Abstract:
:Beta 2 microglobulin is a low molecular weight protein integrating the light chain HLA antigens. Its serum concentration is increased in different neoplasias and in renal failure. Using solid phase RIA we determined the concentration of beta 2 microglobulin in plasma and spinal fluid of 57 healthy individuals and patients with hematologic neoplasia. Serum levels were 1.34 +/- 0.34 mg/l and spinal fluid levels were 1.3 +/- 0.7 mg/l in healthy subjects. Serum levels in 29 patients with myeloma was 7.51 mg/l, significantly higher in those with renal failure (12.35 mg/l) compared to those without (4.54). In 30 patients with non-Hodgkin lymphoma the mean serum levels were 2.90 mg/l, significantly greater in those with active disease (3.18) than in those with remission (1.5). No difference was found according to the degree of malignancy. Patients with acute lymphatic leukemia had elevated values of beta 2 microglobulin while the disease was active (3.37 mg/l), decreasing to normal levels after remission (1.79 mg/l). Spinal fluid levels of beta 2 microglobulin were elevated only in patients with central nervous system involvement. Our results indicate that serum levels of beta 2 microglobulin are helpful in patients with hematologic neoplasia in assessing the activity of the disease and tumor mass, especially in multiple myeloma.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Rodríguez MA,Lira P,Foradori A,Grebe Gsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
538-42issue
6eissn
0034-9887issn
0717-6163journal_volume
116pub_type
杂志文章abstract::Kidney graft loss because arterial thrombosis is not common and is related to risk factors such as recurrent vascular hemodialysis access thrombosis, collagen-vascular disease, repeated miscarriage, diabetes mellitus and thrombophilia. Patients having this last disorder have an increased risk of repeated thrombosis in...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000100014
更新日期:2007-01-01 00:00:00
abstract::Thyroid disfunction in the aged is often misdiagnosed either due to scanty symptoms, masking by other ailments or because function tests can be altered by extrathyroid causes such as chronic diseases, drugs or undernutrition. We surveyed 93 patients from 60 to 104 years old (73 females) living in geriatric homes. Most...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000700009
更新日期:2009-07-01 00:00:00
abstract::We followed 25 patients operated on for Wolff-Parkinson-White syndrome between August 1985 and October 1989. Their mean age was 37 +/- 12 years and arrhythmia had been present for 5 to 30 years. A mean of 3.3 +/- 1.2 antiarrhythmic agents had failed in controlling recurrences. Tachycardia was orthodromic in 21 patient...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Psychiatric disorders that appear during childhood or adolescence should be a public health priority. AIM:To report the results of a national representative survey in the Latin American region examining the prevalence of DSM-IV psychiatric disorders in children and adolescents. MATERIAL AND METHODS:Subject...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012000400005
更新日期:2012-04-01 00:00:00
abstract::We report a 11 years old male diagnosed as a X-linked hyper-IgM syndrome that presented with recurrent infections and sclerosing cholangitis and later developed a gallbladder cancer. Immunological evaluation showed decreased levels of serum IgG and IgA with elevated levels of IgM. Study of CD40 ligand expression on mi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The great diversity of commercially available products for the serologic diagnosis of Chagas disease led us to conduct a study of these products in comparison with the indirect immunofluorescence test. Percent agreement between methods ranged from 79 to 100%, the details for each product being given in the text. Bette...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:There is a correlation between aging and the decrease of plasma levels of vitamin B-12. AIM:To determine the prevalence of vitamin B-12 and folate deficiency and its hematological impact among older adults (AM). MATERIAL AND METHODS:Cross-sectional study, in 1028 subjects aged 65 to 87years, living in comm...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000100006
更新日期:2010-01-01 00:00:00
abstract::Hospital bed availability, trends in number of beds, productivity and administrative aspects in the public and private hospital sectors are analyzed. At present, there are 3.3 beds per 1000 population in Chile. This represents a decrease from previous figures, in spite of increasing demands derived from population agi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM:To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS:Revie...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000400003
更新日期:2017-04-01 00:00:00
abstract::Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral purpuric rash in the limbs with severe malaise. Specific IgM antibodies in ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000500011
更新日期:2008-05-01 00:00:00
abstract::We report a 70 years old man presenting with malaise, anal pain and progressive defecation difficulty, with a decrease in stool caliber. The patient had no contact or past history of tuberculosis. On physical examination, there was an ulcerated anal lesion with purulent discharge, that produced an anal stenosis. The p...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In non smokers, obesi...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872014000200010
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Non alcoholic fatty liver disease (NAFLD) is associated to diabetes mellitus, obesity, disturbances in serum lipid levels, insulin resistance and metabolic syndrome. AIM:To assess glucose tolerance and the presence of metabolic syndrome among patients with biopsy proven NAFLD. PATIENTS AND METHODS:Serum li...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000900002
更新日期:2006-09-01 00:00:00
abstract::Jehovah Witnesses cite religious motives to refuse transfusions of whole blood or its components for themselves and their children, even when life is endangered. An ethical analysis of decision making in health problems is made, giving priority to the alternatives chosen by the patient. One of the elements that turns ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:The 2014 Guidelines for the Management of Patients with Valvular Heart Disease require to know the probability of success and operative mortality of Mitral Valve Repair (MVR) for Degenerative Mitral Insufficiency (DMI) at a given institution. AIM:To assess the probability of success, operative mortality and...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015001000001
更新日期:2015-10-01 00:00:00
abstract::One thousand women hospitalized at a maternity were surveyed after their delivery or abortion about their first sexual intercourse and pregnancy. Mean age at the first sexual intercourse was 18.7 years and only 9.2% used a contraceptive method in spite that 20% were not willing to become pregnant. The mean age of sexu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract:UNLABELLED:Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensitivity. GOAL:To determine values of GHBP for a normal Chilean pediatric population. METHODS:We determined GHBP levels in 73 males and 73 females between 4 to 15.5 ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:We report a 56 year old male hypertensive, who presented with a posterior reversible encephalopathy syndrome (PRES) as an initial manifestation of Guillain-Barré syndrome (GBS). His first symptoms were right hemiparesis and hemihypoesthesia, followed by headache, dizziness, dysarthria and a general feeling o...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012001000012
更新日期:2012-10-01 00:00:00
abstract::Mirizzi syndrome is estimated to occur in about 1% of cases requiring urgent or elective biliary tract surgery. The key anatomic finding is extrinsic compression of the common duct by a stone located in the gallbladder or cystic duct. Among patients operated on in the last 12 years we have found 77 patients meeting cr...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::We performed cerebral biopsy in 4 patients with AIDS and evidence of expanding intracerebral lesions. Three patients had cerebral toxoplasmosis and the fourth had Chagas encephalitis. No patient developed complications. We feel that cerebral biopsy is warranted and safe in patients with AIDS and intracerebral lesions ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::We report a 16-year-old boy, who suffered a right vent ride penetrating injury caused by a sharp blade that evolved to cardiac tampon. He underwent surgery and was discharged four days later. Thirteen days later, a cardiac murmur was found. An echocardiography showed an aorta-right ventricular fistula. Surgical closur...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000200010
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:In Chile, 40% of deaths due to acute myocardial infarction occur in women. AIM:To assess the presence of cardiovascular risk factors in women with acute coronary syndromes. PATIENTS AND METHODS:Thirty four women aged 46 to 55 years old, admitted to the hospital due to an acute coronary syndrome and 102 age...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:With the aim of contributing to he Healthy Goal 2010 of reducing significantly the prevalence of childhood obesity we developed and implemented during 2003 and 2004, a school-based obesity prevention intervention which included nutrition education and the promotion of physical activity. AIM:To report the re...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:/S0034-98872008000100003
更新日期:2008-01-01 00:00:00
abstract::A 68 years old male presented with right hypochondrium abdominal pain and jaundice with no other clinical finding. CAT Scan and Ultrasonography showed right lobe bile duct dilatation. Magnetic Resonance Cholangiopancreatography gave an outstanding vision of a restricted right lobe bile duct dilatation associated to ch...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Central nervous system damage associated to HTLV-I does not limit itself to the spinal cord, but also involves subcortical structures, producing cognitive impairment and behavioral changes which eventually could conform a new form of subcortical dementia. AIM:To study cognitive changes in patients with HTLV...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::In the last decades there has been an important decrease in infant mobidity and mortality, but these achievements are not equally distributed across the whole population. Children are one of the most susceptible groups due to their unique vulnerabilities to environmental factors. Unhealthy environments, indoor polluti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000100016
更新日期:2009-01-01 00:00:00
abstract::Intracranial sinus thrombosis (1ST) after closed head injury is an uncommon but potentially serious complication. It has no correlation with the severity of the injury. The symptoms and clinical course are highly variable. The most frequent but least specific symptom is severe headache. Cerebral lesions and neurologic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013001200016
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The epidemic of cardiovascular diseases in Chile, requires the development of strategies in health promotion and prevention. AIM:To assess the prevalence of risk factors for chronic non communicable diseases among workers of a financial company in Metropolitan Santiago. MATERIAL AND METHODS:Assessment of 2...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000800008
更新日期:2005-08-01 00:00:00
abstract::Heterozygous familial hypercholesterolemia affects one every 400 individuals, is caused by mutations in the LDL receptor gene and is associated with premature coronary artery disease. Nowadays, LDL cholesterol can be efficiently reduced with the new therapies to reduce blood lipids. We report a female patient who cons...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000200011
更新日期:2007-02-01 00:00:00