[Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability].

Abstract:

:The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions. Our in vitro results show that sodium carboxymethylcellulose and methylcellulose cause a significant degradation of diethylpropion, the first having a greater effect. Dissolution essays showed that the availability of the drug is vastly reduced by cellulosic derivatives. Provided the close relation between the dissolution and absorption characteristics of a drug, it is possible to predict that this association will result in a poor bioavailability.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Gómez M,Alvarez A,Cid E

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

1013-6

issue

9

eissn

0034-9887

issn

0717-6163

journal_volume

121

pub_type

杂志文章
  • [Glucose tolerance alterations and frequency of metabolic syndrome among patients with non alcoholic fatty liver disease].

    abstract:BACKGROUND:Non alcoholic fatty liver disease (NAFLD) is associated to diabetes mellitus, obesity, disturbances in serum lipid levels, insulin resistance and metabolic syndrome. AIM:To assess glucose tolerance and the presence of metabolic syndrome among patients with biopsy proven NAFLD. PATIENTS AND METHODS:Serum li...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006000900002

    authors: Araya Q AV,Valera M JM,Contreras B J,Csendes J A,Díaz J JC,Burdiles P P,Rojas C J,Maluenda G F,Smok S G,Poniachik T J

    更新日期:2006-09-01 00:00:00

  • [Istanbul declaration on organ trafficking and transplant tourism].

    abstract::This is a translation into Spanish, done by Mario Uribe, M.D., F.A.C.S., and authorized by the Conference Organization, of the official statements signed by The Transplantation Society, The International Society of Nephrology and the representatives who participated at a WHO sponsored Conference held in Istambul, Turk...

    journal_title:Revista medica de Chile

    pub_type: 共识发展会议,杂志文章

    doi:10.4067/S0034-98872009000800019

    authors: Transplantation Society.,International Society of Nephrology.

    更新日期:2009-08-01 00:00:00

  • [Clinical Practice Guidelines for Smoking Cessation].

    abstract::Considering that a high proportion of the Chilean general population smokes, the Chilean Society of Respiratory Diseases in collaboration with the Chilean Societies of Cardiology and, Endocrinology and Diabetes, formed an interdisciplinary group, who issued a set of recommendations for the treatment of the smoker, met...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,实务指引

    doi:10.4067/s0034-98872017001101471

    authors: Corvalán B MP,Véjar M L,Bambs S C,Pavié G J,Zagolin B M,Cerda L J

    更新日期:2017-11-01 00:00:00

  • [Indication of gastrojejunostomy in unresectable pancreatic cancer].

    abstract:BACKGROUND:Up to 20% of patients with pancreatic carcinoma subjected to a bilio digestive diversion, develop a delayed gastric emptying due to duodenal infiltration. However the role of prophylactic gastrojejunoanastomosis is not well defined. AIM:To compare the effects of gastrojejunoanastomosis performed as prophyla...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Espinoza R,Rivera M,Guzmán S

    更新日期:1999-01-01 00:00:00

  • [Retrospective review of 44 Chilean patients with Behçet disease].

    abstract:BACKGROUND:Behçet's disease (BD) is a rare multisystemic inflammatory disease that is potentially disabling and may cause death. AIM:To describe the characteristics of BD patients from two Chilean centers. PATIENTS AND METHOD:Retrospective review of the clinical records of patients with BD attended in two rheumatolog...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009001000008

    authors: Wurmann P,Díaz G,Sabugo F,Soto L,Solanes F,Pino S,Merino G,Verdaguer JI,Villarroel F,Cuchacovich M

    更新日期:2009-10-01 00:00:00

  • [The notion of decision making capacity in medical and legal practice].

    abstract:BACKGROUND:The relationship between patients and health professionals emphasizes deliberation and joint decision making, that derives in the informed consent. AIM:To evaluate decision making of patients in health care and to identify the notion of capacity for decision making, according to lawyers and physicians. MAT...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872007000900009

    authors: Bórquez E G,Raineri B G,Horwitz C N,Huepe O G

    更新日期:2007-09-01 00:00:00

  • [Proposal to address the mental health problems detected after the February 27, 2010 earthquake].

    abstract::One of the most important topics mentioned by people from places affected by the February 27th, 2010 earthquake to the Presidential Delegation for the Reconstruction, was the urgent need of mental health care. Given the enormous individual and social burden of mental health sequelae after disasters, its treatment beco...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000200014

    authors: Figueroa RA,Cortés PF

    更新日期:2016-02-01 00:00:00

  • [Clinical usefulness of toxicology testing].

    abstract::A toxicology testing is the search by the laboratory of the possible etiologic agents that can cause poisoning. Given the wide variety of substances that can poison a person, the laboratories should work coordinated with the emergency wards in order to determine the appropriate tests menu and the required turn around ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009001000018

    authors: Solari G S,Ríos B JC

    更新日期:2009-10-01 00:00:00

  • [Oral cavity changes in alcoholic patients].

    abstract::The aim of this study was to look for pathological changes in the oral cavity in a group of 40 non cirrhotic male alcoholics, ranging in age from 30 to 40 years old. These subjects were compared with a group of 40 non alcoholic male subjects of similar age. The presence of lip, dental, periodontal, salivary gland and ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Esguep A,Ceballos M,Smith P

    更新日期:1994-02-01 00:00:00

  • [Thyroid stimulating hormone reference values derived from the 2009-2010 Chilean National Health Survey].

    abstract:BACKGROUND:The determination of thyroid stimulating hormone (TSH) reference values is critical for the diagnosis of thyroid diseases. AIM:To explore and discuss different definitions to establish TSH reference values using a Chilean national survey sample. MATERIAL AND METHODS:The 2009-2010 Chilean National Health Su...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872013000100013

    authors: Mosso L,Margozzini P,Trejo P,Domínguez A,Solari S,Valdivia G,Arteaga E

    更新日期:2013-01-01 00:00:00

  • [Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus].

    abstract:BACKGROUND:Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. AIM:To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. MATERIA...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005000700001

    authors: Corvalán A,Akiba S,Valenzuela MT,Cumsille MA,Koriyama C,Argandoña J,Backhouse C,Bal M,Mena F,Palma M,Eizuru Y

    更新日期:2005-07-01 00:00:00

  • [Problems in the diagnosis of thyroid dysfunction of the elderly adult].

    abstract::Thyroid disfunction in the aged is often misdiagnosed either due to scanty symptoms, masking by other ailments or because function tests can be altered by extrathyroid causes such as chronic diseases, drugs or undernutrition. We surveyed 93 patients from 60 to 104 years old (73 females) living in geriatric homes. Most...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Wainstein E,Castillo A,Pineda G

    更新日期:1990-04-01 00:00:00

  • [Infective complications of the use of permanent central venous catheters in oncology].

    abstract::We analyzed the infectious complications associated with the use of permanent central venous catheters (PVC) in pediatric and adult cancer patients. 62 patients used 74 PVC (54 external, 20 subcutaneous), which were in place for an average of 200 days with a total observation period of 14,876 days, 152 febrile episode...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Barriga F,Varas M,Capdeville MV,Sapunar F,Lira P,Grebe G

    更新日期:1992-07-01 00:00:00

  • [Cultural and trivial knowledge among Chilean university students].

    abstract:BACKGROUND:Culture is defined by the Webster's dictionary as acquaintance with and taste in fine arts, humanities, and broad aspects of science as distinguished from vocational and technical skills. AIM:To assess the general cultural knowledge of university students. MATERIAL AND METHODS:A test containing 58 question...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872010000300005

    authors: Vargas C NA,Pinochet T D,Juárez E P

    更新日期:2010-03-01 00:00:00

  • [Medical care in Santiago, 1993].

    abstract::Results of morbidity and medical care surveys performed in Santiago in 1993-94 are presented in this paper. The study has been done in an aleatory population sample of 4,700 people coming from 1,000 dwellings. Main results are as following: The Health National Fund (FONASA) is the most important financing medical care...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Medina E,Kaempffer AM,Cornejo E,Hernández E,Wall V

    更新日期:1995-01-01 00:00:00

  • [Professor Dr. Abraham Horwitz Barak (1910-2000)].

    abstract::Abraham Horwitz, MD, was a prominent leader in Public Health in the Americans. His career started as a clinician and researcher in infectious diseases, then as a teacher in two Chilean Universities, one of the organizers of the Public Health Service in Chile and, subsequently, a prominent staff member in the Pan Ameri...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:10.4067/s0034-98872001000400016

    authors: Kraljevic R

    更新日期:2001-04-01 00:00:00

  • [Epidemiological profile of liver cirrhosis in Chile 1970-1992].

    abstract:BACKGROUND:Liver cirrhosis is an important public health problem in Chile. AIM:To review the main epidemiological features of liver cirrhosis in Chile in the last 22 years. METHODS:Review of yearbooks of mortality and causes of death of the Ministry of Health and Instituto Nacional de Estadísticas, review of hospital...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Serra I,Araneda J,Decinti E

    更新日期:1995-11-01 00:00:00

  • [Association between handgrip strength and functional performance in Chilean older people].

    abstract:BACKGROUND:Handgrip strength is an important predictor of functional performance among older adults. AIM:To measure handgrip strength in older adults and relate its values to their clinical functional assessment. MATERIAL AND METHODS:Handgrip strength was measured in 1047 older adults living in the community and aged...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000500007

    authors: Mancilla S E,Ramos F S,Morales B P

    更新日期:2016-05-01 00:00:00

  • [Enteral nutrition in severe ulcerative colitis. Digestive tolerance and nutritional efficiency].

    abstract:BACKGROUNDS AND AIMS:Total parenteral nutrition (TPN) has been traditionally used as an adjunctive therapy in severe ulcerative colitis patients. We performed a prospective study to ascertain the safety, nutritional efficiency, tolerance and costs of total enteral nutrition in this situation. METHODS:After 48 hours of...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Klaassen J,Zapata R,Mella JG,Aguayo G,Alvarado D,Espinosa O,Maíz A,Zúñiga A,Quintana C

    更新日期:1998-08-01 00:00:00

  • [Isolation of several species of the genus Aspergillus from soil of intrahospital ornamental plants].

    abstract::The earth of ornamental plants is one of the main reservoirs of Aspergillus type of fungi in hospital areas. We studied 174 ornamental interior plants from a hospital at Santiago. Samples were obtained from the soil surface and sowed in Sabouraud-glucose agar, adding streptomycin and G-penicillin. After 72 h of cultur...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Thompson L,Castrillón MA,Delgado M,García M

    更新日期:1994-12-01 00:00:00

  • [Adrenal hyperplasia of late onset: optimization of therapy by measuring the circadian variation of serum 17-OH-progesterone].

    abstract::A 19 yr-old female patient with the diagnosis of late onset adrenal hyperplasia was treated since age 15 with different glucocorticoid preparations and dosage schedules plus spironolactone. In spite of a very good response in terms of amelioration of their hirsutism she experienced cushingoid manifestations associated...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Contreras P,Rojas A,Vega I

    更新日期:1989-06-01 00:00:00

  • [Predictive value of the ergometric test stress parameters for myocardial ischemia according to SPECT thallium-201 scintigraphy].

    abstract:BACKGROUND:Exercise EKG is used as the test of choice in the diagnosis of coronary artery disease. Classical parameters are angor and ST depression representing myocardial ischemia. AIM:To correlate exercise EKG parameters with SPECT 201Thallium to know their likelihood ratios for ischemia. PATIENTS AND METHODS:Two h...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Prat H,Massardo T,Jofré J,Vargas J,González P

    更新日期:1998-05-01 00:00:00

  • [Prepatency, parasitemia and histological lesions in mice infected with two Trypanosoma cruzi populations isolated in Chile].

    abstract:BACKGROUND:The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. AIM:To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated in Chile. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005000400006

    authors: Pizzi P T,Wallace R A,Villagra O R,Muñoz V S,Ortiz Z S,Solari I A

    更新日期:2005-04-01 00:00:00

  • [Prevalence of psychiatric disorders among Chilean children and adolescents].

    abstract:BACKGROUND:Psychiatric disorders that appear during childhood or adolescence should be a public health priority. AIM:To report the results of a national representative survey in the Latin American region examining the prevalence of DSM-IV psychiatric disorders in children and adolescents. MATERIAL AND METHODS:Subject...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872012000400005

    authors: Vicente B,Saldivia S,de la Barra F,Melipillán R,Valdivia M,Kohn R

    更新日期:2012-04-01 00:00:00

  • [Influence of personality and learning styles in the choice of medical specialty].

    abstract:BACKGROUND:Several studies indicate that doctors who work in the same area of the medical profession tend to behave somehow similarly. Thus, it has been suggested that personality relates to the medical specialty choice. However, it is not known whether people self-select into the medical specialties according to their...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005001000008

    authors: Bitran M,Zúñiga D,Lafuente M,Viviani P,Mena B

    更新日期:2005-10-01 00:00:00

  • [With regard to COVID-19 contingency. ECMO in adults. Extracorporeal Membrane Oxygenation). To whom, how and when].

    abstract::ECMO (Extracorporeal Membrane Oxygenation) is an extracorporeal life support system in catastrophic lung failure, shock and cardiopulmonary resuscitation, in different age groups, with multiple physiologic features. When the candidate to be submitted is too unstable to be transported to a hospital with ECMO, cannulati...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872020000300349

    authors: Díaz R,Antonini MV,Orrego R,Abrams D

    更新日期:2020-03-01 00:00:00

  • [Clinical characterization of 450 patients with cerebrovascular disease admitted to a public hospital during 1997].

    abstract:BACKGROUND:In Chile, cerebrovascular diseases are the fifth cause of death among men and the third cause among women. AIM:To assess the clinical features and management of patients with cerebrovascular disease admitted to a public hospital during 1997. PATIENTS AND METHODS:A retrospective analysis of clinical records...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Nogales-Gaete J,Núñez L,Arriagada C,Sáez D,Figueroa T,Fernández R,González J,Aragón A,Barrientos N,Varas P,Troncoso B,Cárcamo C,Chávez M,Gumucio M,Holmgrenn P,Beltrán G,San Martín E,Manríquez E,Figueroa C

    更新日期:2000-11-01 00:00:00

  • [Melkersson-Rosenthal syndrome: report of 3 cases].

    abstract::Melkersson-Rosenthal syndrome is characterized by facial or lip edema, peripheral facial palsy and scrotal tongue. We report three patients with the syndrome. A 17 years old male had malar and superior lip enlargement that coincided with a peripheral facial palsy. A 40 years old male with recurrent facial palsy presen...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Donoso A,Esguep A

    更新日期:1995-12-01 00:00:00

  • [Treatment of refractory ascites using a transjugular intrahepatic portosystemic shunt (TIPS). Clinical case].

    abstract::Approximately, 10% of cirrhotic patients with ascites become refractory to medical treatment, a condition that reduces overall survival. TIPS is a therapeutic alternative for the management of refractory ascites. It corrects sinusoidal portal hypertension, becoming a rational and relatively safe therapeutic approach. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Zapata R,Fava M

    更新日期:1999-10-01 00:00:00

  • [Hernán Iturriaga Ruiz, M.D., President of the Medical Society of Santiago, 1995-1997].

    abstract::Dr. Hernán Iturriaga is now President of Sociedad Médica de Santiago (Chilean Society of Internal Medicine) for the period 1995-1997. He received his M.D. title at the University of Chile in 1961 and his postgraduate training included a USPHS International Postdoctoral Research Fellowship at Mount Sinai School of Medi...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:

    authors:

    更新日期:1996-07-01 00:00:00