Abstract:
BACKGROUND:Glutathione peroxidase (GSHPx) and catalase are two important cellular antioxidant enzymes involved in H2O2 and lipid-peroxide metabolism. AIM:To study the effects of growth, maturation and aging on the activity of these enzymes. MATERIAL AND METHODS:GSHPx and catalase specific activities were measured in samples of diaphragm and intercostal muscle of male Sprague-Dawley rats of different ages (21, 50, 70, 180 and 365 days), anesthetised with chloral hydrate (45 mg/100 g i.p.). RESULTS:The diaphragm and intercostal muscles did not differ in GSHPx activity at 21 days. After that, GSHPx activity increased progressively with age, but following a different pattern, in each muscle, suggesting an increase in enzyme substrates with age. In one year old animals, GSHPx activity was 5 times higher for the diaphragm and 3 times higher for the intercostal muscles, when compared with values observed at 21 days of age. Catalase activity also increased with age in the diaphragm but not in the intercostal muscles. CONCLUSIONS:GSHPx activity increases progressively with age in rat respiratory muscles, with a time course that is specific of each muscle. Catalase activity increases with age only in the diaphragm. These results support the hypothesis that antioxidants in respiratory muscles undergo specific regulatory changes with age.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Montecinos L,Ramírez B,Lisboa C,Borzone Gsubject
Has Abstractpub_date
1999-03-01 00:00:00pages
269-75issue
3eissn
0034-9887issn
0717-6163journal_volume
127pub_type
杂志文章abstract:BACKGROUND:Biliary cholesterol is transported by vesicles and micelles. Cholesterol microcrystals are derived from thermodynamically unstable vesicles. In experimental animals vitamin C deficiency leads to a super-saturation of biliary cholesterol and to the formation of gallstones. AIM:To search for a possible relati...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000100004
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Petcoke is a remnant of the oil refining process that contains Ni and other heavy metals. Undesired human exposure to these compounds may result from petcoke combustion in plants located in the vicinity of the cities. AIM:To compare levels of urinary Ni in schoolchildren residing in cities exposed and not e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000800013
更新日期:2008-08-01 00:00:00
abstract::An analysis of the interaction of evolutionary factors such as migration, mutation, selection random drift, and consanguinity upon the genome of Easter islanders is attempted. As many primitive populations, the Easter islanders genome has at least 2/3 of genetic loci in an isogenic state. The HLA system is reduced; ot...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Renal transplantation can be done in patients with neurogenic bladder and clean intermittent self catheterization maintains renal function AIM:To retrospective assess the results of renal transplantation in patients with neurogenic bladder. PATIENTS AND METHODS:The medical records of seven patients aged 10...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Few trials have studied the prevalence of sexual dysfunction (SD) and related risk factors in postmenopausal women using the DSM-IV criteria. AIM:To evaluate the prevalence of SD in menopausal women and the impact of risk factors. PATIENTS AND METHODS:Five hundred thirty four healthy women, 40 to 64 years ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Aiming to correlate the alterations in evoked potentials with the initial clinical manifestations of multiple sclerosis, 29 patients with the disease were studied and 19 were followed for a lapse ranging from 1 to 11 years. Visual evoked potentials were studied in all the patients and 51% were abnormal. Auditory evoke...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Attention deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness or inattentiveness. AIM:To search for differences in risk for ADHD and its components among Chilean native and mixed populations and to loo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000500006
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. AIM:To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. PATIENTS AND METHODS:Between April 2003 and December 2004, 161 patients with ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000600008
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Patients on chronic hemodialysis have a lower immune response to vaccination against hepatitis B virus (HBV) than the general population. AIM:To identify factors that may interfere with immunization against hepatitis B virus (HBV) in Brazilian hemodialysis patients and analyze the evolution of the level of ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000700008
更新日期:2012-07-01 00:00:00
abstract::Medical specialization has brought about the need to guarantee suitability for its practice. The progressive changes in knowledge and the incorporation of specific technologies, set forth the need to periodically demonstrate this capacity. In developed countries different initiatives, that sooner or later will become ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Wernicke encephalopathy is considered a complication of dialytic therapy, but there are few reports of this complication. We report a 57 years old man and a 45 years old woman, with grade IV renal failure, who after acute peritoneodialysis and chronic hemodialysis respectively, had a confusional syndrome that responde...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::The aim of this work is to analyze the distribution of Duffy blood group and the reproductive history of 148 malformed newborns and their mothers compared to 131 control pairs. The mother-child segregation of the system is analyzed using ITO matrixes. A higher frequency of heterozygote mothers for the system was found...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in t...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The relationship between patients and health professionals emphasizes deliberation and joint decision making, that derives in the informed consent. AIM:To evaluate decision making of patients in health care and to identify the notion of capacity for decision making, according to lawyers and physicians. MAT...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000900009
更新日期:2007-09-01 00:00:00
abstract::We analyzed retrospectively the clinical course and prognosis of 565 consecutive patients with acute myocardial infarction (AMI), 117 of them with a previous history of diabetes mellitus. Male/female ration was 7.9/2.1 in non diabetics and 7.0/3.0 in diabetics (p < 0.03). Incidence of hypertension and hyperlipidemia w...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The number of nonagenarians is rapidly growing in Chile. This age group is mainly female, with higher frailty markers and in higher risk of being placed at nursing homes. AIM:To describe features of nonagenarian women and compare them with a group of women between 60-89 years, both living in nursing homes, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000100005
更新日期:2004-01-01 00:00:00
abstract::Tridimensional printing is becoming relevant in medicine, specially in surgical and interventional specialties. We review the technical aspects and clinical application of airway tridimensional printing. Using this technique, simulation models for bronchoscopy and models for diagnostic and therapeutic procedures such ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872019001001315
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. AIM:To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated in Chile. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000400006
更新日期:2005-04-01 00:00:00
abstract::During colonial times the Royal University of San Felipe was founded in 1738. The first plan for medical studies was outlined in 1779. During the Independence, the National Institute created in 1813 took over higher education. The first Course of Medicine was dictated there in 1833. The University of San Felipe was re...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Multiauthorship and unjustified authorship have been documented in journals with wide international circulation but this has not been thoroughly studied in journals from developing countries. Revista Médica de Chile is published in Spanish and it contains about 40% of the clinical and biomedical manuscripts ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::The association of gastric lymphoma and gastric adenocarcinoma in the same patient is uncommon. We report a 76 year-old male with a previous history of massive upper gastrointestinal bleeding who required a subtotal gastrectomy with Billroth II reconstruction in 1974. Pathology demonstrated a gastric lympho-histiocyti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008001000013
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:In Chile, leukemia is one of the diseases whose treatment is guaranteed by a special law called AUGE (universal access and explicit guaranties). Therefore, the knowledge of its treatment costs is of utmost importance. AIM:To determine and to characterize the direct costs of pharmacotherapy for leukemia at a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009001200002
更新日期:2009-12-01 00:00:00
abstract::We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant ge...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::We report a 65 years old female undergoing hemodialysis, presenting with intense pain in the lower right quadrant and moderate hematochezia. Since symptoms did not abate after an appendectomy, a colonoscopy and barium enema were performed, whose results suggested an advanced cecal carcinoma. Biopsies were negative for...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::Autonomy is an inherent condition of every ethical act. This attribution is expressed, when decisions are made, as capacity. Physician-patient alliance is defied when there is a reasonable doubt of patients' ability to make a choice, an extraordinarily complex scenario. As a response, in the last few decades multiple ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016001000014
更新日期:2016-10-01 00:00:00
abstract::Nucleolar organizer regions may be observed by colloidal silver stains. A considerable increase in the number of regions may be observed in tumors and other pathologic processes as an index of cellular proliferation. Among 20 studies in patients with gastric carcinoma we found a significantly greater number of nucleol...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Subacute combined degeneration is a clinical manifestation of vitamin B12 deficiency, that we observe with unusual frequency. AIM:To report a series of eleven patients with subacute combined degeneration. PATIENTS AND METHODS:Retrospective analysis of 11 patients hospitalized in a public hospital in Santia...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004001100006
更新日期:2004-11-01 00:00:00
abstract::Increased cholesterol levels above 200 mg/dl, LDL levels above 130 mg/dl and total cholesterol/HDL ratio above 4.5 in males and above 5.0 in females are recognized as indicators of increased risk of atherosclerosis. Risk associated to increased triglyceride levels (above 200 mg/dl) must be judged in relation to associ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Self-efficacy refers to people's expectations about personal resources available for goal achievement. Higher self-efficacy expectations are correlated with higher academic performance. AIM:To analyze the psychometric properties of the Academic Behavior Self-Efficacy Scale (ABSES) and to describe Self-effic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700914
更新日期:2019-07-01 00:00:00