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[Genetic polymorphism of isoniazid acetylation in Chilean patients with tuberculosis].

Abstract：

:We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant gene was estimated at 0.612, which is intermediate between values found in american natives (0.46) and western europeans (0.73). No associations of the presence of slow gene with sex, ABO group, ancestors, socioeconomic level, undernutrition, alcoholism or tobacco consumption were found.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Ligueros M,Cruz Coke R,Neira S,Saavedra H,Kramer V,Prieto JC,Gelman M,Saavedra A,Nuñez A,Pescio S

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1339-43

issue

12

eissn

0034-9887

issn

0717-6163

journal_volume

117

pub_type

杂志文章

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