Abstract:
BACKGROUND:The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas. AIM:To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. MATERIAL AND METHODS:Samples of 35 gallbladder, 15 ampulla of Vater, 10 biliary tract and 9 pancreatic tumors, were analyzed. The tumor tissue was microdissected from paraffin embedded biopsies. The mutation was detected by a combination of polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS:Overall, 46% of samples had K-ras gene mutations. Mutation frequency was 80, 56, 50 and 29% for ampulla of Vater, pancreatic, biliary tract and gallbladder tumors, respectively. When compared with the rest, gallbladder tumors had a significantly lower frequency of the mutation. Median survival for biliary tract tumors was 6 months, compared with 65 months for gallbladder tumors (p <0.05). CONCLUSIONS:Gallbladder carcinoma had the lower frequency of K-ras mutation, when compared with pancreatic, biliary tract and ampulla of Vater tumors.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Roa JC,Anabalón L,Tapia O,Melo A,de Aretxabala X,Roa Idoi
/S0034-98872005001200004subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1434-40issue
12eissn
0034-9887issn
0717-6163pii
S0034-98872005001200004journal_volume
133pub_type
杂志文章abstract::The aim of this study was to look for pathological changes in the oral cavity in a group of 40 non cirrhotic male alcoholics, ranging in age from 30 to 40 years old. These subjects were compared with a group of 40 non alcoholic male subjects of similar age. The presence of lip, dental, periodontal, salivary gland and ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Squamous Cell Carcinoma (SCC) of the lip represents about 20% of all oral carcinomas. It is more common in men, peaking during their sixth and seventh decade, and is more prevalent in the lower lip. AIM:To determine the five years survival rate of Chilean patients with lip SCC. MATERIAL AND METHODS:The reg...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000700004
更新日期:2015-07-01 00:00:00
abstract::Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::In a double blind study, 20 patients who presented with acute episodes of asthma were randomized to treatment with nebulized salbutamol (5 mg) of subcutaneous salbutamol (0.5 mg). The clinical conditions were not significantly different before or after treatment in both groups. Significant bronchial dilation was obtai...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-02-01 00:00:00
abstract::Malignant Melanoma (MM) incidence rate is increasing faster than many other cancer at present time. Its epidemiological and clinical behavior varies within countries. We have studied 113 cases of cutaneous melanoma from 1982-1993, that represents until now the largest series of MM studied in Chile. Superficial Spreadi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::To adequately plan the post graduate training of physicians, we need to know the needs for specialists in the country and the most prevalent diseases and causes of consultations. In 2004, the National System of Health Services assessed the number of hours and types of specialties available, their regional distribution...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000100013
更新日期:2008-01-01 00:00:00
abstract::The most significant facts in the development of Chilean cardiology since 1930 are reviewed. The preeminence of great clinicians in the thirties was followed by the creation of Departments of Cardiology in University Hospitals. The emergence of powerful diagnostic tools and cardiac surgery allowed an accelerated devel...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract:UNLABELLED:The lithogenic risk profile is a graphical representation of metabolic factors and urinary saturation involved in the stone formation with their respective critical values. AIM:To determine the lithogenic risk profile in patients with urolithiasis. MATERIAL AND METHODS:Personal data such as anthropometric,...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000600005
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:In Chile, occupational illnesses are defined by the "Work-related accidents and occupational illnesses law". The institutions that administer that law have the legal obligation to determine the "occupational" or "common" origin of accidents and diseases. AIM:To compare symptoms and problems at work in a gro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011001000019
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Autologous hematopoietic cell transplantation (THA) in patients with multiple myeloma and amyloidosis is the standard of care to promote disease free survival and quality of life. AIM:To report our experience with THA in patients with multiple myeloma. MATERIAL AND METHODS:Retrospective review of the hemat...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014001200001
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Culture is defined by the Webster's dictionary as acquaintance with and taste in fine arts, humanities, and broad aspects of science as distinguished from vocational and technical skills. AIM:To assess the general cultural knowledge of university students. MATERIAL AND METHODS:A test containing 58 question...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000300005
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Ultraviolet light exposure has a pathogenic effect on the development of skin cancer, whose prevalence increases worldwide. In Chile and the rest of the world, preventive educational campaigns are carried out to change high risk sun exposure behaviors. AIM:To study the behavior of the Chilean population tow...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872005000600007
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Several studies indicate that doctors who work in the same area of the medical profession tend to behave somehow similarly. Thus, it has been suggested that personality relates to the medical specialty choice. However, it is not known whether people self-select into the medical specialties according to their...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001000008
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The frequency of diseases caused by non tuberculous mycobacteria has increased in the last years. Their clinical diagnosis is difficult, mainly in immunocompromised patients. The identification of these mycobacteria by traditional methods is based on phenotypic characteristics and the results are obtained tw...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000700010
更新日期:2006-07-01 00:00:00
abstract::Priapism is a rare complication of hematological diseases. Among leukemia, it is most frequently seen in patients with chronic myeloid leukemia, due to the high leukocyte counts that these patients achieve. We report a 22 years old male who presented with a priapism lasting more than 24 hours. Thirty six hours after a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Domestic violence can have an important influence on mother and child health. AIM:To assess the consequences of remote and actual, emotional or physical, domestic violence on the reproductive and newborn health in pregnant women. MATERIAL AND METHODS:A longitudinal epidemiological observation from an Urban...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::The aim of this study was to compare in vitro activity, measuring minimal inhibitory concentration, of amoxicillin or its combination with clavulanic acid against 109 strains of Acinetobacter baumanii, 104 strains of Hemophilus influenzae and 94 strains of Staphylococcus aureus. All these were obtained from different ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::This article gives technical orientation to health institutions for the promotion of community participation and sets forth the challenge of constructing a health system for Chile, according to the needs and problems of the country and based on the principles of solidarity, equity and social participation. It presents...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::We are reporting a 37 year old male with severe oligozoospermia and a history of infertility for thirteen years and surgery for severe unilateral varicocele. The hormonal levels for FSH, LH and T, and karyotype were within the normal range. Multiplex PCR revealed the presence of a de novo microdeletion in the azoosper...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::We report a 10 years old boy, admitted with a history of asthenia, anorexia and weight loss of 4 kg. Initial laboratory work up showed metabolic acidosis and hyponatremia. The patient had no circadian rhythm of serum cortisol and an adrenal stimulation test confirmed the presence of adrenal insufficiency. Anti-adrenal...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::This paper undertakes an analysis of the scientific criteria used in the diagnosis of death and underscores the importance of intellectual rigor in the definition of medical concepts, particularly regarding such a critical issue as the diagnosis of death. Under the cardiorespiratory criterion, death is defined as "the...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872004000100015
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Maps have played a critical role in public health since 1855, when John Snow associated a cholera outbreak with contaminated water source in London. After cardiovascular diseases, cancer is the second leading cause of death in Chile. Cancer was responsible for 22.7% of all deaths in 1997-2004 period. AIM:To...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872007001100005
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Smoking may hamper female fertility, probably modifying ovarian reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve. AIM:To look for an association between smoking status and plasma AMH concentration. PATIENTS AND METHODS:A cohort of 141 infertile women in a university setting in...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000100003
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:There is phenotypic and genetic variability among the species Borrelia burgdorferi that produces Lyme disease. Three gene species and seven serotypes have been defined. AIM:To study the efficacy of two gene species in the serological diagnosis of Borrelia burgdorferi infections in Granada, Spain. MATERIAL ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Clinical pathways or structured multidisciplinary care plans are a tool to standardize clinical practice. The aim of this article is to describe and propose a methodology for the development of clinical pathways in a highly complex health institution. We used the guidelines of the European Quality of Care Pathway, whi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872020000901331
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:One third of patients with subarachnoid hemorrhage caused by intracranial aneurysms, die. AIM:Review of medical records of patients with subarachnoid hemorrhage treated at a clinical hospital. MATERIAL AND METHODS:Review of medical records of patients discharged from the hospital between 2006 and 2011 with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000800005
更新日期:2014-08-01 00:00:00
abstract::Kikuchi and Fujimoto disease is a benign subacute necrotizing lymphadenitis, probably associated to a viral infection, that affects mostly young Asian women. We report a 19 years old women, with a vast familiar history of thyroid disease (three uncles with papillary thyroid carcinoma and one with a Hashimoto thyroidit...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:There is paucity of information about viral etiology of community acquired pneumonia in adults. AIM:To investigate the viral etiology of pneumonia among hospitalized patients. MATERIAL AND METHODS:All adults with pneumonia that were hospitalized were prospectively enrolled at Puerto Montt hospital. A micro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000800003
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:There is no conclusive evidence about the association between physical fitness (PF) and health related quality of life (HRQOL) in older adults. AIM:To seek for an association between PF and HRQOL in non-disabled community-dwelling Chilean older adults. MATERIAL AND METHODS:One hundred and sixteen subjects ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000100008
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:During the last few years, multiple new medical schools have emerged in Chile, associated to the constant preoccupation to provide a good quality medical care. This created the need to evaluate medical training programs and to open a discussion about the attributes that a good physician should have. AIM:To ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000800001
更新日期:2006-08-01 00:00:00