Obesity and Kidney Disease.

Abstract:

:Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome. The links between obesity and chronic kidney disease are numerous, bidirectional, multi-layered and complex; this complexity may be explained by shared pathophysiological pathways (e.g. chronic inflammation, increased oxidative stress, and hyper-insulinemia), shared clusters of risk factors as well as associated diseases (e.g. insulin resistance, hypertension and dyslipidemia). We will review these links and their clinical manifestations, and offer a summary of available non-pharmacological as well as pharmacological therapeutic strategies.

journal_name

Prog Cardiovasc Dis

authors

Lakkis JI,Weir MR

doi

10.1016/j.pcad.2018.07.005

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

157-167

issue

2

eissn

0033-0620

issn

1873-1740

pii

S0033-0620(18)30128-2

journal_volume

61

pub_type

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