Abstract:
BACKGROUND:Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. AIM:To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. MATERIAL AND METHODS:Raw data on infant deaths were extracted from the yearbooks of vital statistics of the National Institute of Statistics. The mortality risk associated to DS, relative to population without DS was estimated. RESULTS:There were 456 deaths in infants with DS during the study period (59 early neonatal deaths, 70 late neonatal deaths and 327 post-neonatal deaths). The trend in infant mortality rate in DS was ascending (r: 0.53, p = 0.03), with an average annual percentage change of 4.6% (95% confidence interval (CI) 0.4-9.0%; p < 0.01). Compared to the population without DS, the risk of early neonatal death was lower in DS (Odds ratio (OR) 0.14, 95% CI 0.11-0.19; p < 0.01) whereas the risk of post-neonatal death was higher (OR 4.74, 95% CI 3.85-5.85; p < 0.01). CONCLUSIONS:Infant mortality in Down syndrome has an increasing trend. We postulate that these children are not accessing timely cardiac surgery, the main therapeutic tool to reduce the death risk in the first year of life.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Donoso E,Vera Cdoi
10.4067/S0034-98872016001100009subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1432-1439issue
11eissn
0034-9887issn
0717-6163pii
S0034-98872016001100009journal_volume
144pub_type
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000900013
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,评审
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
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journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
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journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
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journal_title:Revista medica de Chile
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doi:/S0034-98872011000400003
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journal_title:Revista medica de Chile
pub_type: 社论
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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doi:10.4067/S0034-98872013000600011
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000800009
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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doi:/S0034-98872011001000019
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872015000900010
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
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