[Advances in cellular immunotherapy for malignant melanoma].

Abstract:

:An alternative strategy for cancer treatment is the manipulation of the immune system, denominated cancer immunotherapy. The immunotherapeutical use of cells of the immune system, like dendritic cells (DC), is being explored in different clinical protocols. Recently, we finalized a clinical phase I protocol, for the treatment of malignant melanoma, using DCs loaded with tumor lysates. Our results indicate that the subcutaneous application of DCs do not produce adverse effects. We also observed an increase of tumor specific T lymphocytes precursors in the blood, associated to hypersensitivity reactions (DTH) in 60% of the treated patients. In most cases, an stability in the disease was observed, although without a significant association between vaccination and survival. Additionally, therapies based on Interleukin-2 (IL-2) have been used with relative success in the treatment of some kind of tumors since 1985. However, problems associated to the toxicity of IL-2 still restrict its massive use. Our direct experience with the use of IL-2, indicates that low doses and its subcutaneous application, maintains the beneficial effects for patients, eliminating the adverse effects. Based on the accumulated evidence during last the five years, we decided to implement an optimized clinical protocol, which alternatively combines dendritic cells vaccines with the use of low doses of IL-2 for the reinforcement of the immunological system.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

López M,Escobar A,Alfaro J,Fodor M,Larrondo M,Ferrada C,Salazar-Onfray F

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

1115-26

issue

9

eissn

0034-9887

issn

0717-6163

journal_volume

132

pub_type

临床试验,杂志文章,评审
  • [Mushroom poisoning in the IX region. Role of Amanita gemmata].

    abstract::We report four episodes of mushroom poisoning that occurred between 1986 and 1990 in the province of Malleco. Twenty five of 36 individuals who ingested the mushroom became ill; they had an acute gastroenteritis that was followed in 7 by an acute hepatitis and in one by a massive upper gastrointestinal bleeding. Three...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sierralta A,Jeria ME,Figueroa G,Pinto J,Araya JC,San Juan J,Grinbergs J,Valenzuela E

    更新日期:1994-07-01 00:00:00

  • [Spontaneous tendon rupture in disseminated lupus erythematosus. A clinical case].

    abstract::A 37-year-old female with systemic lupus erythematosus and chronic treatment with steroids developed spontaneous bilateral rupture of tendons of both quadriceps muscles below the patella. Surgical treatment was undertaken with good results. The histologic features and a review of the literature are included. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Segovia A,Román JC,Hinojosa M,Ruiz A,Guzmán L

    更新日期:1990-09-01 00:00:00

  • Live birth after transfer of vitrified-warmed embryo derived from vitrified-warmed oocyte and frozen-thawed sperm following failed ICSI: Case report.

    abstract::Since the first successful pregnancy from a frozen human oocyte was reported, remarkable technological progress has been made in the area of cryopreservation of human oocytes. We report a successful delivery of two healthy babies after transfer of vitrified-warmed embryos derived from intracytoplasmic sperm injection ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872017000300017

    authors: Zhang Z,Zhu J,Zhang H,Xi Q,Geng D,Deng S,Liu R

    更新日期:2017-03-01 00:00:00

  • [Value of ultrasonography in the diagnosis of distal choledocolithiasis].

    abstract::We performed real time echotomographic studies in 203 patients with a clinical diagnosis of obstructive jaundice. All patients were operated on and a diagnosis of choledocholithiasis was established in 125. The same diagnosis had been made by echo in 69 of them for a 63% sensitivity rate. The specificity was 92% and t...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Arroyo A,Guerra M,Strauszer T

    更新日期:1989-11-01 00:00:00

  • [Intrarenal arterial doppler ultrasonography in cirrhotic patients with ascites, with and without hepatorenal syndrome].

    abstract:BACKGROUND:The pathophysiological hallmark of the hepatorenal syndrome (HRS) is renal vasoconstriction. Doppler ultrasonography can be used to assess the vascular resistance in small renal intraparenchymal vessels through analysis of the Doppler waveform by a parameter termed Resistive Index (RI). We postulated that th...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Bardi A,Sapunar J,Oksenberg D,Poniachik J,Fernández M,Paolinelli P,Orozco R,Biagini L

    更新日期:2002-02-01 00:00:00

  • [Gastric adenocarcinoma appearing 32 years after the resection of a gastric lymphoma. Report of one case].

    abstract::The association of gastric lymphoma and gastric adenocarcinoma in the same patient is uncommon. We report a 76 year-old male with a previous history of massive upper gastrointestinal bleeding who required a subtotal gastrectomy with Billroth II reconstruction in 1974. Pathology demonstrated a gastric lympho-histiocyti...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872008001000013

    authors: Butte JM,Torres J,Duarte I,Guzmán S,Llanos O

    更新日期:2008-10-01 00:00:00

  • [Eating disorders inventory scores among mothers of adolescents with and without eating disorders].

    abstract:BACKGROUND:Parents have a control role in the development and treatment of eating disorders among teenagers. AIM:To compare attitudes, beliefs and behaviors between mothers of patients with eating disorders and mothers of teenagers without these disorders. MATERIAL AND METHODS:Twenty one mother-sibling pairs of adole...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000600008

    authors: Cordella P,Castro L,Díaz C,Zavala C,Lizana P

    更新日期:2009-06-01 00:00:00

  • [Measurement of 17 OH progesterone in blood in Chilean newborns: antecedents for implementing a grogram for the neonatal detection of congenital adrenal hyperplasia].

    abstract:BACKGROUND:The early diagnosis and therapy of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency can prevent adrenal crises and erroneous gender assignment in affected newborns. To achieve this goal neonatal mass-screening programs have been developed, measuring blood 17 alpha-hydroxyprogesterone (17...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cattani A,Reyes ML,Azócar M,Soto J,Romeo E,Valdivia L,Poggi H,Foradori A

    更新日期:2000-10-01 00:00:00

  • [Familial recurrence of non syndromic cleft lip with or without cleft palate in Chilean populations].

    abstract:BACKGROUND:The presence of major genes in the susceptibility of non syndromic cleft lip with or without cleft palate (CL/P) in Chile has been postulated, considering the high prevalence and familial aggregation of this condition. AIM:To study the familial recurrence of CL/P in Chile. PATIENTS AND METHODS:The recurren...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Palomino H,Guzmán E,Blanco R

    更新日期:2000-03-01 00:00:00

  • [The medical history of Edgar Allan Poe].

    abstract::Edgar Allan Poe, one of the best American storytellers and poets, suffered an episodic behaviour disorder partially triggered by alcohol and opiate use. Much confusion still exists about the last days of his turbulent life and the cause of his death at an early age. Different etiologies have been proposed to explain h...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:10.4067/s0034-98872007000900019

    authors: Miranda C M

    更新日期:2007-09-01 00:00:00

  • [Effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis: evidence for an alternative therapeutic mechanism in hepatic encephalopathy].

    abstract:BACKGROUND:Despite non absorbable antibiotics and neomycin may have antagonistic effects on intestinal bacterial environment, both have synergistic effects in the treatment of hepatic encephalopathy. This could be due to their action on different enteric flora or a neomycin induced carbohydrate malabsorption. AIM:To i...

    journal_title:Revista medica de Chile

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Chesta J,Antezana C

    更新日期:1994-04-01 00:00:00

  • [Recent case law about the right to die].

    abstract::This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a jud...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872016000400009

    authors: Bascuñán R A

    更新日期:2016-04-01 00:00:00

  • [Illicit and psychotropic drug use among medical students at the Pontificia Universidad Católica de Chile].

    abstract:BACKGROUND:Illicit drug abuse is a public health problem, generally starting in adolescence. Medical students are not an exception. AIM:To assess the consumption of illicit drugs among medical students of the Pontificia Universidad Católica de Chile. MATERIAL AND METHODS:A questionnaire used by the National Council f...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000400002

    authors: Romero MI,Santander J,Hitschfeld MJ,Labbé M,Zamora V

    更新日期:2009-04-01 00:00:00

  • [Automatic keyword retrieval from clinical texts: an application of natural language processing to massive data of Chilean suspected diagnosis].

    abstract:BACKGROUND:Free-text imposes a challenge in health data analysis since the lack of structure makes the extraction and integration of information difficult, particularly in the case of massive data. An appropriate machine-interpretation of electronic health records in Chile can unleash knowledge contained in large volum...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872019001001229

    authors: Villena F,Dunstan J

    更新日期:2019-10-01 00:00:00

  • [Spontaneous bacterial peritonitis caused by Listeria in a patient with cirrhosis: Case report].

    abstract::Infections caused by Listeria monocytogenes are usually found in cattle and occasionally appear in humans, particularly pregnant women and immunocompromised individuals. Peritonitis by Listeria monocytogenes is a rare but dangerous condition that must be recognized early, since it requires a specific treatment. We rep...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006000900013

    authors: Espinoza-Gómez F,Newton-Sánchez O,Melnikov V,Pinzón S L

    更新日期:2006-09-01 00:00:00

  • [The social meaning of medical professionalism].

    abstract::This essay looks into the meaning of today's professionalism and the apparent inconsistency between its growing status and a context of profound changes and dissatisfaction with medical practice. The cultural climate of our times is reviewed, as the framework for understanding changes in the social organization of med...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006000400017

    authors: Horwitz Campos N

    更新日期:2006-04-01 00:00:00

  • [The hepatitis viruses: from A to TT].

    abstract::A great progress in the knowledge about hepatitis virus has occurred in the last decades and several virus have been identified. Virus B, C and D are transmitted parenterally, while virus A and E use the enteral route. Highly effective vaccines for A and B hepatitis are presently available. Virus C is an important cau...

    journal_title:Revista medica de Chile

    pub_type: 社论,评审

    doi:

    authors: Soto JR

    更新日期:1999-10-01 00:00:00

  • [Correlation between ultrasound and pathology of the gallbladder].

    abstract::Ultrasound is a sensible and specific method for the diagnosis, study of natural course and follow up of medical treatment of gallstones. Thus it is important to specify the concordance between echographic and pathological findings of the gallbladder. Ninety one patients were subjected to an ultrasound gallbladder exa...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Covarrubias C,Merino G,Cruz F,Pablo del Rio P,Vallespir A,Duarte I,Morales B,Valdivieso V

    更新日期:1992-11-01 00:00:00

  • [Hygiene and urban health as seen by physicians, architects and planners during the first half of the twentieth century].

    abstract::Physicians took part in the promotion of public policies that regulated urban and architectural work, before engineers, architects, planners, and even before the State had a chance to take part in the formulation of such policies. Starting in the late nineteenth century, and especially during the first decade of the t...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章

    doi:10.4067/S0034-98872016000100015

    authors: Ibarra M

    更新日期:2016-01-01 00:00:00

  • [Management of pediatric patients with esophageal varices].

    abstract:BACKGROUND:There is a paucity of good quality research about the diagnosis of esophageal varices and the prophylaxis and treatment of variceal bleeding in pediatric patients with portal hypertension There is little consensus and practically no evidence-based approach about the management of these patients. AIM:To desc...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000700008

    authors: Verdaguer D S,Gana A JC

    更新日期:2016-07-01 00:00:00

  • [The right to a good quality of health care].

    abstract::Quality has a central role in medical care. The satisfaction of the rights of people to medical care, presupposes good quality medical acts. The meaning of quality goes further than a good attention based on scientific evidence and with competent skills. It comprises patient-physician relationship where professional b...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rosselot E

    更新日期:2000-12-01 00:00:00

  • [Hemorrhage caused by the rupture of a pancreatic pseudoaneurysm. Case report].

    abstract::We report a 52 year old man with a pancreatic pseudocyst, that was admitted with severe abdominal pain, severe vomiting, fever and malaise. The clinical picture was considered secondary to a pseudocyst infection and the patient was operated, draining the infected cyst performing a necrosis surgery and pancreatojejunos...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Bosman C,Sanhueza M,Schnettler D,Rossi R,Whittle C,Valderrama R

    更新日期:2001-01-01 00:00:00

  • [Depressive symptomatology and psychological well-being among Chilean university students].

    abstract:BACKGROUND:Quality of life and psychological well-being are readily hampered by depression. The changes that students face during college life impact their psychological health and well-being, including the emergence of mental health problems like depression Aim: To determine the relationship between depressive symptom...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872019000500579

    authors: Rossi JL,Jiménez JP,Barros P,Assar R,Jaramillo K,Herrera L,Quevedo Y,Botto A,Leighton C,Martínez F

    更新日期:2019-05-01 00:00:00

  • [Renal oncocytoma: 4 cases].

    abstract::Oncocytomas are tumors characterized by cells with an eosinophilic cytoplasm. Renal oncocytomas were described in 1942. Among 46 consecutive patients operated on for renal tumors, oncocytomas were found in 4 (8.7%). In spite of a supposedly benign nature, renal oncocytoma cannot be adequately differentiated from renal...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Castillo O,van Cauwelaert R,Aguirre C,Arellano L,Medina FJ

    更新日期:1992-05-01 00:00:00

  • [Comparative analysis of A(H1N1) influenza epidemiological dynamics in Chile].

    abstract::In order to increase awareness of the pandemic and to streamline control measures before any new outbreak of influenza we analyze the behavior of the cases of Chile and from 9 countries with more cases in 2009. Reproductive numbers, doubling times and estimations of susceptible and infected at the end of the epidemic ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872010000900016

    authors: Canals L M

    更新日期:2010-09-01 00:00:00

  • [Ménétrier disease. Report of one case].

    abstract:BACKGROUND:Ménétrier disease is a rare disorder of the stomach, characterized by giant hypertrophic folds that usually involve the gastric body and fundus, associated to hypoalbuminemia due to serum protein loss across the gastric mucosa. We report a 55-years-old male presenting with abdominal pain, vomiting, weight lo...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872012000900011

    authors: Gompertz M,Montenegro C,Bufadel ME,Defilippi C,Castillo J,Morales C

    更新日期:2012-09-01 00:00:00

  • [Cholesterol and triglycerides in atherosclerosis: epidemiologic and physiopathologic considerations].

    abstract::Increased cholesterol levels above 200 mg/dl, LDL levels above 130 mg/dl and total cholesterol/HDL ratio above 4.5 in males and above 5.0 in females are recognized as indicators of increased risk of atherosclerosis. Risk associated to increased triglyceride levels (above 200 mg/dl) must be judged in relation to associ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Davidoff P

    更新日期:1991-09-01 00:00:00

  • [Evolutionary perspective of eating disorders].

    abstract:BACKGROUND:Evolutionary theory has contributed with physiological, psychological and behavioral explanations to the comprehension and treatment of eating disorders (ED). The aim of this review is to analyze the relationship between ED and the attachment theory and natural selection based hypotheses (famine flight, repr...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872012000400015

    authors: Behar A R

    更新日期:2012-04-01 00:00:00

  • [Chilean hospitals: availability and productivity of the public and private sectors].

    abstract::Hospital bed availability, trends in number of beds, productivity and administrative aspects in the public and private hospital sectors are analyzed. At present, there are 3.3 beds per 1000 population in Chile. This represents a decrease from previous figures, in spite of increasing demands derived from population agi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Medina E,Kaempffer AM

    更新日期:1992-03-01 00:00:00

  • [Geographical distribution of mortality caused by stomach, trachea, bronchi and lung malignant tumors in Chile].

    abstract:BACKGROUND:Maps have played a critical role in public health since 1855, when John Snow associated a cholera outbreak with contaminated water source in London. After cardiovascular diseases, cancer is the second leading cause of death in Chile. Cancer was responsible for 22.7% of all deaths in 1997-2004 period. AIM:To...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872007001100005

    authors: Icaza N MG,Núñez F ML,Torres A FJ,Díaz S NL,Várela G DE

    更新日期:2007-11-01 00:00:00