Abstract:
:A 19 yr-old female patient with the diagnosis of late onset adrenal hyperplasia was treated since age 15 with different glucocorticoid preparations and dosage schedules plus spironolactone. In spite of a very good response in terms of amelioration of their hirsutism she experienced cushingoid manifestations associated with adrenal suppression. To overcome these side effects the patient was placed on hydrocortisone 20 mg at 8 AM plus spironalactone 50 mg q.i.d. Cushingoid features vanished and response to cosyntropin (ACTH 250 ug i.m.) was reestablished. To better ascertain the effects of this treatment we studied the circadian variation in serum 17-OH progesterone after hydrocortisone was administered at 8 AM and compared it with circadian variations under basal conditions or after late-evening (11 PM) administration of hydrocortisone, 20 mg. The early morning administration of hydrocortisone was unable to prevent the nocturnal elevation of 17-OH-progesterone in spite of normal levels from 9.30 AM to 3 AM. This nocturnal peak was associated with a slightly blunted nocturnal elevation of serum cortisol. In contrast, the late evening administration of hydrocortisone was able to suppress 17-OH-progesterone to within normal levels during all day. Serum cortisol during late evening therapy was not different from that observed during early morning administration (12.2 +/- 13.1 vs 9.9 +/- 11.3 micrograms/dl, p = 0.53), yet the corresponding 17-OH-progesterone levels were much lower (0.8 +/- 0.6 vs 5.9 +/- 6.9 ng/ml). We conclude that individualization of therapy is essential in patients with late-onset adrenal hyperplasia.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Contreras P,Rojas A,Vega Isubject
Has Abstractpub_date
1989-06-01 00:00:00pages
552-7issue
6eissn
0034-9887issn
0717-6163journal_volume
116pub_type
杂志文章abstract:BACKGROUND:Stroke is the second cause of mortality and the first cause of morbidity in Chile and worldwide. Nowadays there is a major interest in introducing new therapies applying evidence based medicine for these patients. AIM:To describe the clinical profile of patients attended after a stroke, to determine stroke ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001100002
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas. AIM:To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. MATERIAL AND METHODS:Samples of 35 gallbladder, 15 ampul...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872005001200004
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Multiauthorship and unjustified authorship have been documented in journals with wide international circulation but this has not been thoroughly studied in journals from developing countries. Revista Médica de Chile is published in Spanish and it contains about 40% of the clinical and biomedical manuscripts ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::A toxicology testing is the search by the laboratory of the possible etiologic agents that can cause poisoning. Given the wide variety of substances that can poison a person, the laboratories should work coordinated with the emergency wards in order to determine the appropriate tests menu and the required turn around ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009001000018
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Depression is considered the second leading cause of disability worldwide. AIM:To describe the clinical characteristics and the evolution of major depressive disorder (MDD) in secondary care. To evaluate the association between socio-demographic and clinic variables with the first or recurrent major depress...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000300007
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known. AIM:To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000100008
更新日期:2015-01-01 00:00:00
abstract::Technology for diabetes care has undergone major development during recent decades. These technological advances include continuous subcutaneous insulin infusion (CSII), also known as insulin pumps, and real-time continuous glucose monitoring system (RT-CGMS). The integration of CSII and RT-CGMS into a single device h...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872017000500011
更新日期:2017-05-01 00:00:00
abstract::Recent studies strongly suggest that Helicobacter pylori might have a significant role in the pathogenesis and rate of recurrence of peptic duodenal ulcer. Various factors, such as the existence of ulcerogenic strains of the bacteria and susceptible subjects, might explain the fact that not more than 10% of the patien...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Maturity-Onset Diabetes of the Young (MODY) refers to a heterogeneous group of monogenic diabetes. Unlike other types of MODY characterized by genetic defects in transcription factors, MODY 2 is triggered by metabolic alterations caused by mutations of glucokinase (GCK), the first enzyme of the glycolytic pathway. We ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872017000901203
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:There is close association between maltreatment during pregnancy and child abuse after birth. AIM:To compare anthropometric growth and use of health services of children whose mothers suffered maltreatment with children coming from families without domestic violence. SUBJECTS AND METHODS:A longitudinal stu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:We report a 56 year old male hypertensive, who presented with a posterior reversible encephalopathy syndrome (PRES) as an initial manifestation of Guillain-Barré syndrome (GBS). His first symptoms were right hemiparesis and hemihypoesthesia, followed by headache, dizziness, dysarthria and a general feeling o...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012001000012
更新日期:2012-10-01 00:00:00
abstract::Kikuchi and Fujimoto disease is a benign subacute necrotizing lymphadenitis, probably associated to a viral infection, that affects mostly young Asian women. We report a 19 years old women, with a vast familiar history of thyroid disease (three uncles with papillary thyroid carcinoma and one with a Hashimoto thyroidit...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::Physicians took part in the promotion of public policies that regulated urban and architectural work, before engineers, architects, planners, and even before the State had a chance to take part in the formulation of such policies. Starting in the late nineteenth century, and especially during the first decade of the t...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:10.4067/S0034-98872016000100015
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. AIM:To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. PATIENTS AND METHODS:Cross-sectional study of ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000500009
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Endometriosis affects at least 15% of infertile women. The diagnosis is made by direct visualization of implants either at laparoscopy or laparotomy. Elevation of plasma CA-125 levels has been associated with the presence of endometriosis. AIM:To search for a correlation between CA-125 and the presence of e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::Struma ovarii is a teratoma composed of thyroid tissue and can be a rare cause of hyperthyroidism. We report a 35 years old woman with a left ovarian mass whose pathology revealed a Struma ovarii. This tumor was partially excised initially to avoid fertility problems and after a successful gestation, the tumor was com...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The history, objectives and aims of this programme are described in detail. The principal goals achieved on anticonception, reproductive biology and abortion are analyzed, with special reference to the research done in Chile. The strengthening of research capabilities at national level was pointed out with special men...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::We report a 56 years old male patient presenting with a sympathetic denervation of the right upper limb due to an apical lung cancer. Vasomotor paralysis of the limb was objectively documented with a contact termography. The clinical presentation of this patient was unusual, considering that the alteration occurred wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Soft tissue foreign bodies are a frequent cause of consultation in emergency rooms. It is difficult to verify their existence since conventional radiology only detects radio opaque objects. Ultrasound can be a useful diagnostic procedure. AIM:To report our experience in the detection of soft tissue foreign ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Between June 1983 and September 1987, 2799 disability pensions were given in the East Santiago Area, population 676,269. Of them, 222 (7.9%) were due to ophthalmological causes. Blindness as defined by the WHO was present in 57 cases. It was caused by myopia (33%), glaucoma (21%), diabetic retinopathy (9.8%), retinal ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::The preliminary results of a prospective and cooperative protocol for the treatment of soft tissue sarcomas of trunk and extremities, stages IB-IIIB are presented. Thirty one patients (17 males, 22 with a tumor larger than 5 cm) aged 16 to 68 years, were treated with one dose of epirubicin 70 mg/m2 i.v. and radiothera...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Human and animal trichinosis has been recorded in Chile since the late XIX century and is irregularly distributed along the country. From high rates of infection in the early 1900, the frequency of this parasitosis in man has progressively decreased. AIM:To describe and discuss the epidemiological situation...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:There is a very strong documented correlation between the appearance of cancer cells in blood and occurrence of metastasis in gastrointestinal cancer. AIM:To determine MUC1, CK19, CK20 and CEA mRNA expression in bone marrow of patients with gallbladder cancer and evaluate its clinical significance. MATERIA...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:An atypical cervical smear may represent a wide variety of lesions, from banal diseases to invasive neoplastic lesions. AIM:To study the evolution of atypical cervical smears in a highly controlled women population. MATERIAL AND METHODS:A retrospective analysis of 117 women with atypical cervical smears, d...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:The current recommendations for treatment of patients with newly diagnosed acute promyelocytic leukemia (APL) include all-trans-retinoic acid (ATRA) and anthracycline based chemotherapy. AIM:To evaluate the results of the Chilean protocol following the LPA99 regimen of the Spanish PETHEMA group, except for ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013001000001
更新日期:2013-10-01 00:00:00
abstract::The aim of this article is to analyze the current situation of AIDS in Latin American countries. Specifically, to compare their situation with other geographic areas of the planet, the prevalence index per countries, distribution per sex and age and, finally, the main ways of transmission in each country. The most rec...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Twenty to twenty two percent of work related accidents have a direct or indirect relationship with recent alcohol use. AIM:To detect recent alcohol or drug use in patients who required hospitalization for severe work related accidents. PATIENTS AND METHODS:Blood and urine samples were obtained from patient...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:In Chile, cholelithiasis is a serious public health problem and there are no studies about its natural history. AIM:To assess the long term evolution of patients with symptomatic and asymptomatic cholelithiasis. PATIENTS AND METHODS:Ninety two patients with cholelithiasis (57 female), aged 15 to 80 years o...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:The detection of cognitive changes (CC) and psychiatric disorders in relapsing remitting multiple sclerosis (MS-RR) contributes to patient clinical monitoring. AIM:To assess the frequency and characteristics of CC and psychiatric disorders in Chilean patients with MS-RR, before starting immunomodulatory tre...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012001100009
更新日期:2012-11-01 00:00:00