Abstract:
BACKGROUND:Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. AIM:To evaluate the impact of IFNL4 rs12979860 polymorphism on the risk of fibrosis in patients with CHC. MATERIAL AND METHODS:One hundred fifty patients with CHC aged 50 ± 11 years (89 females) were genotyped for IFNL4 rs12979860 using real time PCR. Fibrosis present in liver biopsies was assessed using the METAVIR score, comparing patients with either no fibrosis, mild fibrosis, or intermediate fibrosis (F0+F1+F2, n = 96), with patients with severe fibrosis or cirrhosis (F3+F4, n = 54). RESULTS:In F0-F2 patients the distribution of rs12979860 genotypes was 22 CC, 57 CT and 17 TT, whereas in patients F3-F4 the distribution was 10, 29 and 15, respectively. No association between IFNL4 rs12979860 genotype and risk of fibrosis was observed in uni or multivariate analyses. CONCLUSIONS:IFNL4 rs12979860 C>T polymorphism is not associated with risk of liver fibrosis in this group of patients with CHC.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Brahm J,Urzúa A,Poniachik J,Cáceres DD,Carreño L,Venegas Mdoi
10.4067/s0034-98872018000700823subject
Has Abstractpub_date
2018-07-01 00:00:00pages
823-829issue
7eissn
0034-9887issn
0717-6163pii
S0034-98872018000700823journal_volume
146pub_type
杂志文章abstract::Persistent left superior vena cava is the most common venous congenital malformation and is usually asymptomatic. Its presence could increase the difficulty for transvenous lead implantation. We report a 71-year-old woman with an idiopathic dilated cardiomyopathy, atrial fibrillation and heart failure that required bi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872012000100012
更新日期:2012-01-01 00:00:00
abstract::We report a 70-year-old woman, who had recently consumed shellfish, that was admitted to the intensive care unit with septic shock and died 19 hours later due to a multi-organic failure. Microbiological, serological and molecular assays confirmed a hemolytic tdh+ Vibrio cholerae non-01, non 0139 as the etiologic agent...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000900008
更新日期:2009-09-01 00:00:00
abstract::Hematopoietic precursors transplantation is a therapeutic alternative for leukemia, some metabolic diseases and some immune deficiency syndromes. In its allogeneic variety leukemia eradication is based in the conditioning prior to transplantation and the allograñ effect against leukemia. Umbilical cord blood is an alt...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000800009
更新日期:2009-08-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::We describe findings in 188 patients with Berger's disease, the most frequent primary glomerulopathy in our renal biopsy material (25%). Diagnosis was made by finding IgA and dense mesangial deposits with immunofluorescence and electronmicroscopy, respectively. Patient's age ranged from 3 to 64 years (mean 27), 72 wer...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::One of the main challenges in environmental management is to prevent the public health impact of projects that can cause pollution. To tackle this problem, the new Chilean bill on environmental management has defined the need to determine the potential health risks of a given Project. This paper gives a summary of the...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872011000800015
更新日期:2011-08-01 00:00:00
abstract::Congenital malformations of the spleen are rare. We report a patient with an ectopic spleen located in the left iliac fossa, which was excised in order to prevent severe complications such as torsion of the pedicle, rupture or infection. A second patient with idiopathic thrombocytopenic purpura presented with an acces...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:In Chile, the number of sick leaves due to mental health problems has systematically increased in recent years. AIM:To perform an analysis of sick leaves due to mental problems managed by the Fondo Nacional de Salud (FONASA) during 2008. MATERIAL AND METHODS:Analysis of all sick leaves awarded during 2008 ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000200009
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract::The association of hyperthyroxinemia and euthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 micrograms/dl (N 6.1-12.5), a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 评论,社论
doi:/S0034-98872008000500001
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. AIM:To describe the features of GBS in adult Chilean patients admitted to a tertiar...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000200005
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016001000004
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Thyroid disfunction in the aged is often misdiagnosed either due to scanty symptoms, masking by other ailments or because function tests can be altered by extrathyroid causes such as chronic diseases, drugs or undernutrition. We surveyed 93 patients from 60 to 104 years old (73 females) living in geriatric homes. Most...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Low plasma HDL cholesterol levels are an independent risk factor for atherosclerotic cardiovascular disease. During the past years, the study of HDL has been stimulated by the discovery of novel genes and proteins, which have provided new insights into the molecular and cellular mechanisms involved in HDL metabolism. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872005000700011
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
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doi:
更新日期:1996-08-01 00:00:00
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::We report a 29 years old male, with a history of cocaine abuse and excessive alcohol intake, who was admitted to the hospital with an acute peritonitis. The patient was operated and multiple perforations of the cecum were found. A right hemicolectomy was performed and the pathological study of the surgical piece showe...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2002-06-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract::Malignant Melanoma (MM) incidence rate is increasing faster than many other cancer at present time. Its epidemiological and clinical behavior varies within countries. We have studied 113 cases of cutaneous melanoma from 1982-1993, that represents until now the largest series of MM studied in Chile. Superficial Spreadi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The epidemic of cardiovascular diseases in Chile, requires the development of strategies in health promotion and prevention. AIM:To assess the prevalence of risk factors for chronic non communicable diseases among workers of a financial company in Metropolitan Santiago. MATERIAL AND METHODS:Assessment of 2...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000800008
更新日期:2005-08-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00