 00:00:00

  • Prevention of myocardial infarction.

    abstract::The possible methods of preventing myocardial infarction have been discussed. The desirability of prevention in the total problem of myocardial infarction is stressed. The methods consist of the prevention of the underlying coronary atherosclerosis, and the secondary prevention of myocardial ischemia contributed by ot...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章

    doi:10.1016/s0033-0620(71)80011-7

    authors: Dawber TR,Thomas HE Jr

    更新日期:1971-01-01 00:00:00

  • Stress nuclear myocardial perfusion imaging versus stress echocardiography: prognostic comparisons.

    abstract::The use of noninvasive stress cardiac imaging for stratifying risk in patients with known or suspected coronary artery disease is growing as a tool for identification of the subgroup most likely to benefit from the expense and risk of more invasive procedures, including cardiac catheterization and coronary revasculari...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1053/pcad.2000.19314

    authors: Brown KA,Rosman DR,Dave RM

    更新日期:2000-11-01 00:00:00

  • Percutaneous Treatment for Native Mitral Regurgitation.

    abstract::Severe mitral regurgitation (MR) confers an adverse prognosis, frequently with debilitating symptoms of heart failure. While open surgical correction has been the standard of care for decades, novel catheter-based technologies have emerged that are highly effective in the treatment of MR. These percutaneous technologi...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2017.11.003

    authors: Sorajja P,Maisano F

    更新日期:2017-01-01 00:00:00

  • QT Variability Index.

    abstract::The QT Variability Index (QTVI) is a non-invasive measure of repolarization lability that has been applied to a wide variety of subjects with cardiovascular disease. It is a ratio of normalized QT variability to normalized heart rate variability, and therefore includes an assessment of autonomic nervous system tone. T...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2013.07.004

    authors: Dobson CP,Kim A,Haigney M

    更新日期:2013-09-01 00:00:00

  • Economic impact of mechanical cardiac assistance.

    abstract::In contrast to heart transplantation, little effort has been made to estimate the economic implications of mechanical cardiac assistance from either a procedure- or a program-level perspective. With annual direct and indirect expenditures for the treatment of coronary artery disease and congestive heart failure now ex...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1053/pcad.2000.7201

    authors: Evans RW

    更新日期:2000-07-01 00:00:00

  • Electrophysiology and adult congenital heart disease: advances and options.

    abstract::Although "congenital heart disease" incorporates a broad and diverse spectrum of inborn cardiac disorders, one shared feature is the propensity for cardiac arrhythmias, albeit to varying degrees. The magnitude of this issue is underscored by its high prevalence, major impact on morbidity and disability, considerable c...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2010.07.003

    authors: Abadir S,Khairy P

    更新日期:2011-01-01 00:00:00

  • Initial Assessment and Triage of the Stroke Patient.

    abstract::Nearly 800,000 strokes occur in the United States each year, and stroke is the leading cause of preventable permanent disability. Timely recognition and treatment are imperative to reduce stroke-related morbidity and mortality. Given the evidence supporting intravenous thrombolysis and mechanical thrombectomy for isch...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2017.04.004

    authors: Zweifler RM

    更新日期:2017-01-01 00:00:00

  • The Current Global State of Key Lifestyle Characteristics: Health and Economic Implications.

    abstract::The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2017.02.002

    authors: Arena R,McNeil A,Sagner M,Hills AP

    更新日期:2017-01-01 00:00:00

  • Biology of ischemic cerebral cell death.

    abstract::With the approval of alteplase (tPA) therapy for stroke, it is likely that combination therapy with tPA to restore blood flow, and agents like glutamate receptor antagonists to halt or reverse the cascade of neuronal damage, will dominate the future of stroke care. The authors describe events and potential targets of ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-0620(99)70002-2

    authors: Small DL,Morley P,Buchan AM

    更新日期:1999-11-01 00:00:00

  • In Defense of Sugar: A Critique of Diet-Centrism.

    abstract::Sugars are foundational to biological life and played essential roles in human evolution and dietary patterns for most of recorded history. The simple sugar glucose is so central to human health that it is one of the World Health Organization's Essential Medicines. Given these facts, it defies both logic and a large b...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2018.04.007

    authors: Archer E

    更新日期:2018-01-01 00:00:00

  • Guidelines for the delivery and monitoring of high intensity interval training in clinical populations.

    abstract::High intensity interval training (HIIT) is now recognized in international clinical-based exercise guidelines as an appropriate and beneficial adjunct to moderate intensity continuous training. HIIT involves alternating periods of high intensity aerobic exercise with light recovery exercise or no exercise, allowing fo...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,实务指引,评审

    doi:10.1016/j.pcad.2019.01.004

    authors: Taylor JL,Holland DJ,Spathis JG,Beetham KS,Wisløff U,Keating SE,Coombes JS

    更新日期:2019-01-01 00:00:00

  • Influence of Holter monitor and electrophysiologic study methods and efficacy criteria on the outcome of patients with ventricular tachycardia and ventricular fibrillation in the ESVEM trial.

    abstract::Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...

    journal_title:Progress in cardiovascular diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0033-0620(96)80029-6

    authors: Reiffel JA,Reiter MJ,Freedman RA,Mann D,Huang SK,Hahn E,Hartz V,Mason J,ESVEM Investigators.

    更新日期:1996-03-01 00:00:00

  • Triple Antithrombotic Therapy for Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.

    abstract::Dual antiplatelet therapy (DAPT) has been the cornerstone of antithrombotic management for patients undergoing percutaneous coronary intervention (PCI). However, approximately 10% of these patients have concomitant atrial fibrillation (AF) and require chronic oral anticoagulant (OAC) in addition to DAPT. This traditio...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2018.01.008

    authors: Kerneis M,Talib U,Nafee T,Daaboul Y,Pahlavani S,Pitliya A,Furqan MM,Datta S,Kazmi HA,Younes A,Gibson CM

    更新日期:2018-01-01 00:00:00

  • Implementing movement at the workplace: Approaches to increase physical activity and reduce sedentary behavior in the context of work.

    abstract::The purpose of this article is to highlight approaches to increase movement, physical activity (PA), and cardiorespiratory fitness, and reduce sedentary behavior (SB) in the context of the workplace. A deliberate strategy that will enable the successful promotion of movement at the workplace includes a business plan a...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2020.10.004

    authors: Pronk NP

    更新日期:2020-10-24 00:00:00

  • Pacemaker hemodynamics: clinical implications.

    abstract::Our review of the current literature and experience in caring for pacemaker patients suggests that a consideration of hemodynamics is a logical way to approach pacemaker selection and programming. Multiple clinical factors enter into the selection of a pacemaker or pacemaker programming settings in each case. It appea...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/0033-0620(92)90039-3

    authors: Buckingham TA,Janosik DL,Pearson AC

    更新日期:1992-03-01 00:00:00

  • The cellular ionic basis of hypertension and allied clinical conditions.

    abstract::Two central concepts of human hypertensive disease remain poorly understood: (1) elevated blood pressure as merely one component of an underlying systemic condition, characterized by multiple defects in diverse tissues (eg, "Syndrome X"), and (2) the heterogeneity of hypertension, in which different and even opposite ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-0620(99)70006-x

    authors: Resnick L

    更新日期:1999-07-01 00:00:00

  • Exercise in valvular heart disease: risks and benefits.

    abstract::Valvular heart disease (VHD) carries documented risks for active individuals. At the same time, many individuals with intermediate degrees of valve disease can safely exercise and even participate in competitive athletics. Unfortunately for clinicians caring for these patients, data are scarce. Understanding the patho...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2011.02.010

    authors: Parker MW,Thompson PD

    更新日期:2011-05-01 00:00:00

  • Management of trastuzumab-related cardiac dysfunction.

    abstract::Trastuzumab is the standard of care for the treatment of patients with ERB2-positive breast cancer. In a minority of patients, trastuzumab is associated with an increased incidence of cardiac dysfunction that ranges from asymptomatic decreases in left ventricular ejection fraction to symptomatic heart failure. In tria...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2010.07.001

    authors: Carver JR

    更新日期:2010-09-01 00:00:00

  • Ethics priorities in adult congenital heart disease.

    abstract::The success of modern therapies in congenital heart disease has produced a large and growing population of adults with congenital heart disease as a chronic condition. Such success increasingly raises a host of ethical issues, from resource utilization to end of life decision-making. The importance of a multidisciplin...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2012.10.004

    authors: Kirkpatrick JN,Kim YY,Kaufman BD

    更新日期:2012-11-01 00:00:00

  • Coronary angiography is the gold standard for patients with significant left ventricular dysfunction.

    abstract::Left ventricular (LV) dysfunction has been shown to be significantly related to ongoing myocardial ischemia, hibernation, and thus, coronary artery disease. Current treatments for patients with LV dysfunction and concomitant coronary artery disease center around the potential benefit of coronary revascularization, in ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2013.01.003

    authors: Lim MJ,White CJ

    更新日期:2013-03-01 00:00:00

  • Are the neuroprotective effects of exercise training systemically mediated?

    abstract::To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to system...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2019.02.003

    authors: Tari AR,Norevik CS,Scrimgeour NR,Kobro-Flatmoen A,Storm-Mathisen J,Bergersen LH,Wrann CD,Selbæk G,Kivipelto M,Moreira JBN,Wisløff U

    更新日期:2019-01-01 00:00:00

  • Consumer Health Informatics: Empowering Healthy-Living-Seekers Through mHealth.

    abstract::People are at risk from noncommunicable diseases (NCD) and poor health habits, with interventions like medications and surgery carrying further risk of adverse effects. This paper addresses ways people are increasingly moving to healthy living medicine (HLM) to mitigate such health threats. HLM-seekers increasingly le...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2016.12.006

    authors: Faiola A,Holden RJ

    更新日期:2017-01-01 00:00:00

  • The contribution of the Framingham Heart Study to the prevention of cardiovascular disease: a global perspective.

    abstract::The Framingham Heart Study has been a trailblazer in the field of cardiovascular epidemiology. The wealth of novel scientific data that it has generated over 5 decades has made a significant contribution to cardiovascular disease (CVD) prevention in the United States and indirectly influenced global CVD prevention str...

    journal_title:Progress in cardiovascular diseases

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.pcad.2010.01.001

    authors: Mendis S

    更新日期:2010-07-01 00:00:00

  • Positron-emitting myocardial blood flow tracers and clinical potential.

    abstract::Positron-emitting myocardial flow radiotracers such as (15)O-water, (13)N-ammonia and (82)Rubidium in conjunction with positron-emission-tomography (PET) are increasingly applied in clinical routine for coronary artery disease (CAD) detection, yielding high diagnostic accuracy, while providing valuable information on ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2015.01.001

    authors: Schindler TH

    更新日期:2015-05-01 00:00:00

  • Personalized Weight Management Interventions for Cardiovascular Risk Reduction: A Viable Option for African-American Women.

    abstract::Obesity is an independent contributor to cardiovascular disease (CVD) and a major driving force behind racial/ethnic and gender disparities in risk. Due to a multitude of interrelating factors (i.e., personal, social, cultural, economic and environmental), African-American (AA) women are disproportionately obese and t...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2016.02.003

    authors: Franklin NC,Arena R

    更新日期:2016-05-01 00:00:00

  • New Concepts in Hypertension Management: A Population-Based Perspective.

    abstract::Hypertension (HTN) is the most common chronic disease in the U.S., and the standard model of office-based care delivery has yielded suboptimal outcomes, with approximately 50% of affected patients not achieving blood pressure (BP) control. Poor population-level BP control has been primarily attributed to therapeutic i...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/j.pcad.2016.09.005

    authors: Milani RV,Lavie CJ,Wilt JK,Bober RM,Ventura HO

    更新日期:2016-01-01 00:00:00

  • Metabolic control of the circulation: implications for congestive heart failure.

    abstract::The role of metabolic processes in the control of the normal circulation will be discussed with particular emphasis on how metabolic events, particularly those that occur with the performance of exercise, result in production of vasoactive substances and sympathetic activation. Heart failure patients will have altered...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审

    doi:10.1016/s0033-0620(05)80013-1

    authors: Delehanty JM,Liang CS

    更新日期:1995-07-01 00:00:00