Abstract:
BACKGROUND:Vitamin K antagonist medications (VKA) are essential for the prevention of thromboembolic events, but their effectiveness is influenced by multiple factors, such as the type of medication chosen. AIM:To evaluate the efficacy in anticoagulant control of the bioequivalent and non-bioequivalent drugs of acenocoumarol compared to the reference drug. To evaluate the efficacy of warfarin bioequivalents available in Chile. To contrast the overall anticoagulant control efficacy between acenocoumarol and warfarin. MATERIAL AND METHODS:The results of 69333 outpatient oral anticoagulation controls were analyzed. Patient were separated in groups according to the drug that they used. Subsequently, the proportions of controls outside the range for each of acenocoumarol and warfarin bioequivalent drugs were compared. Acenocoumarol non-bioequivalent drugs were also compared with the reference drug. Acenocoumarol was compared with warfarin. RESULTS:Acenocoumarol bioequivalent drugs and the reference drug had a similar proportion of controls outside the range (Odds ratios (OR) 0.812; 0.969; 0.974 and 0.963). Non-bioequivalent drugs had a higher proportion than the reference drug (OR 1.561 and 2.037). Both warfarin brands have a similar proportion of controls outside of the range (OR 1.050). Acenocoumarol compared to warfarin had a significant higher proportion of controls outside the range (OR 1.191). CONCLUSIONS:The pharmacological presentation of vitamin K antagonists could influence anticoagulant control. Therefore, it is not prudent to switch these presentations frequently.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Rodríguez D,Nieto E,Quiroga T,Rojas E,Vera Fdoi
10.4067/S0034-98872020000901254subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1254-1260issue
9eissn
0034-9887issn
0717-6163pii
S0034-98872020000901254journal_volume
148pub_type
杂志文章abstract::Specialists must be trained in properly certified university centers. There are established applicant selection programs and mechanisms and faculties maintain a favorable learning environment. The careful selection of teachers must be based in their personal attributes, their interest and dedication to academic work a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::The author in this short text remembers the passing of a beloved pet cat. Cats are beautiful animals and wonderful companions. They evolved together with humans in Africa, subsequently spread over the five continents with them, and became the subject of many human cultural activities, including art, poetry and religio...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000100091
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Postpartum depression (PPD) is a public health issue, and appropriate screening may lead to clinical gains. AIM:To describe the screening for PPD, its relationship with the use of health care services, and treatment access barriers in Chilean public primary health care (PHC) centers. MATERIAL AND METHODS:P...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:10.4067/s0034-98872018000901001
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Women in childbearing ages (WCBA) represent a strategic intervention group to reverse the global trend of increasing obesity. AIM:To conduct a review of studies reporting obesity prevalence in WCBA in Chile in the last 25 years. MATERIAL AND METHODS:To describe obesity prevalence, we used three approaches,...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872014001100011
更新日期:2014-11-01 00:00:00
abstract:UNLABELLED:Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensitivity. GOAL:To determine values of GHBP for a normal Chilean pediatric population. METHODS:We determined GHBP levels in 73 males and 73 females between 4 to 15.5 ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Human and animal trichinosis has been recorded in Chile since the late XIX century and is irregularly distributed along the country. From high rates of infection in the early 1900, the frequency of this parasitosis in man has progressively decreased. AIM:To describe and discuss the epidemiological situation...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Dr. Hernán Iturriaga is now President of Sociedad Médica de Santiago (Chilean Society of Internal Medicine) for the period 1995-1997. He received his M.D. title at the University of Chile in 1961 and his postgraduate training included a USPHS International Postdoctoral Research Fellowship at Mount Sinai School of Medi...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::An alternative strategy for cancer treatment is the manipulation of the immune system, denominated cancer immunotherapy. The immunotherapeutical use of cells of the immune system, like dendritic cells (DC), is being explored in different clinical protocols. Recently, we finalized a clinical phase I protocol, for the t...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
abstract::The aim of this work was to analyze the global incidence of congenital malformations at the Maternity of University of Chile Clinical Hospital in the periods between 1971 and 1977 and between 1982 and 1992. A significant and sustained increase in incidence was observed in the first period from 10.64 per 1000 born aliv...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::We investigated medical leaves of personnel at Temuco's hospital from 1986 to 1987. 57% of persons had at least one leave and 54% of these had 2 or more leaves. Women and paramedicals had more medical leaves. Most absences occurred in june, july, august (p less than 0.01). Most leaves were caused by respiratory diseas...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::A revolution is taking place in Medicine as a consequence of advances in biotechnology and informatics. The unraveling of the human genome with a description of chromosomal maps for all structural genes affords a new framework for the understanding of etiology, diagnosis and prevention of every disease. More than thre...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-05-01 00:00:00
abstract::Hemophagocytic syndrome is a severe condition of excessive immune activation that has a high mortality in the absence of treatment. The syndrome is classified as primary if associated with congenital or hereditary problems, or secondary/acquired if associated with infectious, autoimmune or oncology diseases. We report...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872015000900010
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Intestinal intussusception, a medical emergency, is more commonly idiopathic and ileocolic and occurs with higher frequency in children aged 6 months to 2 years. Barium enema confirms the diagnosis and allows its hydrostatic reduction, that is the treatment of choice of this condition. AIM:To report our exp...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The permanent surveillance of antimicrobial susceptibility of Shigella sp in the Temuco Regional Hospital, allowed us to define the empirical use of antimicrobials in dysenteric syndrome. AIM:To study antimicrobial susceptibility of Shigella strains collected from 1997 to May 2001 and compare the results wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::We evaluated 77 patients with symptomatic mitral stenosis for balloon valvuloplasty. Five patients were excluded from the procedure due to the presence of intra-atrial thrombi or mitral valve endocarditis as detected by 2D echocardiography. The mean age of the 72 treated patients was 38 +/- 11 years, 68 were NYHA func...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::We studied 36 men and 94 women aged 60 to 85 years, without nutritional deficiencies or illness that could interfere with hematopoiesis, to characterize the normal limits of red and white blood cell counts. Lower limit of hemoglobin normal values were 132 g/l for men and 125 g/l for women. The corresponding figures fo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:With the aim of contributing to he Healthy Goal 2010 of reducing significantly the prevalence of childhood obesity we developed and implemented during 2003 and 2004, a school-based obesity prevention intervention which included nutrition education and the promotion of physical activity. AIM:To report the re...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:/S0034-98872008000100003
更新日期:2008-01-01 00:00:00
abstract::Nausea and vomiting of pregnancy, "morning sickness", is a common contemporary complaint. Many pregnant patients note alterations in smell and taste which can precipitate "morning sickness", symptoms that characterize early gestation. Epidemiologic studies suggest that pregnancies accompanied by "morning sickness" hav...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872002000500014
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:in fulminant hepatic failure, different organs systems become involved and a multiple systems organic failure may ensure. AIM:to perform a retrospective analysis of patients with fulminant hepatic failure admitted to UC Hospital Intensive Care Unit. PATIENTS AND METHODS:the charts of fourteen patients (8 m...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::This article explores the causes of the crisis in the role of internists. As in the United States, the progressive specialization of internists lead to a dehumanized, expensive and technical practice of medicine. Aiming to better incomes and prestige, more than 60% of internists practice as specialists. Primary care p...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Noncardiogenic pulmonary edema is a well recognized complication of upper airway obstruction. We report the case of a previously healthy 18-year-old male who presented this complication following laryngospasm after anesthesia. He developed severe pulmonary edema with hypoxemia, high cardiac output and low pulmonary ca...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::We report a 29 years old male, with a history of cocaine abuse and excessive alcohol intake, who was admitted to the hospital with an acute peritonitis. The patient was operated and multiple perforations of the cecum were found. A right hemicolectomy was performed and the pathological study of the surgical piece showe...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Mental disorders may interfere, aggravate or mimic medical conditions. AIM:To study the prevalence of psychiatric disorders among patients hospitalized in a medical ward of a general hospital. PATIENTS AND METHODS:A structured interview for DSM-III, devised for "non patients", was applied to 203 men and 20...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::We report a 34-years-old male, with a history of hepatitis B and human immunodeficiency virus (HIV) infection that was admitted to the hospital with malaise, weight loss, frontal behavior and chest pain. Imaging studies showed two frontal cortical/subcortical nodules. A stereotactic cerebral biopsy showed reactive gli...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000200012
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccin...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Secondary acute myeloid leukemia is a very rare complication in patients with solid organ transplantation. We report a 62 years old female who received a right single lung allograft for idiopathic pulmonary fibrosis. Her immunosuppression scheme consisted in prednisone, azathioprine, and tacrolimus. Two years after th...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000200015
更新日期:2015-02-01 00:00:00
abstract::We studied 60 females using either intrauterine device or taking oral contraceptive pills. Hemoglobin, serum iron, total iron binding capacity and saturation of transferrin were determined before and 4 and 10 months after starting a responsible paternity program. Women with a basal hemoglobin level below 12 g/dl were ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::Geographical inequalities arising in the death of children under 1 year are studied. Causes regarded as avoidable at the present moment and leading to death are determined and the 27 Regional Chilean Health Services are ranked from best to worse in levels of mortality using cluster analysis. Results show that: 1) t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1982-04-01 00:00:00
abstract::This is a comparative review of sick leave and wage replacement policies among countries of the Organization for Economic Co-operation and Development (EOCD), an organism that Chile joined recently. This review also deals with the main transformations applied to the system to improve its effciency and the variables th...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872011000400013
更新日期:2011-04-01 00:00:00
abstract::Since 1981, we have treated 46 adults aged 56 +/- 21 years, of whom 17 were diabetic, with intermittent peritoneal dialysis. Their mean time on dialysis has been 21 months with an accumulated experience of 493 months/patient. The program included 2 dialyses per week, 25 exchanges of 21 per session and 30 min of dwell ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00