Abstract:
BACKGROUND:Systemic fungal infections and specifically invasive aspergillosis (IA) are associated with a high morbi-mortality rate in patients with hematologic malignancies. Itraconazole kinetic studies show that plasma levels are not satisfactory, even though there is a reduction of the severity in clinical cases. AIM:To evaluate the results of oral prophylaxis with high dose itraconazole, 400 mg bid, among patients with adult acute leukemia. MATERIAL AND METHODS:Prospective analysis of 93 high risk febrile episodes (with an absolute neutrophil count of less than 500 x mm3 for more 10 days), that occurred in 76 patients. RESULTS:Seventy five percent of episodes occurred in patients with acute myeloid leukemia and 25% in patients with acute lymphoblastic leukemia. Fifty two percent occurred during the induction of chemotherapy. Median duration of severe neutropenia was 21 days (range 10-48). Median duration of itraconazole prophylaxis was 17 days (range 6-34). A low frequency of invasive fungal infections was observed (17%). According to diagnostic criteria, 5% of episodes corresponded to persistent fever , 1% and 11% of episodes, to probable or possible IA, respectively. No confirmed or proven IA was observed. Mortality of IA was 18%. No serious adverse events due to itraconazole were observed. CONCLUSIONS:The use of high dose itraconazole prophylaxis in adult patients with acute leukemia and severe neutropenia was associated to low incidence and mortality of invasive mycoses.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Andrade M A,Puga L B,Guerra C C,Molina E J,Capurro C Mdoi
/S0034-98872011000900003subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1128-34issue
9eissn
0034-9887issn
0717-6163pii
S0034-98872011000900003journal_volume
139pub_type
杂志文章abstract:BACKGROUND:The age at which children born preterm normalize their bone mineral density, is not well known. AIM:To study if children born preterm have normalized their bone mineral density at age 5 to 7 years. PATIENTS AND METHODS:Twenty six infants born preterm (14 male), were studied at age 5 to 7 years. Birth weigh...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Attention is considered a central control mechanism in cognitive processing systems. Attention deficits contribute to the symptomatic profile of Alzheimer's disease (AD). Physical exercise and cognitive reserve, could delay cognitive impairment and constitute a protective factor against clinical manifestatio...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000500570
更新日期:2018-05-01 00:00:00
abstract::Background Sleep duration may be a risk factor for cognitive impairment. Aim To investigate the association between sleep duration and cognitive function in Chilean older adults. Material and Methods We analyzed information from 1,384 participants aged > 60 years participating in the National Health Survey 2009-2010 w...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019001101398
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The etiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) is heterogeneous and still under discussion. Inflammation increases during exacerbation of COPD. The identification of inflammatory changes will increase our knowledge and potentially guide therapy. AIM:To identify which inf...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872012000100002
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:It is not clear if old age is a risk factor for adverse drug reactions. AIM:To study the incidence of adverse drug reactions and the effect of age in patients admitted to an Internal Medicine Service in an university hospital. PATIENTS AND METHODS:Two hundred one patients, hospitalized at the Clinical Hosp...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::We followed 25 patients operated on for Wolff-Parkinson-White syndrome between August 1985 and October 1989. Their mean age was 37 +/- 12 years and arrhythmia had been present for 5 to 30 years. A mean of 3.3 +/- 1.2 antiarrhythmic agents had failed in controlling recurrences. Tachycardia was orthodromic in 21 patient...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::The september 1888 issue of the Journal contains an article by Luis Asta-Buruaga MD, "Ambulances in New York: a system to be instituted in Santiago. In addition to encouraging this project, the idea of establishing small hospitals in peripheral quarters of the city is discussed. Dr Asta-Buruaga was a graduate from Col...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The nutritional impact of CONIN nutritional recovery centers must be evaluated, considering the current epidemiological situation in Chile and the new therapeutic focus giving more emphasis to ambulatory treatment. AIM:To analyze the nutritional status of children treated at traditional CONIN centers, the r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The prevalence of obesity among children and teenagers is increasing by 1.5% per year, probably due to a higher consumption of highly caloric foods and to physical inactivity. Hypercholesterolemia, increased insulin levels and high blood pressure of childhood obesity, precede atherosclerosis, coronary artery disease, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Acute appendicitis is the most common non obstetric surgical emergency during pregnancy. AIM:To asses our experience in the diagnosis and management of acute appendicitis occurring during pregnancy. PATIENTS AND METHODS:Data from all pregnant patients who were subjected to an appendectomy for a suspected a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000200002
更新日期:2006-02-01 00:00:00
abstract::In a double blind study, 20 patients who presented with acute episodes of asthma were randomized to treatment with nebulized salbutamol (5 mg) of subcutaneous salbutamol (0.5 mg). The clinical conditions were not significantly different before or after treatment in both groups. Significant bronchial dilation was obtai...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-02-01 00:00:00
abstract::Aspirin use is necessary after a coronary angioplasty. It should not be used in patients with a history of hypersensitivity. However, rapid desensitization protocols have been reported to allow its use in such patients. One of these protocols consists in the administration of progressive doses of aspirin, from 1 to 10...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000200016
更新日期:2013-02-01 00:00:00
abstract::This article deals with the history and evolution of student's scientific journals in Latin-America, their beginnings, how many still exist and which is their future projection. Relevant events show the growth of student's scientific journals in Latin-America and how are they working together to improve their quality....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010001200016
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:An important agent of food intoxication is Staphylococcus aureus, that is able to produce enterotoxins. AIM:To detect Staphylococcus aureus contamination in cafeteria food handlers of a Chilean University. SUBJECTS AND METHODS:Nose, throat, hands and nail samples from 87 food handlers were obtained for mic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Amiodarone is a benzofuranic derivative widely used in cardiologic practice because of its excellent antiarrhythmic properties. Due to its high iodine content, it interferes with thyroid physiology and can cause either hyper or hypothyroidism. Amiodarone-induced hyperthyroidism should be considered as a serious compli...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Medical specialization has brought about the need to guarantee suitability for its practice. The progressive changes in knowledge and the incorporation of specific technologies, set forth the need to periodically demonstrate this capacity. In developed countries different initiatives, that sooner or later will become ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::We report the case of a 42 years old male, with a bipolar disorder and receiving lithium therapy, valproic acid and clonazepam. Due to an exacerbation of his underlying disease, he was admitted to a psychiatric clinic and received 50 mg of intramuscular chlorpromazine in two occasions. Afterwards, the patient had an a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Genes for dopamine receptor DRD4 and dopamine transporter DAT1 have been implicated in attention deficit with hyperactivity disorder (ADHD). However, the findings are not conclusive. More studies in populations with different genetic backgrounds may contribute to solve the discrepancies observed. AIM:To tes...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000900004
更新日期:2004-09-01 00:00:00
abstract::This is a translation into Spanish, done by Mario Uribe, M.D., F.A.C.S., and authorized by the Conference Organization, of the official statements signed by The Transplantation Society, The International Society of Nephrology and the representatives who participated at a WHO sponsored Conference held in Istambul, Turk...
journal_title:Revista medica de Chile
pub_type: 共识发展会议,杂志文章
doi:10.4067/S0034-98872009000800019
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes mellitus (DM1) is a disease of increasing incidence among children. The time elapsed between the beginning of symptoms and the diagnosis of the disease is, in most cases, very extended. AIM:To report the clinical picture at onset and laboratory features of children with DM1. MATERIAL AND ME...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006001200007
更新日期:2006-12-01 00:00:00
abstract::Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract::Examinations performed beside the bed of patients ("Point-of-care testing, POCT") provide immediate results and are simple to perform. The most common of these tests is the self control of blood glucose levels in diabetic patients. The use of these devices at the hospital level, introduces a new set of requirements to...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000900018
更新日期:2009-09-01 00:00:00
abstract::A 45 year old male who manipulated tropical fish ponds developed painless nodular plaques in both hands. Biopsy showed mononuclear infiltrate of the dermis with few granulomata. Repeated cultures revealed M. marinum (diagnosis confirmed at the WHO/PAHO Reference Center in Canada). Good initial results were obtained wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::The decrease in mortality in critical patient units led to an increase in intensive care unit acquired weakness (ICUAW), which significantly affects the functional performance and quality of life of patients. There are several scales that measure functionality in critical patients. The aim of this systematic review is...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872017000901137
更新日期:2017-09-01 00:00:00
abstract::Massive pulmonary embolism (PE) is associated with high mortality. There is still a broad assortment of severity classifications for patients with PE, which affects the choice of therapies to use. The main clinical criteria for defining a PE as massive is systemic arterial hypotension, which depends on the extent of v...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013000400010
更新日期:2013-04-01 00:00:00
abstract::This paper presents recommendations on the care of HIV infected adults based upon the authors' personal experience with close to 700 patients in a multiprofessional pilot center. This medical care has 5 main objectives: 1) Promotion of good health (through standard recommendation of hygiene, health habits and regular ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Self-efficacy refers to people's expectations about personal resources available for goal achievement. Higher self-efficacy expectations are correlated with higher academic performance. AIM:To analyze the psychometric properties of the Academic Behavior Self-Efficacy Scale (ABSES) and to describe Self-effic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700914
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Malnutrition has been strongly associated with morbidity and mortality in hemodialysis patients. In the other hand, dialysis allows a nutritional improvement in patients with more than 12 months in dialysis. AIM:To study the prevalence of malnutrition among patients in hemodialysis. PATIENTS AND METHODS:We...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::We report a girl with a chronic hepatitis caused by C virus diagnosed at the age of nine, unsuccessfully treated with interferon and ribavirine. Two years later, she was subjected to a liver transplantation. She maintained elevated viral loads with a normal pathological study of the liver until 22 months after transpl...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000400010
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM:To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS:Revie...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000400003
更新日期:2017-04-01 00:00:00