Precision Medicine, Healthy Living and the Complex Patient: Managing the Patient With Multimorbidity.


:Multimorbidity is the most common chronic health condition in adults and is associated with poor health outcomes. Optimal care for people with multimorbidity requires a person-centred approach that considers goals and preferences, improves quality of life and coordinates care across services. Because care is focused on patient outcomes, rather than disease outcomes, this provides an ideal setting for delivery of the Healthy Living Polypill (HLPP). Precision in delivery of the HLPP for people with multimorbidity involves active participation of patients in goal setting, strategies to address functional limitations and frailty, and support to develop the self-management skills necessary to adopt and sustain healthy behaviours. The multidisciplinary team is a key feature of integrated care for people with multimorbidity and all members should have the necessary skills to deliver the HLPP. Integration and continuity across health and social care sectors enhances outcomes and increases opportunities for personalised delivery of the HLPP.


Prog Cardiovasc Dis


Holland AE,Lee AL




Has Abstract


2019-01-01 00:00:00














  • What is the place of beta-blockade in patients who have experienced a myocardial infarction with preserved left ventricular function? Evidence and (mis)interpretation.

    abstract::Beta blockers have long been used in patients who have experienced a myocardial infarction. However, many new therapies are available for this patient group, and as a result, the current role of beta blockers may have become uncertain. In this article we address a series of questions related to the important and conti...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Freemantle N,Urdahl H,Eastaugh J,Hobbs FD

    更新日期:2002-01-01 00:00:00

  • Initial Assessment and Triage of the Stroke Patient.

    abstract::Nearly 800,000 strokes occur in the United States each year, and stroke is the leading cause of preventable permanent disability. Timely recognition and treatment are imperative to reduce stroke-related morbidity and mortality. Given the evidence supporting intravenous thrombolysis and mechanical thrombectomy for isch...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Zweifler RM

    更新日期:2017-01-01 00:00:00

  • Nonvascular stents.

    abstract::Stents or endoprostheses have evolved since their introduction. Initially used only in the vascular system, the use of stents has expanded to use in the biliary, urinary, and gastrointestinal tracts and in the tracheo-bronchial tree. Current use of stents includes treatment of both benign and malignant conditions, wit...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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    更新日期:1996-09-01 00:00:00

  • Obesity and Kidney Disease.

    abstract::Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Lakkis JI,Weir MR

    更新日期:2018-01-01 00:00:00

  • Secondary analysis of clinical trials--a cautionary note.

    abstract::There is concern in published reports and reviews that patients are being harmed or denied effective treatment by the use of questionable results from secondary analyses of data from clinical trials. A well-reported secondary analysis must make clear to the reader the uncertainty of the result--so clear, in fact, that...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Marler JR

    更新日期:2012-01-01 00:00:00

  • Personalized Weight Management Interventions for Cardiovascular Risk Reduction: A Viable Option for African-American Women.

    abstract::Obesity is an independent contributor to cardiovascular disease (CVD) and a major driving force behind racial/ethnic and gender disparities in risk. Due to a multitude of interrelating factors (i.e., personal, social, cultural, economic and environmental), African-American (AA) women are disproportionately obese and t...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Franklin NC,Arena R

    更新日期:2016-05-01 00:00:00

  • Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management.

    abstract::First isolated in the early 1960s, doxorubicin (DOX) remains among the most effective anticancer drug ever developed. However, this drug has proven to be a double-edged sword because it also causes a cardiomyopathy that leads to a form of congestive heart failure that is usually refractory to common medications. It is...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Takemura G,Fujiwara H

    更新日期:2007-03-01 00:00:00

  • Noninvasive assessment of atherosclerosis.

    abstract::The application of ultrasound to clinical evaluation of the symptomatic patient requires less precision and accuracy than when it is used as an instrument to study atherogenesis. The clinician's goal is to locate hemodynamically significant lesions; studies of atherogenesis require auxometry (measurement of the growth...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章


    authors: Blankenhorn DH,Rooney JA,Curry PJ

    更新日期:1984-01-01 00:00:00

  • Heart failure in patients with preserved left ventricular systolic function: do digitalis glycosides have a role?

    abstract::It is being increasingly appreciated that a substantial number of patients with congestive heart failure (CHF) have relatively preserved systolic function. Although these individuals appear to have a somewhat better prognosis than those with low ejection fractions, they experience significant symptoms and frequently r...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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  • Optimal use of coronary care units: a review.

    abstract::Patients at a low probability of acute cardiac pathology constitute a considerable proportion in many coronary care units (CCUs), such that physicians should consider more effective alternatives than CCU admission "to rule out myocardial infarction." In this article, strategies to increase the efficiency of managing p...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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  • Are the neuroprotective effects of exercise training systemically mediated?

    abstract::To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to system...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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    更新日期:2019-01-01 00:00:00

  • Prevention of myocardial infarction.

    abstract::The possible methods of preventing myocardial infarction have been discussed. The desirability of prevention in the total problem of myocardial infarction is stressed. The methods consist of the prevention of the underlying coronary atherosclerosis, and the secondary prevention of myocardial ischemia contributed by ot...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章


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  • Hypertrophic cardiomyopathy--therapy with slow channel inhibiting agents.

    abstract::Slow channel inhibiting agents, particularly verapamil, appear to produce beneficial effects in relieving symptoms of dyspnea, chest pain, and syncope or presyncope in over 70% of patients with hypertrophic cardiomyopathy. Symptomatic relief occurs in patients with and without left ventricular outflow obstruction. Exe...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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    更新日期:1982-11-01 00:00:00

  • Quantifying left ventricular function in heart failure: What makes a clinically valuable parameter?

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    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


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    更新日期:2020-01-01 00:00:00

  • Culprit-Only vs. Complete Revascularization During ST-Segment Elevation Myocardial Infarction.

    abstract::Primary percutaneous intervention (PCI) is the treatment of choice for ST-segment elevation myocardial infarction (STEMI). Patients with STEMI frequently have obstructive non-culprit lesions. In addition, STEMI patients with multivessel disease are at increased risk of major adverse cardiac events. However, current gu...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Qamar A,Bhatt DL

    更新日期:2015-11-01 00:00:00

  • Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients.

    abstract::Pulmonary and/or tricuspid valve dysfunction is common among individuals with congenital heart disease, and surgical intervention often carries prohibitive risks. Transcatheter valve replacement (TVR) of the right-sided cardiac valves has become a viable treatment option over the past two decades, while continued tech...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Gales J,Krasuski RA,Fleming GA

    更新日期:2018-01-01 00:00:00

  • The use of echocardiography for quantitative evaluation of left ventricular function.

    abstract::Echocardiography is a valuable technique for the diagnosis and serial follow-up of patients with impaired cardiac function. It is subject to certain limitations due to the assumptions inherent in deriving ventricular volume from a one-dimensional measurement and must be interpreted with caution in cases of suspected r...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Mason SJ,Fortuin NJ

    更新日期:1978-09-01 00:00:00

  • Update on Obesity and Obesity Paradox in Heart Failure.

    abstract::Obesity has reached epidemic proportions in most of the Westernized world. Overweightness and obesity adversely impact cardiac structure and function, including on both the right and, especially, left sides of the heart, with adverse affects on systolic and, especially, diastolic ventricular function. Therefore, it is...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Lavie CJ,Sharma A,Alpert MA,De Schutter A,Lopez-Jimenez F,Milani RV,Ventura HO

    更新日期:2016-01-01 00:00:00

  • Heart Failure Transitions of Care: A Pharmacist-Led Post-Discharge Pilot Experience.

    abstract:OBJECTIVE:To perform a pilot evaluation of a pharmacist-led, multidisciplinary transitional care clinic for heart failure (HF) patients. BACKGROUND:Transitions of care in HF should include: medication reconciliation, multidisciplinary care, early post-discharge follow-up, and prompt intervention on HF signs and sympto...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章


    authors: Milfred-LaForest SK,Gee JA,Pugacz AM,Piña IL,Hoover DM,Wenzell RC,Felton A,Guttenberg E,Ortiz J

    更新日期:2017-01-01 00:00:00

  • Systolic dysfunction in heart failure with normal ejection fraction: speckle-tracking echocardiography.

    abstract::Left ventricular (LV) ejection fraction (EF) and LV end-systolic volumes are important measures of LV global function. However, in many patients with symptoms of heart failure, these measures are within normal limits. This condition is classified as heart failure with normal ejection fraction (HFNEF). Reduced EF and i...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Edvardsen T,Helle-Valle T,Smiseth OA

    更新日期:2006-11-01 00:00:00

  • Myocardial perfusion imaging using contrast echocardiography.

    abstract::Microbubbles are an excellent intravascular tracer, and both the rate of myocardial opacification (analogous to coronary microvascular perfusion) and contrast intensity (analogous to myocardial blood volume) provide unique insights into myocardial perfusion. A strong evidence base has been accumulated to show comparab...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Pathan F,Marwick TH

    更新日期:2015-05-01 00:00:00

  • Implementing movement at the workplace: Approaches to increase physical activity and reduce sedentary behavior in the context of work.

    abstract::The purpose of this article is to highlight approaches to increase movement, physical activity (PA), and cardiorespiratory fitness, and reduce sedentary behavior (SB) in the context of the workplace. A deliberate strategy that will enable the successful promotion of movement at the workplace includes a business plan a...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Pronk NP

    更新日期:2020-10-24 00:00:00

  • An Update on the Role of Cardiorespiratory Fitness, Structured Exercise and Lifestyle Physical Activity in Preventing Cardiovascular Disease and Health Risk.

    abstract::The cardiovascular disease (CVD) pandemic has placed considerable strain on healthcare systems, quality of life, and physical function, while remaining the leading cause of death globally. Decades of scientific investigations have fortified the protective effects of cardiorespiratory fitness (CRF), exercise training, ...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Ozemek C,Laddu DR,Lavie CJ,Claeys H,Kaminsky LA,Ross R,Wisloff U,Arena R,Blair SN

    更新日期:2018-01-01 00:00:00

  • Electrophysiological basis of QT dispersion measurements.

    abstract::Dispersion of ventricular repolarization is a now widely used term describing nonhomogeneous recovery of excitability or heterogeneity of ventricular repolarization. It is usually expressed as the difference or the range of various repolarization measurements obtained from a heart. Experimentally, an increased dispers...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Franz MR,Zabel M

    更新日期:2000-03-01 00:00:00

  • Adverse reactions to quinidine in hospitalized patients: findings based on data from the Boston Collaborative Drug Surveillance Program.

    abstract::This study systematically analyzed the incidence and variety of adverse reactions to quinidine sulfate in 652 consecutively monitored hospitalized patients. Fourteen percent of the patients sustained adverse reactions of sufficient severity to warrant discontinuation of the drug. These reactions include GI intolerance...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Cohen IS,Jick H,Cohen SI

    更新日期:1977-09-01 00:00:00

  • Exercise blood pressure, cardiorespiratory fitness and mortality risk.

    abstract:OBJECTIVE:To assess the cardiorespiratory fitness (CRF) impact on the association between exercise blood pressure (BP) and mortality risk. PATIENTS AND METHODS:We assessed CRF in 15,004 US Veterans (mean age 57.5 ± 11.2 years) who completed a standardized treadmill test between January 1, 1988 and July 28, 2017 and ha...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Kokkinos P,Faselis C,Sidossis L,Zhang J,Samuel IBH,Ahmed A,Karasik P,Pittaras A,Doumas M,Grassos C,Rosenberg S,Myers J

    更新日期:2021-01-26 00:00:00

  • Cardiac imaging in the geriatric population: what do we think we know, and what do we need to learn?

    abstract::Cardiac imaging plays an important role in coronary artery disease (CAD), congestive heart failure (HF) and valvular heart disease (VHD) in the elderly. Imaging defines the structure and function of the cardiac system, refining the understanding of patients' anatomy and physiology and informing a host of clinical care...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Mehta N,Chokshi NP,Kirkpatrick JN

    更新日期:2014-09-01 00:00:00

  • The 'perfect storm' and acute coronary syndrome onset: do psychosocial factors play a role?

    abstract::The revolution in cardiac care over the past two decades, characterized by emergent revascularization, drug eluting stents, anti-platelet medications, and advanced imaging has had little impact on overall ACS recurrence, or ACS prevention. The "Perfect Storm" refers to a confluence of events and processes, including a...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Burg MM,Edmondson D,Shimbo D,Shaffer J,Kronish IM,Whang W,Alcántara C,Schwartz JE,Muntner P,Davidson KW

    更新日期:2013-05-01 00:00:00

  • Acute mountain sickness: pathophysiology, prevention, and treatment.

    abstract::Barometric pressure falls with increasing altitude and consequently there is a reduction in the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending to altitude. A spectrum of high altitude illnesses can occur when the hypoxic stress outstrips the subject's ability to acclimatize. Ac...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Imray C,Wright A,Subudhi A,Roach R

    更新日期:2010-05-01 00:00:00

  • Myocardial infarction and risk region relationships: evaluation by direct and noninvasive methods.

    abstract::Optimal quantitation of myocardial infarction requires resolution of the three-dimensional geometry of the ischemic region at a time that progression of tissue necrosis has been completed and can be sharply delineated from noninfarcted myocardium but before significant remodeling of the ventricular chamber. Although t...

    journal_title:Progress in cardiovascular diseases

    pub_type: 杂志文章,评审


    authors: Cobb FR,Chu A

    更新日期:1988-03-01 00:00:00