Abstract:
:Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome. The links between obesity and chronic kidney disease are numerous, bidirectional, multi-layered and complex; this complexity may be explained by shared pathophysiological pathways (e.g. chronic inflammation, increased oxidative stress, and hyper-insulinemia), shared clusters of risk factors as well as associated diseases (e.g. insulin resistance, hypertension and dyslipidemia). We will review these links and their clinical manifestations, and offer a summary of available non-pharmacological as well as pharmacological therapeutic strategies.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Lakkis JI,Weir MRdoi
10.1016/j.pcad.2018.07.005subject
Has Abstractpub_date
2018-01-01 00:00:00pages
157-167issue
2eissn
0033-0620issn
1873-1740pii
S0033-0620(18)30128-2journal_volume
61pub_type
杂志文章,评审abstract::The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2017.02.002
更新日期:2017-01-01 00:00:00
abstract::Radiocontrast media can lead to a reversible form of acute renal failure that begins soon after the contrast dye administration and generally is benign. Contrast media accounts for 10% of all causes of hospital-acquired acute renal failure and represents the third leading cause of in-hospital renal function deteriorat...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2003.YPCAD16
更新日期:2003-05-01 00:00:00
abstract::To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to system...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.02.003
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abstract::The role of antiarrhythmic agents in the post-MI patients has been investigated for several years. Recently, clinical trials have assessed the effects of amiodarone in the post-MI population. The Basel Antiarrhythmic Study of Infarct Survival (BASIS) trial showed a reduction in total mortality, sudden death, and life-...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(98)80023-6
更新日期:1998-07-01 00:00:00
abstract::Infective endocarditis continues to be associated with significant morbidity and mortality despite recent advances in its management and remains a serious and challenging condition requiring a multidisciplinary approach. Surgery is essential in at least 50% of cases. Surgical outcomes have improved with the introducti...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2008.08.007
更新日期:2009-05-01 00:00:00
abstract::There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. In the majority of cases, CAD in the ACHD population is driven ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.07.018
更新日期:2018-01-01 00:00:00
abstract::It is being increasingly appreciated that a substantial number of patients with congestive heart failure (CHF) have relatively preserved systolic function. Although these individuals appear to have a somewhat better prognosis than those with low ejection fractions, they experience significant symptoms and frequently r...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(98)80053-4
更新日期:1998-01-01 00:00:00
abstract::Functional tricuspid regurgitation (FTR) has been neglected for a long time, however its prevalence and clinical relevance is not negligible. In presence of FTR, a certain quote of annular dilatation is present thus contributing to the mechanism of regurgitation. Historically, surgical annuloplasty has been the main t...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.10.002
更新日期:2019-01-01 00:00:00
abstract::The definition of syncope has clinical and pathophysiological parts. The clinical part is that syncope is a form of transient loss of consciousness (TLOC), while the pathophysiological element is that syncope differs from other forms of TLOC by virtue of the basis of true syncope - specifically cerebral hypoperfusion....
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.10.016
更新日期:2013-01-01 00:00:00
abstract::Beta blockers have long been used in patients who have experienced a myocardial infarction. However, many new therapies are available for this patient group, and as a result, the current role of beta blockers may have become uncertain. In this article we address a series of questions related to the important and conti...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2002.31586
更新日期:2002-01-01 00:00:00
abstract::Left ventricular (LV) ejection fraction (EF) and LV end-systolic volumes are important measures of LV global function. However, in many patients with symptoms of heart failure, these measures are within normal limits. This condition is classified as heart failure with normal ejection fraction (HFNEF). Reduced EF and i...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2006.08.008
更新日期:2006-11-01 00:00:00
abstract::Thoracic aortic aneurysms (TAAs) are a prevalent and deadly disease that, without diagnosis and treatment, eventuates in life-threatening aortic dissection or rupture. While TAAs normally grow in an indolent manner, once a certain size (a "hinge point") is reached, the risk of dissection, rupture, and death increases ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2013.05.007
更新日期:2013-07-01 00:00:00
abstract::Trastuzumab is the standard of care for the treatment of patients with ERB2-positive breast cancer. In a minority of patients, trastuzumab is associated with an increased incidence of cardiac dysfunction that ranges from asymptomatic decreases in left ventricular ejection fraction to symptomatic heart failure. In tria...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2010.07.001
更新日期:2010-09-01 00:00:00
abstract::We will review the epidemiology, risk factors, and consequences of obstructive sleep apnea (OSA) and short/long sleep duration. Obstructive sleep apnea is a disease characterized by recurrent upper airway obstruction during sleep. Obstructive sleep apnea is common, with moderate to severe disease present in approximat...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2008.08.001
更新日期:2009-01-01 00:00:00
abstract::Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovasc...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.pcad.2011.02.001
更新日期:2011-03-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2011.09.006
更新日期:2012-01-01 00:00:00
abstract::Cardiovascular magnetic resonance (CMR) imaging is a recognized technique for characterization of myocardial tissue in stable ischemic heart disease. In addition, CMR is emerging as a noninvasive imaging tool that can provide supporting information to guide treatment in acute coronary syndromes (ACSs). The advantages ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2011.09.001
更新日期:2011-11-01 00:00:00
abstract::There has been a lot of progress in measurement techniques of the pulmonary circulation in recent years, and this has required updating of basic physiological knowledge. Pulmonary artery pressures (PAP) are normally low and dependent on left atrial pressure (LAP) and cardiac output (CO). Therefore, defining the functi...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2014.12.003
更新日期:2015-03-01 00:00:00
abstract::The first step in the diagnostic evaluation of patients with suspected syncope begins with an "initial evaluation" consisting of careful history taking, physical examination including orthostatic blood pressure measurement and electrocardiogram. However, even in expert centers the diagnostic yield of this "initial eva...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.11.002
更新日期:2013-01-01 00:00:00
abstract::Stents or endoprostheses have evolved since their introduction. Initially used only in the vascular system, the use of stents has expanded to use in the biliary, urinary, and gastrointestinal tracts and in the tracheo-bronchial tree. Current use of stents includes treatment of both benign and malignant conditions, wit...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(96)80025-9
更新日期:1996-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(98)80004-2
更新日期:1998-05-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.03.006
更新日期:2012-05-01 00:00:00
abstract::Key questions concerning strategies for diagnosis, prevention, and treatment of heart disease in women remain unanswered. Thrombolytic therapy has been shown to reduce mortality similarly in men and women. In addition, percutaneous coronary intervention for acute coronary syndromes is as effective in women as in men. ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2010.07.004
更新日期:2010-11-01 00:00:00
abstract::The sympathetic nervous system occupies a prominent role in heart failure both as a marker of severity of disease and also as an important factor in its progression. Beta blocker therapy, once thought heretical in heart failure, has consistently improved cardiac function and slowed progression of disease. Large clinic...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.1999.0410301
更新日期:1999-01-01 00:00:00
abstract::The response to injury in the vasculature and the heart is inflammation. Atherosclerosis is often the result of injury followed by inflammation and atherosclerosis. Vascular and myocardial infections from various pathogens, including viruses, bacteria, chlamydia, and other infections result in vascular inflammation an...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2002.123782
更新日期:2002-05-01 00:00:00
abstract::With the progressive increase in life-expectancy of human immunodeficiency virus (HIV)-positive patients in the "highly active antiretroviral therapy" (HAART) era, co-morbidities, particularly cardiovascular (CV) diseases (CVD) are emerging as an important concern. The pathophysiology of CVD in this population is comp...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2016.02.008
更新日期:2016-03-01 00:00:00
abstract::Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...
journal_title:Progress in cardiovascular diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0033-0620(96)80029-6
更新日期:1996-03-01 00:00:00
abstract::In recent years, a number of peptide and nonpeptide signalling autacoids have been implicated in the regulation of cardiac myocyte growth as well as vasculogenesis and angiogenesis, and in the function of cardiac muscle following development. In this review, we first examine the evidence for a role for specific cytoki...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(97)80033-3
更新日期:1997-01-01 00:00:00
abstract::The role of metabolic processes in the control of the normal circulation will be discussed with particular emphasis on how metabolic events, particularly those that occur with the performance of exercise, result in production of vasoactive substances and sympathetic activation. Heart failure patients will have altered...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(05)80013-1
更新日期:1995-07-01 00:00:00
abstract::Obesity has reached epidemic proportions in most of the Westernized world. Overweightness and obesity adversely impact cardiac structure and function, including on both the right and, especially, left sides of the heart, with adverse affects on systolic and, especially, diastolic ventricular function. Therefore, it is...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2015.12.003
更新日期:2016-01-01 00:00:00