Abstract：
:Positron-emitting myocardial flow radiotracers such as (15)O-water, (13)N-ammonia and (82)Rubidium in conjunction with positron-emission-tomography (PET) are increasingly applied in clinical routine for coronary artery disease (CAD) detection, yielding high diagnostic accuracy, while providing valuable information on cardiovascular (CV) outcome. Owing to a cyclotron dependency of (15)O-water and (13)N-ammonia, their clinical use for PET myocardial perfusion imaging is limited to a few centers. This limitation could be overcome by the increasing use of (82)Rubidium as it can be eluted from a commercially available (82)Strontium generator and, thus, is independent of a nearby cyclotron. Another novel F-18-labeled myocardial flow radiotracer is flurpiridaz which has attracted increasing interest due to its excellent radiotracer characteristics for perfusion and flow imaging with PET. In particular, the relatively long half-life of 109 minutes of flurpiridaz may afford a general application of this radiotracer for PET perfusion imaging comparable to technetium-99m-labeled single-photon emission computed tomography (SPECT). The ability of PET in conjunction with several radiotracers to assess myocardial blood flow (MBF) in ml/g/min at rest and during vasomotor stress has contributed to unravel pathophysiological mechanisms underlying coronary artery disease (CAD), to improve the detection and characterization of CAD burden in multivessel disease, and to provide incremental prognostic information in individuals with subclinical and clinically-manifest CAD. The concurrent evaluation of myocardial perfusion and MBF may lead to a new era of a personalized, image-guided therapy approach that may offer potential to further improve clinical outcome in CV disease patients but needing validation in large-scale clinical trials.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Schindler THdoi
10.1016/j.pcad.2015.01.001subject
Has Abstractpub_date
2015-05-01 00:00:00pages
588-606issue
6eissn
0033-0620issn
1873-1740pii
S0033-0620(15)00002-Xjournal_volume
57pub_type
杂志文章,评审abstract：:Due to advances in prevention, early detection and treatment, early breast cancer mortality has decreased by nearly 40% during the last four decades. Yet, the risk of cardiovascular disease (CVD) mortality is significantly elevated following a breast cancer diagnosis, and it is a leading cause of death in this populat...
journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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更新日期：1998-01-01 00:00:00
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
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journal_title：Progress in cardiovascular diseases
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