[Association between glutathione peroxidase levels and clinical manifestations of dengue].

Abstract:

BACKGROUND:Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. AIM:To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. PATIENTS AND METHODS:Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up. RESULTS:Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L. CONCLUSIONS:GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Rojas EM,Díaz-Quijano FA,Coronel-Ruiz C,Martínez-Vega RA,Rueda E,Villar-Centeno LA

doi

10.4067/s0034-98872007000600008

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

743-50

issue

6

eissn

0034-9887

issn

0717-6163

pii

S0034-98872007000600008

journal_volume

135

pub_type

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