[Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: advances in pathogenesis and treatment].

Abstract:

:ANCA (anti-neutrophil cytoplasmic antibodies) associated vasculitis or AAV are a group of diseases with predominant inflammation of small vessels and the presence of detectable ANCA in serum. Due to these common features, it is considered that AAV share pathogenic mechanisms. Consequently, a similar therapeutic approach has been developed. A new nomenclature has been recently proposed, with AAV including "granulomatosis with polyangiitis" (GPA, formerly Wegener's granulomatosis), "microscopic polyangiitis" (MPA), "eosinophilic granulomatosis with polyangiitis" (EGPA, formerly Churg-Strauss disease) and renal limited vasculitis. Research on AAV has shown significant advances in the last two decades, including advances in the knowledge of pathogenic mechanisms such as the pro-inflammatory role of ANCA, AAV murine models and genetic links. Evidence on previous immunosuppressive therapies has improved significantly and new, promissory drugs have been introduced, Rituximab being the most important. We review the advances of pathogenic mechanisms and treatment for these diseases.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Silva F,Cisternas M

doi

10.4067/S0034-98872013000600011

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

765-73

issue

6

eissn

0034-9887

issn

0717-6163

pii

S0034-98872013000600011

journal_volume

141

pub_type

杂志文章,评审
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  • [Current life expectancy in Chile].

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    doi:

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  • [Aseptic techniques for minor surgical procedures].

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    authors: Conte G,Torrens M,Larraín C,Be C,Daher V,Youlton R

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  • [Soft tissue sarcoma. Combined treatment of drug therapy, radiotherapy and conservative surgery].

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    authors: San Martín S,Pérez R,Sepúlveda M,Rodríguez M,Durán B,Trujillo C,Arraztoa J

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    authors: Vial PA,Vial C,Abarca K,Noriega M,Jiménez G,Labarca J,Gasep J,Palacios O,Pérez C,Acuña G

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  • [Bioethical challenges of stem cell tourism].

    abstract::Stem cells have drawn extraordinary attention from scientists and the general public due to their potential to generate effective therapies for incurable diseases. At the same time, the production of embryonic stem cells involves a serious ethical issue concerning the destruction of human embryos. Although adult stem ...

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    abstract::The "Revista Medica de Chile" founded in 1872 is the second oldest medical journal in Latin America after the "Gaceta Medica de Mexico" (1864). Among medical journals in the world it is placed 24. It has been published monthly without interruption, except for the period January through December 1891, due to the revolu...

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    authors: Huidobro A,Velasco N,Rojas T

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  • [Usefulness of AgNOR technique in the interpretation of serous effusions].

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    pub_type: 杂志文章

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    authors: Rocher AE,Blanco AM,Palaoro LA

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    doi:/S0034-98872009000400012

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