当前位置： SCI文献检索 > REVISTA MEDICA DE CHILE期刊下所有文献 > [Hodgkin lymphoma in Chile: experience of the national adult cancer program].

[Hodgkin lymphoma in Chile: experience of the national adult cancer program].

Abstract：

BACKGROUND:Hodgkin lymphoma is a highly curable disease. AIM:To evaluate the clinical characteristics and the treatment results of Hodgkin lymphoma patients of the National Cancer Program in Chile. PATIENTS AND METHODS:Prospective assessment of 682 patients treated in 18 adult cancer centers. Progression free survival (PFS) and overall survival (OS) were calculated. Median follow up was 127, 95, 87, 72 and 50 months for C-MOPP, radiotherapy (RT), C-MOPP/ABV, NOVP and ABVD, respectively. RESULTS:Median age was 37 years (15-84). Nodular sclerosis and mixed cellularity were equally expressed. Advanced stages (III & IV) were present at diagnosis in 61% of cases. Age over 40 was an adverse prognostic factor (p<0.001). The rate of PFS at 5 and 10 years for early stages was 73% and 66% with RT, 80% and 74% with C-MOPP+RT, 73% and 71% with C-MOPP/ABV, 59% and 59% with NOVP+RT, and 81% with ABVD+RT, at 5 years, being significantly lower for NOVP (p=0.02). The rate of OS at 5 and 10 years for advanced stages was 82% and 70% with RT, 82% and 76% with C-MOPP+RT, 82% and 80% with C-MOPP/ABV, 68% and 60% with NOVP, and 85% with ABVD at 5 years, also significantly lower for NOVP (p=0.04). For advanced stages, the rate of PFS at 5 and 10 years was 49% and 43% with C-MOPP, 69% and 62% with C-MOPP/ABVD or C-MOPP/ABV, and 71% at 5 years with ABVD, significantly lower for C-MOPP (p=0.01). The rate of OS at 5 and 10 years was 52% and 46% with C-MOPP, 70% and 63% with C-MOPP/ABVD or C-MOPP/ABV and 76% with ABVD at 5 years, significantly lower for C-MOPP (p=0.0002). CONCLUSIONS:Age over 40 years was an adverse prognostic factor. C-MOPP/ABVD, C-MOPP/ABV and ABVD had comparable results and reached a high tumor control and overall survival in both early and advanced stages.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Cabrera ME,García H,Lois V,León A,Peña K,Rossle A,Cerda B,Rojas H,Meneses P,Merino C,Aspillaga A,Vittini de C,Oliva J,Hales C,Rosas J,Programa Nacional de Cáncer del Adulto, Ministerio de Salud.

doi

10.4067/s0034-98872007000300009

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

341-50

issue

eissn

0034-9887

issn

0717-6163

pii

S0034-98872007000300009

journal_volume

135

pub_type

杂志文章,多中心研究

在线工具

[Hodgkin lymphoma in Chile: experience of the national adult cancer program].