Abstract:
BACKGROUND:Cellular immune mechanisms of the resistance to infection by T cruzi as well as the pathogenesis of Chagas disease are still controversial. AIM:To quantify and analyse the peripheral blood immune cells from chagasic and non chagasic patients by flow cytometry. PATIENTS AND METHODS:Peripheral blood samples were taken from 21 individuals seropositive for Chagas disease, under no specific treatment. Control samples from 21 healthy blood donors were also obtained. To quantify immune cells populations by flow cytometry, antibodies against CD3, CD4, CD8, CD16/56, CD45/14, CD19 and HLA-DR markers were used. RESULTS:The percentage of CD8+ cells was low and the CD4+/CD8+ ratio was high in chagasic patients, compared to their non infected counterparts. No statistically significant differences in the number of CD4+, NK, B, CD4+HLADR+ and CD8+HLADR+ cells, were observed within the two groups. CONCLUSIONS:These results show that Chilean chronic chagasic patients have lower percentage of CD8+ cells and higher CD4+/CD8+ ratio than non infected individuals.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Sánchez G,Zulantay I,Gajardo M,Venegas J,Villanueva R,Pérez A,Liendo F,Apt W,Solari Asubject
Has Abstractpub_date
2002-04-01 00:00:00pages
363-7issue
4eissn
0034-9887issn
0717-6163journal_volume
130pub_type
杂志文章abstract::Dr. Hernán Iturriaga is now President of Sociedad Médica de Santiago (Chilean Society of Internal Medicine) for the period 1995-1997. He received his M.D. title at the University of Chile in 1961 and his postgraduate training included a USPHS International Postdoctoral Research Fellowship at Mount Sinai School of Medi...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:In patients with colorectal carcinoma, insertions or deletions of short sequences of DNA, a phenomenon called microsatellite instability, are observed. AIM:To look for microsatellite instability and mutations of MLH1 and MSH2 gene mutations in patients with colorectal carcinoma. MATERIAL AND METHODS:Ten pa...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006001000002
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Aging is the main risk factor to acquire breast cancer (BC). Nevertheless BC in elderly patients is sub-represented in clinical trials. AIM:To describe the clinical characteristics and long term treatment results of localized BC in older women. MATERIAL AND METHODS:Review of medical records of 65 women age...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013001200006
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Renal transplantation can be done in patients with neurogenic bladder and clean intermittent self catheterization maintains renal function AIM:To retrospective assess the results of renal transplantation in patients with neurogenic bladder. PATIENTS AND METHODS:The medical records of seven patients aged 10...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Down syndrome (DS) is associated with higher child mortality especially due to cardiac malformations. AIM:To describe the trend in Chilean infant mortality in DS in the period 1997-2013 as compared to the general population without DS. MATERIAL AND METHODS:Raw data on infant deaths were extracted from the ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016001100009
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Several studies indicate that doctors who work in the same area of the medical profession tend to behave somehow similarly. Thus, it has been suggested that personality relates to the medical specialty choice. However, it is not known whether people self-select into the medical specialties according to their...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001000008
更新日期:2005-10-01 00:00:00
abstract::We compared 2 techniques for determination of plasma levels of phenytoin, liquid-gas chromatography (LGC) and homogeneous enzymatic immunoassay (EI) in samples from 72 patients receiving monotherapy with this drug. Determinations were also made in samples of normal plasma with known concentrations of phenytoin. Good c...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::We report a 11 years old male diagnosed as a X-linked hyper-IgM syndrome that presented with recurrent infections and sclerosing cholangitis and later developed a gallbladder cancer. Immunological evaluation showed decreased levels of serum IgG and IgA with elevated levels of IgM. Study of CD40 ligand expression on mi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions. Our in vitro results show that sodium carboxymethylcellulose and methylcellulose cause a significant degradation of diethylpropion, the first having a greater e...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Systemic vasculitis are a group of heterogeneous diseases characterized by inflammation and necrosis of blood vessel walls. The etiology is not known, but geographic and environmental factors are implicated. AIM:To describe the clinical features of microscopic polyangiitis (MPA) and Wegener's granulomatosis...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000300001
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Chile, a middle-income country with an HIV epidemic of moderate proportions (global infection rate 0.2%) began a government sponsored, free, highly active antiretroviral therapy (HAART) for patients from the public health system in 2001 reaching in 2004 a 100% coverage. Arriaran Foundation (AF) is the larges...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000500006
更新日期:2006-05-01 00:00:00
abstract::We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::In an open, pilot study, the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy was investigated. Four patients received 1 g/day of UDCA during 20 days and another 2 patients received 2 identical periods of treatment separated by a 14-day interval free of drug....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::A great progress in the knowledge about hepatitis virus has occurred in the last decades and several virus have been identified. Virus B, C and D are transmitted parenterally, while virus A and E use the enteral route. Highly effective vaccines for A and B hepatitis are presently available. Virus C is an important cau...
journal_title:Revista medica de Chile
pub_type: 社论,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::The prevalence of hepatitis C antibody was studied using the EIA 2 Abbott assay in patients and staff of the San Juan de Dios Hospital Hemodialysis Unit. The antibody was detected in 29.8% of patients, no member of the staff had positive antibodies. Patients with a positive antibody had been on hemodialysis for a long...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Heterozygous familial hypercholesterolemia affects one every 400 individuals, is caused by mutations in the LDL receptor gene and is associated with premature coronary artery disease. Nowadays, LDL cholesterol can be efficiently reduced with the new therapies to reduce blood lipids. We report a female patient who cons...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000200011
更新日期:2007-02-01 00:00:00
abstract::Splenic abscesses are infrequent and usually associated to sepsis and immunodepression. The diagnosis is commonly made in the necropsy. We report two cases of multiple splenic abscesses in type II diabetic patients that were diagnosed by ultrasound. Both patients were successfully managed with surgery (drainage of lef...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::Constrictive Pericarditis (CP) is an unusual disease. Its most common causes are idiopathic or secondary to cardiac surgery. Less frequently it is caused by connective tissue diseases. We report a 30 years old woman hospitalized due to progressive dyspnea, chest pain and signs of right sided heart failure. During her ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000800015
更新日期:2014-08-01 00:00:00
abstract::Approximately 15% of patients with Wolff Parkinson White's syndrome who undergo electrophysiologic study have more than one accessory pathway. We describe the electrophysiologic testing and findings in 2 patients with multiple pathways. Identification of these is highly relevant since successful surgical therapy depen...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a jud...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000400009
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. AIM:To evaluate the impact of IFNL4 rs12979860 polymorphism ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000700823
更新日期:2018-07-01 00:00:00
abstract::The rapid advances in immunobiology, pharmacology and molecular biology have made successful renal transplantation the optimal therapeutic modality for adults and children, reaching a near--90% of patient-graft survival among the first years of transplant. But this knowledge also presents clinicians and scientists wit...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Myocardial bridging of the epicardic coronary arteries is not an uncommon finding in angiographic or necropsic studies. Patients who have symptoms usually improve with medical treatment. However, in refractory patients a surgical myotomy of overlying myocardium and/or a coronary bypass may be needed. We report two pat...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Vitamin K antagonist medications (VKA) are essential for the prevention of thromboembolic events, but their effectiveness is influenced by multiple factors, such as the type of medication chosen. AIM:To evaluate the efficacy in anticoagulant control of the bioequivalent and non-bioequivalent drugs of acenoc...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872020000901254
更新日期:2020-09-01 00:00:00
abstract::Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the pers...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872009000500014
更新日期:2009-05-01 00:00:00
abstract::We surveyed 605 households selected by conglomerate random sampling in a typical Chilean city in order to study patterns of utilization of medicinal agents. The critical item investigated drug use in the week preceding the interview. The 95% confidence limits for drug utilization were 24.1 and 26.8% and for medicinal ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor. AIM:To assess the severity of CHD in pre and postmenopausal patients undergoing coronary angiography and the impact of T2DM in both groups. M...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872020000200145
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The dual potential to promote tolerance or inflammation when facing self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. There is an association between smoking and DCs maturation in patients with rheumatoid arthritis (RA). However, ethnicity is a key factor in autoimmune disorders....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000200150
更新日期:2018-02-01 00:00:00
abstract::We followed 25 patients operated on for Wolff-Parkinson-White syndrome between August 1985 and October 1989. Their mean age was 37 +/- 12 years and arrhythmia had been present for 5 to 30 years. A mean of 3.3 +/- 1.2 antiarrhythmic agents had failed in controlling recurrences. Tachycardia was orthodromic in 21 patient...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Human and animal trichinosis has been recorded in Chile since the late XIX century and is irregularly distributed along the country. From high rates of infection in the early 1900, the frequency of this parasitosis in man has progressively decreased. AIM:To describe and discuss the epidemiological situation...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00