Abstract:
BACKGROUND:Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. AIM:To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. MATERIAL AND METHODS:Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. RESULTS:Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). CONCLUSIONS:Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Corvalán A,Akiba S,Valenzuela MT,Cumsille MA,Koriyama C,Argandoña J,Backhouse C,Bal M,Mena F,Palma M,Eizuru Ydoi
10.4067/s0034-98872005000700001subject
Has Abstractpub_date
2005-07-01 00:00:00pages
753-60issue
7eissn
0034-9887issn
0717-6163pii
S0034-98872005000700001journal_volume
133pub_type
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