Abstract:
:ANCA (anti-neutrophil cytoplasmic antibodies) associated vasculitis or AAV are a group of diseases with predominant inflammation of small vessels and the presence of detectable ANCA in serum. Due to these common features, it is considered that AAV share pathogenic mechanisms. Consequently, a similar therapeutic approach has been developed. A new nomenclature has been recently proposed, with AAV including "granulomatosis with polyangiitis" (GPA, formerly Wegener's granulomatosis), "microscopic polyangiitis" (MPA), "eosinophilic granulomatosis with polyangiitis" (EGPA, formerly Churg-Strauss disease) and renal limited vasculitis. Research on AAV has shown significant advances in the last two decades, including advances in the knowledge of pathogenic mechanisms such as the pro-inflammatory role of ANCA, AAV murine models and genetic links. Evidence on previous immunosuppressive therapies has improved significantly and new, promissory drugs have been introduced, Rituximab being the most important. We review the advances of pathogenic mechanisms and treatment for these diseases.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Silva F,Cisternas Mdoi
10.4067/S0034-98872013000600011subject
Has Abstractpub_date
2013-06-01 00:00:00pages
765-73issue
6eissn
0034-9887issn
0717-6163pii
S0034-98872013000600011journal_volume
141pub_type
杂志文章,评审abstract:BACKGROUND:Quality of life and psychological well-being are readily hampered by depression. The changes that students face during college life impact their psychological health and well-being, including the emergence of mental health problems like depression Aim: To determine the relationship between depressive symptom...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000500579
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Systemic fungal infections and specifically invasive aspergillosis (IA) are associated with a high morbi-mortality rate in patients with hematologic malignancies. Itraconazole kinetic studies show that plasma levels are not satisfactory, even though there is a reduction of the severity in clinical cases. AI...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000900003
更新日期:2011-09-01 00:00:00
abstract::An increased life expectancy is associated to a nation's progress. Life expectancy at birth is 78 years in developed countries, 72 in Latin America, 70 in China, 63 in Eastern Europe and 51 in Africa. Chile is the Latin American country with the higher increment in life expectancy, reaching 75 years at birth, during t...
journal_title:Revista medica de Chile
pub_type: 社论
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Teaching practice is one of the most complex topics of the training process in medicine and other health care careers. The Teaching Practices Questionnaire (TPQ) evaluates teaching skills. AIM:To assess the factor structure and internal consistency of the Spanish version of the TPP among health care teacher...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000600015
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas. AIM:To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. MATERIAL AND METHODS:Samples of 35 gallbladder, 15 ampul...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872005001200004
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Approximately 150 subjects per year suffer severe burns in Chile. AIM:To analyze sociodemographic/clinical features and outcomes of severely burned patients. MATERIAL AND METHODS:Retrospective cohort study of 936 patients aged 47 ± 20 years (66% males), admitted to the National Burn Center of Chile between...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000200006
更新日期:2013-02-01 00:00:00
abstract::The effect of a prolonged course of oral acyclovir was evaluated in 55 pts with recurrent genital herpes (36 men and 19 women). The pts were voluntarily enrolled after an acute episode, with tissue culture viral isolation. All the pts received an initial course with 200 mg of acyclovir x 5 for 10 days. Then they were ...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-08-01 00:00:00
abstract::We report a 10 years old boy, admitted with a history of asthenia, anorexia and weight loss of 4 kg. Initial laboratory work up showed metabolic acidosis and hyponatremia. The patient had no circadian rhythm of serum cortisol and an adrenal stimulation test confirmed the presence of adrenal insufficiency. Anti-adrenal...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patients risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there a...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000800011
更新日期:2016-08-01 00:00:00
abstract::From 1983 to 1987 we studied 30 patients with leukemia searching for chromosomal alterations. Cytogenetic studies of bone marrow showed an abnormal karyotype in 19 (67%). Seven out of 14 cases of acute leukemia presented different chromosomic alterations. The Philadelphia chromosome was found in 11 patients with chron...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::The preliminary results of a prospective and cooperative protocol for the treatment of soft tissue sarcomas of trunk and extremities, stages IB-IIIB are presented. Thirty one patients (17 males, 22 with a tumor larger than 5 cm) aged 16 to 68 years, were treated with one dose of epirubicin 70 mg/m2 i.v. and radiothera...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Beliefs about professionals' healthcare may influence healthcare behaviors. Such beliefs are in part the result of the interactions that professionals have with their patients. Recent studies highlight the importance of beliefs about physicians, their effect on health-care behaviors, and the requirement of c...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000300308
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:All winters, there is an increase in the number of pediatric consultations, associated to three factors: cold weather, air pollution and respiratory virus epidemics. AIM:To study the influence of these three factors in the demand for pediatric consultations between March and September, in an area of Metropo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Priapism is a rare complication of hematological diseases. Among leukemia, it is most frequently seen in patients with chronic myeloid leukemia, due to the high leukocyte counts that these patients achieve. We report a 22 years old male who presented with a priapism lasting more than 24 hours. Thirty six hours after a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Cerebral vasodilators (CVD) account for 1.6% of the annual expenditure on drugs in Chile. Two kinds are typified: what we have called orthodox CVD and calcium-channel blockers. They have two main uses in neurology: firstly, in acute ischaemic stroke where orthodox CVD (buflomedil, codergocrine mesylate, and nicergolin...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Resistance of HIV to AZT is the result of mutations in the pol gene that codifies the enzyme reverse transcriptase. AIM:To assess the resistance to antiretroviral drugs in Chilean patients infected with HIV. MATERIAL AND METHODS:The presence of mutations was searched in 22 patients infected with HIV. The e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Stem cells have drawn extraordinary attention from scientists and the general public due to their potential to generate effective therapies for incurable diseases. At the same time, the production of embryonic stem cells involves a serious ethical issue concerning the destruction of human embryos. Although adult stem ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013000800010
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Enterococcus is a bacterial genus with low virulence. However, in the last years, the importance of some enterococcus species as nosocomial pathogens has increased, specially due to their resistance to some antimicrobial. AIM:To identify enterococcus strains using classical biochemical techniques and genomi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The "Revista Medica de Chile" founded in 1872 is the second oldest medical journal in Latin America after the "Gaceta Medica de Mexico" (1864). Among medical journals in the world it is placed 24. It has been published monthly without interruption, except for the period January through December 1891, due to the revolu...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Hemophagocytic syndrome is a severe condition of excessive immune activation that has a high mortality in the absence of treatment. The syndrome is classified as primary if associated with congenital or hereditary problems, or secondary/acquired if associated with infectious, autoimmune or oncology diseases. We report...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872015000900010
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:In July 2010 end stage renal disease anemia correction was incorporated to the program of explicit health guaranties of the Ministry of Health. The treatment plan included intravenous iron and erythropoietin. The prescription of these medications carne from the deriving health organizations. AIM:To describe...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000500003
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Malnutrition has been strongly associated with morbidity and mortality in hemodialysis patients. In the other hand, dialysis allows a nutritional improvement in patients with more than 12 months in dialysis. AIM:To study the prevalence of malnutrition among patients in hemodialysis. PATIENTS AND METHODS:We...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::A great progress in the knowledge about hepatitis virus has occurred in the last decades and several virus have been identified. Virus B, C and D are transmitted parenterally, while virus A and E use the enteral route. Highly effective vaccines for A and B hepatitis are presently available. Virus C is an important cau...
journal_title:Revista medica de Chile
pub_type: 社论,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::We report a 50-year-old woman with a recent myocardial infarction in whom a myocardial perfusion single photon emission computed tomography (SPECT) with Thallium201 was done simultaneously with a F18-fluorodeoxyglucose (FDG) SPECT to study glucose metabolism. Myocardial infarction was located in the anteroseptal and a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:AgNOR technique detects, using silver salts, argyrophylic proteins of the nucleolar organizer region (NOR). The number and size of NOR reflect cell activity, proliferation and transformation and may help to differentiate benign from malignant cells. AIM:To assess the value of AgNOR assay to differentiate re...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::We report a 74-year-old male with liver metastases from a neuroendocrine tumor (NET) of unknown origin. Conventional imaging studies with ultrasound, computed tomography colonoscopy and Positron emission tomography-computed tomography (PET/CT) with 18Fluor odeoxyglucose did not identify the site of origin of the prima...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000400012
更新日期:2009-04-01 00:00:00
abstract::Aneurysmal bone cysts are benign fibro osseous lesions, rarely present in maxillary region. We report the CT and morphological findings of aneurysmal bone cyst of the maxilla in a 15 years old female. The patient was subjected to a maxillectomy, preserving the orbit floor. The postoperative evolution has been uneventf...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001100012
更新日期:2005-11-01 00:00:00
abstract::Microalbuminuria is a new tool in the management of patients with diabetes mellitus or hypertension. Microalbuminuria is an easily measured biomarker in a urine sample. Urinary albumin to creatinine ratio in first morning urine sample correlates with 24 hours urinary albumin excretion, but it is easier to obtain, and ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872012000600016
更新日期:2012-06-01 00:00:00
abstract::Nucleolar organizer regions may be observed by colloidal silver stains. A considerable increase in the number of regions may be observed in tumors and other pathologic processes as an index of cellular proliferation. Among 20 studies in patients with gastric carcinoma we found a significantly greater number of nucleol...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:The Chilean Ministry of Health proposed the use of "Mini Nutritional Assessment", to identify elders at nutritional risk. This score considers anthropometric, dietary and quality of life items. AIM:To assess the concordance of the mini nutritional assessment with body mass index and dietary parameters in Ch...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00