[Interferon Lambda 4 RS12979860 C>T polymorphism is not associated with liver fibrosis in patients with hepatitis C].

Abstract:

BACKGROUND:Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between Interferon-L 4 (IFNL4) rs12979860 C>T polymorphism and risk of liver fibrosis in CHC is contradictory. AIM:To evaluate the impact of IFNL4 rs12979860 polymorphism on the risk of fibrosis in patients with CHC. MATERIAL AND METHODS:One hundred fifty patients with CHC aged 50 ± 11 years (89 females) were genotyped for IFNL4 rs12979860 using real time PCR. Fibrosis present in liver biopsies was assessed using the METAVIR score, comparing patients with either no fibrosis, mild fibrosis, or intermediate fibrosis (F0+F1+F2, n = 96), with patients with severe fibrosis or cirrhosis (F3+F4, n = 54). RESULTS:In F0-F2 patients the distribution of rs12979860 genotypes was 22 CC, 57 CT and 17 TT, whereas in patients F3-F4 the distribution was 10, 29 and 15, respectively. No association between IFNL4 rs12979860 genotype and risk of fibrosis was observed in uni or multivariate analyses. CONCLUSIONS:IFNL4 rs12979860 C>T polymorphism is not associated with risk of liver fibrosis in this group of patients with CHC.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Brahm J,Urzúa A,Poniachik J,Cáceres DD,Carreño L,Venegas M

doi

10.4067/s0034-98872018000700823

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

823-829

issue

7

eissn

0034-9887

issn

0717-6163

pii

S0034-98872018000700823

journal_volume

146

pub_type

杂志文章
  • [Placement of a biventricular resynchronization device in a patient with a persistent left superior vena cava: report of one case].

    abstract::Persistent left superior vena cava is the most common venous congenital malformation and is usually asymptomatic. Its presence could increase the difficulty for transvenous lead implantation. We report a 71-year-old woman with an idiopathic dilated cardiomyopathy, atrial fibrillation and heart failure that required bi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872012000100012

    authors: Vergara SI,Frangini SP,Barrero VR

    更新日期:2012-01-01 00:00:00

  • [Non-toxigenic hemolytic Vibrio cholerae non-O1 non-O139 fatal septicemia. Report of one case].

    abstract::We report a 70-year-old woman, who had recently consumed shellfish, that was admitted to the intensive care unit with septic shock and died 19 hours later due to a multi-organic failure. Microbiological, serological and molecular assays confirmed a hemolytic tdh+ Vibrio cholerae non-01, non 0139 as the etiologic agent...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000900008

    authors: Briceño L I,Puebla A C,Guerra A F,Jensen F D,Núñez B H,Ulloa F MT,Osorio A CG

    更新日期:2009-09-01 00:00:00

  • [Umbilical cord hematopoietic precursors transplantation. Report of five patients].

    abstract::Hematopoietic precursors transplantation is a therapeutic alternative for leukemia, some metabolic diseases and some immune deficiency syndromes. In its allogeneic variety leukemia eradication is based in the conditioning prior to transplantation and the allograñ effect against leukemia. Umbilical cord blood is an alt...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000800009

    authors: Burotto P M,Bertín C-M P,Galindo A H,Garrido S M,Melgoza P G,Nervi N B,Ramírez V P,Ocqueteau T M,Besa de C P,García V V,Jara A V,Alvarez J E,Betancur B M,Rivera L M,Alvarez Z M

    更新日期:2009-08-01 00:00:00

  • [Tumorogenesis and mdm2 protein].

    abstract::Tumorogenesis is associated with several events by which a normal cell transforms itself into a tumour cell with an increased proliferation rate. One of the most important research initiatives in this area is the characterization of the molecular mechanisms involved in tumorogenesis and cancer. Oncogenes and tumour su...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Flores C,Sobrevia L

    更新日期:2000-05-01 00:00:00

  • [Primary nephropathy due to mesangial deposits of IgA (Berger's disease)].

    abstract::We describe findings in 188 patients with Berger's disease, the most frequent primary glomerulopathy in our renal biopsy material (25%). Diagnosis was made by finding IgA and dense mesangial deposits with immunofluorescence and electronmicroscopy, respectively. Patient's age ranged from 3 to 64 years (mean 27), 72 wer...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rosenberg H

    更新日期:1990-02-01 00:00:00

  • [Evaluation of public health risk. A new instrument for environmental management in Chile].

    abstract::One of the main challenges in environmental management is to prevent the public health impact of projects that can cause pollution. To tackle this problem, the new Chilean bill on environmental management has defined the need to determine the potential health risks of a given Project. This paper gives a summary of the...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872011000800015

    authors: Matus C P

    更新日期:2011-08-01 00:00:00

  • [Ectopic or migrating spleen and supernumerary spleens: detection and identification with 99mTc, 51Cr and 113In radioisotopes].

    abstract::Congenital malformations of the spleen are rare. We report a patient with an ectopic spleen located in the left iliac fossa, which was excised in order to prevent severe complications such as torsion of the pedicle, rupture or infection. A second patient with idiopathic thrombocytopenic purpura presented with an acces...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Etcheverry R,Allamand JP,Guzmán G,Robinson MI

    更新日期:1989-12-01 00:00:00

  • [Analysis of sick leaves due to mental and behavioral problems].

    abstract:BACKGROUND:In Chile, the number of sick leaves due to mental health problems has systematically increased in recent years. AIM:To perform an analysis of sick leaves due to mental problems managed by the Fondo Nacional de Salud (FONASA) during 2008. MATERIAL AND METHODS:Analysis of all sick leaves awarded during 2008 ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872012000200009

    authors: Miranda GH,Alvarado SO,Kaufman JS

    更新日期:2012-02-01 00:00:00

  • [Spontaneous tendon rupture in disseminated lupus erythematosus. A clinical case].

    abstract::A 37-year-old female with systemic lupus erythematosus and chronic treatment with steroids developed spontaneous bilateral rupture of tendons of both quadriceps muscles below the patella. Surgical treatment was undertaken with good results. The histologic features and a review of the literature are included. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Segovia A,Román JC,Hinojosa M,Ruiz A,Guzmán L

    更新日期:1990-09-01 00:00:00

  • [Hyperthyroxinemia and clinical euthyroidism. Report of one case].

    abstract::The association of hyperthyroxinemia and euthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 micrograms/dl (N 6.1-12.5), a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: López JM,Mosso L,Campino C

    更新日期:1999-02-01 00:00:00

  • [Fighting the coronary artery disease epidemic in Chile: caveats in the control of cardiovascular risk factors].

    abstract::In this issue of the journal Lanas et al report an estimation of population attributable risk (PAR) for myocardial infarction (MI) derived from different risk factors in Chile. Cigarette smoking, dyslipidemia and hypertension accounted for 71% of total PAR. Mortality from MI has decreased in Chile, but epidemiologic s...

    journal_title:Revista medica de Chile

    pub_type: 评论,社论

    doi:/S0034-98872008000500001

    authors: Chamorro S G

    更新日期:2008-05-01 00:00:00

  • [Obese women of high and low socioeconomic status diet composition and serum levels of lipoproteins].

    abstract::We studied plasma lipoproteins in 2 groups of 50 women each, one with a high (A) and the other low socio-economic status (B). Age, caloric intake, energy output and weight for height relation were comparable in both groups. A significant difference was found in plasma levels of triglycerides (A = 138.9 vs B = 104.8 mg...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Albalá C,Villarroel P,Olivares S,Truffello I,Vio Del F,Andrade M

    更新日期:1989-01-01 00:00:00

  • [Clinical features of Guillain-Barré syndrome in 41 patients admitted to a public hospital].

    abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%. AIM:To describe the features of GBS in adult Chilean patients admitted to a tertiar...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015000200005

    authors: Cea G,Jara P,Quevedo F

    更新日期:2015-02-01 00:00:00

  • [Implications of chilean legal framework in teen pregnancy prevention: conflict and insecurity in health professionals].

    abstract:BACKGROUND:Teenage pregnancy is a psychosocial and multifactorial problem described as a lack of exercise of rights in sexual and reproductive health. There are important aspects in the doctor-patient relationship and confidentiality that directly affect the continuity and quality of care. There are controversies in th...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016001000004

    authors: Luttges D C,Leyton M C,Leal F I,Troncoso E P,Molina G T

    更新日期:2016-10-01 00:00:00

  • [The value of cerebral biopsy in patients with AIDS and extensive cerebral lesions].

    abstract::We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Torrealba G,Acuña G,Tagle P,Tapia J,Huete I

    更新日期:1990-12-01 00:00:00

  • [Carotid endarterectomy combined with myocardial revascularization: report of 27 patients].

    abstract::Atherosclerosis is a systemic disease that may involve more than one territory. Myocardial infarction can occur after carotid endarterectomy and stroke is a well documented morbidity of coronary artery bypass grafting. To optimize results, we have performed concomitant carotid endarterectomy and myocardial revasculari...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Mertens R,Valdés F,Krämer A,Morán S,Zalaquett R,Irarrázaval M,Maturana G

    更新日期:1996-12-01 00:00:00

  • [Problems in the diagnosis of thyroid dysfunction of the elderly adult].

    abstract::Thyroid disfunction in the aged is often misdiagnosed either due to scanty symptoms, masking by other ailments or because function tests can be altered by extrathyroid causes such as chronic diseases, drugs or undernutrition. We surveyed 93 patients from 60 to 104 years old (73 females) living in geriatric homes. Most...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Wainstein E,Castillo A,Pineda G

    更新日期:1990-04-01 00:00:00

  • [HDL cholesterol: a new target in the treatment of lipid disorders and atherosclerosis?].

    abstract::Low plasma HDL cholesterol levels are an independent risk factor for atherosclerotic cardiovascular disease. During the past years, the study of HDL has been stimulated by the discovery of novel genes and proteins, which have provided new insights into the molecular and cellular mechanisms involved in HDL metabolism. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/s0034-98872005000700011

    authors: Laris Mdel R,Arteaga A,Cuevas A,Rigotti A

    更新日期:2005-07-01 00:00:00

  • [Ethical problems in daily medical practice].

    abstract::The practice of Medicine is exposed to everyday's ethical ventures that, even though not fundamental in a philosophical scope, are most crucial given its incidence and consequences to accessibility and equity in health care. A very special perception must emerge to allow us looking for those situations where moral con...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rosselot E

    更新日期:1994-01-01 00:00:00

  • [Learning strategies of autonomous medical students].

    abstract:BACKGROUND:Understanding how autonomous students are capable of regulating their own learning process is essential to develop self-directed teaching methods. AIM:To understand how self-directed medical students approach learning in medical schools at University of Concepción, Chile. MATERIAL AND METHODS:A qualitative...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015001200011

    authors: Márquez U C,Fasce H E,Ortega B J,Bustamante D C,Pérez V C,Ibáñez G P,Ortiz M L,Espinoza P C,Bastías V N

    更新日期:2015-12-01 00:00:00

  • [Intraoperative monitoring of gastric intramucosal pH].

    abstract:BACKGROUND:Gastric mucosal pH may be a good indicator of splanchnic tissue oxygenation. AIM:To study the effects of abdominal surgical procedures on gastric mucosal pH. PATIENTS AND METHODS:Eighteen patients subjected to abdominal surgery were studied. All patients received general anesthesia and hemodynamic paramete...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Concha M,Añazco R,González A,Becker D,Gajardo A

    更新日期:1996-08-01 00:00:00

  • [The duty to inform in the Chilean legislation].

    abstract::The new Chilean regulation about patients' rights and duties is generating a significant change in the information that health care professionals must provide to their patients. This issue will gravitate on medical liability. If this duty is accomplished incorrectly, professionals would fall into an illicit act and be...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872018000800909

    authors: Pizarro W C

    更新日期:2018-08-01 00:00:00

  • [Immunologic and insulin secretion markers in non insulin dependent diabetic patients with secondary failure to oral hypoglycemic drugs].

    abstract:BACKGROUND:The pathogenesis of secondary failure to hypoglycemic agents is heterogeneous. Some patients are true insulin dependent diabetics with a slow autoimmune disease suggested by their positive islet cell antibodies. Others, have an increased insulin resistance. AIM:To assess the frequency of positive islet cell...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Maiz A,Manrique M,Arteaga A,Acosta AM,Andrade L

    更新日期:1995-10-01 00:00:00

  • [Chronic kidney disease: classification, mechanisms of progression and strategies for renoprotection].

    abstract::Chronic kidney disease is a worldwide health problem. The incidence and prevalence of kidney failure is in constant increase, involving poor outcomes and high costs. The leading causes of kidney failure are type 2 diabetes and hypertension. The new initiative "Kidney Disease Improving Global Outcomes (KDIGO)" is a glo...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/s0034-98872005000300011

    authors: Mezzano S,Aros C

    更新日期:2005-03-01 00:00:00

  • [Evolution of atypical gynecological cervical smears in a captive population].

    abstract:BACKGROUND:An atypical cervical smear may represent a wide variety of lesions, from banal diseases to invasive neoplastic lesions. AIM:To study the evolution of atypical cervical smears in a highly controlled women population. MATERIAL AND METHODS:A retrospective analysis of 117 women with atypical cervical smears, d...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Vilches K,Escalona A

    更新日期:1998-03-01 00:00:00

  • [Ischemic colitis induced by cocaine. Clinical case].

    abstract::We report a 29 years old male, with a history of cocaine abuse and excessive alcohol intake, who was admitted to the hospital with an acute peritonitis. The patient was operated and multiple perforations of the cecum were found. A right hemicolectomy was performed and the pathological study of the surgical piece showe...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Boza C,Dagnino B,Garrido AM,Llanos O

    更新日期:2002-06-01 00:00:00

  • [Spontaneous hemoperitoneum caused by intraabdominal variceal rupture in a patient with liver cirrhosis. Clinical case].

    abstract::Spontaneous hemoperitoneum secondary to intraabdominal variceal rupture, is an uncommon and highly lethal complication of cirrhosis. We report a case of a 68 years old male submitted because of abdominal pain and fainting. The clinical and laboratory work up concluded that the patient had cirrhosis and hemoperitoneum....

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Moreno JP,Piña R,Rodríguez F,Korn O

    更新日期:2002-04-01 00:00:00

  • [Clinical study of 113 cases of malignant melanoma].

    abstract::Malignant Melanoma (MM) incidence rate is increasing faster than many other cancer at present time. Its epidemiological and clinical behavior varies within countries. We have studied 113 cases of cutaneous melanoma from 1982-1993, that represents until now the largest series of MM studied in Chile. Superficial Spreadi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cabrera R,Silva S,Díaz de Medina J,Hoell I,Guglielmetti A,Rohmann I

    更新日期:1994-08-01 00:00:00

  • [Risk factors for non communicable chronic diseases among workers of a financial company].

    abstract:BACKGROUND:The epidemic of cardiovascular diseases in Chile, requires the development of strategies in health promotion and prevention. AIM:To assess the prevalence of risk factors for chronic non communicable diseases among workers of a financial company in Metropolitan Santiago. MATERIAL AND METHODS:Assessment of 2...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005000800008

    authors: Fagalde Mdel P,del Solar JA,Guerrero M,Atalah E

    更新日期:2005-08-01 00:00:00

  • [Familial recurrence of non syndromic cleft lip with or without cleft palate in Chilean populations].

    abstract:BACKGROUND:The presence of major genes in the susceptibility of non syndromic cleft lip with or without cleft palate (CL/P) in Chile has been postulated, considering the high prevalence and familial aggregation of this condition. AIM:To study the familial recurrence of CL/P in Chile. PATIENTS AND METHODS:The recurren...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Palomino H,Guzmán E,Blanco R

    更新日期:2000-03-01 00:00:00