Abstract:
BACKGROUND:The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower requirements of OAC. AIM:To study the association between average maintenance doses of oral anticoagulant therapy required to maintain a stable INR and CYP2C9 and VKORC1 gene variants in Chilean adults. MATERIAL AND METHODS:Prospective study of patients on anticoagulant treatment and with a stable international normalized ratio (INR) for prothrombin time for at least three months. Patients were classified as having high or low acenocoumarol or warfarin requirements. Peripheral blood DNA genotyping was performed by polymerase chain reaction and restriction fragment polymorphism or sequencing and electrophoresis. RESULTS:The study included 185 patients, 125 on acenocoumarol and 60 on warfarin. Patients with VKORC1-1639A allele were more likely to require lower doses of both drugs than patients with the G allele (Odds ratio [OR] for acenocoumarol 9.06, and OR for warfarin = 18.7). There was no association between CYP2C9*2 and*3 and acenocoumarol or warfarin requirements. CONCLUSIONS:There is an association between VKORC1-1639A variant and anticoagulant doses.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Benavides F,Grossman N,Poggi H,Nieto E,Bertrán A,Araos D,Vásquez M,Ibarra I,Cáceres F,Espinoza K,Lagos M,Repetto M Gdoi
10.4067/S0034-98872015001100001subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1369-76issue
11eissn
0034-9887issn
0717-6163pii
S0034-98872015001100001journal_volume
143pub_type
杂志文章abstract:BACKGROUND:The permanent surveillance of antimicrobial susceptibility of Shigella sp in the Temuco Regional Hospital, allowed us to define the empirical use of antimicrobials in dysenteric syndrome. AIM:To study antimicrobial susceptibility of Shigella strains collected from 1997 to May 2001 and compare the results wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::We analyze the effect of inspiratory muscle training (IMT) in patients with chronic obstructive pulmonary disease (COPD), with special emphasis on its effects on inspiratory muscle function and clinical outcomes. We reviewed only randomized, controlled studies that have either controlled both the load and the breathin...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::The incidence of hepatitis, mumps, poliomyelitis, scarlet fever, pertussis and measles from 1954 to 1984 was studied from the annual records of infectious diseases. Fluctuations were evaluated by Fourier analysis. Periodic recurrency was detected for poliomyelitis, scarlet fever, pertussis and measles and was likely f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::We report a 44 years old male, presenting with an eight months history of right lower quadrant pain, diarrhea and weight loss. Colonoscopy showed a proliferative and ulcerated lesion in the cecum, with necrotic areas. Barium enema showed an extensive irregular stenosis with rigidity of cecum and ascending colon. The e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::We report a 56 years-old man presenting with chest pain with exercise, seven years after an orthotopic heart transplant. A coronary angiography showed an atherosclerotic lesion in the common left main coronary artery with more than 90% obstruction. The lesion was successfully treated with a transluminal angioplasty wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872007001200012
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Malnutrition has been strongly associated with morbidity and mortality in hemodialysis patients. In the other hand, dialysis allows a nutritional improvement in patients with more than 12 months in dialysis. AIM:To study the prevalence of malnutrition among patients in hemodialysis. PATIENTS AND METHODS:We...
journal_title:Revista medica de Chile
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更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:p53/p21WAF1/CIP1 and mdm-2 proteins play an important role in cell cycle regulation. The study of the pathogenesis of gastric cancer is important to understand how these tumors progress during their natural history. AIM:To study the relationship between the immunohistochemical expression of p53/p21WAF1/CIP1...
journal_title:Revista medica de Chile
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更新日期:2000-02-01 00:00:00
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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doi:
更新日期:2001-09-01 00:00:00
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journal_title:Revista medica de Chile
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doi:
更新日期:1989-04-01 00:00:00
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journal_title:Revista medica de Chile
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更新日期:1995-08-01 00:00:00
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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更新日期:1991-03-01 00:00:00
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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更新日期:2001-09-01 00:00:00