[An update on the pathogenesis of celiac disease].

Abstract:

:Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis (IELs) and leukocyte infiltration of the lamina propriety. Patients achieve a complete clinical and endoscopic remission with a gluten free diet. However, symptoms and anatomical alterations recur when this protein is reintroduced in the diet. The pathogenic mechanisms in this disease are not yet well understood, but it is clear that genetic, environmental and immunological factors play a role. The latter are the focus of this review, since this is the only autoimmune disease whose precipitating factor for immunological tissue damage is known.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Herrera MJ,Hermoso MA,Quera R

doi

/S0034-98872009001200012

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1617-26

issue

12

eissn

0034-9887

issn

0717-6163

pii

S0034-98872009001200012

journal_volume

137

pub_type

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