Abstract：
:Tumor necrosis factor alpha (TNF-alpha), a protein belonging to the family of cytokines, is one of the leading mediators of the immune response to inflammation. Its widespread biological effects are modulated by two circulating binding proteins corresponding to the extracellular domain of the membrane receptors, namely soluble TNF receptors. TNF-alpha was first supposed to be linked with congestive heart failure (CHF) on a cachexia-inducing basis. In patients with advanced CHF, elevated levels of circulating TNF-alpha and soluble TNF receptors have been found. The pathophysiological implications of activation of the TNF system in CHF seem to rely mainly on its effects on the heart and the endothelium. TNF-alpha exerts a negative inotropic effect both directly and indirectly, this latter being mediated by enhancement of nitric oxide production. Moreover, TNF-alpha has been suggested to trigger the apoptotic process in cardiac myocytes. There is consensus on the detrimental role played by TNF-alpha in CHF further supported by the evidence of a temporal association between TNF activation and transition from asymptomatic to symptomatic CHF.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Ceconi C,Curello S,Bachetti T,Corti A,Ferrari Rdoi
10.1016/s0033-0620(98)80028-5subject
Has Abstractpub_date
1998-07-01 00:00:00pages
25-30issue
1 Suppl 1eissn
0033-0620issn
1873-1740pii
S0033-0620(98)80028-5journal_volume
41pub_type
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
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pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2014.07.003
更新日期：2014-09-01 00:00:00
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：1988-03-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章
doi：10.1016/j.pcad.2017.08.005
更新日期：2017-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2010.01.002
更新日期：2010-03-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2017.04.002
更新日期：2017-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2015.04.003
更新日期：2015-07-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2010.07.004
更新日期：2010-11-01 00:00:00
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：1983-11-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：1997-01-01 00:00:00
abstract：:Multimorbidity is the most common chronic health condition in adults and is associated with poor health outcomes. Optimal care for people with multimorbidity requires a person-centred approach that considers goals and preferences, improves quality of life and coordinates care across services. Because care is focused o...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2018.12.010
更新日期：2019-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2014.05.009
更新日期：2014-07-01 00:00:00
abstract：:The benefits of physical activity in cardiovascular diseases have long been appreciated. However, the molecular mechanisms that trigger and sustain the cardiac benefits of exercise are poorly understood, and it is anticipated that unveiling these mechanisms will identify novel therapeutic targets. In search of these m...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
abstract：:Infective endocarditis continues to be associated with significant morbidity and mortality despite recent advances in its management and remains a serious and challenging condition requiring a multidisciplinary approach. Surgery is essential in at least 50% of cases. Surgical outcomes have improved with the introducti...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2008.08.007
更新日期：2009-05-01 00:00:00
