[Metabolic Syndrome: clinical and pathophysiological basis for a rational therapeutical approach].

Abstract:

:Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistence of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, which inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferators-activated receptors (PPAR) seems promising.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Martínez R G,Alonso K R,Novik A V

doi

/S0034-98872009000500014

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

685-94

issue

5

eissn

0034-9887

issn

0717-6163

pii

S0034-98872009000500014

journal_volume

137

pub_type

杂志文章,评审
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  • [Sexually transmitted diseases: epidemiological characteristics of cases notified in the health service of Viña del Mar-Quillota].

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    pub_type: 杂志文章,评审

    doi:

    authors: Cruz-Coke R

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