[Association of the TCF7L2 (RS7903146) genotype with adiposity and metabolic markers in the Chilean adult population].

Abstract:

BACKGROUND:Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. AIM:To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population. MATERIAL AND METHODS:The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin). RESULTS:There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p = 0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p = 0.04)]. There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome. CONCLUSIONS:These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Petermann-Rocha F,Lasserre-Laso N,Villagrán M,Mardones L,Martínez MA,Leiva AM,Ulloa N,Celis-Morales C

doi

10.4067/S0034-98872019000800965

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

965-976

issue

8

eissn

0034-9887

issn

0717-6163

pii

S0034-98872019000800965

journal_volume

147

pub_type

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