Abstract:
:A revolution is taking place in Medicine as a consequence of advances in biotechnology and informatics. The unraveling of the human genome with a description of chromosomal maps for all structural genes affords a new framework for the understanding of etiology, diagnosis and prevention of every disease. More than three thousand million nucleotides codifying over 100 thousand genes may be manipulated by RNA recombinant techniques in order to identify location and help understand pathogeny as well as diagnosis and treatment of disease. Relevant techniques for genome desciphering include familial linkage, somatic cell hybridization, RFLPs, enzymatic quantification and analysis of chromosomal aberrations. Pathology of the genome may originate from germinal or somatic mutations. Resulting diseases may be classified as classic disease, physiologic disorders, congenital malformations and chromosomal aberrations. All diseases arise from alterations in the genome. Substitution of defective genes offers new forms of therapy. Advancing knowledge in this may lead to better control and prevention of genetic diseases.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Cruz-Coke Rsubject
Has Abstractpub_date
1989-05-01 00:00:00pages
572-80issue
5eissn
0034-9887issn
0717-6163journal_volume
117pub_type
杂志文章,评审abstract::The association between Good's syndrome (hypogammaglobulinemia and thymoma) with pure red aplasia is very uncommon. We report a 70-year-old male, who had a thymoma excised nine years before. Afterwards, he suffered frequent respiratory infections, which were attributed to a humoral immunodeficiency. Nine years later, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872012000800013
更新日期:2012-08-01 00:00:00
abstract::Quality has a central role in medical care. The satisfaction of the rights of people to medical care, presupposes good quality medical acts. The meaning of quality goes further than a good attention based on scientific evidence and with competent skills. It comprises patient-physician relationship where professional b...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patients risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there a...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000800011
更新日期:2016-08-01 00:00:00
abstract::Results of morbidity and medical care surveys performed in Santiago in 1993-94 are presented in this paper. The study has been done in an aleatory population sample of 4,700 people coming from 1,000 dwellings. Main results are as following: The Health National Fund (FONASA) is the most important financing medical care...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Clients and providers of health care can have contrasting perceptions about the quality of service. Provider perceptions are mostly devoted to design and delivery of services while those of clients are focused in the attention received. AIM:To assess perceptions of health care providers and clients about cl...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000500015
更新日期:2010-05-01 00:00:00
abstract::This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a jud...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000400009
更新日期:2016-04-01 00:00:00
abstract::The history, objectives and aims of this programme are described in detail. The principal goals achieved on anticonception, reproductive biology and abortion are analyzed, with special reference to the research done in Chile. The strengthening of research capabilities at national level was pointed out with special men...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:There is paucity of information about viral etiology of community acquired pneumonia in adults. AIM:To investigate the viral etiology of pneumonia among hospitalized patients. MATERIAL AND METHODS:All adults with pneumonia that were hospitalized were prospectively enrolled at Puerto Montt hospital. A micro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000800003
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:Lack of social support can be one of the factors that influences recurrences of drug consumption after treatment of addictions. AIM:To assess the role of social support in maintaining drug abstinence after treatment. MATERIAL AND METHODS:We studied 306 subjects that were treated in drug addiction centers, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:/S0034-98872008000200005
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:In patients with colorectal carcinoma, insertions or deletions of short sequences of DNA, a phenomenon called microsatellite instability, are observed. AIM:To look for microsatellite instability and mutations of MLH1 and MSH2 gene mutations in patients with colorectal carcinoma. MATERIAL AND METHODS:Ten pa...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006001000002
更新日期:2006-10-01 00:00:00
abstract::In the last decades there has been an important decrease in infant mobidity and mortality, but these achievements are not equally distributed across the whole population. Children are one of the most susceptible groups due to their unique vulnerabilities to environmental factors. Unhealthy environments, indoor polluti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000100016
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Maximal oxygen uptake is considered by the International Biological Programme as the international standard of cardiorespiratory adequacy and physical condition. AIM:To measure maximal oxygen uptake in normal Chilean subjects, to establish normal reference values. SUBJECTS AND METHODS:Maximal oxygen uptake...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. AIM:To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. MATERIA...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000700001
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Up to 20% of patients with pancreatic carcinoma subjected to a bilio digestive diversion, develop a delayed gastric emptying due to duodenal infiltration. However the role of prophylactic gastrojejunoanastomosis is not well defined. AIM:To compare the effects of gastrojejunoanastomosis performed as prophyla...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The author in this short text remembers the passing of a beloved pet cat. Cats are beautiful animals and wonderful companions. They evolved together with humans in Africa, subsequently spread over the five continents with them, and became the subject of many human cultural activities, including art, poetry and religio...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000100091
更新日期:2019-01-01 00:00:00
abstract::We analyzed 1529 diabetic patients seen between 1959 and 1982 at a teaching hospital in Concepción, Chile. 116 of them were insulin dependent diabetics. Gestational diabetes was excluded. The 10 year actuarial risk of acquiring tuberculosis was 24.2% for insulin-dependent diabetics and 4.8% for the rest (p less than 0...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:In Chile, there is a high prevalence of cardiovascular diseases. Because atherosclerosis starts in childhood, it is important to assess serum lipid levels in children. AIM:To measure serum lipid levels in normal Chilean newborns. SUBJECTS AND METHODS:A sample of umbilical cord venous blood was obtained fro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Dr. Hernán Iturriaga is now President of Sociedad Médica de Santiago (Chilean Society of Internal Medicine) for the period 1995-1997. He received his M.D. title at the University of Chile in 1961 and his postgraduate training included a USPHS International Postdoctoral Research Fellowship at Mount Sinai School of Medi...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:There is no conclusive evidence about the association between physical fitness (PF) and health related quality of life (HRQOL) in older adults. AIM:To seek for an association between PF and HRQOL in non-disabled community-dwelling Chilean older adults. MATERIAL AND METHODS:One hundred and sixteen subjects ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000100008
更新日期:2017-01-01 00:00:00
abstract::The aim of this work was to analyze the global incidence of congenital malformations at the Maternity of University of Chile Clinical Hospital in the periods between 1971 and 1977 and between 1982 and 1992. A significant and sustained increase in incidence was observed in the first period from 10.64 per 1000 born aliv...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Glucose toxicity refers to the structural and functional damage in the beta cells and target tissues of insulin, caused by chronic hyperglycemia. These alterations cause a lower hormonal secretion and action (insulin resistance). Lipid toxicity refers to the damage caused by persistently high free fatty acid levels, a...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Free-text imposes a challenge in health data analysis since the lack of structure makes the extraction and integration of information difficult, particularly in the case of massive data. An appropriate machine-interpretation of electronic health records in Chile can unleash knowledge contained in large volum...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872019001001229
更新日期:2019-10-01 00:00:00
abstract::Leptospirosis is a world-spread zoonosis that is incidentally acquired by humans. It causes a diphasic febrile illness in which the Weil syndrome is its severest form, with renal, hepatic, clotting and central nervous system involvement. We report a 73 years old male, that was admitted to an intensive care unit with m...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Cardiovascular diseases are the main causes of death in Chile and there is a high prevalence of cardiovascular risk factors in the population. AIM:To assess the prevalence of those risk factors in a group of employees. SUBJECTS AND METHODS:We studied 2,219 individuals, 1,378 males with a mean age of 46.2 +...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
abstract::We report the case of a 42 years old male, with a bipolar disorder and receiving lithium therapy, valproic acid and clonazepam. Due to an exacerbation of his underlying disease, he was admitted to a psychiatric clinic and received 50 mg of intramuscular chlorpromazine in two occasions. Afterwards, the patient had an a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Sickle cell anemia was a rare disease in Chile, especially in adults, however the recent immigration wave from Haiti is changing this scenario. We report a 29 year old black female from Haiti with a non-disclosed history of sickle cell anemia. She was transfused with two units of red blood cells, found unconscious and...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872018001101347
更新日期:2018-11-01 00:00:00
abstract::Amiodarone is a benzofuranic derivative widely used in cardiologic practice because of its excellent antiarrhythmic properties. Due to its high iodine content, it interferes with thyroid physiology and can cause either hyper or hypothyroidism. Amiodarone-induced hyperthyroidism should be considered as a serious compli...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Uterine cervical cancer (UCC) is an important public health problem in Chile. Although HPV infection has been established as the main cause of UCC, little is known of its frequency and distribution in our population. AIM:To determine the presence and frequency of viral genotypes in uterine cervical specimen...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::We studied 60 females using either intrauterine device or taking oral contraceptive pills. Hemoglobin, serum iron, total iron binding capacity and saturation of transferrin were determined before and 4 and 10 months after starting a responsible paternity program. Women with a basal hemoglobin level below 12 g/dl were ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:Biliary cholesterol is transported by vesicles and micelles. Cholesterol microcrystals are derived from thermodynamically unstable vesicles. In experimental animals vitamin C deficiency leads to a super-saturation of biliary cholesterol and to the formation of gallstones. AIM:To search for a possible relati...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000100004
更新日期:2014-01-01 00:00:00