Abstract:
:The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in this neoplasia. Genetic deletions affecting tumor suppressor genes are the most common mechanism of inactivation of these genes. Studies using conventional molecular techniques such as restriction fragment length polymorphism (RFLP) and Southern Blot showed low frequency of deletions in cervical carcinomas. Detection of deletions by using RFLP and Southern Blot presents several disadvantages, the most important being the difficulty in analyzing pure tumor cells. More sensitive approaches include tissue microdissection and PCR analysis of micro-satellites. Using these approaches, it has been shown that genetic deletions are, in fact, frequent events in cervical cancers, being detected in up to 95% of the cases. Multiple genetic loci are involved, including chromosomes 3p, 5p, 6p and 11q. Deletions are detected even in precursor lesions (cervical intraepithelial neoplasia, CIN). Some deletions have been correlated with prognostic parameters, such as stage, depth of invasion, and vascular space involvement. It is concluded that cervical carcinogenesis, like in other tumors, is a multistep process, characterized by the accumulation of events including activation of oncogenes, as well as inactivation of tumor suppressor genes.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Chuaqui R,Cuello M,Emmert-Buck Msubject
Has Abstractpub_date
1999-12-01 00:00:00pages
1501-12issue
12eissn
0034-9887issn
0717-6163journal_volume
127pub_type
杂志文章,评审abstract:BACKGROUND:Intensity modulated radiotherapy (IMRT) is an important step forward in cancer treatment. AIM:To report the first experience in Chile with IMRT for prostate cancer and compare the results obtained with different doses. PATIENTS AND METHODS:From January 1997 through June 2008, 156 patients with a mean age o...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011001100009
更新日期:2011-11-01 00:00:00
abstract::The history, objectives and aims of this programme are described in detail. The principal goals achieved on anticonception, reproductive biology and abortion are analyzed, with special reference to the research done in Chile. The strengthening of research capabilities at national level was pointed out with special men...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::We studied 501 prostitutes from the northern and eastern areas of Santiago in november and december, 1987. HIV infection was studied by the HIV antibody and also by HIV antigen. At that time no positive reactors were found. Prostitutes from the northern area were older, of a lower socioeconomic background and less pro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Acute appendicitis is the most common non obstetric surgical emergency during pregnancy. AIM:To asses our experience in the diagnosis and management of acute appendicitis occurring during pregnancy. PATIENTS AND METHODS:Data from all pregnant patients who were subjected to an appendectomy for a suspected a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000200002
更新日期:2006-02-01 00:00:00
abstract::Tridimensional printing is becoming relevant in medicine, specially in surgical and interventional specialties. We review the technical aspects and clinical application of airway tridimensional printing. Using this technique, simulation models for bronchoscopy and models for diagnostic and therapeutic procedures such ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872019001001315
更新日期:2019-10-01 00:00:00
abstract::We report four episodes of mushroom poisoning that occurred between 1986 and 1990 in the province of Malleco. Twenty five of 36 individuals who ingested the mushroom became ill; they had an acute gastroenteritis that was followed in 7 by an acute hepatitis and in one by a massive upper gastrointestinal bleeding. Three...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. AIM:To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. PATIENTS AND METHODS:Cross-sectional study of ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000500009
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Clinical reasoning is the most important competente in the training process of a physician. AIM:To develop a method for teaching clinical reasoning based on prototypes of clinical cases. MATERIAL AND METHODS:The study was conducted on sixty-four third year medical students. The study and control groups att...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000700001
更新日期:2013-07-01 00:00:00
abstract::To study the rate of infection by Epstein Barr virus (EBV) in Santiago, Chile, the prevalence of antibody to the viral capsid antigen (VCA-IgG) was determined in a group of 663 healthy individuals grouped by age and socioeconomic level (SEL). In addition, several risk factors for infection were studied. VCA-IgG was de...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:BACKGROUNDS AND AIMS:Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. METHODS:After 48 hours of...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Bacteria have developed sophisticated and successful genetic mechanisms to evade the action of antimicrobials. Bacterial multiresistance has caused serious problems in the treatment of nosocomial infections. Integrons and gene cassettes are considered the main genetic elements in the evolution of plasmids and transpos...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872004000500013
更新日期:2004-05-01 00:00:00
abstract::In this issue of the journal Lanas et al report an estimation of population attributable risk (PAR) for myocardial infarction (MI) derived from different risk factors in Chile. Cigarette smoking, dyslipidemia and hypertension accounted for 71% of total PAR. Mortality from MI has decreased in Chile, but epidemiologic s...
journal_title:Revista medica de Chile
pub_type: 评论,社论
doi:/S0034-98872008000500001
更新日期:2008-05-01 00:00:00
abstract::In an open, pilot study, the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy was investigated. Four patients received 1 g/day of UDCA during 20 days and another 2 patients received 2 identical periods of treatment separated by a 14-day interval free of drug....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:The age at which children born preterm normalize their bone mineral density, is not well known. AIM:To study if children born preterm have normalized their bone mineral density at age 5 to 7 years. PATIENTS AND METHODS:Twenty six infants born preterm (14 male), were studied at age 5 to 7 years. Birth weigh...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::This article explores the causes of the crisis in the role of internists. As in the United States, the progressive specialization of internists lead to a dehumanized, expensive and technical practice of medicine. Aiming to better incomes and prestige, more than 60% of internists practice as specialists. Primary care p...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::We report the case of a woman with rapidly progressive IgA nephropathy. She was treated with pulse methylprednisolone sodium succinate (1 g/d for three days), cyclophosphamide, dipyridamole and aspirin. The rapid progression of renal failure was apparently halted after 6 months. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Evolutionary theory has contributed with physiological, psychological and behavioral explanations to the comprehension and treatment of eating disorders (ED). The aim of this review is to analyze the relationship between ED and the attachment theory and natural selection based hypotheses (famine flight, repr...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872012000400015
更新日期:2012-04-01 00:00:00
abstract::Hemophagocytic syndrome is a severe condition of excessive immune activation that has a high mortality in the absence of treatment. The syndrome is classified as primary if associated with congenital or hereditary problems, or secondary/acquired if associated with infectious, autoimmune or oncology diseases. We report...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872015000900010
更新日期:2015-09-01 00:00:00
abstract::In a double blind study, 20 patients who presented with acute episodes of asthma were randomized to treatment with nebulized salbutamol (5 mg) of subcutaneous salbutamol (0.5 mg). The clinical conditions were not significantly different before or after treatment in both groups. Significant bronchial dilation was obtai...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-02-01 00:00:00
abstract::Results of morbidity and medical care surveys performed in Santiago in 1993-94 are presented in this paper. The study has been done in an aleatory population sample of 4,700 people coming from 1,000 dwellings. Main results are as following: The Health National Fund (FONASA) is the most important financing medical care...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::A 68 years old male presented with right hypochondrium abdominal pain and jaundice with no other clinical finding. CAT Scan and Ultrasonography showed right lobe bile duct dilatation. Magnetic Resonance Cholangiopancreatography gave an outstanding vision of a restricted right lobe bile duct dilatation associated to ch...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::A narrative review of the evidence regarding the role of inflammation in the pathophysiology of coronary heart disease and depression is presented. As a common pathogenic factor, inflammation could explain the frequent association of both diseases. We discuss the benefit of exercise and diet modifications in both cond...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872020000200224
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Intensive medicine is especially expensive and requires an efficient management. AIM:To measure the real costs of diseases treated in an intensive care unit and compare them with the costs assigned by the Chilean National Health Fund (FONASA) for 2008. MATERIAL AND METHODS:Retrospective review of 225 patie...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000500005
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:The absence of lymph node involvement (N0) in gastric cancer is associated with a better survival. However some N0 gastric tumors still have a bad prognosis. AIM:To study demographic and morphological variables associated with prognosis in N0 gastric carcinoma. MATERIAL AND METHODS:Review of pathological r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000400003
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM:To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS:Revie...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000400003
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Liver cirrhosis is an important public health problem in Chile. AIM:To review the main epidemiological features of liver cirrhosis in Chile in the last 22 years. METHODS:Review of yearbooks of mortality and causes of death of the Ministry of Health and Instituto Nacional de Estadísticas, review of hospital...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::This paper undertakes an analysis of the scientific criteria used in the diagnosis of death and underscores the importance of intellectual rigor in the definition of medical concepts, particularly regarding such a critical issue as the diagnosis of death. Under the cardiorespiratory criterion, death is defined as "the...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872004000100015
更新日期:2004-01-01 00:00:00
abstract::Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Education may induce voluntary behavioral changes in patients that lead to an improvement in health status. AIM:To assess the impact of the educational manual "Aches and Pain" on knowledge and attitudes of patients with chronic rheumatism and paramedics, using an instrument with 40 asseverations extracted f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The model of epidemiological transition proposed by Omram explains the changes in disease patterns in communities. In societies with a high level of development this model has been complemented with the study of the post transition process. In this context, the emergence of allergic diseases, asthma and subsequently, ...
journal_title:Revista medica de Chile
pub_type: 社论
doi:10.4067/s0034-98872006000600001
更新日期:2006-06-01 00:00:00