[Effect of VKORC1 and CYP2C9 variants on dosage of oral anticoagulants in Chilean individuals].

Abstract:

BACKGROUND:The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower requirements of OAC. AIM:To study the association between average maintenance doses of oral anticoagulant therapy required to maintain a stable INR and CYP2C9 and VKORC1 gene variants in Chilean adults. MATERIAL AND METHODS:Prospective study of patients on anticoagulant treatment and with a stable international normalized ratio (INR) for prothrombin time for at least three months. Patients were classified as having high or low acenocoumarol or warfarin requirements. Peripheral blood DNA genotyping was performed by polymerase chain reaction and restriction fragment polymorphism or sequencing and electrophoresis. RESULTS:The study included 185 patients, 125 on acenocoumarol and 60 on warfarin. Patients with VKORC1-1639A allele were more likely to require lower doses of both drugs than patients with the G allele (Odds ratio [OR] for acenocoumarol 9.06, and OR for warfarin = 18.7). There was no association between CYP2C9*2 and*3 and acenocoumarol or warfarin requirements. CONCLUSIONS:There is an association between VKORC1-1639A variant and anticoagulant doses.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Benavides F,Grossman N,Poggi H,Nieto E,Bertrán A,Araos D,Vásquez M,Ibarra I,Cáceres F,Espinoza K,Lagos M,Repetto M G

doi

10.4067/S0034-98872015001100001

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1369-76

issue

11

eissn

0034-9887

issn

0717-6163

pii

S0034-98872015001100001

journal_volume

143

pub_type

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