[Safety and efficacy of Vildagliptin in real life Chilean diabetic patients].

Abstract:

BACKGROUND:Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known. AIM:To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with a poor glycemic control. PATIENTS AND METHODS:Retrospective assessment of the effects of Vildagliptin treatment during 12 weeks in 103 T2D patients aged 29 to 92 years (47% males). The main outcomes were changes in glycosylated hemoglobin and the occurrence of adverse effects. RESULTS:After 12 weeks of Vildagliptin use, glycosylated hemoglobin decreased from 8.3 ± 1.4 to 7.2 ± 1.1% (p < 0.01). Fasting plasma glucose and the number of hypoglycemic events also decreased significantly. No significant weight change was observed. The treatment had good compliance, tolerance and patient satisfaction. CONCLUSIONS:Vildagliptin treatment reduced glycosylated hemoglobin by 1.1% and was well tolerated in this group of diabetic patients.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Godoy J G,Gutiérrez V,Montecinos M,Yenes A

doi

10.4067/S0034-98872015000100008

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

63-8

issue

1

eissn

0034-9887

issn

0717-6163

pii

S0034-98872015000100008

journal_volume

143

pub_type

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