Abstract:
BACKGROUND:Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. AIM:To evaluate the impact of IFNL4 rs12979860 polymorphism on the risk of fibrosis in patients with CHC. MATERIAL AND METHODS:One hundred fifty patients with CHC aged 50 ± 11 years (89 females) were genotyped for IFNL4 rs12979860 using real time PCR. Fibrosis present in liver biopsies was assessed using the METAVIR score, comparing patients with either no fibrosis, mild fibrosis, or intermediate fibrosis (F0+F1+F2, n = 96), with patients with severe fibrosis or cirrhosis (F3+F4, n = 54). RESULTS:In F0-F2 patients the distribution of rs12979860 genotypes was 22 CC, 57 CT and 17 TT, whereas in patients F3-F4 the distribution was 10, 29 and 15, respectively. No association between IFNL4 rs12979860 genotype and risk of fibrosis was observed in uni or multivariate analyses. CONCLUSIONS:IFNL4 rs12979860 C>T polymorphism is not associated with risk of liver fibrosis in this group of patients with CHC.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Brahm J,Urzúa A,Poniachik J,Cáceres DD,Carreño L,Venegas Mdoi
10.4067/s0034-98872018000700823subject
Has Abstractpub_date
2018-07-01 00:00:00pages
823-829issue
7eissn
0034-9887issn
0717-6163pii
S0034-98872018000700823journal_volume
146pub_type
杂志文章abstract:BACKGROUND:In Chile, cerebrovascular diseases are the fifth cause of death among men and the third cause among women. AIM:To assess the clinical features and management of patients with cerebrovascular disease admitted to a public hospital during 1997. PATIENTS AND METHODS:A retrospective analysis of clinical records...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::The recent panorama of medical practice regulation in Mexico is exposed. The dynamics of regulation changes is observed in different areas, with particular intensity in the labor market. Changes seem to be moving towards the constitution of a new regulatory model. A full state regulation for the last 50 years, is bein...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::We report preliminary results of treatment of Hodgkin disease according to the National Protocol on Antineoplastic Drugs. 37 males and 22 females with a median age of 34 years (range 16 to 76) were treated. Patients with stages I or II received radiotherapy alone or chemotherapy (C-MOPP) followed by radiotherapy. Pati...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::This article reports the results of 1080 ultrasonographic examinations of the liver in a clinic of the Ninth Region of Chile, using a SSD 620 Aloka equipment. In 61 examinations (5.6%) a focal liver lesion was found. Of these, 9 (14.7% of lesions) appeared as malignant (6 metastasis and 3 hepatomas) and 52 (85.3% of l...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Brain functioning is mainly intrinsic, not primarily reflexive. This is supported by the high energy requirements of the resting brain (20% of all the energy consumed) which only marginally increases with changes in brain activity. Modern neuroimaging and neurophysiological techniques have led to the discovery of the ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872013000300014
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Mitral balloon valvuloplasty (MBV) is the therapy of choice for the treatment of symptomatic mitral stenosis with suitable anatomy. Although its short and mid-term results are favorable, there is a paucity of information about long-term follow-up. AIM:To assess the late results of MBV. MATERIAL AND METHODS...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014001100001
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:It is not clear if old age is a risk factor for adverse drug reactions. AIM:To study the incidence of adverse drug reactions and the effect of age in patients admitted to an Internal Medicine Service in an university hospital. PATIENTS AND METHODS:Two hundred one patients, hospitalized at the Clinical Hosp...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Aortic valve stenosis is the most prevalent valvulopathy in the elderly, but it is frequently undertreated. AIM:To assess early and long term results of valve replacement with bioprostheses in patients 70 years old or older with aortic stenosis. PATIENTS AND METHODS:A review of the database of the Cardiova...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000200002
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:During the last few years, multiple new medical schools have emerged in Chile, associated to the constant preoccupation to provide a good quality medical care. This created the need to evaluate medical training programs and to open a discussion about the attributes that a good physician should have. AIM:To ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000800001
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Illicit drug abuse is a public health problem, generally starting in adolescence. Medical students are not an exception. AIM:To assess the consumption of illicit drugs among medical students of the Pontificia Universidad Católica de Chile. MATERIAL AND METHODS:A questionnaire used by the National Council f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000400002
更新日期:2009-04-01 00:00:00
abstract::Since the first successful pregnancy from a frozen human oocyte was reported, remarkable technological progress has been made in the area of cryopreservation of human oocytes. We report a successful delivery of two healthy babies after transfer of vitrified-warmed embryos derived from intracytoplasmic sperm injection ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000300017
更新日期:2017-03-01 00:00:00
abstract::Aneurysmal bone cysts are benign fibro osseous lesions, rarely present in maxillary region. We report the CT and morphological findings of aneurysmal bone cyst of the maxilla in a 15 years old female. The patient was subjected to a maxillectomy, preserving the orbit floor. The postoperative evolution has been uneventf...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001100012
更新日期:2005-11-01 00:00:00
abstract:UNLABELLED:The lithogenic risk profile is a graphical representation of metabolic factors and urinary saturation involved in the stone formation with their respective critical values. AIM:To determine the lithogenic risk profile in patients with urolithiasis. MATERIAL AND METHODS:Personal data such as anthropometric,...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000600005
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Behçet's disease (BD) is a rare multisystemic inflammatory disease that is potentially disabling and may cause death. AIM:To describe the characteristics of BD patients from two Chilean centers. PATIENTS AND METHOD:Retrospective review of the clinical records of patients with BD attended in two rheumatolog...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009001000008
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Non alcoholic fatty liver disease (NAFLD) is associated to diabetes mellitus, obesity, disturbances in serum lipid levels, insulin resistance and metabolic syndrome. AIM:To assess glucose tolerance and the presence of metabolic syndrome among patients with biopsy proven NAFLD. PATIENTS AND METHODS:Serum li...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000900002
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:the six minute walking distance test (6MWD) is widely used to evaluate exercise capacity in several diseases due to its simplicity and low cost. AIM:to establish reference values for 6MWD in healthy Chilean individuals. MATERIAL AND METHODS:we studied 175 healthy volunteers aged 20-80 years (98 women) with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000900006
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The incidence of morbid obesity is increasing and gastric bypass is the most effective surgical treatment. AIM:To assess the long term results of resection gastric bypass among morbidly obese patients aged less than 18 and over 65 years in terms of weight loss and correction comorbidities. MATERIAL AND MET...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008001000003
更新日期:2008-10-01 00:00:00
abstract::A revolution is taking place in Medicine as a consequence of advances in biotechnology and informatics. The unraveling of the human genome with a description of chromosomal maps for all structural genes affords a new framework for the understanding of etiology, diagnosis and prevention of every disease. More than thre...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Scientific Ethics is the theory and praxis of decisions. Philosophical Ethics is presented as the theory and praxis of the good. As the good differs among cultures, Philosophical Ethics is dependent on the endo-cultural good conception. The decision (included that one of adhesion or not to a world vision) de...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::Priapism is a rare complication of hematological diseases. Among leukemia, it is most frequently seen in patients with chronic myeloid leukemia, due to the high leukocyte counts that these patients achieve. We report a 22 years old male who presented with a priapism lasting more than 24 hours. Thirty six hours after a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::The mortality of acute bacterial meningitis (BM) has remained stable in the last decades in spite of the use of new antibiotics, probably due to vascular complications. We report a 68-year-old woman with BM who had a malignant infarction of left middle cerebral artery territory 72 hours after admission to the hospital...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004001000009
更新日期:2004-10-01 00:00:00
abstract::Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Determination of Alanine aminotransferase serum levels ([ALT]s) is a sensitive ana reliable test for liver diseases. AIM:To report the prevalence of abnormal [ALT]s in Chilean population and to identify associated variables. METHODS:We analyzed data from a random sub-sample of 2,794 adults surveyed during ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000700011
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Domestic violence can have an important influence on mother and child health. AIM:To assess the consequences of remote and actual, emotional or physical, domestic violence on the reproductive and newborn health in pregnant women. MATERIAL AND METHODS:A longitudinal epidemiological observation from an Urban...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Aspirin use is necessary after a coronary angioplasty. It should not be used in patients with a history of hypersensitivity. However, rapid desensitization protocols have been reported to allow its use in such patients. One of these protocols consists in the administration of progressive doses of aspirin, from 1 to 10...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000200016
更新日期:2013-02-01 00:00:00
abstract::The effect of a prolonged course of oral acyclovir was evaluated in 55 pts with recurrent genital herpes (36 men and 19 women). The pts were voluntarily enrolled after an acute episode, with tissue culture viral isolation. All the pts received an initial course with 200 mg of acyclovir x 5 for 10 days. Then they were ...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-08-01 00:00:00
abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000700009
更新日期:2009-07-01 00:00:00
abstract::Endothelial lipase (EL) is synthetized by endothelial cells and its main substrates are lipoprotein phospholipids. Over expression of EL reduces high density lipoprotein (HDL) cholesterol and phospholipids, in vivo and in vitro. Inhibition of the enzyme achieves the opposite effects. The synthesis of the enzyme is reg...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872012000300015
更新日期:2012-03-01 00:00:00
abstract::The accrual of anatomical preparations since the nineteenth century in Santiago, Chile, became the so called "anatomical cabinet" under the supervision of professor Julio F Lafargue. Afterwards, this cabinet evolved to form an anatomical museum in the mid twentieth century. It contained preparations using corpses whos...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
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更新日期:2018-12-01 00:00:00
abstract::The practice of Medicine is exposed to everyday's ethical ventures that, even though not fundamental in a philosophical scope, are most crucial given its incidence and consequences to accessibility and equity in health care. A very special perception must emerge to allow us looking for those situations where moral con...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00