[Multiple organ failure syndrome in fulminant hepatic failure].

Abstract:

BACKGROUND:in fulminant hepatic failure, different organs systems become involved and a multiple systems organic failure may ensure. AIM:to perform a retrospective analysis of patients with fulminant hepatic failure admitted to UC Hospital Intensive Care Unit. PATIENTS AND METHODS:the charts of fourteen patients (8 male) were analyzed. Multiple systems organic failure was defined as the presence of 2 or more organic dysfunctions. The evolution and mortality of these patients was analyzed. RESULTS:patient's ages ranged from 30 to 74 years. The etiology of hepatic failure was B hepatitis in 4, non A non B hepatitis in 5, acute fatty liver of pregnancy in 3 and use of halothane and HIN in 2. ICU stay ranged from 1 to 44 days and 2 patients survived (one with drug induced liver failure and one with acute fatty live of pregnancy). Mean prothrombin time was 19 +/- 9.5%, total bilirrubin was 24 +/- 8.9 mg/dl and 12 patients reached grade IV encephalopathy. Mean admission APACHE II score was 21.5 +/- 6. Twelve patients developed multiple systems organic failure, that appeared 1.5 days after or was already present at ICU admission; it lasted a mean of 2.5 days and all these 12 patients died. Neurologic involvement occurred in 13 patients, renal in 10, cardiovascular in 9, respiratory in 5 and hematological involvement in 1. CONCLUSIONS:multiple systems organic failure is frequent in fulminant hepatic failure and is associated with a high mortality.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Andresen M,Arrese M,Dussaillant G,Dougnac A,Campusano C,Glasinovic JC

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

661-6

issue

6

eissn

0034-9887

issn

0717-6163

journal_volume

122

pub_type

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