[Resistance of human immunodeficiency virus (HIV) to zidovudine. Genotypic analysis in strains isolated from Chilean patients].

Abstract:

BACKGROUND:Resistance of HIV to AZT is the result of mutations in the pol gene that codifies the enzyme reverse transcriptase. AIM:To assess the resistance to antiretroviral drugs in Chilean patients infected with HIV. MATERIAL AND METHODS:The presence of mutations was searched in 22 patients infected with HIV. The emergence or persistence of these mutations was studied in sequential samples of 19 patients. The presence of the mutation that confers resistance to didanosine (DDI) was studied in those subjects exposed to the drug. Polymerase chain reaction techniques were used to analyze mutations in codons 41, 70 and 215 of the pol gene (resistance to AZT) and the mutation in codon 71 (resistance to DDI). RESULTS:On admission, none of the patients without previous exposure to AZT had drug resistance mutations. Seven of 12 patients (58.3%) that had received AZT had mutations in codon 215. In two, they were associated to a mutation in codon 41 and in two, a mutation in codon 70. After a mean follow up of 14 months, 13 of 15 patients (86%) that received AZT had viral strains genotypically resistant to the drug. In nine of these, the resistance was associated with disease progression. None of the 10 patients that received DDI had the mutation in codon 74 that confers resistance to the drug. However, in one of these patients, that never received AZT, a virus with a mutation in codon 215 was detected. CONCLUSIONS:A high percentage of patients that have received monotherapy with AZT have genotypic resistance to the drug. This resistance is associated with clinical and immunological derangement in 70% of these subjects.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Vial PA,Vial C,Abarca K,Noriega M,Jiménez G,Labarca J,Gasep J,Palacios O,Pérez C,Acuña G

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

17-26

issue

1

eissn

0034-9887

issn

0717-6163

journal_volume

126

pub_type

杂志文章
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  • [Intraoperative monitoring of gastric intramucosal pH].

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  • [Response rates to first-line treatment in eligible patients to autologous stem transplantation in Chile].

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    doi:10.4067/S0034-98872019001201561

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  • [Work absenteeism in a mining company: trends in 1985-1988].

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    abstract::We investigated medical leaves of personnel at Temuco's hospital from 1986 to 1987. 57% of persons had at least one leave and 54% of these had 2 or more leaves. Women and paramedicals had more medical leaves. Most absences occurred in june, july, august (p less than 0.01). Most leaves were caused by respiratory diseas...

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    authors: Silva CG,Baechler R

    更新日期:1989-07-01 00:00:00

  • [Sexual behavior and contraceptive practices among university students].

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  • [Present status of medical specialties in the Chilean public health system].

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    journal_title:Revista medica de Chile

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  • [Development of an instrument to assess cultural beliefs about physicians].

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  • [Antihypertensive effects of valsartan. National multicentric study].

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